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Results for nkx3-2+nkx3.3

Z-value: 0.69

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Transcription factors associated with nkx3-2+nkx3.3

Gene Symbol Gene ID Gene Info
nkx3-2
ENSDARG00000037639 NK3 homeobox 2
nkx3.3
ENSDARG00000069327 NK3 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx3.2dr10_dc_chr14_-_7772_7799-0.401.2e-01Click!

Activity profile of nkx3-2+nkx3.3 motif

Sorted Z-values of nkx3-2+nkx3.3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx3-2+nkx3.3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
KN150589v1_-_5209 2.17 ENSDART00000157761
ENSDART00000157531
elovl7b
ELOVL fatty acid elongase 7b
chr13_+_8508786 2.10 ENSDART00000059321
epcam
epithelial cell adhesion molecule
chr19_+_40558066 1.41 ENSDART00000049968
si:ch211-173p18.3
si:ch211-173p18.3
chr1_-_51075777 1.33 ENSDART00000152745
snrpb2
small nuclear ribonucleoprotein polypeptide B2
chr24_+_21531899 1.15 ENSDART00000158833
si:ch211-140b10.6
si:ch211-140b10.6
chr25_+_19572283 1.14 ENSDART00000073472
zgc:113426
zgc:113426
chr8_-_3974320 1.13 ENSDART00000159895
mtmr3
myotubularin related protein 3
chr24_+_16861121 1.05 ENSDART00000149149
zfx
zinc finger protein, X-linked
chr5_-_26164683 1.00 ENSDART00000140392
rnf181
ring finger protein 181
chr15_+_24741931 0.98 ENSDART00000143137
poldip2
polymerase (DNA-directed), delta interacting protein 2
chr11_-_24300905 0.92 ENSDART00000171004
plekhg5a
pleckstrin homology domain containing, family G (with RhoGef domain) member 5a
chr8_-_37023410 0.92 ENSDART00000111513
si:ch211-218o21.4
si:ch211-218o21.4
chr19_+_20404995 0.89 ENSDART00000142841
osbpl3a
oxysterol binding protein-like 3a
chr15_+_24741620 0.88 ENSDART00000078014
poldip2
polymerase (DNA-directed), delta interacting protein 2
chr21_+_20350152 0.87 ENSDART00000144366
si:dkey-30k6.5
si:dkey-30k6.5
chr21_-_23873574 0.86

chr3_+_62051674 0.86 ENSDART00000113144
zgc:173575
zgc:173575
chr16_-_41718971 0.81

chr5_-_26164728 0.78 ENSDART00000140392
rnf181
ring finger protein 181
chr19_+_20405107 0.74 ENSDART00000151066
osbpl3a
oxysterol binding protein-like 3a
chr16_+_25248840 0.73 ENSDART00000179520
znf576.2
zinc finger protein 576, tandem duplicate 2
chr11_-_24300849 0.67 ENSDART00000171004
plekhg5a
pleckstrin homology domain containing, family G (with RhoGef domain) member 5a
chr7_+_53952626 0.66 ENSDART00000158518
pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr11_-_30388949 0.64 ENSDART00000063775
ENSDARG00000043442
ENSDARG00000043442
chr21_-_2322963 0.61 ENSDART00000160337
si:ch73-299h12.8
si:ch73-299h12.8
chr20_+_49380442 0.61

chr7_+_13573107 0.60 ENSDART00000035067
abhd2a
abhydrolase domain containing 2a
chr25_-_19927083 0.59 ENSDART00000140182
cnot4a
CCR4-NOT transcription complex, subunit 4a
chr6_-_21755349 0.58

chr25_+_16259634 0.58 ENSDART00000136454
tead1a
TEA domain family member 1a
chr10_-_29945491 0.57 ENSDART00000063923
ENSDART00000136264
zpr1
ZPR1 zinc finger
chr16_+_25248941 0.55 ENSDART00000179520
znf576.2
zinc finger protein 576, tandem duplicate 2
chr20_+_6783996 0.55 ENSDART00000169966
igfbp3
insulin-like growth factor binding protein 3
chr6_-_21756853 0.55 ENSDART00000169035
p4hb
prolyl 4-hydroxylase, beta polypeptide
chr5_-_22090338 0.53

chr20_+_30475949 0.51 ENSDART00000148242
rnaseh1
ribonuclease H1
chr1_+_15928362 0.51 ENSDART00000149026
ENSDART00000159785
ENSDART00000164899
pcm1
pericentriolar material 1
chr11_+_30389309 0.50 ENSDART00000087909
tmem246
transmembrane protein 246
chr7_+_53952463 0.48 ENSDART00000158518
pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr13_-_24614604 0.48 ENSDART00000031564
sfr1
SWI5-dependent homologous recombination repair protein 1
chr20_-_23595575 0.46 ENSDART00000174638
anapc4
anaphase promoting complex subunit 4
chr11_-_24300785 0.45 ENSDART00000171004
plekhg5a
pleckstrin homology domain containing, family G (with RhoGef domain) member 5a
chr18_-_20469413 0.45 ENSDART00000012241
kif23
kinesin family member 23
chr18_+_22185449 0.43 ENSDART00000089549
fam65a
family with sequence similarity 65, member A
chr18_-_20469253 0.43 ENSDART00000012241
kif23
kinesin family member 23
chr5_-_22090397 0.43

chr12_-_13690748 0.42 ENSDART00000078021
foxh1
forkhead box H1
chr1_+_28860492 0.42 ENSDART00000154342
ENSDART00000088290
raph1b
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b
chr8_+_25279900 0.41 ENSDART00000114676
gstm.2
glutathione S-transferase mu tandem duplicate 2
chr17_+_24699773 0.40 ENSDART00000007271
mtfr1l
mitochondrial fission regulator 1-like
chr4_+_13932693 0.39 ENSDART00000142466
pphln1
periphilin 1
chr18_+_22185526 0.39 ENSDART00000089549
fam65a
family with sequence similarity 65, member A
chr20_-_8847351 0.39 ENSDART00000141375
CR388209.1
ENSDARG00000091901
chr15_-_24007305 0.38 ENSDART00000002824
appbp2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr22_+_2386743 0.38 ENSDART00000132925
zgc:112977
zgc:112977
chr2_-_40067342 0.38

chr7_-_40307611 0.35 ENSDART00000173926
ENSDART00000010035
dnajb6b
DnaJ (Hsp40) homolog, subfamily B, member 6b
chr11_-_24301030 0.34 ENSDART00000171004
plekhg5a
pleckstrin homology domain containing, family G (with RhoGef domain) member 5a
chr3_+_52951742 0.33

chr11_+_30389137 0.33 ENSDART00000087909
tmem246
transmembrane protein 246
chr10_+_24079292 0.32 ENSDART00000149265
gbe1a
glucan (1,4-alpha-), branching enzyme 1a
chr8_-_48858897 0.32 ENSDART00000122458
ENSDART00000010591
wrap73
WD repeat containing, antisense to TP73
chr11_-_5956333 0.31 ENSDART00000123601
dda1
DET1 and DDB1 associated 1
chr15_-_24007488 0.31 ENSDART00000002824
appbp2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr12_-_13690539 0.30 ENSDART00000078021
foxh1
forkhead box H1
chr16_-_29470491 0.30 ENSDART00000175571
tlr18
toll-like receptor 18
chr15_+_24741845 0.27 ENSDART00000143137
poldip2
polymerase (DNA-directed), delta interacting protein 2
chr4_-_11126782 0.25 ENSDART00000150419
BX784029.1
ENSDARG00000096039
chr18_-_22105000 0.25 ENSDART00000100904
pard6a
par-6 family cell polarity regulator alpha
chr15_-_24007354 0.25 ENSDART00000002824
appbp2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr16_-_22669752 0.24 ENSDART00000134239
si:dkey-238m4.3
si:dkey-238m4.3
chr14_-_1186603 0.22

chr18_-_22185401 0.21

chr7_-_28300008 0.20

chr11_+_6450876 0.20 ENSDART00000170180
CU062501.2
ENSDARG00000103967
chr5_+_26165043 0.20 ENSDART00000144169
si:ch211-102c2.8
si:ch211-102c2.8
chr7_+_71255442 0.19

chr11_-_25495956 0.19 ENSDART00000171935
brpf3a
bromodomain and PHD finger containing, 3a
chr12_+_22459371 0.16 ENSDART00000171725
capgb
capping protein (actin filament), gelsolin-like b
chr3_-_36126124 0.16

chr15_-_38027496 0.16 ENSDART00000157550
si:dkey-238d18.15
si:dkey-238d18.15
chr21_-_1956120 0.15 ENSDART00000165547
CABZ01045062.1
ENSDARG00000100274
chr7_+_13573147 0.13 ENSDART00000035067
abhd2a
abhydrolase domain containing 2a
chr15_-_38027363 0.12 ENSDART00000157550
si:dkey-238d18.15
si:dkey-238d18.15
chr6_-_39201256 0.12 ENSDART00000077938
c1galt1b
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b
chr13_+_24453943 0.09 ENSDART00000057599
fuom
fucose mutarotase
chr24_-_31285903 0.09 ENSDART00000164001
alg14
ALG14, UDP-N-acetylglucosaminyltransferase subunit
chr21_+_1997858 0.07

chr5_-_48377307 0.07 ENSDART00000097452
si:dkey-172m14.1
si:dkey-172m14.1
chr25_+_35762694 0.06 ENSDART00000136456
ENSDART00000175090
CR354435.8
zgc:173552
Histone H3.2
zgc:173552
chr14_-_1186789 0.06

chr14_-_1186858 0.04 ENSDART00000106672
arl9
ADP-ribosylation factor-like 9
chr5_-_22613185 0.03 ENSDART00000051529
uprt
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr15_+_862607 0.03 ENSDART00000174813
si:dkey-7i4.7
si:dkey-7i4.7

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 0.7 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.1 0.9 GO:0040016 embryonic cleavage(GO:0040016)
0.1 0.7 GO:0010159 specification of organ position(GO:0010159)
0.1 0.4 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.1 1.1 GO:0014028 notochord formation(GO:0014028)
0.1 0.5 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 2.2 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 2.1 GO:0048920 posterior lateral line neuromast primordium migration(GO:0048920)
0.1 0.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 2.1 GO:0043534 blood vessel endothelial cell migration(GO:0043534)
0.1 0.5 GO:0045842 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.3 GO:0016203 muscle attachment(GO:0016203)
0.0 0.6 GO:0035329 hippo signaling(GO:0035329)
0.0 0.3 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.4 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.2 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.3 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.9 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0036065 fucosylation(GO:0036065)
0.0 0.3 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 2.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 1.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 0.5 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.1 1.3 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 2.4 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 2.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.5 GO:0034399 anaphase-promoting complex(GO:0005680) nuclear periphery(GO:0034399)
0.0 0.9 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0008126 acetylesterase activity(GO:0008126)
0.1 1.3 GO:0030619 U1 snRNA binding(GO:0030619)
0.1 0.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 1.6 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 2.2 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.5 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.2 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.2 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.7 GO:0046332 SMAD binding(GO:0046332)
0.0 2.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID AURORA B PATHWAY Aurora B signaling
0.0 0.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.2 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 0.9 REACTOME KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.5 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes