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Results for nkx6.3

Z-value: 0.23

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Transcription factors associated with nkx6.3

Gene Symbol Gene ID Gene Info
nkx6.3
ENSDARG00000060529 NK6 homeobox 3

Activity profile of nkx6.3 motif

Sorted Z-values of nkx6.3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx6.3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr16_+_46145286 1.08 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr21_+_28408329 0.65 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr17_+_15425559 0.64 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr10_-_15896595 0.57 ENSDART00000092343
tjp2a
tight junction protein 2a (zona occludens 2)
chr1_+_13779755 0.55

chr20_-_9107294 0.55 ENSDART00000140792
OMA1
OMA1 zinc metallopeptidase
chr14_+_14356509 0.50 ENSDART00000170211
cetn2
centrin, EF-hand protein, 2
chr20_-_48677794 0.46 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr12_-_10372055 0.42 ENSDART00000052001
eef2k
eukaryotic elongation factor 2 kinase
chr5_+_62987426 0.42 ENSDART00000178937
dnm1b
dynamin 1b
chr6_+_3873114 0.42 ENSDART00000159952
sema5bb
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Bb
chr6_-_16590883 0.38 ENSDART00000153552
nomo
nodal modulator
chr25_+_24193604 0.33 ENSDART00000083407
b4galnt4a
beta-1,4-N-acetyl-galactosaminyl transferase 4a
chr17_+_25500291 0.31 ENSDART00000041721
aim1a
crystallin beta-gamma domain containing 1a
chr16_-_12282596 0.29 ENSDART00000110567
clstn3
calsyntenin 3
chr3_-_59884282 0.21 ENSDART00000156597
si:ch73-364h19.1
si:ch73-364h19.1
chr18_-_7184699 0.19 ENSDART00000135587
cd9a
CD9 molecule a
chr9_-_43736549 0.15 ENSDART00000140526
znf385b
zinc finger protein 385B
chr18_+_1353738 0.13 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr2_-_10020770 0.13 ENSDART00000046587
ap2m1a
adaptor-related protein complex 2, mu 1 subunit, a
chr18_+_1353857 0.12 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr3_-_20861178 0.12 ENSDART00000109578
fam117aa
family with sequence similarity 117, member Aa
chr22_-_12905648 0.10 ENSDART00000157820
mfsd6a
major facilitator superfamily domain containing 6a
chr3_+_18645970 0.09 ENSDART00000042368
fahd1
fumarylacetoacetate hydrolase domain containing 1
chr2_+_1881022 0.09 ENSDART00000101038
tmie
transmembrane inner ear
chr9_+_31204464 0.08

chr13_+_22346304 0.06 ENSDART00000137220
ldb3a
LIM domain binding 3a
chr23_-_35691396 0.05 ENSDART00000011004
mfsd5
major facilitator superfamily domain containing 5
chr1_-_18059469 0.05 ENSDART00000140981
tbc1d1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr6_+_54179493 0.02 ENSDART00000056830
pacsin1b
protein kinase C and casein kinase substrate in neurons 1b
chr8_+_8889274 0.01 ENSDART00000142075
pim2
Pim-2 proto-oncogene, serine/threonine kinase
chr10_-_20545884 0.00

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 0.4 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 0.5 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.1 0.6 GO:0044247 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.3 GO:0051965 regulation of synapse assembly(GO:0051963) positive regulation of synapse assembly(GO:0051965)
0.0 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.1 GO:0002478 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.0 0.4 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.5 GO:0007099 centriole replication(GO:0007099)
0.0 0.1 GO:0002093 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0 1.1 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 0.3 GO:0045921 positive regulation of exocytosis(GO:0045921)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 1.1 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.5 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0008184 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.1 0.3 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.1 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes