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Results for nr2f6a+nr2f6b

Z-value: 0.85

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Transcription factors associated with nr2f6a+nr2f6b

Gene Symbol Gene ID Gene Info
nr2f6b
ENSDARG00000003165 nuclear receptor subfamily 2, group F, member 6b
nr2f6a
ENSDARG00000003607 nuclear receptor subfamily 2, group F, member 6a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr2f6bdr10_dc_chr11_+_6118826_61188410.926.3e-07Click!
nr2f6adr10_dc_chr2_+_24718945_247189970.811.7e-04Click!

Activity profile of nr2f6a+nr2f6b motif

Sorted Z-values of nr2f6a+nr2f6b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2f6a+nr2f6b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_25157675 4.70 ENSDART00000136984
fabp2
fatty acid binding protein 2, intestinal
chr13_-_39033893 4.54 ENSDART00000045434
col9a1b
collagen, type IX, alpha 1b
chr4_+_12033088 4.40 ENSDART00000044154
tnnt2c
troponin T2c, cardiac
chr8_+_933677 4.12 ENSDART00000149528
fabp1b.1
fatty acid binding protein 1b, tandem duplicate 1
chr22_+_26543146 3.30

chr4_-_16461748 3.02 ENSDART00000128835
wu:fc23c09
wu:fc23c09
chr23_+_44817648 2.86 ENSDART00000143688
dlg4b
discs, large homolog 4b (Drosophila)
chr6_-_13654186 2.71 ENSDART00000150102
ENSDART00000041269
cryba2a
crystallin, beta A2a
chr3_+_39425125 2.71 ENSDART00000146867
aldoaa
aldolase a, fructose-bisphosphate, a
chr5_-_1325831 2.55

chr15_-_35563367 2.27

chr20_+_2255204 1.95 ENSDART00000137579
si:ch73-18b11.2
si:ch73-18b11.2
chr5_+_49093250 1.87 ENSDART00000133384
nr2f1a
nuclear receptor subfamily 2, group F, member 1a
chr11_+_11217547 1.80 ENSDART00000087105
myom2a
myomesin 2a
chr9_-_41982635 1.76 ENSDART00000144573
obsl1b
obscurin-like 1b
chr5_+_49093134 1.69 ENSDART00000133384
nr2f1a
nuclear receptor subfamily 2, group F, member 1a
chr8_+_29751639 1.56

chr6_+_60060297 1.38 ENSDART00000178621
pck1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr11_+_30482530 1.33 ENSDART00000103270
slc22a7a
solute carrier family 22 (organic anion transporter), member 7a
chr10_-_44180588 1.32 ENSDART00000145404
crybb1
crystallin, beta B1
chr17_+_443558 1.29 ENSDART00000171386
zgc:194887
zgc:194887
chr5_-_47519273 1.16

chr23_+_27985224 1.14 ENSDART00000171859
ENSDARG00000100606
ENSDARG00000100606
chr5_-_21520111 1.09

chr1_+_23093114 1.07

chr7_-_23775835 1.03 ENSDART00000144616
dhrs4
dehydrogenase/reductase (SDR family) member 4
chr25_+_15551474 0.99 ENSDART00000137375
spon1b
spondin 1b
chr13_-_39033849 0.96 ENSDART00000045434
col9a1b
collagen, type IX, alpha 1b
chr8_+_7974156 0.96

chr16_+_55167489 0.95 ENSDART00000149795
nr0b2a
nuclear receptor subfamily 0, group B, member 2a
chr16_-_50024848 0.94 ENSDART00000161782
etfb
electron-transfer-flavoprotein, beta polypeptide
chr13_-_37001997 0.90 ENSDART00000135510
syne2b
spectrin repeat containing, nuclear envelope 2b
chr9_-_48152388 0.88

chr22_-_16971180 0.82 ENSDART00000090237
nfia
nuclear factor I/A
chr10_+_29966252 0.78 ENSDART00000141549
hspa8
heat shock protein 8
chr22_-_16970979 0.70 ENSDART00000090237
nfia
nuclear factor I/A
chr5_-_63031745 0.70

chr22_-_16971035 0.64 ENSDART00000090237
nfia
nuclear factor I/A
chr12_-_31342432 0.64 ENSDART00000148603
acsl5
acyl-CoA synthetase long-chain family member 5
chr6_+_28127444 0.59

chr10_+_29965951 0.55 ENSDART00000116893
SNORD14
Small nucleolar RNA SNORD14
chr6_+_28127514 0.54

chr6_+_42478185 0.53 ENSDART00000150226
mst1ra
macrophage stimulating 1 receptor a
chr13_+_45843567 0.52 ENSDART00000005195
ENSDART00000074547
bsdc1
BSD domain containing 1
chr15_+_6870469 0.52

chr10_+_29966381 0.50 ENSDART00000141549
hspa8
heat shock protein 8
chr13_+_45843396 0.48 ENSDART00000005195
ENSDART00000074547
bsdc1
BSD domain containing 1
chr2_-_49060868 0.46

chr12_+_26579396 0.43 ENSDART00000144355
arhgap12b
Rho GTPase activating protein 12b
chr24_-_21027589 0.35 ENSDART00000154259
atp6v1ab
ATPase, H+ transporting, lysosomal, V1 subunit Ab
chr13_-_37002066 0.34 ENSDART00000135510
syne2b
spectrin repeat containing, nuclear envelope 2b
chr12_+_26579286 0.32 ENSDART00000144355
arhgap12b
Rho GTPase activating protein 12b
chr8_+_39768744 0.29 ENSDART00000018862
hnf1a
HNF1 homeobox a
chr10_+_29966533 0.27 ENSDART00000141549
hspa8
heat shock protein 8
chr4_+_25868802 0.26

chr9_+_33049445 0.24 ENSDART00000168992
si:dkey-145p14.5
si:dkey-145p14.5
KN150421v1_+_14181 0.24

chr1_+_11485480 0.23 ENSDART00000132560
stra6l
STRA6-like
chr1_-_51086211 0.21 ENSDART00000045894
rnaseh2a
ribonuclease H2, subunit A
chr14_-_33468547 0.20

chr11_+_30482504 0.18 ENSDART00000103270
slc22a7a
solute carrier family 22 (organic anion transporter), member 7a
chr25_+_21919595 0.17 ENSDART00000156517
ENSDARG00000062199
ENSDARG00000062199
chr9_+_33049549 0.16 ENSDART00000121751
si:dkey-145p14.5
si:dkey-145p14.5
chr3_+_25868480 0.13 ENSDART00000024316
mcm5
minichromosome maintenance complex component 5
chr14_-_136402 0.12

chr22_-_17570275 0.10 ENSDART00000099056
gpx4a
glutathione peroxidase 4a
chr24_-_7558008 0.08 ENSDART00000093163
galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr23_+_36241656 0.07 ENSDART00000011201
copz1
coatomer protein complex, subunit zeta 1
chr4_-_16461881 0.04 ENSDART00000128835
wu:fc23c09
wu:fc23c09
chr14_-_4117151 0.03

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0072578 neurotransmitter-gated ion channel clustering(GO:0072578)
0.3 1.4 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) glycerol biosynthetic process from pyruvate(GO:0046327) cellular response to dexamethasone stimulus(GO:0071549)
0.3 3.6 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011)
0.2 1.3 GO:1902946 protein localization to early endosome(GO:1902946)
0.2 0.6 GO:2000193 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) regulation of organic acid transport(GO:0032890) positive regulation of organic acid transport(GO:0032892) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transport(GO:1903793) regulation of anion transmembrane transport(GO:1903959) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.1 2.7 GO:0001966 thigmotaxis(GO:0001966) fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 4.4 GO:0006937 regulation of muscle contraction(GO:0006937)
0.1 8.8 GO:0033993 response to lipid(GO:0033993)
0.1 4.0 GO:0007601 visual perception(GO:0007601)
0.1 0.9 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 1.4 GO:0007416 synapse assembly(GO:0007416)
0.0 0.2 GO:0034633 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.0 0.4 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 1.8 GO:0006936 muscle contraction(GO:0006936)
0.0 0.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 1.5 GO:0098656 anion transmembrane transport(GO:0098656)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.2 4.4 GO:0005861 troponin complex(GO:0005861)
0.2 1.8 GO:0031430 M band(GO:0031430)
0.1 5.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 8.8 GO:0005504 fatty acid binding(GO:0005504)
0.5 4.4 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.3 1.4 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.3 2.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 4.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.6 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 3.6 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.9 GO:0009055 electron carrier activity(GO:0009055)
0.0 2.9 GO:0046982 protein heterodimerization activity(GO:0046982)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 1.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.6 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport