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Results for nr3c2

Z-value: 0.44

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Transcription factors associated with nr3c2

Gene Symbol Gene ID Gene Info
nr3c2
ENSDARG00000102082 nuclear receptor subfamily 3, group C, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr3c2dr10_dc_chr1_-_36356001_36356009-0.749.8e-04Click!

Activity profile of nr3c2 motif

Sorted Z-values of nr3c2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nr3c2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_50452131 1.36 ENSDART00000155051
mych
myelocytomatosis oncogene homolog
chr6_-_46740359 1.22 ENSDART00000011970
zgc:66479
zgc:66479
chr20_-_14885629 1.19 ENSDART00000160481
suco
SUN domain containing ossification factor
chr23_+_27777325 1.08 ENSDART00000134008
lmbr1l
limb development membrane protein 1-like
chr20_-_14885599 1.03 ENSDART00000160481
suco
SUN domain containing ossification factor
chr18_-_20619155 0.95 ENSDART00000151864
bcl2l13
BCL2-like 13 (apoptosis facilitator)
chr6_+_41098443 0.93 ENSDART00000143741
fkbp5
FK506 binding protein 5
chr5_-_9036049 0.89 ENSDART00000160079
gak
cyclin G associated kinase
chr6_+_277714 0.86

chr6_+_277946 0.78

chr18_-_20618924 0.73 ENSDART00000090156
ENSDART00000151980
bcl2l13
BCL2-like 13 (apoptosis facilitator)
chr15_+_40340914 0.69 ENSDART00000063779
efhd1
EF-hand domain family, member D1
chr14_-_47125993 0.68 ENSDART00000124925
si:ch211-235e9.8
si:ch211-235e9.8
chr22_-_35003371 0.64 ENSDART00000133537
arhgap19
Rho GTPase activating protein 19
chr5_-_9035789 0.63 ENSDART00000124384
gak
cyclin G associated kinase
chr23_+_27777111 0.62 ENSDART00000134008
lmbr1l
limb development membrane protein 1-like
chr8_+_39734109 0.57 ENSDART00000017153
hps4
Hermansky-Pudlak syndrome 4
chr24_-_23639458 0.54 ENSDART00000090368
sgk3
serum/glucocorticoid regulated kinase family, member 3
chr24_-_23639325 0.49 ENSDART00000090368
sgk3
serum/glucocorticoid regulated kinase family, member 3
chr6_+_50452229 0.45 ENSDART00000155051
mych
myelocytomatosis oncogene homolog
chr19_+_33551956 0.42 ENSDART00000043039
fam84b
family with sequence similarity 84, member B
chr11_+_5883229 0.40 ENSDART00000129663
dazap1
DAZ associated protein 1
chr7_-_51474531 0.39 ENSDART00000083190
hdac8
histone deacetylase 8
chr13_-_33348231 0.39 ENSDART00000160520
mad2l1bp
MAD2L1 binding protein
chr24_-_23639592 0.38 ENSDART00000090368
sgk3
serum/glucocorticoid regulated kinase family, member 3
chr5_-_54169271 0.36 ENSDART00000056213
pik3r1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr3_-_25144722 0.35 ENSDART00000055445
ddx5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr11_+_5883270 0.33 ENSDART00000130768
dazap1
DAZ associated protein 1
chr9_+_24084807 0.31 ENSDART00000131953
cops8
COP9 signalosome subunit 8
chr5_+_18837448 0.31

chr5_+_26205999 0.30 ENSDART00000111019
rabl6b
RAB, member RAS oncogene family-like 6b
chr8_+_21127033 0.30 ENSDART00000033491
spryd4
SPRY domain containing 4
chr18_-_44617805 0.30 ENSDART00000173095
ENSDART00000136420
spred3
sprouty-related, EVH1 domain containing 3
chr8_-_25889113 0.23

chr10_+_29963102 0.20 ENSDART00000168898
hspa8
heat shock protein 8
chr20_+_24047842 0.19 ENSDART00000128616
ENSDART00000144195
casp8ap2
caspase 8 associated protein 2
chr18_-_19501985 0.15 ENSDART00000090413
snapc5
small nuclear RNA activating complex, polypeptide 5
chr6_-_27067072 0.14 ENSDART00000149363
stk25a
serine/threonine kinase 25a
chr25_-_20993910 0.11

chr7_-_16345978 0.10 ENSDART00000128488
e2f8
E2F transcription factor 8
chr5_+_29918213 0.10 ENSDART00000161836
hmbsa
hydroxymethylbilane synthase a
chr10_-_1690504 0.07 ENSDART00000137620
si:ch73-46j18.5
si:ch73-46j18.5
chr24_-_36248243 0.07 ENSDART00000065336
tmem14cb
transmembrane protein 14Cb
chr5_-_9035835 0.04 ENSDART00000160079
gak
cyclin G associated kinase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0072318 clathrin coat disassembly(GO:0072318) vesicle uncoating(GO:0072319)
0.3 2.2 GO:0046850 regulation of bone remodeling(GO:0046850)
0.2 0.6 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.3 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.1 0.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 0.7 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.3 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.2 GO:1902946 protein localization to early endosome(GO:1902946)
0.0 0.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.4 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 1.7 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.3 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.1 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 1.7 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 0.2 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0031085 BLOC-3 complex(GO:0031085)
0.0 0.3 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.7 GO:0034046 poly(G) binding(GO:0034046)
0.1 1.4 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.4 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 1.6 GO:0030276 clathrin binding(GO:0030276)
0.0 0.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription