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Results for nr6a1b

Z-value: 1.13

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Transcription factors associated with nr6a1b

Gene Symbol Gene ID Gene Info
nr6a1b
ENSDARG00000014480 nuclear receptor subfamily 6, group A, member 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr6a1bdr10_dc_chr21_+_8106096_8106185-0.524.1e-02Click!

Activity profile of nr6a1b motif

Sorted Z-values of nr6a1b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of nr6a1b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_30673985 3.85 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr25_+_7318688 3.85 ENSDART00000166496
cat
catalase
chr5_-_36503296 3.54 ENSDART00000149211
il13ra2
interleukin 13 receptor, alpha 2
chr20_+_9141086 3.26 ENSDART00000064144
ENSDART00000144396
bpnt1
bisphosphate nucleotidase 1
chr17_-_45021393 3.19

chr2_-_50491234 3.06 ENSDART00000165678
mcm6l
MCM6 minichromosome maintenance deficient 6, like
chr25_+_17764396 2.78 ENSDART00000146845
pth1a
parathyroid hormone 1a
chr2_-_22631167 2.67 ENSDART00000168653
ENSDART00000158558
fam110b
BX927330.1
family with sequence similarity 110, member B
ENSDARG00000098356
chr7_-_31346802 2.59 ENSDART00000111388
igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr24_-_10253851 2.52 ENSDART00000127568
ENSDART00000106260
ankha
ANKH inorganic pyrophosphate transport regulator a
chr5_-_11471707 2.48 ENSDART00000166285
si:ch73-47f2.1
si:ch73-47f2.1
chr8_-_11806698 2.32 ENSDART00000064017
rapgef1a
Rap guanine nucleotide exchange factor (GEF) 1a
chr4_+_9835529 2.31 ENSDART00000004879
hsp90b1
heat shock protein 90, beta (grp94), member 1
chr7_-_31346844 2.28 ENSDART00000111388
igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr18_+_8954323 2.25 ENSDART00000134827
tmem243a
transmembrane protein 243, mitochondrial a
chr8_+_25126238 2.17 ENSDART00000136505
gnai3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr8_-_11806733 2.07 ENSDART00000064017
rapgef1a
Rap guanine nucleotide exchange factor (GEF) 1a
chr17_+_18217416 1.92 ENSDART00000156616
BX465857.1
ENSDARG00000097921
chr7_-_25252260 1.55 ENSDART00000173657
CU929416.1
ENSDARG00000105572
chr11_+_44909949 1.47 ENSDART00000173116
ENSDART00000167011
ENSDART00000167226
pycr1b
pyrroline-5-carboxylate reductase 1b
chr14_+_29932533 1.46 ENSDART00000017122
asah1a
N-acylsphingosine amidohydrolase (acid ceramidase) 1a
chr15_-_16950049 1.42

chr7_-_31346991 1.38 ENSDART00000111388
igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr10_-_16910230 1.33 ENSDART00000171755
ENSDART00000170953
stoml2
stomatin (EPB72)-like 2
chr9_-_7308912 1.28 ENSDART00000128352
mitd1
MIT, microtubule interacting and transport, domain containing 1
chr2_-_56848527 1.21 ENSDART00000164330
CU634008.1
ENSDARG00000100430
chr1_-_7882397 1.11 ENSDART00000114613
ptcd1
pentatricopeptide repeat domain 1
chr8_-_54103762 1.08

chr23_-_32239909 1.07

chr8_-_54103635 1.00

chr4_+_9835639 1.00 ENSDART00000004879
hsp90b1
heat shock protein 90, beta (grp94), member 1
chr1_+_16834347 0.97 ENSDART00000005593
ENSDART00000140076
casp3a
caspase 3, apoptosis-related cysteine peptidase a
chr18_-_2954175 0.94 ENSDART00000166382
clns1a
chloride channel, nucleotide-sensitive, 1A
chr12_-_18286637 0.93 ENSDART00000078767
tom1l2
target of myb1 like 2 membrane trafficking protein
chr5_-_36503236 0.90 ENSDART00000149211
il13ra2
interleukin 13 receptor, alpha 2
chr2_+_38959335 0.89 ENSDART00000109219
rem2
RAS (RAD and GEM)-like GTP binding 2
chr3_-_9504876 0.88 ENSDART00000128731
rnps1
RNA binding protein S1, serine-rich domain
chr1_+_29058085 0.86 ENSDART00000133905
pcca
propionyl CoA carboxylase, alpha polypeptide
chr11_+_15743714 0.85 ENSDART00000167191
pank4
pantothenate kinase 4
chr13_+_583640 0.84 ENSDART00000109737
cox15
cytochrome c oxidase assembly homolog 15 (yeast)
chr7_-_7533176 0.84 ENSDART00000173376
intu
inturned planar cell polarity protein
chr21_-_32341308 0.83 ENSDART00000112550
mapk9
mitogen-activated protein kinase 9
chr25_+_7318825 0.82 ENSDART00000159748
cat
catalase
KN149698v1_+_88937 0.82 ENSDART00000163341
ENSDARG00000100188
ENSDARG00000100188
chr23_-_533016 0.82 ENSDART00000105316
samhd1
SAM domain and HD domain 1
chr10_-_16910257 0.82 ENSDART00000171755
ENSDART00000170953
stoml2
stomatin (EPB72)-like 2
chr23_-_532974 0.82 ENSDART00000105316
samhd1
SAM domain and HD domain 1
chr2_-_41888389 0.81

chr15_+_26667763 0.77 ENSDART00000155352
ENSDARG00000074561
ENSDARG00000074561
chr13_+_583744 0.75 ENSDART00000109737
cox15
cytochrome c oxidase assembly homolog 15 (yeast)
chr12_+_33294613 0.70 ENSDART00000129458
fasn
fatty acid synthase
chr4_+_9477541 0.68 ENSDART00000030738
lmf2b
lipase maturation factor 2b
chr24_-_24999067 0.66 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr23_-_27647386 0.65

chr19_+_24334831 0.55 ENSDART00000090200
snapin
SNAP-associated protein
chr24_+_24999138 0.55 ENSDART00000152095
ENSDART00000154988
ENSDART00000156098
CR383672.2
ENSDARG00000096452
chr2_+_52639159 0.54 ENSDART00000006216
plpp2a
phospholipid phosphatase 2a
chr15_+_16950144 0.52 ENSDART00000049196
gdpd1
glycerophosphodiester phosphodiesterase domain containing 1
chr17_-_41000670 0.52 ENSDART00000124715
si:dkey-16j16.4
si:dkey-16j16.4
chr12_-_18286666 0.49 ENSDART00000078767
tom1l2
target of myb1 like 2 membrane trafficking protein
chr16_+_27289443 0.49 ENSDART00000059013
sec61b
Sec61 translocon beta subunit
chr16_+_27289472 0.48 ENSDART00000059013
sec61b
Sec61 translocon beta subunit
chr18_-_2954048 0.43 ENSDART00000166382
clns1a
chloride channel, nucleotide-sensitive, 1A
chr5_-_61644464 0.43 ENSDART00000168993
spata22
spermatogenesis associated 22
chr19_-_6503643 0.42

chr11_+_44805115 0.36 ENSDART00000167828
tmc6b
transmembrane channel-like 6b
chr16_+_45726666 0.35 ENSDART00000060809
smg5
SMG5 nonsense mediated mRNA decay factor
chr1_-_45941649 0.33 ENSDART00000148893
cdadc1
cytidine and dCMP deaminase domain containing 1
chr9_+_31469848 0.33

chr3_-_40834641 0.29 ENSDART00000018676
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr16_+_14326410 0.28 ENSDART00000113093
gba
glucosidase, beta, acid
chr19_+_24334731 0.17 ENSDART00000090200
snapin
SNAP-associated protein
chr19_+_5218562 0.14 ENSDART00000151310
si:dkey-89b17.4
si:dkey-89b17.4
chr22_+_18218979 0.14

chr24_-_22369651 0.14

chr3_-_13449591 0.09 ENSDART00000166639
tufm
Tu translation elongation factor, mitochondrial
chr10_+_41237437 0.09 ENSDART00000141657
anxa4
annexin A4
chr6_-_30283366 0.09

chr2_-_59019569 0.03

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.3 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.8 3.3 GO:0035889 otolith tethering(GO:0035889)
0.5 1.6 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) purine deoxyribonucleotide catabolic process(GO:0009155) purine deoxyribonucleoside triphosphate metabolic process(GO:0009215) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.4 4.7 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.3 1.0 GO:0097237 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.3 3.1 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) mitotic DNA replication(GO:1902969)
0.2 1.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.2 3.3 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.1 2.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 0.5 GO:0070291 N-acylethanolamine metabolic process(GO:0070291)
0.1 1.4 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 1.0 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.3 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.1 0.9 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 1.6 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 4.3 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.9 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.7 GO:0032418 lysosome localization(GO:0032418) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 2.8 GO:0009913 epidermal cell differentiation(GO:0009913)
0.0 0.8 GO:0001736 establishment of planar polarity(GO:0001736) establishment of tissue polarity(GO:0007164)
0.0 0.4 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.0 0.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 2.2 GO:0007188 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187) adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.0 0.8 GO:0007254 JNK cascade(GO:0007254)
0.0 0.4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 3.3 GO:0007264 small GTPase mediated signal transduction(GO:0007264)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0034709 methylosome(GO:0034709)
0.3 0.9 GO:0061574 ASAP complex(GO:0061574)
0.2 3.1 GO:0042555 MCM complex(GO:0042555)
0.1 1.0 GO:0005784 Sec61 translocon complex(GO:0005784)
0.1 4.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 0.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 1.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.7 GO:0045180 basal cortex(GO:0045180)
0.0 3.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.8 3.1 GO:1990518 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.5 1.5 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.4 1.5 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
0.3 2.7 GO:0008252 nucleotidase activity(GO:0008252)
0.2 0.8 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 4.7 GO:0004601 peroxidase activity(GO:0004601)
0.1 1.6 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 3.9 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 4.4 GO:0019955 cytokine binding(GO:0019955)
0.1 0.9 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.3 GO:0004348 glucosylceramidase activity(GO:0004348)
0.1 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.7 GO:0016421 CoA carboxylase activity(GO:0016421)
0.1 1.0 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1 0.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 2.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 2.8 GO:0005179 hormone activity(GO:0005179)
0.1 0.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.5 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 1.1 GO:0000049 tRNA binding(GO:0000049)
0.0 1.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 1.4 GO:0030276 clathrin binding(GO:0030276)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.3 3.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3 2.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 0.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 3.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 4.2 PID FOXO PATHWAY FoxO family signaling
0.0 0.7 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.8 3.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.7 3.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.4 2.2 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.3 3.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.5 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.9 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.4 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.7 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.4 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 1.0 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis