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Results for olig1_olig2+olig4
Z-value: 1.55
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Transcription factors associated with olig1_olig2+olig4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000040948 | oligodendrocyte transcription factor 1 | |
| ENSDARG00000040946 | oligodendrocyte lineage transcription factor 2 | |
| ENSDARG00000052610 | oligodendrocyte transcription factor 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| olig2 | dr10_dc_chr9_-_32942783_32942789 | -0.90 | 1.8e-06 | Click! |
| olig4 | dr10_dc_chr13_+_45830454_45830473 | -0.87 | 9.3e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of olig1_olig2+olig4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_27394361 Show fit | 6.00 |
ENSDART00000132740
|
protein phosphatase 3, catalytic subunit, gamma isozyme, a |
|
| chr19_-_27093095 Show fit | 5.67 |
|
|
|
| chr2_-_39070943 Show fit | 5.54 |
ENSDART00000129963
|
retinol binding protein 1b, cellular |
|
| chr18_-_40718244 Show fit | 4.10 |
ENSDART00000077577
|
si:ch211-132b12.8 |
|
| chr20_+_34021257 Show fit | 3.87 |
ENSDART00000146292
|
LIM homeobox transcription factor 1, alpha |
|
| chr9_+_28293831 Show fit | 3.85 |
ENSDART00000101338
|
isocitrate dehydrogenase 1 (NADP+), soluble |
|
| chr19_+_41419851 Show fit | 3.76 |
ENSDART00000138555
ENSDART00000158587 ENSDART00000049842 |
CAS1 domain containing 1 |
|
| chr15_+_14656797 Show fit | 3.57 |
ENSDART00000162350
|
F-box protein 46 |
|
| chr18_+_284210 Show fit | 3.54 |
ENSDART00000158040
|
La ribonucleoprotein domain family, member 6 |
|
| chr5_-_27394324 Show fit | 3.53 |
ENSDART00000132740
|
protein phosphatase 3, catalytic subunit, gamma isozyme, a |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.1 | 4.5 | GO:1904029 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.0 | 4.4 | GO:0051603 | proteolysis involved in cellular protein catabolic process(GO:0051603) |
| 0.1 | 4.0 | GO:1901800 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800) |
| 0.0 | 4.0 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 1.3 | 3.9 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.6 | 3.7 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 0.2 | 3.6 | GO:0072091 | regulation of stem cell proliferation(GO:0072091) |
| 0.9 | 3.5 | GO:0032732 | positive regulation of interleukin-1 production(GO:0032732) |
| 0.7 | 3.5 | GO:0030219 | megakaryocyte differentiation(GO:0030219) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 9.9 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 8.9 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.2 | 5.2 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 4.6 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 4.6 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.7 | 4.5 | GO:0097134 | cyclin E1-CDK2 complex(GO:0097134) |
| 0.3 | 3.6 | GO:0031332 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.4 | 3.5 | GO:0005921 | gap junction(GO:0005921) |
| 0.1 | 3.0 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 3.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 9.9 | GO:0033192 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.2 | 7.1 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 6.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 6.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.5 | 5.8 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.2 | 4.7 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 4.7 | GO:0019783 | ubiquitin-like protein-specific protease activity(GO:0019783) |
| 1.3 | 3.9 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 0.6 | 3.6 | GO:0090624 | endoribonuclease activity, cleaving miRNA-paired mRNA(GO:0090624) |
| 0.4 | 3.5 | GO:0022829 | wide pore channel activity(GO:0022829) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.8 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.3 | 4.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 3.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 2.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 2.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 2.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 2.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 2.0 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 1.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.8 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.3 | 3.9 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.2 | 3.6 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 3.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 3.1 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.1 | 3.0 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 3.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 2.9 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.1 | 2.7 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.2 | 2.5 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |