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Results for onecut1
Z-value: 3.65
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Transcription factors associated with onecut1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| onecut1 | dr10_dc_chr18_+_38773971_38774018 | 0.87 | 9.3e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of onecut1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_60973097 Show fit | 12.05 |
ENSDART00000055062
|
parvalbumin 1 |
|
| chr19_-_8961733 Show fit | 10.73 |
ENSDART00000039629
|
cugbp, Elav-like family member 3a |
|
| chr13_+_24271932 Show fit | 10.03 |
ENSDART00000043002
|
RAB1A, member RAS oncogene family b |
|
| chr19_-_6384776 Show fit | 9.06 |
|
|
|
| chr14_-_25688444 Show fit | 8.59 |
ENSDART00000172909
|
antioxidant 1 copper chaperone |
|
| chr1_-_9387290 Show fit | 8.09 |
ENSDART00000135522
ENSDART00000135676 |
fibrinogen alpha chain |
|
| chr22_-_15567180 Show fit | 7.78 |
ENSDART00000123125
|
tropomyosin 4a |
|
| chr10_+_1812271 Show fit | 7.67 |
|
|
|
| chr7_+_57423271 Show fit | 7.65 |
ENSDART00000056466
|
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 |
|
| chr10_+_42530040 Show fit | 7.56 |
ENSDART00000025691
|
drebrin-like a |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.5 | GO:0055085 | transmembrane transport(GO:0055085) |
| 3.2 | 12.7 | GO:0086065 | atrial cardiac muscle cell action potential(GO:0086014) cell-cell signaling involved in cardiac conduction(GO:0086019) atrial cardiac muscle cell to AV node cell signaling(GO:0086026) cell communication involved in cardiac conduction(GO:0086065) atrial cardiac muscle cell to AV node cell communication(GO:0086066) |
| 0.0 | 11.1 | GO:0009952 | anterior/posterior pattern specification(GO:0009952) |
| 0.7 | 10.7 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.4 | 8.9 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.7 | 8.7 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 1.2 | 8.6 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) |
| 0.1 | 8.5 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.7 | 8.1 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 0.8 | 7.8 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation(GO:0033138) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 20.5 | GO:0005829 | cytosol(GO:0005829) |
| 0.0 | 13.7 | GO:0000785 | chromatin(GO:0000785) |
| 0.6 | 11.1 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 11.0 | GO:1990904 | ribonucleoprotein complex(GO:1990904) |
| 1.3 | 10.6 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 8.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 2.7 | 8.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 7.9 | GO:0043005 | neuron projection(GO:0043005) |
| 0.6 | 7.5 | GO:0043209 | myelin sheath(GO:0043209) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.5 | GO:1990837 | sequence-specific double-stranded DNA binding(GO:1990837) |
| 0.1 | 28.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 20.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 18.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 17.3 | GO:0005102 | receptor binding(GO:0005102) |
| 0.2 | 12.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 2.1 | 10.3 | GO:0004639 | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639) |
| 0.0 | 10.2 | GO:0022857 | transmembrane transporter activity(GO:0022857) |
| 0.3 | 8.9 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.2 | 8.7 | GO:0005267 | potassium channel activity(GO:0005267) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 8.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 7.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 7.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 4.8 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.2 | 4.1 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 4.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 3.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.5 | 3.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.8 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 1.3 | 8.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.6 | 5.2 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 4.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 4.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.3 | 4.1 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.3 | 3.7 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.4 | 3.2 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 3.1 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.3 | 2.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |