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Results for onecut1

Z-value: 3.65

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Transcription factors associated with onecut1

Gene Symbol Gene ID Gene Info
onecut1
ENSDARG00000007982 one cut homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
onecut1dr10_dc_chr18_+_38773971_387740180.879.3e-06Click!

Activity profile of onecut1 motif

Sorted Z-values of onecut1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of onecut1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_60973097 12.05 ENSDART00000055062
pvalb1
parvalbumin 1
chr19_-_8961733 10.73 ENSDART00000039629
celf3a
cugbp, Elav-like family member 3a
chr13_+_24271932 10.03 ENSDART00000043002
rab1ab
RAB1A, member RAS oncogene family b
chr19_-_6384776 9.06

chr14_-_25688444 8.59 ENSDART00000172909
atox1
antioxidant 1 copper chaperone
chr1_-_9387290 8.09 ENSDART00000135522
ENSDART00000135676
fga
fibrinogen alpha chain
chr22_-_15567180 7.78 ENSDART00000123125
tpm4a
tropomyosin 4a
chr10_+_1812271 7.67

chr7_+_57423271 7.65 ENSDART00000056466
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr10_+_42530040 7.56 ENSDART00000025691
dbnla
drebrin-like a
chr10_-_24422257 7.47 ENSDART00000141332
ENSDART00000100772
slc43a2b
solute carrier family 43 (amino acid system L transporter), member 2b
chr17_-_9869142 7.41 ENSDART00000008355
cfl2
cofilin 2 (muscle)
chr11_-_26428979 7.35 ENSDART00000111539
efcc1
EF-hand and coiled-coil domain containing 1
chr12_-_25796463 7.18 ENSDART00000152983
si:dkey-193p11.2
si:dkey-193p11.2
chr10_+_10843384 7.10 ENSDART00000130283
ambp
alpha-1-microglobulin/bikunin precursor
chr16_+_5284778 7.08 ENSDART00000156685
ENSDART00000156765
soga3a
soga3a
SOGA family member 3a
SOGA family member 3a
chr11_-_41357639 7.01 ENSDART00000055709
her2
hairy-related 2
chr11_+_7148830 7.00 ENSDART00000035560
tmem38a
transmembrane protein 38A
chr1_-_24747855 6.95 ENSDART00000111686
fhdc1
FH2 domain containing 1
chr19_+_31046291 6.89 ENSDART00000052124
fam49al
family with sequence similarity 49, member A-like
chr18_+_5899355 6.82

chr16_-_24602919 6.79 ENSDART00000147478
cadm4
cell adhesion molecule 4
chr16_+_24045774 6.78 ENSDART00000133484
apoeb
apolipoprotein Eb
chr23_-_31446156 6.73 ENSDART00000053367
hmgn3
high mobility group nucleosomal binding domain 3
chr19_-_22182031 6.63 ENSDART00000104279
znf516
zinc finger protein 516
chr3_+_23561215 6.57 ENSDART00000078453
hoxb7a
homeobox B7a
chr23_+_21610798 6.49 ENSDART00000111966
arhgef10lb
Rho guanine nucleotide exchange factor (GEF) 10-like b
chr21_-_41445163 6.44 ENSDART00000170457
hmp19
HMP19 protein
chr21_-_35806638 6.24 ENSDART00000172245
sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr1_+_16681778 6.23

chr21_+_17731439 6.13 ENSDART00000124173
rxraa
retinoid X receptor, alpha a
chr15_-_26619404 5.76 ENSDART00000150152
serpinf2b
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr10_+_10252074 5.76 ENSDART00000144214
sh2d3ca
SH2 domain containing 3Ca
chr17_-_12343975 5.65 ENSDART00000149551
emilin1b
elastin microfibril interfacer 1b
chr15_+_21231406 5.59 ENSDART00000038499
CR626907.1
ENSDARG00000077872
chr6_-_586251 5.59 ENSDART00000148867
ENSDART00000149414
ENSDART00000149248
lgals2b
lectin, galactoside-binding, soluble, 2b
chr14_-_23784679 5.58 ENSDART00000158576
msx2a
muscle segment homeobox 2a
chr1_-_44009572 5.56 ENSDART00000144900
ENSDARG00000079632
ENSDARG00000079632
chr14_-_2682064 5.53 ENSDART00000161677
si:dkey-201i24.6
si:dkey-201i24.6
chr8_-_16223730 5.37 ENSDART00000057590
dmrta2
DMRT-like family A2
chr2_-_23516930 5.36 ENSDART00000165355
prrx1a
paired related homeobox 1a
chr17_+_32550616 5.28

chr15_-_24934442 5.27 ENSDART00000127047
tusc5a
tumor suppressor candidate 5a
chr24_-_32750010 5.23 ENSDART00000038364
ca2
carbonic anhydrase II
chr5_+_18740715 5.15 ENSDART00000089173
atp8b5a
ATPase, class I, type 8B, member 5a
chr12_-_37921731 5.15

chr3_-_16100715 5.01 ENSDART00000146699
bckdhbl
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr19_-_7501777 4.98 ENSDART00000081741
rab25a
RAB25, member RAS oncogene family a
chr20_-_54192057 4.95 ENSDART00000023550
hsp90aa1.2
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2
chr20_+_3095763 4.92 ENSDART00000133435
CEP170B
centrosomal protein 170B
chr15_+_28269289 4.90 ENSDART00000077736
vtna
vitronectin a
chr20_-_25727145 4.83 ENSDART00000126716
paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr17_-_42288726 4.79 ENSDART00000154423
CR628331.1
ENSDARG00000097567
chr6_-_32362232 4.78 ENSDART00000140004
angptl3
angiopoietin-like 3
chr21_-_27845076 4.78 ENSDART00000132583
nrxn2a
neurexin 2a
chr25_+_31769985 4.77

chr25_+_34340139 4.77 ENSDART00000061996
tmem231
transmembrane protein 231
chr20_-_21031504 4.75 ENSDART00000152726
btbd6b
BTB (POZ) domain containing 6b
chr11_-_29410649 4.71 ENSDART00000125753
rpl22
ribosomal protein L22
chr8_-_19250414 4.70 ENSDART00000100473
ENSDARG00000013711
ENSDARG00000013711
chr20_-_25726868 4.69 ENSDART00000126716
paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr15_+_14918849 4.68 ENSDART00000164119
diabloa
diablo, IAP-binding mitochondrial protein a
chr9_-_24398363 4.68 ENSDART00000134599
zgc:153521
zgc:153521
chr5_+_36093701 4.62 ENSDART00000019259
dlb
deltaB
chr7_-_72278552 4.59 ENSDART00000168532
HECTD4
HECT domain E3 ubiquitin protein ligase 4
chr3_+_23561306 4.57 ENSDART00000078453
hoxb7a
homeobox B7a
chr7_+_32451041 4.47 ENSDART00000126565
si:ch211-150g13.3
si:ch211-150g13.3
chr2_-_23517033 4.45 ENSDART00000041365
prrx1a
paired related homeobox 1a
chr3_-_23277066 4.40 ENSDART00000155658
rapgefl1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr25_+_23494481 4.35 ENSDART00000089199
cpt1ab
carnitine palmitoyltransferase 1Ab (liver)
chr2_+_2374651 4.30 ENSDART00000132500
c8a
complement component 8, alpha polypeptide
chr6_+_13833991 4.23

chr1_-_44002772 4.14 ENSDART00000133210
si:dkey-28b4.8
si:dkey-28b4.8
chr2_+_52473102 4.09 ENSDART00000146418
shda
Src homology 2 domain containing transforming protein D, a
chr5_-_49091552 4.07 ENSDART00000140464
CR751602.1
ENSDARG00000094128
chr25_+_4909062 4.07 ENSDART00000170049
parvb
parvin, beta
chr5_-_62821458 4.06 ENSDART00000022348
prdm12b
PR domain containing 12b
KN150670v1_-_61400 3.99

chr15_-_32738134 3.93 ENSDART00000164670
frem2b
Fras1 related extracellular matrix protein 2b
chr7_-_28339836 3.83 ENSDART00000054366
scube2
signal peptide, CUB domain, EGF-like 2
chr8_+_46210023 3.79 ENSDART00000159740
angptl7
angiopoietin-like 7
chr13_+_28286826 3.73 ENSDART00000043658
slc2a15a
solute carrier family 2 (facilitated glucose transporter), member 15a
chr25_-_23949331 3.73 ENSDART00000047569
igf2b
insulin-like growth factor 2b
chr7_+_36280563 3.64 ENSDART00000027807
chd9
chromodomain helicase DNA binding protein 9
chr20_+_7337738 3.58 ENSDART00000165596
dsg2.1
desmoglein 2, tandem duplicate 1
chr22_+_16471319 3.58 ENSDART00000014330
ier5
immediate early response 5
chr1_+_23093475 3.58

chr5_-_12186795 3.55

chr19_+_27895343 3.51 ENSDART00000049368
atat1
alpha tubulin acetyltransferase 1
chr15_-_25457193 3.50 ENSDART00000124205
si:dkey-54n8.4
si:dkey-54n8.4
chr21_+_142265 3.48

chr5_+_54956286 3.48 ENSDART00000168908
ENSDART00000161412
ntrk2b
neurotrophic tyrosine kinase, receptor, type 2b
chr12_-_34612821 3.46 ENSDART00000153272
bahcc1b
BAH domain and coiled-coil containing 1b
chr6_+_8956398 3.44 ENSDART00000150916
ENSDARG00000071159
ENSDARG00000071159
chr23_+_11350727 3.39

chr11_-_21422588 3.32

chr14_-_32553399 3.31 ENSDART00000169380
slc25a43
solute carrier family 25, member 43
chr5_+_296856 3.31

chr1_-_51862897 3.30 ENSDART00000136469
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr5_+_71611136 3.29 ENSDART00000163906
CABZ01115396.1
ENSDARG00000099805
chr6_+_52262973 3.23 ENSDART00000014819
esyt1b
extended synaptotagmin-like protein 1b
chr25_-_8475902 3.21 ENSDART00000176751
CU929451.3
ENSDARG00000107886
chr13_+_16390948 3.20 ENSDART00000122557
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr21_+_9483423 3.20 ENSDART00000162834
mapk10
mitogen-activated protein kinase 10
chr21_-_35646193 3.19

chr5_-_29150278 3.18 ENSDART00000051474
barhl1a
BarH-like homeobox 1a
chr20_-_25582221 3.17 ENSDART00000157559
si:dkey-183n20.15
si:dkey-183n20.15
chr9_+_49961721 3.16

chr25_-_10992022 3.15 ENSDART00000154748
sv2bb
synaptic vesicle glycoprotein 2Bb
chr19_+_19939410 3.14

chr3_+_19582280 3.13 ENSDART00000109409
mrc2
mannose receptor, C type 2
chr19_-_31785558 3.09 ENSDART00000046609
scin
scinderin
chr17_-_28690941 3.00 ENSDART00000135752
ap4s1
adaptor-related protein complex 4, sigma 1 subunit
chr7_-_57727148 2.99

chr11_+_42821961 2.99 ENSDART00000013642
foxg1b
forkhead box G1b
chr3_-_45237479 2.99 ENSDART00000160923
si:ch73-167f10.1
si:ch73-167f10.1
chr3_-_60522527 2.96 ENSDART00000166334
srsf2b
serine/arginine-rich splicing factor 2b
chr2_-_1752776 2.96 ENSDART00000126566
slc22a23
solute carrier family 22, member 23
chr4_+_20596509 2.94

chr1_+_15827083 2.93

chr3_-_61889061 2.92 ENSDART00000097345
TOM1L2
target of myb1 like 2 membrane trafficking protein
chr23_-_29630277 2.92 ENSDART00000138021
rbp7a
retinol binding protein 7a, cellular
chr3_-_43730993 2.90

chr5_-_54383466 2.88

chr5_+_3172101 2.87 ENSDART00000080486
ywhag1
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1
chr10_+_1610794 2.84 ENSDART00000060946
sgsm1b
small G protein signaling modulator 1b
chr15_-_1042743 2.83 ENSDART00000154195
si:dkey-77f5.6
si:dkey-77f5.6
chr19_+_19031013 2.80 ENSDART00000160992
fkbp10a
FK506 binding protein 10a
chr24_+_24316486 2.79 ENSDART00000147658
bhlhe22
basic helix-loop-helix family, member e22
chr4_-_17960341 2.79 ENSDART00000144956
anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr14_+_26247858 2.78 ENSDART00000105932
si:dkeyp-110e4.11
si:dkeyp-110e4.11
chr13_+_42280697 2.78 ENSDART00000084354
cpeb3
cytoplasmic polyadenylation element binding protein 3
chr19_+_24340673 2.77

chr19_+_26065401 2.73 ENSDART00000146947
tac1
tachykinin 1
chr1_-_50947523 2.72 ENSDART00000100869
ppp3r1b
protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b
chr12_-_34612758 2.72 ENSDART00000153272
bahcc1b
BAH domain and coiled-coil containing 1b
chr2_+_26585236 2.71 ENSDART00000129895
palm1b
paralemmin 1b
chr13_+_38176374 2.68 ENSDART00000145777
adgrb3
adhesion G protein-coupled receptor B3
chr22_-_16468179 2.64 ENSDART00000062727
stx6
syntaxin 6
chr5_-_33169062 2.60 ENSDART00000133504
dab2ipb
DAB2 interacting protein b
chr16_-_11028959 2.60

chr24_-_23155932 2.60

chr19_+_12066023 2.58 ENSDART00000130537
spag1a
sperm associated antigen 1a
chr1_+_28955739 2.58 ENSDART00000054059
cpb2
carboxypeptidase B2 (plasma)
chr20_-_54192092 2.54 ENSDART00000023550
hsp90aa1.2
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2
chr16_-_25691856 2.53 ENSDART00000077447
ENSDART00000131528
zgc:110410
zgc:110410
chr1_+_44009649 2.52 ENSDART00000131296
ssrp1b
structure specific recognition protein 1b
chr15_-_34198695 2.51 ENSDART00000170130
ENSDARG00000101697
ENSDARG00000101697
chr10_+_877701 2.51 ENSDART00000176303
FO704646.1
ENSDARG00000107355
chr18_+_5707066 2.49

chr2_-_52202004 2.49 ENSDART00000165350
BX908782.1
ENSDARG00000098957
chr24_-_26157275 2.44 ENSDART00000130696
myeov2
myeloma overexpressed 2
chr2_+_45447068 2.40 ENSDART00000083957
ENSDART00000160867
camsap2b
calmodulin regulated spectrin-associated protein family, member 2b
chr12_+_22137783 2.39 ENSDART00000131175
wnt3
wingless-type MMTV integration site family, member 3
chr7_-_68229145 2.38

chr2_-_1753058 2.37 ENSDART00000126566
slc22a23
solute carrier family 22, member 23
chr15_+_21399127 2.37 ENSDART00000154914
BX663520.1
ENSDARG00000097950
chr5_-_18895882 2.32 ENSDART00000008994
foxn4
forkhead box N4
chr25_+_4711457 2.32 ENSDART00000168016
gnb5a
guanine nucleotide binding protein (G protein), beta 5a
chr10_+_877636 2.31 ENSDART00000176303
FO704646.1
ENSDARG00000107355
chr6_-_40101104 2.31 ENSDART00000017402
ip6k2b
inositol hexakisphosphate kinase 2b
chr8_+_23704956 2.31 ENSDART00000132734
mkrn4
makorin, ring finger protein, 4
chr12_-_13848616 2.28 ENSDART00000110503
adam11
ADAM metallopeptidase domain 11
chr15_-_34198725 2.27 ENSDART00000170130
ENSDARG00000101697
ENSDARG00000101697
chr3_-_36940675 2.26 ENSDART00000026701
tubg1
tubulin, gamma 1
chr11_+_1495509 2.26 ENSDART00000139079
srsf6b
serine/arginine-rich splicing factor 6b
chr3_-_28534446 2.24 ENSDART00000151670
fbxl16
F-box and leucine-rich repeat protein 16
chr7_+_69664384 2.24 ENSDART00000058763
sec24d
SEC24 homolog D, COPII coat complex component
chr3_+_38651644 2.20 ENSDART00000083394
si:dkey-106c17.3
si:dkey-106c17.3
chr8_+_25984588 2.18

chr15_+_21399299 2.17 ENSDART00000154914
BX663520.1
ENSDARG00000097950
chr15_-_14439483 2.16 ENSDART00000160675
dpf1
D4, zinc and double PHD fingers family 1
chr5_-_13335073 2.14 ENSDART00000114841
add2
adducin 2 (beta)
chr19_+_27895558 2.13 ENSDART00000103922
atat1
alpha tubulin acetyltransferase 1
chr9_-_30073641 2.12

chr10_-_23130343 2.11 ENSDART00000148333
nle1
notchless homolog 1 (Drosophila)
chr17_-_35128694 2.10 ENSDART00000146590
ENSDART00000152035
mboat2a
membrane bound O-acyltransferase domain containing 2a
chr18_+_9646128 2.10 ENSDART00000160284
pclob
piccolo presynaptic cytomatrix protein b
chr7_-_20201358 2.09 ENSDART00000174001
ntn5
netrin 5
chr13_+_16391195 2.07 ENSDART00000122557
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr10_+_10252239 2.05 ENSDART00000144214
sh2d3ca
SH2 domain containing 3Ca
KN150531v1_+_12583 2.03

chr2_-_26987186 2.02 ENSDART00000132854
u2surp
U2 snRNP-associated SURP domain containing
chr2_-_57133471 1.99

chr23_-_29330879 1.98 ENSDART00000142658
CR677617.1
ENSDARG00000093492
chr13_-_23139971 1.96 ENSDART00000132828
si:dkey-103j14.5
si:dkey-103j14.5
chr10_+_37193690 1.96 ENSDART00000114909
cuedc1a
CUE domain containing 1a
chr22_-_62082 1.95 ENSDART00000166010
ENSDART00000125700
mrpl20
mitochondrial ribosomal protein L20
chr14_-_7579282 1.95 ENSDART00000029981
ppp3cb
protein phosphatase 3, catalytic subunit, beta isozyme
chr3_-_43730944 1.92

chr5_+_26217533 1.91

chr7_-_23492042 1.89

chr24_-_21529774 1.87 ENSDART00000123216
lnx2a
ligand of numb-protein X 2a
chr1_+_11541423 1.86 ENSDART00000170760
tmod1
tropomodulin 1
chr24_-_25545773 1.85 ENSDART00000015391
chrnd
cholinergic receptor, nicotinic, delta (muscle)
chr23_+_29431173 1.84 ENSDART00000027255
tardbpl
TAR DNA binding protein, like
chr7_-_20201693 1.84 ENSDART00000174001
ntn5
netrin 5
chr3_-_41649319 1.82 ENSDART00000049687
grifin
galectin-related inter-fiber protein
chr17_-_35128752 1.82 ENSDART00000146590
ENSDART00000152035
mboat2a
membrane bound O-acyltransferase domain containing 2a
chr16_+_54729975 1.80

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 12.7 GO:0086065 atrial cardiac muscle cell action potential(GO:0086014) cell-cell signaling involved in cardiac conduction(GO:0086019) atrial cardiac muscle cell to AV node cell signaling(GO:0086026) cell communication involved in cardiac conduction(GO:0086065) atrial cardiac muscle cell to AV node cell communication(GO:0086066)
2.2 6.7 GO:0071831 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
1.9 7.6 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
1.9 7.4 GO:0030043 actin filament fragmentation(GO:0030043)
1.7 5.2 GO:0015670 carbon dioxide transport(GO:0015670)
1.6 4.8 GO:0055091 negative regulation of phospholipase activity(GO:0010519) phospholipid homeostasis(GO:0055091)
1.5 7.5 GO:0046677 response to antibiotic(GO:0046677)
1.4 4.1 GO:0031062 positive regulation of histone methylation(GO:0031062)
1.3 5.3 GO:0010996 response to auditory stimulus(GO:0010996)
1.2 8.6 GO:0006878 cellular copper ion homeostasis(GO:0006878)
1.2 7.0 GO:0007405 neuroblast proliferation(GO:0007405)
1.2 3.5 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
1.1 6.8 GO:0003232 bulbus arteriosus development(GO:0003232)
1.1 6.7 GO:0071333 cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.9 4.3 GO:0002455 humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)
0.9 2.6 GO:0042730 fibrinolysis(GO:0042730)
0.8 7.8 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.7 2.2 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.7 8.1 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.7 4.4 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.7 10.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.7 5.6 GO:0048798 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.7 8.7 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.6 7.1 GO:0018298 protein-chromophore linkage(GO:0018298)
0.6 6.5 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.6 4.7 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.6 4.0 GO:0035881 amacrine cell differentiation(GO:0035881) ventral spinal cord interneuron fate commitment(GO:0060579)
0.5 2.5 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.5 3.8 GO:0042694 muscle cell fate specification(GO:0042694)
0.5 1.4 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.4 2.6 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.4 3.7 GO:0070665 positive regulation of mononuclear cell proliferation(GO:0032946) positive regulation of T cell proliferation(GO:0042102) positive regulation of lymphocyte proliferation(GO:0050671) positive regulation of leukocyte proliferation(GO:0070665)
0.4 2.0 GO:0006528 asparagine metabolic process(GO:0006528)
0.4 5.0 GO:0045332 phospholipid translocation(GO:0045332)
0.4 8.9 GO:0015804 neutral amino acid transport(GO:0015804)
0.4 6.1 GO:0032526 response to retinoic acid(GO:0032526)
0.3 2.1 GO:1990709 presynaptic active zone organization(GO:1990709)
0.3 1.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 5.4 GO:0021984 adenohypophysis development(GO:0021984)
0.3 3.7 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.3 1.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.3 1.8 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.3 1.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.3 2.8 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.3 6.9 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.2 2.4 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.2 4.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 2.7 GO:0042551 neuron maturation(GO:0042551)
0.2 1.4 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.2 1.2 GO:0051965 regulation of synapse assembly(GO:0051963) positive regulation of synapse assembly(GO:0051965)
0.2 0.8 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.2 5.2 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.2 1.6 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.2 4.1 GO:0030032 lamellipodium assembly(GO:0030032) lamellipodium organization(GO:0097581)
0.2 2.6 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 4.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 2.8 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 1.7 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.1 2.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 8.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 0.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.7 GO:0099638 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.1 5.8 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 2.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.6 GO:0060078 regulation of postsynaptic membrane potential(GO:0060078)
0.1 2.3 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 2.9 GO:0060972 left/right pattern formation(GO:0060972)
0.1 7.0 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 2.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.9 GO:0048669 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.1 3.2 GO:0048484 enteric nervous system development(GO:0048484)
0.1 5.3 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.1 0.5 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 0.5 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.1 1.2 GO:0015914 phospholipid transport(GO:0015914)
0.1 5.6 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.1 2.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 5.6 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 1.9 GO:0042391 regulation of membrane potential(GO:0042391)
0.0 4.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 1.9 GO:0035272 exocrine pancreas development(GO:0031017) exocrine system development(GO:0035272)
0.0 2.5 GO:0032880 regulation of protein localization(GO:0032880)
0.0 2.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 11.1 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 2.3 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 3.2 GO:0006869 lipid transport(GO:0006869)
0.0 0.4 GO:0006448 regulation of translational elongation(GO:0006448)
0.0 0.7 GO:0045766 positive regulation of angiogenesis(GO:0045766)
0.0 0.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 2.2 GO:0010506 regulation of autophagy(GO:0010506)
0.0 14.5 GO:0055085 transmembrane transport(GO:0055085)
0.0 1.6 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.3 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 2.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.8 GO:0001525 angiogenesis(GO:0001525)
0.0 2.4 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 0.2 GO:0048899 anterior lateral line development(GO:0048899)
0.0 0.2 GO:0021794 thalamus development(GO:0021794)
0.0 4.6 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.0 1.6 GO:0071772 BMP signaling pathway(GO:0030509) response to BMP(GO:0071772) cellular response to BMP stimulus(GO:0071773)
0.0 2.3 GO:0006887 exocytosis(GO:0006887)
0.0 2.5 GO:0006955 immune response(GO:0006955)
0.0 0.6 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 1.3 GO:0030258 lipid modification(GO:0030258)
0.0 0.4 GO:1901214 regulation of neuron death(GO:1901214)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.1 GO:0005577 fibrinogen complex(GO:0005577)
1.7 6.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
1.3 10.6 GO:0002102 podosome(GO:0002102)
0.9 5.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.9 4.3 GO:0005579 membrane attack complex(GO:0005579)
0.6 2.6 GO:0043083 synaptic cleft(GO:0043083)
0.6 7.5 GO:0043209 myelin sheath(GO:0043209)
0.6 11.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.5 3.7 GO:0005955 calcineurin complex(GO:0005955)
0.5 6.6 GO:0060170 ciliary membrane(GO:0060170)
0.4 2.1 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.3 2.4 GO:0036449 microtubule minus-end(GO:0036449)
0.3 2.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 2.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 1.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 3.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 0.9 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 0.4 GO:0042583 chromaffin granule(GO:0042583)
0.1 5.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 2.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.6 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.6 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 8.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 3.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 4.1 GO:0030018 Z disc(GO:0030018)
0.1 0.4 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 3.9 GO:0005604 basement membrane(GO:0005604)
0.1 6.9 GO:0005884 actin filament(GO:0005884)
0.1 2.2 GO:0071565 nBAF complex(GO:0071565)
0.1 3.8 GO:0030141 secretory granule(GO:0030141)
0.1 0.2 GO:0070209 ASTRA complex(GO:0070209)
0.1 5.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 5.0 GO:0055037 recycling endosome(GO:0055037)
0.1 36.7 GO:0005615 extracellular space(GO:0005615)
0.1 1.9 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1 2.1 GO:0014069 postsynaptic density(GO:0014069)
0.1 6.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 7.1 GO:0009986 cell surface(GO:0009986)
0.0 13.7 GO:0000785 chromatin(GO:0000785)
0.0 4.8 GO:0016607 nuclear speck(GO:0016607)
0.0 6.7 GO:0005840 ribosome(GO:0005840)
0.0 7.9 GO:0043005 neuron projection(GO:0043005)
0.0 2.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.5 GO:0035371 microtubule plus-end(GO:0035371)
0.0 11.0 GO:1990904 ribonucleoprotein complex(GO:1990904)
0.0 1.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 20.5 GO:0005829 cytosol(GO:0005829)
0.0 2.9 GO:0015629 actin cytoskeleton(GO:0015629)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
2.1 10.3 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
1.4 5.6 GO:0016936 galactoside binding(GO:0016936)
1.2 6.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.0 8.6 GO:0016531 copper chaperone activity(GO:0016531)
0.9 6.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.9 3.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.8 3.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.7 2.0 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.6 4.4 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.6 2.4 GO:0030507 spectrin binding(GO:0030507)
0.5 3.7 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.5 2.1 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.5 3.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.4 1.7 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.4 4.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.4 1.8 GO:0070492 oligosaccharide binding(GO:0070492)
0.4 3.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.3 7.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.3 2.3 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.3 8.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.3 5.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 4.6 GO:0005112 Notch binding(GO:0005112)
0.2 12.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.2 0.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 1.4 GO:0004935 adrenergic receptor activity(GO:0004935)
0.2 2.8 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 8.7 GO:0005267 potassium channel activity(GO:0005267)
0.2 2.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 1.5 GO:0008422 beta-glucosidase activity(GO:0008422)
0.2 4.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 1.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 2.3 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.2 1.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.2 6.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 2.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 1.6 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.2 1.6 GO:0015026 coreceptor activity(GO:0015026)
0.2 0.6 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.2 0.6 GO:0004046 aminoacylase activity(GO:0004046)
0.1 2.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.9 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.8 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 3.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 1.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.9 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 18.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 20.4 GO:0051015 actin filament binding(GO:0051015)
0.1 0.4 GO:0008312 7S RNA binding(GO:0008312)
0.1 3.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 5.0 GO:0031406 carboxylic acid binding(GO:0031406)
0.1 0.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 2.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 28.8 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.7 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 2.2 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 1.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.5 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.8 GO:0008483 transaminase activity(GO:0008483)
0.0 2.0 GO:0019843 rRNA binding(GO:0019843)
0.0 2.2 GO:0000149 SNARE binding(GO:0000149)
0.0 17.3 GO:0005102 receptor binding(GO:0005102)
0.0 4.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 4.7 GO:0042393 histone binding(GO:0042393)
0.0 3.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.6 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 29.5 GO:1990837 sequence-specific double-stranded DNA binding(GO:1990837)
0.0 0.4 GO:0051787 misfolded protein binding(GO:0051787)
0.0 10.2 GO:0022857 transmembrane transporter activity(GO:0022857)
0.0 0.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.6 GO:0003779 actin binding(GO:0003779)
0.0 2.7 GO:0008168 methyltransferase activity(GO:0008168)
0.0 3.3 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 8.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 3.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.4 7.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 4.1 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 4.8 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 3.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 4.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 9.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 7.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 1.2 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 1.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.6 PID BMP PATHWAY BMP receptor signaling
0.0 1.8 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.4 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 8.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.6 5.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.5 8.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.4 3.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 4.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.3 4.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 2.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 3.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.3 1.9 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 2.6 REACTOME BOTULINUM NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.2 1.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 1.5 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.2 0.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 2.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 3.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 0.6 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 4.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.2 REACTOME PI METABOLISM Genes involved in PI Metabolism
0.0 0.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+