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Results for otpa+otpb

Z-value: 0.54

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Transcription factors associated with otpa+otpb

Gene Symbol Gene ID Gene Info
otpa
ENSDARG00000014201 orthopedia homeobox a
otpb
ENSDARG00000058379 orthopedia homeobox b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
otpadr10_dc_chr21_+_7844259_78443680.572.1e-02Click!
otpbdr10_dc_chr5_-_50972677_509727400.514.2e-02Click!

Activity profile of otpa+otpb motif

Sorted Z-values of otpa+otpb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of otpa+otpb

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr21_+_25199691 2.13 ENSDART00000168140
ENSDART00000112783
tmem45b
transmembrane protein 45B
chr8_-_33372638 1.54 ENSDART00000076420
lmx1bb
LIM homeobox transcription factor 1, beta b
chr6_-_43094573 1.37 ENSDART00000084389
lrrn1
leucine rich repeat neuronal 1
chr20_-_9107294 1.23 ENSDART00000140792
OMA1
OMA1 zinc metallopeptidase
chr9_-_30437160 1.23 ENSDART00000147241
BX936337.1
ENSDARG00000092870
chr20_-_45908435 1.16 ENSDART00000147637
fermt1
fermitin family member 1
chr17_+_15425559 1.15 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr19_+_43763483 1.01 ENSDART00000136695
yrk
Yes-related kinase
chr15_-_14616083 0.99 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr9_-_37940101 0.96 ENSDART00000087663
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr16_+_46145286 0.93 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr1_-_25272318 0.92 ENSDART00000134192
synpo2b
synaptopodin 2b
chr5_-_45276904 0.91 ENSDART00000041503
slc4a4a
solute carrier family 4 (sodium bicarbonate cotransporter), member 4a
chr1_-_674449 0.90 ENSDART00000160564
cyyr1
cysteine/tyrosine-rich 1
chr1_-_4757890 0.87 ENSDART00000114035
mnx2b
motor neuron and pancreas homeobox 2b
chr3_-_15849644 0.82 ENSDART00000160668
nme3
NME/NM23 nucleoside diphosphate kinase 3
chr23_+_11412329 0.82 ENSDART00000135406
chl1a
cell adhesion molecule L1-like a
chr6_-_43094926 0.81 ENSDART00000084389
lrrn1
leucine rich repeat neuronal 1
chr4_+_9668755 0.75 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr1_-_30801520 0.71 ENSDART00000007770
lbx1b
ladybird homeobox 1b
chr12_-_7902815 0.70 ENSDART00000088100
ank3b
ankyrin 3b
chr23_-_36922175 0.64

chr14_+_47326080 0.60 ENSDART00000047525
cryba1l1
crystallin, beta A1, like 1
chr3_-_19218660 0.57 ENSDART00000132987
s1pr5a
sphingosine-1-phosphate receptor 5a
chr11_-_40414239 0.56 ENSDART00000165163
si:ch211-222l21.1
si:ch211-222l21.1
chr7_+_25052687 0.54 ENSDART00000110347
cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
chr23_+_11350727 0.54

chr1_-_9256864 0.52 ENSDART00000041849
tmem8a
transmembrane protein 8A
chr12_-_31679959 0.51 ENSDART00000153449
nat9
N-acetyltransferase 9 (GCN5-related, putative)
chr7_-_17129072 0.48

chr10_-_11303185 0.47 ENSDART00000146727
ptbp3
polypyrimidine tract binding protein 3
chr16_+_29060022 0.47 ENSDART00000088023
gon4l
gon-4-like (C. elegans)
chr4_-_24038200 0.46 ENSDART00000131690
cpm
carboxypeptidase M
chr1_+_50395721 0.40 ENSDART00000134065
dpy30
dpy-30 histone methyltransferase complex regulatory subunit
chr20_+_109649 0.40 ENSDART00000022725
si:ch1073-155h21.1
si:ch1073-155h21.1
chr5_-_37850885 0.40 ENSDART00000136428
ENSDART00000112487
chrne
cholinergic receptor, nicotinic, epsilon
chr18_-_188494 0.39 ENSDART00000166207
ENSDART00000172235
ENSDART00000170884
gart
phosphoribosylglycinamide formyltransferase
KN150129v1_-_68034 0.39 ENSDART00000178130
CABZ01057446.1
ENSDARG00000106873
chr13_-_49983998 0.38

chr14_+_1152700 0.37 ENSDART00000125203
hopx
HOP homeobox
chr5_-_45276748 0.37 ENSDART00000041503
slc4a4a
solute carrier family 4 (sodium bicarbonate cotransporter), member 4a
chr3_-_15889742 0.35 ENSDART00000143324
spsb3a
splA/ryanodine receptor domain and SOCS box containing 3a
chr4_+_74845382 0.35 ENSDART00000159789
zgc:172128
zgc:172128
chr5_+_45823481 0.35

chr20_-_54206786 0.35 ENSDART00000004756
hsp90aa1.1
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
chr5_-_9162684 0.34

chr8_-_12253026 0.34 ENSDART00000091612
dab2ipa
DAB2 interacting protein a
chr2_-_17721575 0.34 ENSDART00000141188
ENSDART00000100201
st3gal3b
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr7_+_21006803 0.32 ENSDART00000052942
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr21_-_36886505 0.31 ENSDART00000113678
wwc1
WW and C2 domain containing 1
chr3_-_38642067 0.30 ENSDART00000155518
znf281a
zinc finger protein 281a
chr10_+_26786051 0.30 ENSDART00000100329
f9b
coagulation factor IXb
chr15_-_21078596 0.30 ENSDART00000154019
ENSDARG00000093199
ENSDARG00000093199
chr4_-_1952201 0.28 ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr10_+_11303321 0.28 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr6_+_52350428 0.28 ENSDART00000151612
si:ch211-239j9.1
si:ch211-239j9.1
chr6_+_14854101 0.27 ENSDART00000087782
mrps9
mitochondrial ribosomal protein S9
chr14_-_1342450 0.27 ENSDART00000060417
cetn4
centrin 4
chr11_-_25017693 0.26

chr16_+_54350976 0.25 ENSDART00000172622
ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr14_-_6901415 0.25 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b
chr17_+_42003279 0.25 ENSDART00000111537
kiz
kizuna centrosomal protein
chr16_+_40074850 0.25 ENSDART00000110100
hint3
histidine triad nucleotide binding protein 3
chr22_-_36561247 0.24 ENSDART00000056188
polr2h
info polymerase (RNA) II (DNA directed) polypeptide H
chr11_-_40414131 0.24 ENSDART00000165163
si:ch211-222l21.1
si:ch211-222l21.1
chr22_+_1551406 0.23 ENSDART00000163223
si:ch211-255f4.9
si:ch211-255f4.9
chr4_+_17666867 0.22 ENSDART00000066999
ccdc53
coiled-coil domain containing 53
chr3_+_3994248 0.21

chr10_-_27087472 0.21 ENSDART00000143451
cnih2
cornichon family AMPA receptor auxiliary protein 2
chr9_+_24255064 0.20 ENSDART00000101577
ENSDART00000159324
ENSDART00000023196
ENSDART00000079689
ENSDART00000172743
ENSDART00000171577
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr25_+_35771748 0.20

chr2_+_50873893 0.19

chr16_-_53008678 0.18

chr17_+_24803152 0.16 ENSDART00000112313
wdr43
WD repeat domain 43
chr18_+_1353738 0.15 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr18_-_15451738 0.14 ENSDART00000091466
polr3b
polymerase (RNA) III (DNA directed) polypeptide B
chr7_+_38540519 0.14 ENSDART00000052322
zgc:110699
zgc:110699
chr3_-_51038166 0.14

chr17_+_44583892 0.14 ENSDART00000156625
pgfb
placental growth factor b
chr6_+_25161456 0.13 ENSDART00000157790
ccbl2
cysteine conjugate-beta lyase 2
chr2_-_37157969 0.13 ENSDART00000144220
tspan37
tetraspanin 37
chr9_-_32366320 0.12 ENSDART00000078568
sf3b1
splicing factor 3b, subunit 1
chr2_+_37157979 0.12 ENSDART00000045016
pex19
peroxisomal biogenesis factor 19
chr6_+_11014565 0.11 ENSDART00000132677
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr3_+_26211888 0.10 ENSDART00000163832
si:ch211-156b7.4
si:ch211-156b7.4
chr17_-_21398340 0.10 ENSDART00000007021
atp6v1ba
ATPase, H+ transporting, lysosomal, V1 subunit B, member a
chr13_-_51743395 0.10

chr5_+_71028018 0.09 ENSDART00000164893
ENSDART00000159658
ENSDART00000097164
ENSDART00000124939
ENSDART00000171230
LHX3
LIM homeobox 3
chr24_-_14447136 0.09

chr24_+_35500964 0.08 ENSDART00000058571
snai2
snail family zinc finger 2
chr1_+_44971899 0.08 ENSDART00000149565
trappc5
trafficking protein particle complex 5
chr8_+_49076542 0.07 ENSDART00000032277
ddx51
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr8_+_53919318 0.05

chr14_-_1187074 0.04 ENSDART00000106672
arl9
ADP-ribosylation factor-like 9
chr20_-_29961621 0.04 ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr2_+_50873843 0.03

chr14_-_33604914 0.03 ENSDART00000168546
zdhhc24
zinc finger, DHHC-type containing 24
chr2_+_1881022 0.03 ENSDART00000101038
tmie
transmembrane inner ear
chr17_+_49198580 0.03 ENSDART00000059255
ENSDART00000155599
zgc:113176
zgc:113176
chr19_-_32175977 0.02

chr12_+_35755300 0.02 ENSDART00000131300
unk
unkempt family zinc finger
chr19_-_29196131 0.02 ENSDART00000155766
ENSDART00000151806
BX957317.2
ENSDARG00000096312
chr22_+_12306260 0.02

chr8_-_44932155 0.01 ENSDART00000084417
timm17b
translocase of inner mitochondrial membrane 17 homolog B (yeast)
chr22_-_17571993 0.01

chr25_-_27279272 0.00 ENSDART00000148121
zgc:153935
zgc:153935
chr18_+_41537683 0.00 ENSDART00000146972
selt1b
selenoprotein T, 1b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.2 0.5 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.2 1.0 GO:0050975 sensory perception of touch(GO:0050975)
0.2 1.5 GO:0021592 fourth ventricle development(GO:0021592)
0.1 0.8 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.1 0.3 GO:0032475 otolith formation(GO:0032475)
0.1 1.3 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.4 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 0.9 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 1.0 GO:0048246 macrophage chemotaxis(GO:0048246)
0.1 0.3 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.1 0.4 GO:0046084 adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.1 0.3 GO:0045428 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.1 0.3 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 1.0 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.1 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.9 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.1 GO:0060753 mast cell chemotaxis(GO:0002551) positive regulation of leukocyte chemotaxis(GO:0002690) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 1.2 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.1 GO:1901908 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.1 GO:0044805 late nucleophagy(GO:0044805)
0.0 0.1 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.0 0.9 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 0.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0043209 myelin sheath(GO:0043209)
0.0 0.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.1 GO:1990072 TRAPPIII protein complex(GO:1990072)
0.0 1.2 GO:0005925 focal adhesion(GO:0005925)
0.0 0.9 GO:0030018 Z disc(GO:0030018)
0.0 2.2 GO:0031012 extracellular matrix(GO:0031012)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.4 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.5 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 1.1 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.2 GO:0005178 integrin binding(GO:0005178)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.0 0.1 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism