Project
DANIO-CODE
Navigation
Downloads
Results for pax2a+pax5
Z-value: 3.36
Motif logo
Transcription factors associated with pax2a+pax5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pax5 | dr10_dc_chr1_+_21033379_21033391 | 0.93 | 1.7e-07 | Click! |
| pax2a | dr10_dc_chr13_+_29640492_29640494 | 0.89 | 3.9e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of pax2a+pax5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_12033088 Show fit | 17.98 |
ENSDART00000044154
|
troponin T2c, cardiac |
|
| chr7_+_29680967 Show fit | 14.92 |
ENSDART00000173540
|
alpha-tropomyosin |
|
| chr3_-_54893038 Show fit | 8.32 |
ENSDART00000155871
ENSDART00000109016 |
hemoglobin alpha embryonic-3 |
|
| chr3_-_48865474 Show fit | 7.80 |
ENSDART00000133036
|
ELAV like neuron-specific RNA binding protein 3 |
|
| chr3_-_35928594 Show fit | 7.59 |
|
|
|
| chr3_-_34363698 Show fit | 7.30 |
|
|
|
| chr2_+_2628865 Show fit | 7.28 |
ENSDART00000061955
|
myosin, light chain 13 |
|
| chr16_+_24063849 Show fit | 7.24 |
ENSDART00000135084
|
apolipoprotein A-II |
|
| chr15_+_32853646 Show fit | 7.16 |
ENSDART00000167515
|
periostin, osteoblast specific factor b |
|
| chr13_-_39365252 Show fit | 7.02 |
ENSDART00000019379
|
MARVEL domain containing 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 29.4 | GO:0006937 | regulation of muscle contraction(GO:0006937) |
| 0.4 | 24.7 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.1 | 20.2 | GO:0050767 | regulation of neurogenesis(GO:0050767) |
| 0.1 | 12.6 | GO:0030198 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.4 | 12.2 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.6 | 10.9 | GO:0051492 | regulation of stress fiber assembly(GO:0051492) |
| 1.0 | 10.8 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.1 | 9.0 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.2 | 8.9 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
| 0.7 | 8.3 | GO:0016203 | muscle attachment(GO:0016203) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 40.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 38.7 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.3 | 28.2 | GO:0005861 | troponin complex(GO:0005861) |
| 0.2 | 16.8 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 13.6 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.2 | 12.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 11.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 1.5 | 10.8 | GO:0031838 | hemoglobin complex(GO:0005833) haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 10.7 | GO:0030054 | cell junction(GO:0030054) |
| 0.3 | 10.3 | GO:0005604 | basement membrane(GO:0005604) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 55.7 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 49.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 3.2 | 25.2 | GO:0031013 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.2 | 20.3 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.3 | 18.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 16.9 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.3 | 13.9 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.1 | 13.1 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 1.5 | 10.8 | GO:0031720 | haptoglobin binding(GO:0031720) |
| 0.0 | 10.7 | GO:1990837 | sequence-specific double-stranded DNA binding(GO:1990837) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 8.2 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.3 | 7.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 6.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.3 | 5.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 5.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 5.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 3.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 1.1 | 3.2 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 7.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 7.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.9 | 7.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 7.1 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.6 | 5.2 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.7 | 5.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.4 | 4.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.2 | 4.6 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.1 | 4.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |