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Results for pax2b
Z-value: 1.85
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Transcription factors associated with pax2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pax2b | dr10_dc_chr12_-_45714172_45714180 | -0.75 | 8.2e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of pax2b
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_23704663 Show fit | 4.67 |
ENSDART00000104346
|
makorin, ring finger protein, 4 |
|
| chr8_+_52456064 Show fit | 4.21 |
ENSDART00000012758
|
zgc:77112 |
|
| chr19_+_15536640 Show fit | 4.06 |
ENSDART00000098970
|
lin-28 homolog A (C. elegans) |
|
| chr2_+_25281122 Show fit | 3.55 |
ENSDART00000025962
|
glycogenin 1a |
|
| chr8_-_2557556 Show fit | 3.45 |
ENSDART00000140033
|
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a |
|
| chr10_+_16543480 Show fit | 3.24 |
ENSDART00000121864
|
solute carrier family 27 (fatty acid transporter), member 6 |
|
| chr24_-_24999240 Show fit | 3.23 |
ENSDART00000152104
|
pleckstrin homology-like domain, family B, member 2b |
|
| chr23_-_22596648 Show fit | 3.10 |
ENSDART00000079019
|
splA/ryanodine receptor domain and SOCS box containing 1 |
|
| chr7_-_55346967 Show fit | 2.74 |
ENSDART00000135304
|
poly(A) binding protein, nuclear 1-like (cytoplasmic) |
|
| chr6_+_135002 Show fit | 2.64 |
ENSDART00000097468
|
zinc finger, GATA-like protein 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.8 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.3 | 7.7 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.2 | 6.3 | GO:0015908 | fatty acid transport(GO:0015908) |
| 0.0 | 6.3 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.5 | 5.9 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.3 | 5.9 | GO:0070167 | regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167) |
| 0.1 | 5.4 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 1.3 | 5.3 | GO:1990379 | maintenance of blood-brain barrier(GO:0035633) lysophospholipid transport(GO:0051977) lipid transport across blood brain barrier(GO:1990379) |
| 0.9 | 5.3 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.1 | 4.9 | GO:0055088 | lipid homeostasis(GO:0055088) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 7.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.6 | 7.6 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 1.6 | 4.8 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.0 | 4.8 | GO:0005764 | lysosome(GO:0005764) |
| 0.1 | 4.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.3 | 3.9 | GO:0045180 | basal cortex(GO:0045180) |
| 0.1 | 3.7 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 3.6 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.5 | 3.2 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.3 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 1.0 | 5.9 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.4 | 5.9 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.1 | 5.5 | GO:0005516 | calmodulin binding(GO:0005516) |
| 1.3 | 5.3 | GO:0051978 | lysophospholipid transporter activity(GO:0051978) |
| 0.4 | 5.3 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 5.2 | GO:0005347 | ATP transmembrane transporter activity(GO:0005347) |
| 0.2 | 5.1 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 5.0 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.2 | 3.7 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 2.9 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.2 | 2.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 2.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 1.9 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 1.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 1.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 1.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 1.5 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.4 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.3 | 4.4 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 3.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 3.1 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.1 | 3.1 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.4 | 2.7 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.1 | 2.7 | REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | Genes involved in CDT1 association with the CDC6:ORC:origin complex |
| 0.2 | 1.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.9 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |