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Results for pbx1a+pbx2+pbx3a+pbx3b

Z-value: 3.01

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Transcription factors associated with pbx1a+pbx2+pbx3a+pbx3b

Gene Symbol Gene ID Gene Info
ENSDARG00000013615 pre-B-cell leukemia homeobox 3b
ENSDARG00000019717 pre-B-cell leukemia homeobox 2
ENSDARG00000089262 pre-B-cell leukemia homeobox 3a
ENSDARG00000100494 pre-B-cell leukemia homeobox 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pbx2dr10_dc_chr16_+_48674071_48674107-0.923.8e-07Click!
pbx3bdr10_dc_chr8_-_34077387_340774830.845.3e-05Click!
pbx1adr10_dc_chr2_-_19181409_191814320.821.0e-04Click!

Activity profile of pbx1a+pbx2+pbx3a+pbx3b motif

Sorted Z-values of pbx1a+pbx2+pbx3a+pbx3b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of pbx1a+pbx2+pbx3a+pbx3b

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr9_-_43178744 14.88

chr12_+_36796886 13.12 ENSDART00000125900
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b
chr20_-_54206610 9.72 ENSDART00000004756
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
chr3_+_32394653 8.36 ENSDART00000150897
si:ch73-367p23.2
chr13_-_5440923 8.18 ENSDART00000102576
Meis homeobox 1 b
chr7_+_55797053 6.81 ENSDART00000127046
cadherin 15, type 1, M-cadherin (myotubule)
chr7_-_50827308 6.77 ENSDART00000121574
collagen, type IV, alpha 6
KN150640v1_+_5728 6.74

chr16_-_31959111 6.64 ENSDART00000135669
RNA binding protein, fox-1 homolog (C. elegans) 1-like
chr6_+_14822990 6.47 ENSDART00000149949
POU class 3 homeobox 3b
chr6_+_14823185 6.28 ENSDART00000149202
POU class 3 homeobox 3b
chr1_-_5796394 6.22 ENSDART00000109356
Kruppel-like factor 7a
chr20_-_25063937 6.09 ENSDART00000159122
eph receptor A7
chr7_-_26767182 6.06 ENSDART00000052731
nucleobindin 2a
chr11_+_27970922 5.97 ENSDART00000169360
ENSDART00000043756
eph receptor B2b
chr20_+_29840979 5.94 ENSDART00000101603
kinase D-interacting substrate 220b
chr12_+_14970278 5.85 ENSDART00000003847
myosin light chain, phosphorylatable, fast skeletal muscle b
chr3_+_56970554 5.79 ENSDART00000162930
BAH domain and coiled-coil containing 1a
chr20_+_28531684 5.56 ENSDART00000123387
D4, zinc and double PHD fingers, family 3
chr4_-_17735989 5.51 ENSDART00000016658
choline phosphotransferase 1
chr6_+_40631517 5.49 ENSDART00000103757
solute carrier family 6 (neurotransmitter transporter), member 11a
chr23_+_28656263 5.27 ENSDART00000020296
neural adhesion molecule L1.2
chr12_-_26760324 5.21 ENSDART00000047724
zinc finger E-box binding homeobox 1b
chr19_-_24859287 5.15 ENSDART00000163763
thrombospondin 3b
chr20_-_29517770 5.13 ENSDART00000147464
ryanodine receptor 3
chr7_+_26978970 5.08 ENSDART00000150068
SRY (sex determining region Y)-box 6
chr8_-_985673 5.08 ENSDART00000170737
SET and MYND domain containing 1b
chr8_+_15987710 5.03 ENSDART00000165141
ELAV like neuron-specific RNA binding protein 4
chr15_+_40707917 4.97 ENSDART00000154187
ENSDART00000042082
FAT atypical cadherin 3a
chr12_-_30988279 4.94 ENSDART00000122972
ENSDART00000005562
ENSDART00000031408
ENSDART00000125046
ENSDART00000009237
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr21_-_23710216 4.93 ENSDART00000132570
neural cell adhesion molecule 1a
chr20_-_20634087 4.92 ENSDART00000125039
SIX homeobox 6b
chr1_-_46292847 4.92 ENSDART00000125032
pbx/knotted 1 homeobox 1.2
chr25_+_18467217 4.92 ENSDART00000170841
caveolin 1
chr5_-_28090077 4.90

chr20_-_23184142 4.82 ENSDART00000176282
ENSDARG00000108718
chr5_-_3244261 4.79 ENSDART00000060162
heat shock protein, alpha-crystallin-related, 1
chr2_+_20748431 4.75 ENSDART00000137848
palmdelphin a
chr7_+_34417030 4.62 ENSDART00000108473
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr20_+_13279404 4.59 ENSDART00000025644
protein phosphatase 2, regulatory subunit B', alpha isoform
chr2_+_43619752 4.59 ENSDART00000142078
ENSDART00000098265
ENSDART00000098267
neuropilin 1b
chr2_-_55737505 4.58 ENSDART00000059003
retinal homeobox gene 2
chr5_+_23126577 4.57 ENSDART00000013745
connexin 39.9
chr17_+_52736192 4.57 ENSDART00000158273
ENSDART00000161414
Meis homeobox 2a
chr19_+_156649 4.53 ENSDART00000167717
leucine rich repeat containing 16A
chr12_+_3043444 4.51 ENSDART00000149427
sarcoglycan, alpha
chr12_+_28739504 4.51 ENSDART00000152991
nuclear factor, erythroid 2-like 1b
chr8_+_6989445 4.49 ENSDART00000134440
glycerol-3-phosphate dehydrogenase 1a
chr6_-_10593395 4.44 ENSDART00000020261
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr11_-_28367271 4.39 ENSDART00000065853
dehydrogenase/reductase (SDR family) member 3b
chr18_+_23198330 4.32 ENSDART00000143977
myocyte enhancer factor 2aa
chr12_+_25509394 4.31 ENSDART00000077157
SIX homeobox 3b
chr20_+_29731714 4.28 ENSDART00000101556
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2b
chr23_-_29138952 4.27 ENSDART00000002812
castor zinc finger 1
chr10_+_43950311 4.26 ENSDART00000027242
nuclear receptor subfamily 2, group F, member 1b
chr1_+_21037251 4.22

chr7_-_69399273 4.13 ENSDART00000159823
ENSDART00000075178
ENSDART00000168942
ENSDART00000126739
tetraspanin 5a
chr1_-_45709828 4.08 ENSDART00000150029
ATPase, class VI, type 11A
chr25_+_35901081 4.07 ENSDART00000042271
ENSDART00000158027
iroquois homeobox 3b
chr3_+_60637167 4.05 ENSDART00000157772
forkhead box J1a
chr5_+_53854279 4.04 ENSDART00000165889
taperin
chr6_-_2294751 4.02 ENSDART00000165223
pre-B-cell leukemia homeobox 1b
chr16_-_31963977 4.01 ENSDART00000027364
RNA binding protein, fox-1 homolog (C. elegans) 1-like
chr2_+_27344633 3.96 ENSDART00000178275
cadherin 7, type 2
chr4_+_9668755 3.94 ENSDART00000004604
si:dkey-153k10.9
chr21_+_30434147 3.91 ENSDART00000147375
sorting nexin 12
chr1_+_12076622 3.89 ENSDART00000159226
protocadherin 10a
chr10_+_25407847 3.87 ENSDART00000047541
BTB and CNC homology 1, basic leucine zipper transcription factor 1 b
chr9_-_44493074 3.87 ENSDART00000167685
neuronal differentiation 1
chr2_-_10394639 3.86 ENSDART00000128535
diencephalon/mesencephalon homeobox 1a
chr2_+_54218444 3.85 ENSDART00000161221
calcyphosine-like a
chr3_+_48362748 3.78 ENSDART00000157199
MKL/myocardin-like 2b
chr5_+_58608658 3.78 ENSDART00000160025
RAS p21 protein activator 4
chr10_-_31838886 3.77 ENSDART00000128839
fasciculation and elongation protein zeta 1 (zygin I)
chr12_+_34026544 3.67 ENSDART00000153413
cytohesin 1b
chr3_-_62143464 3.63 ENSDART00000155853
G protein-coupled receptor, class C, group 5, member Ba
chr2_+_2374651 3.61 ENSDART00000132500
complement component 8, alpha polypeptide
chr12_-_4351825 3.60 ENSDART00000152168
si:ch211-173d10.1
chr21_+_35181329 3.57 ENSDART00000135256
ubiquitin domain containing 2
chr7_-_33678058 3.57 ENSDART00000173513
protein inhibitor of activated STAT, 1a
chr9_+_26292183 3.56

chr3_-_32464649 3.56 ENSDART00000103239
tetraspanin 4b
chr18_+_24575639 3.55 ENSDART00000099463
LysM, putative peptidoglycan-binding, domain containing 4
chr11_-_23206021 3.54 ENSDART00000032844
pleckstrin homology domain containing, family A member 6
chr21_+_45227200 3.52 ENSDART00000155681
ENSDART00000157136
transcription factor 7 (T-cell specific, HMG-box)
chr4_-_18606513 3.51 ENSDART00000049061
cyclin-dependent kinase inhibitor 1Ba
chr4_+_7406743 3.48 ENSDART00000168327
caldesmon 1a
chr17_+_52736535 3.47 ENSDART00000158273
ENSDART00000161414
Meis homeobox 2a
chr23_+_7537089 3.47 ENSDART00000135551
si:ch211-200e2.1
chr10_-_35293024 3.46 ENSDART00000145804
yippee-like 2a
chr5_+_58608842 3.41 ENSDART00000097374
RAS p21 protein activator 4
chr7_+_35769973 3.39 ENSDART00000168658
iroquois homeobox 3a
chr21_+_17073163 3.37

chr9_-_21257082 3.36 ENSDART00000124533
T-box 15
chr1_-_54269904 3.35 ENSDART00000129710
cartilage acidic protein 1a
chr21_-_34623741 3.32 ENSDART00000023038
dachshund a
chr5_-_36349284 3.31 ENSDART00000047269
H3 histone, family 3B.1
chr14_-_425659 3.31

chr1_-_6976446 3.31 ENSDART00000085203
ephrin-B2b
chr7_-_72278552 3.29 ENSDART00000168532
HECT domain E3 ubiquitin protein ligase 4
chr24_+_21395671 3.26 ENSDART00000091529
WAS protein family, member 3b
chr6_-_49900124 3.25 ENSDART00000150204
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
chr19_-_32214978 3.23 ENSDART00000103640
hes-related family bHLH transcription factor with YRPW motif 1
chr12_+_48888044 3.22 ENSDART00000109315
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr2_+_53253623 3.21 ENSDART00000121980
cAMP responsive element binding protein 3-like 3b
chr9_-_22499899 3.20 ENSDART00000147358
crystallin, gamma M2d10
chr21_-_9708608 3.20

chr9_+_16437408 3.18 ENSDART00000006787
eph receptor A3
chr8_+_33010788 3.17 ENSDART00000172672
angiopoietin-like 2b
chr7_-_29300402 3.17 ENSDART00000099477
RAR-related orphan receptor A, paralog b
chr16_+_16941228 3.16 ENSDART00000142155
myosin, heavy chain 14, non-muscle
chr12_-_4351924 3.15 ENSDART00000152168
si:ch211-173d10.1
chr7_-_3900223 3.11 ENSDART00000019949
NDRG family member 2
chr23_-_20402258 3.10 ENSDART00000136204
ENSDARG00000093223
chr13_+_22119569 3.10 ENSDART00000108472
synaptopodin 2-like a
chr10_+_34482499 3.08 ENSDART00000102566
neurobeachin a
chr3_-_19050721 3.03 ENSDART00000131503
regulatory factor X, 1a (influences HLA class II expression)
chr17_-_38494727 3.02 ENSDART00000085438
ribosomal protein S6 kinase, polypeptide 5
chr13_-_3022033 3.01 ENSDART00000050934
protein kinase domain containing, cytoplasmic a
chr3_+_23580269 3.00 ENSDART00000151584
homeobox B4a
chr24_+_9231693 2.99 ENSDART00000082422
si:ch211-285f17.1
chr7_-_52142689 2.98 ENSDART00000110265
myocardial zonula adherens protein
KN149738v1_+_8819 2.98

chr1_-_53403731 2.96 ENSDART00000171722
single-pass membrane protein with aspartate-rich tail 1b
chr19_-_28546417 2.92 ENSDART00000130922
ENSDART00000079114
iroquois homeobox 1b
chr23_-_23474703 2.91 ENSDART00000078936
hairy-related 9
chr17_+_11353143 2.90 ENSDART00000013170
kinesin family member 26Ba
chr17_+_45931793 2.90 ENSDART00000155372
kinesin family member 26Ab
chr3_-_61889061 2.88 ENSDART00000097345
target of myb1 like 2 membrane trafficking protein
chr2_+_3370130 2.86 ENSDART00000098391
wingless-type MMTV integration site family, member 9A
chr25_+_5232865 2.86

chr8_+_53118919 2.86

chr7_-_29300448 2.85 ENSDART00000019140
RAR-related orphan receptor A, paralog b
chr1_-_40208544 2.83 ENSDART00000027463
H6 family homeobox 4
chr3_+_17760847 2.82 ENSDART00000080946
tetratricopeptide repeat domain 25
chr7_-_58427369 2.82 ENSDART00000149347
coiled-coil-helix-coiled-coil-helix domain containing 7
chr20_+_34497817 2.79 ENSDART00000061632
family with sequence similarity 129, member Aa
chr13_-_10128903 2.78 ENSDART00000080808
SIX homeobox 3a
chr5_-_18895882 2.77 ENSDART00000008994
forkhead box N4
chr13_-_31516399 2.77 ENSDART00000172375
ENSDART00000125987
ENSDART00000143903
ENSDART00000158719
SIX homeobox 4a
chr17_+_52736844 2.76 ENSDART00000160507
Meis homeobox 2a
chr2_-_45093067 2.76 ENSDART00000036997
calcium/calmodulin-dependent protein kinase II inhibitor 1a
chr19_+_10912601 2.76 ENSDART00000053325
translocase of outer mitochondrial membrane 40 homolog, like
chr10_-_32580145 2.72 ENSDART00000137608
diacylglycerol O-acyltransferase 2
chr5_-_3244042 2.72 ENSDART00000060162
heat shock protein, alpha-crystallin-related, 1
chr12_-_8780098 2.70 ENSDART00000113148
jumonji domain containing 1Cb
chr14_-_32404076 2.69 ENSDART00000075617
SRY (sex determining region Y)-box 3
chr12_-_7790348 2.69 ENSDART00000148673
ankyrin 3b
chr2_+_32036450 2.67 ENSDART00000140776
ENSDARG00000091946
chr13_+_28286826 2.67 ENSDART00000043658
solute carrier family 2 (facilitated glucose transporter), member 15a
chr10_+_34482404 2.66 ENSDART00000102566
neurobeachin a
chr24_-_38928988 2.66 ENSDART00000063231
noggin 2
chr18_-_45750 2.64 ENSDART00000148821
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr6_-_1728063 2.61 ENSDART00000156936
discs, large (Drosophila) homolog-associated protein 4b
chr7_+_55797154 2.61 ENSDART00000098453
cadherin 15, type 1, M-cadherin (myotubule)
chr1_-_40208469 2.60 ENSDART00000027463
H6 family homeobox 4
chr17_+_45594103 2.58 ENSDART00000153922
si:ch211-202f3.3
chr16_-_543957 2.58 ENSDART00000016303
iroquois homeobox 2a
chr13_-_10128836 2.57 ENSDART00000080808
SIX homeobox 3a
chr2_-_26872047 2.55 ENSDART00000138693
si:ch211-106k21.5
chr3_-_56969897 2.52

chr21_+_4964891 2.52 ENSDART00000102572
thrombospondin 4b
chr13_-_5440751 2.50 ENSDART00000102576
Meis homeobox 1 b
chr20_-_1218693 2.48 ENSDART00000140650
ENSDART00000133216
ankyrin repeat domain 6b
chr4_-_8005840 2.46 ENSDART00000036153
coiled-coil domain containing 3a
chr6_+_4712785 2.45 ENSDART00000151674
protocadherin 9
chr11_-_41750987 2.45 ENSDART00000166999
zgc:175088
chr7_+_23306546 2.45 ENSDART00000049885
si:dkey-172j4.3
chr22_-_38621100 2.44 ENSDART00000164609
si:ch211-126j24.1
chr9_-_22318918 2.41 ENSDART00000124272
crystallin, gamma M2d17
chr16_+_1073570 2.40

chr2_+_2895642 2.39 ENSDART00000032459
aquaporin 1a (Colton blood group), tandem duplicate 1
chr9_-_30463616 2.39 ENSDART00000089526
ornithine carbamoyltransferase
chr16_+_34157866 2.36 ENSDART00000140552
transcription elongation factor A (SII), 3
chr13_-_5440558 2.36 ENSDART00000102576
Meis homeobox 1 b
chr15_+_3296905 2.36 ENSDART00000171723
forkhead box O1 a
chr2_-_7560202 2.35 ENSDART00000164494
agouti signaling protein, nonagouti homolog (mouse) 2b
chr8_+_47909655 2.34

chr22_-_26307952 2.34

chr25_-_13737344 2.33

chr20_+_49975268 2.33 ENSDART00000008808
homeobox containing 1 b
chr21_-_38571536 2.32 ENSDART00000139178
ENSDART00000036600
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr19_+_21783111 2.31 ENSDART00000024639
teashirt zinc finger homeobox 1
chr14_+_35885903 2.31 ENSDART00000052569
paired-like homeodomain 2
chr6_-_343209 2.30

chr19_+_21783429 2.30 ENSDART00000024639
teashirt zinc finger homeobox 1
chr6_-_45903830 2.28 ENSDART00000025428
eph receptor A2 a
chr9_-_2588401 2.28 ENSDART00000161018
sp9 transcription factor
chr20_-_54192057 2.27 ENSDART00000023550
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2
chr25_+_18467034 2.27 ENSDART00000170841
caveolin 1
chr9_-_49239691 2.26 ENSDART00000075627
ceramide synthase 6
chr25_-_35539585 2.23 ENSDART00000073432
retinoblastoma-like 2 (p130)
chr17_-_31204651 2.22 ENSDART00000137834
l-isoaspartyl protein carboxyl methyltransferase, like
chr19_-_15288270 2.22 ENSDART00000151451
phosphatase and actin regulator 4a
chr22_-_23238714 2.21 ENSDART00000054807
LIM homeobox 9
chr12_-_268910 2.21 ENSDART00000045071
forkhead box K2
chr17_-_14683648 2.20 ENSDART00000152005
protein phosphatase 1, regulatory subunit 13Ba
chr9_-_22311713 2.19 ENSDART00000108748
crystallin, gamma M2d18
chr22_-_28922834 2.18 ENSDART00000104828
GTP binding protein 2b
chr14_-_17000025 2.17 ENSDART00000168853
janus kinase and microtubule interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 17.8 GO:0048769 sarcomerogenesis(GO:0048769)
2.7 10.7 GO:0048739 cardiac muscle fiber development(GO:0048739)
2.3 2.3 GO:0008343 adult feeding behavior(GO:0008343)
1.8 7.2 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
1.7 5.2 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
1.6 4.9 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
1.5 7.5 GO:0046685 regulation of myofibril size(GO:0014881) response to arsenic-containing substance(GO:0046685)
1.4 4.2 GO:0006601 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
1.3 8.0 GO:0035767 endothelial cell chemotaxis(GO:0035767)
1.2 4.9 GO:0010226 response to lithium ion(GO:0010226)
1.2 7.2 GO:0032095 regulation of response to food(GO:0032095) negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
1.2 3.5 GO:0014821 phasic smooth muscle contraction(GO:0014821)
1.0 17.3 GO:0060841 venous blood vessel development(GO:0060841)
0.9 4.5 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.9 4.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.8 4.1 GO:0035777 pronephric distal tubule development(GO:0035777)
0.8 3.2 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.8 2.4 GO:0015670 renal water homeostasis(GO:0003091) renal water transport(GO:0003097) carbon dioxide transport(GO:0015670)
0.8 2.4 GO:0048659 smooth muscle cell proliferation(GO:0048659) smooth muscle tissue development(GO:0048745)
0.7 3.7 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.7 2.2 GO:0097377 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.7 5.1 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.7 3.6 GO:0002455 humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)
0.7 3.5 GO:0033151 V(D)J recombination(GO:0033151)
0.7 3.4 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.7 2.0 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.7 4.1 GO:0003356 regulation of cilium beat frequency(GO:0003356) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.7 3.4 GO:0046677 response to antibiotic(GO:0046677)
0.7 6.5 GO:0042572 retinol metabolic process(GO:0042572)
0.6 8.4 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.6 4.5 GO:0035881 amacrine cell differentiation(GO:0035881)
0.6 2.5 GO:0035989 tendon development(GO:0035989)
0.6 2.4 GO:0019627 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.6 2.3 GO:0061072 iris morphogenesis(GO:0061072)
0.6 1.7 GO:2000136 cell proliferation involved in heart morphogenesis(GO:0061323) regulation of cell proliferation involved in heart morphogenesis(GO:2000136)
0.6 3.9 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.5 1.4 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine(GO:0019284)
0.5 10.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.4 3.5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.4 1.7 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.4 1.2 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.4 2.3 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.4 6.8 GO:0071711 basement membrane organization(GO:0071711)
0.4 3.7 GO:0097324 melanocyte migration(GO:0097324)
0.4 3.9 GO:0061074 regulation of neural retina development(GO:0061074)
0.3 7.2 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.3 2.9 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.3 2.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.3 4.1 GO:0045332 phospholipid translocation(GO:0045332)
0.3 0.9 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.3 1.8 GO:0034036 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.3 5.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.3 2.0 GO:0016572 histone phosphorylation(GO:0016572)
0.3 1.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.3 2.5 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.3 5.4 GO:0032963 collagen metabolic process(GO:0032963) multicellular organismal macromolecule metabolic process(GO:0044259)
0.3 3.3 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.3 6.6 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.3 2.3 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.3 1.8 GO:0061620 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2 1.5 GO:0007343 egg activation(GO:0007343)
0.2 2.6 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.2 1.4 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.2 0.7 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.2 5.1 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.2 2.2 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.2 2.0 GO:0048937 lateral line nerve glial cell differentiation(GO:0048895) myelination of lateral line nerve axons(GO:0048897) posterior lateral line nerve glial cell differentiation(GO:0048931) myelination of posterior lateral line nerve axons(GO:0048932) lateral line nerve glial cell development(GO:0048937) lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048938) posterior lateral line nerve glial cell development(GO:0048941) posterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048942)
0.2 1.3 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.2 1.9 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.2 5.6 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.2 1.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 3.9 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.2 13.3 GO:0007601 visual perception(GO:0007601)
0.2 2.0 GO:0051639 actin filament network formation(GO:0051639)
0.2 4.3 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.2 0.5 GO:0010084 specification of organ axis polarity(GO:0010084) specification of axis polarity(GO:0065001)
0.2 0.5 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 2.6 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.2 6.7 GO:0007416 synapse assembly(GO:0007416)
0.2 1.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 3.6 GO:0016925 protein sumoylation(GO:0016925)
0.2 2.6 GO:0072160 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014) nephron tubule epithelial cell differentiation(GO:0072160)
0.1 1.0 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 15.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 5.2 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 3.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 0.8 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 2.7 GO:0001649 osteoblast differentiation(GO:0001649)
0.1 1.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.8 GO:0036065 fucosylation(GO:0036065)
0.1 4.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 4.5 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.1 0.8 GO:0070571 regulation of myelination(GO:0031641) negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.1 1.4 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.1 3.9 GO:0032456 endocytic recycling(GO:0032456)
0.1 2.7 GO:0043049 otic placode formation(GO:0043049)
0.1 2.5 GO:0048264 determination of ventral identity(GO:0048264)
0.1 0.1 GO:0070849 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.1 1.6 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.1 1.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 1.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 3.0 GO:0031638 zymogen activation(GO:0031638)
0.1 1.4 GO:0032836 glomerular basement membrane development(GO:0032836)
0.1 0.4 GO:0097510 base-excision repair, AP site formation via deaminated base removal(GO:0097510)
0.1 0.5 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.1 7.1 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.1 1.0 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.8 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 1.5 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.1 5.3 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.1 0.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 1.3 GO:0009154 purine ribonucleotide catabolic process(GO:0009154) ribonucleotide catabolic process(GO:0009261)
0.1 0.9 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 1.8 GO:0008593 regulation of Notch signaling pathway(GO:0008593)
0.1 0.6 GO:0032108 negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.1 2.1 GO:0016525 negative regulation of angiogenesis(GO:0016525) negative regulation of vasculature development(GO:1901343) negative regulation of blood vessel morphogenesis(GO:2000181)
0.1 0.4 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 2.9 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 8.3 GO:0033674 positive regulation of kinase activity(GO:0033674)
0.1 4.0 GO:0050768 negative regulation of neurogenesis(GO:0050768)
0.1 1.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.9 GO:0030199 collagen fibril organization(GO:0030199)
0.1 4.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.1 GO:0097581 lamellipodium assembly(GO:0030032) lamellipodium organization(GO:0097581)
0.0 2.1 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.6 GO:0032438 melanosome organization(GO:0032438)
0.0 1.3 GO:0051592 response to calcium ion(GO:0051592)
0.0 2.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 3.2 GO:0001708 cell fate specification(GO:0001708)
0.0 1.8 GO:0007422 peripheral nervous system development(GO:0007422)
0.0 0.2 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 0.3 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031) regulation of response to oxidative stress(GO:1902882) cellular response to leucine starvation(GO:1990253)
0.0 4.3 GO:0045664 regulation of neuron differentiation(GO:0045664)
0.0 2.0 GO:0006414 translational elongation(GO:0006414)
0.0 1.4 GO:0035272 exocrine pancreas development(GO:0031017) exocrine system development(GO:0035272)
0.0 0.7 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0003197 endocardial cushion development(GO:0003197)
0.0 0.2 GO:0021794 thalamus development(GO:0021794)
0.0 2.1 GO:0061515 myeloid cell development(GO:0061515)
0.0 1.4 GO:0040008 regulation of growth(GO:0040008)
0.0 1.6 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 1.9 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.3 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 2.1 GO:0050877 neurological system process(GO:0050877)
0.0 0.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.4 GO:0048278 vesicle docking(GO:0048278)
0.0 1.2 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.7 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.3 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.6 GO:0021510 spinal cord development(GO:0021510)
0.0 0.6 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.4 GO:0042593 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.0 0.2 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 2.3 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.7 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.3 GO:0021587 cerebellum morphogenesis(GO:0021587)
0.0 1.5 GO:0060047 heart contraction(GO:0060047)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.8 GO:0098644 complex of collagen trimers(GO:0098644)
1.2 4.9 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
1.2 14.4 GO:0043209 myelin sheath(GO:0043209)
0.9 3.6 GO:0070062 extracellular exosome(GO:0070062)
0.9 7.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.9 5.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.8 4.5 GO:0016012 sarcoglycan complex(GO:0016012)
0.7 4.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.7 3.6 GO:0005579 membrane attack complex(GO:0005579)
0.7 3.9 GO:1990246 uniplex complex(GO:1990246)
0.6 1.7 GO:0030314 junctional membrane complex(GO:0030314)
0.4 4.8 GO:0031430 M band(GO:0031430)
0.4 1.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.4 1.1 GO:0043034 costamere(GO:0043034)
0.3 1.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 9.4 GO:0016342 catenin complex(GO:0016342)
0.3 11.4 GO:0005811 lipid particle(GO:0005811)
0.3 0.9 GO:0097524 sperm plasma membrane(GO:0097524)
0.3 2.1 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.3 2.5 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.3 3.3 GO:0031209 SCAR complex(GO:0031209)
0.3 2.6 GO:0098978 glutamatergic synapse(GO:0098978)
0.3 1.8 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.2 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 1.4 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.2 2.8 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 7.2 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.2 5.0 GO:0043204 perikaryon(GO:0043204)
0.2 5.6 GO:0071565 nBAF complex(GO:0071565)
0.2 1.3 GO:0014704 intercalated disc(GO:0014704)
0.1 2.6 GO:0016528 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.1 8.4 GO:0005871 kinesin complex(GO:0005871)
0.1 0.6 GO:0031931 TORC1 complex(GO:0031931)
0.1 3.7 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1 5.9 GO:0031902 late endosome membrane(GO:0031902)
0.1 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 3.9 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 5.5 GO:0030016 myofibril(GO:0030016)
0.1 27.1 GO:0043005 neuron projection(GO:0043005)
0.1 18.8 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.2 GO:0016459 myosin complex(GO:0016459)
0.1 0.7 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 3.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.4 GO:0030027 lamellipodium(GO:0030027)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 5.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 12.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 21.2 GO:0005576 extracellular region(GO:0005576)
0.0 0.6 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.5 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:0044545 NSL complex(GO:0044545)
0.0 0.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 57.5 GO:0005634 nucleus(GO:0005634)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 13.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
1.8 5.5 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
1.3 18.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
1.1 6.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.9 4.5 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.9 8.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.9 5.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.8 2.4 GO:0015168 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
0.8 2.4 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.8 5.5 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.8 3.0 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.7 3.7 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140) succinate transmembrane transporter activity(GO:0015141)
0.7 7.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.7 2.8 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.6 4.9 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.5 3.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.5 13.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 1.8 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 2.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.4 1.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.4 3.1 GO:0050811 GABA receptor binding(GO:0050811)
0.4 8.3 GO:0017022 myosin binding(GO:0017022)
0.4 3.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.4 9.5 GO:0044325 ion channel binding(GO:0044325)
0.3 1.0 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 3.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 0.9 GO:0008126 acetylesterase activity(GO:0008126)
0.3 5.5 GO:0030165 PDZ domain binding(GO:0030165)
0.3 1.8 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.3 2.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 0.8 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.3 3.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 1.3 GO:0070273 phosphatidylinositol-5-phosphate binding(GO:0010314) phosphatidylinositol-4-phosphate binding(GO:0070273)
0.3 1.3 GO:0019215 intermediate filament binding(GO:0019215)
0.3 1.8 GO:0070095 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095)
0.2 2.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 1.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 1.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 2.3 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.2 4.4 GO:0035497 cAMP response element binding(GO:0035497)
0.2 3.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 0.6 GO:0004394 heparan sulfate 2-O-sulfotransferase activity(GO:0004394)
0.2 4.2 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 3.7 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.2 24.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 2.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 14.4 GO:0051082 unfolded protein binding(GO:0051082)
0.2 9.4 GO:0045296 cadherin binding(GO:0045296)
0.2 2.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 2.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 8.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.2 GO:0002039 p53 binding(GO:0002039)
0.1 7.3 GO:0008201 heparin binding(GO:0008201)
0.1 5.2 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 7.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.8 GO:0008320 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.1 0.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 1.7 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.3 GO:0044620 ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process(GO:0000036) ACP phosphopantetheine attachment site binding(GO:0044620) prosthetic group binding(GO:0051192)
0.1 2.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 3.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.1 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
0.1 2.5 GO:0008013 beta-catenin binding(GO:0008013)
0.1 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 3.6 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.1 1.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.4 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.1 97.4 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1 1.4 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 4.5 GO:0019902 phosphatase binding(GO:0019902)
0.1 1.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 15.7 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.1 1.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 2.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 4.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 28.3 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 2.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 6.2 GO:0019901 protein kinase binding(GO:0019901)
0.0 1.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 13.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 6.8 GO:0051015 actin filament binding(GO:0051015)
0.0 1.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 6.6 GO:0005543 phospholipid binding(GO:0005543)
0.0 3.6 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 2.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.1 GO:0045499 semaphorin receptor binding(GO:0030215) chemorepellent activity(GO:0045499)
0.0 2.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.3 GO:0043022 ribosome binding(GO:0043022)
0.0 0.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.4 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 PID LPA4 PATHWAY LPA4-mediated signaling events
0.6 8.1 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.5 13.7 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.4 7.1 PID RAS PATHWAY Regulation of Ras family activation
0.3 9.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.3 6.8 NABA COLLAGENS Genes encoding collagen proteins
0.2 2.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 2.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.4 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 4.9 PID AP1 PATHWAY AP-1 transcription factor network
0.1 4.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 4.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.6 PID AURORA A PATHWAY Aurora A signaling
0.0 0.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.2 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.0 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.9 7.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.8 6.6 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.6 15.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.5 5.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.3 3.6 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.3 3.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.3 4.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.3 3.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 6.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.2 3.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 4.9 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 7.5 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 1.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.4 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 2.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 3.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 3.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.5 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 3.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 1.2 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 5.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 1.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport