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Results for pdx1

Z-value: 1.12

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Transcription factors associated with pdx1

Gene Symbol Gene ID Gene Info
ENSDARG00000002779 pancreatic and duodenal homeobox 1

Activity profile of pdx1 motif

Sorted Z-values of pdx1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of pdx1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr7_-_25426346 8.62 ENSDART00000082620
dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)
chr21_-_23271127 4.44 ENSDART00000007806
zinc finger and BTB domain containing 16a
chr3_-_32686790 4.39 ENSDART00000075465
myosin light chain, phosphorylatable, fast skeletal muscle a
chr16_+_24057260 3.78 ENSDART00000132742
ENSDART00000145330
apolipoprotein C-I
chr8_-_16662185 3.57 ENSDART00000076542
retinal pigment epithelium-specific protein 65b
chr1_-_19152361 3.52 ENSDART00000132958
glyoxylate reductase/hydroxypyruvate reductase b
chr13_-_5440923 3.19 ENSDART00000102576
Meis homeobox 1 b
chr19_+_25009921 3.02

chr20_-_29517770 2.66 ENSDART00000147464
ryanodine receptor 3
chr16_+_24063849 2.49 ENSDART00000135084
apolipoprotein A-II
chr12_+_28739504 2.36 ENSDART00000152991
nuclear factor, erythroid 2-like 1b
chr5_-_36237656 2.35 ENSDART00000032481
creatine kinase, muscle a
chr19_+_20209561 2.35 ENSDART00000168833
ENSDARG00000098798
chr14_+_4489377 2.34 ENSDART00000041468
adaptor-related protein complex 1 associated regulatory protein
chr16_+_21121428 2.33

chr16_+_14817799 2.31 ENSDART00000137912
collagen, type XIV, alpha 1a
chr6_+_4712785 2.30 ENSDART00000151674
protocadherin 9
chr11_-_5868257 2.29 ENSDART00000104360
guanidinoacetate N-methyltransferase
chr23_+_2391223 2.23

chr18_+_45893199 2.23 ENSDART00000158246
dishevelled segment polarity protein 3b
chr3_+_33168814 2.21 ENSDART00000114023
heat shock protein, alpha-crystallin-related, 9
chr13_-_24316940 2.16 ENSDART00000127741
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr24_-_6868340 2.13 ENSDART00000158646
dipeptidyl-peptidase 6a
chr17_+_27417635 2.13 ENSDART00000052446
vestigial-like family member 2b
chr6_-_14821305 2.07

chr7_-_8128948 1.95 ENSDART00000057101
aerolysin-like protein
chr4_-_2615160 1.94 ENSDART00000140760
E2F transcription factor 7
chr2_+_42874975 1.94 ENSDART00000075392
brain abundant, membrane attached signal protein 1
chr11_+_40652239 1.91 ENSDART00000169817
ENSDART00000162157
ENSDART00000172008
paired box 7a
chr13_+_23152038 1.91 ENSDART00000171676
KH domain containing, RNA binding, signal transduction associated 2
chr21_+_20678383 1.91 ENSDART00000015224
growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1
chr15_-_31687 1.87

chr23_+_10211543 1.81 ENSDART00000048073
zgc:171775
chr12_-_26314881 1.77 ENSDART00000178687
myozenin 1b
chr7_+_42124857 1.75 ENSDART00000004120
ADAM metallopeptidase with thrombospondin type 1 motif, 18
KN150074v1_-_1031 1.75

chr25_+_24520476 1.74

chr2_-_36058327 1.74 ENSDART00000003550
nicotinamide nucleotide adenylyltransferase 2
chr16_+_14817718 1.74 ENSDART00000027982
collagen, type XIV, alpha 1a
chr12_+_9664920 1.73 ENSDART00000091489
protein phosphatase 1, regulatory subunit 9Bb
chr17_+_52736192 1.72 ENSDART00000158273
ENSDART00000161414
Meis homeobox 2a
chr25_+_20118286 1.71 ENSDART00000104297
troponin T2d, cardiac
chr13_+_30781652 1.69 ENSDART00000133138
dorsal root ganglia homeobox
chr17_-_52735250 1.66

chr4_-_19027117 1.66 ENSDART00000166160
si:dkey-31f5.11
chr24_-_4941954 1.65 ENSDART00000127597
zic family member 1 (odd-paired homolog, Drosophila)
chr16_-_54638972 1.64

chr8_-_34077387 1.63 ENSDART00000159208
ENSDART00000040126
ENSDART00000048994
ENSDART00000098822
pre-B-cell leukemia homeobox 3b
chr5_+_37113743 1.62

chr5_+_44407763 1.62 ENSDART00000010786
doublesex and mab-3 related transcription factor 2a
chr3_+_30790513 1.60 ENSDART00000130422
claudin i
chr5_+_49103778 1.58 ENSDART00000155405
ENSDARG00000098045
chr16_+_24032160 1.58 ENSDART00000103190
apolipoprotein A-IV b, tandem duplicate 2
chr11_+_7518953 1.58 ENSDART00000171813
adhesion G protein-coupled receptor L2a
chr9_+_25964943 1.56 ENSDART00000147229
ENSDART00000127834
zinc finger E-box binding homeobox 2a
chr16_+_21122024 1.56

chr20_-_42805703 1.51 ENSDART00000045816
plasminogen
chr15_-_33688186 1.50

chr21_-_28883441 1.48 ENSDART00000132884
CXXC finger protein 5a
chr13_+_22350043 1.46 ENSDART00000136863
LIM domain binding 3a
chr16_-_19154920 1.46 ENSDART00000088818
formin homology 2 domain containing 3b
chr3_-_34363698 1.46

chr1_+_16983775 1.45 ENSDART00000030665
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr20_+_19613133 1.44 ENSDART00000152548
ENSDART00000063696
all-trans retinoic acid-induced differentiation factor
chr18_-_14891913 1.42 ENSDART00000018502
mitogen-activated protein kinase 12a
chr24_+_24308055 1.41

chr5_-_18457877 1.39 ENSDART00000142531
ankyrin repeat and LEM domain containing 2
chr16_+_10885785 1.37 ENSDART00000161969
ATPase, Na+/K+ transporting, alpha 3b polypeptide
chr13_-_11404389 1.37 ENSDART00000018155
adenylosuccinate synthase
chr23_+_35819625 1.36 ENSDART00000049551
retinoic acid receptor gamma a
chr7_-_33558939 1.36 ENSDART00000074729
uveal autoantigen with coiled-coil domains and ankyrin repeats b
chr1_-_46292847 1.35 ENSDART00000125032
pbx/knotted 1 homeobox 1.2
chr10_+_31358236 1.33 ENSDART00000145562
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr23_-_6707246 1.33 ENSDART00000023793
major intrinsic protein of lens fiber b
chr15_+_21231406 1.30 ENSDART00000038499
ENSDARG00000077872
chr10_-_26782374 1.30 ENSDART00000162710
fibroblast growth factor 13b
chr5_+_53178362 1.29 ENSDART00000169565
spermidine/spermine N1-acetyltransferase family member 2b
chr24_-_12794564 1.28 ENSDART00000024084
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr7_+_26357875 1.28 ENSDART00000101044
heat shock factor binding protein 1a
chr1_-_25600988 1.28 ENSDART00000160381
CXXC finger 4
chr5_+_34857986 1.27 ENSDART00000141239
ER lipid raft associated 2
chr13_+_30781718 1.25 ENSDART00000133138
dorsal root ganglia homeobox
KN149932v1_+_27584 1.25

chr9_-_20562293 1.23 ENSDART00000113418
immunoglobulin superfamily, member 3
chr1_-_9387290 1.20 ENSDART00000135522
ENSDART00000135676
fibrinogen alpha chain
chr7_-_39170016 1.20 ENSDART00000161191
ENSDARG00000101872
chr6_+_24299180 1.18 ENSDART00000167482
transforming growth factor, beta receptor III
chr7_+_20251345 1.15 ENSDART00000157699
si:dkey-19b23.12
chr3_+_23638277 1.15 ENSDART00000110682
homeobox B1a
chr16_+_24058139 1.14

chr14_+_21999898 1.14

chr21_+_22386643 1.14 ENSDART00000133190
calcyphosine-like b
chr21_+_22808694 1.14 ENSDART00000065555
baculoviral IAP repeat containing 2
chr4_-_16344954 1.13 ENSDART00000079523
epiphycan
chr23_+_43284714 1.12

chr12_-_26339002 1.11 ENSDART00000153214
synaptopodin 2-like b
chr16_+_51319421 1.10

chr25_-_13737344 1.10

chr4_+_13811932 1.09 ENSDART00000067168
PDZ domain containing ring finger 4
chr13_-_25067585 1.09 ENSDART00000159585
adenosine kinase a
chr22_+_16509286 1.09 ENSDART00000083063
T-cell acute lymphocytic leukemia 1
chr23_+_17294623 1.09 ENSDART00000054761
nucleolar protein 4-like b
chr7_+_44269171 1.08 ENSDART00000149981
CKLF-like MARVEL transmembrane domain containing 3
chr7_+_45980684 1.08 ENSDART00000167149
zinc finger protein 536
chr13_-_5440751 1.08 ENSDART00000102576
Meis homeobox 1 b
chr5_-_62747812 1.08

chr25_-_3853819 1.07 ENSDART00000124749
myelin regulatory factor
chr12_-_48948928 1.07 ENSDART00000163734
retinal G protein coupled receptor b
chr8_+_18552850 1.07 ENSDART00000177476
proline rich Gla (G-carboxyglutamic acid) 1
chr4_-_998370 1.06

chr3_-_50386208 1.04 ENSDART00000156709
ENSDARG00000097178
chr2_+_57903155 1.04

chr13_-_5440558 1.04 ENSDART00000102576
Meis homeobox 1 b
chr21_-_43083936 1.04 ENSDART00000040169
janus kinase and microtubule interacting protein 2
chr15_+_31036717 1.03 ENSDART00000129474
oligodendrocyte myelin glycoprotein b
chr23_+_16962770 1.03 ENSDART00000146895
si:dkey-147f3.8
chr5_+_296856 1.02

chr6_+_15141723 1.02 ENSDART00000128090
esophageal cancer related gene 4b
chr19_-_10324632 1.02 ENSDART00000148073
shisa family member 7
chr6_-_10991748 1.02 ENSDART00000151252
myosin X-like 1
chr8_-_25055333 0.99 ENSDART00000134190
sortilin 1b
chr9_-_23406315 0.98 ENSDART00000159256
kinesin family member 5C
chr4_+_828545 0.98 ENSDART00000067461
si:ch211-152c2.3
chr21_+_43674754 0.98 ENSDART00000136025
trimethyllysine hydroxylase, epsilon
chr7_+_26770097 0.97 ENSDART00000173822
ribosomal protein S13
chr8_+_22910147 0.97 ENSDART00000063096
synaptophysin a
chr9_+_3147601 0.97 ENSDART00000135619
finTRIM family, member 52, pseudogene
chr16_+_51317933 0.96 ENSDART00000157736
high mobility group nucleosomal binding domain 2
chr17_+_23892232 0.96

chr11_+_13470883 0.96 ENSDART00000011362
arrestin domain containing 2
chr23_+_36023748 0.95

chr24_-_12794672 0.95 ENSDART00000024084
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr8_+_15216833 0.95 ENSDART00000141185
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr17_-_19606453 0.94 ENSDART00000011432
receptor accessory protein 3a
chr11_-_6051096 0.94 ENSDART00000147761
vessel-specific 1
chr24_-_6048914 0.94 ENSDART00000146830
ENSDART00000021981
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr23_+_35996491 0.92 ENSDART00000127384
homeobox C9a
chr21_+_13063614 0.92

chr18_+_23891068 0.91 ENSDART00000146490
ENSDARG00000092402
chr7_-_33558771 0.89 ENSDART00000074729
uveal autoantigen with coiled-coil domains and ankyrin repeats b
chr19_-_27284726 0.89 ENSDART00000089699
proline-rich transmembrane protein 1
chr22_-_24286717 0.89 ENSDART00000161480
urotensin 2 domain containing
chr2_-_844040 0.87 ENSDART00000028159
forkhead box F2a
chr15_-_35802739 0.87 ENSDART00000174714
ENSDARG00000106192
chr19_+_14197118 0.86 ENSDART00000166230
trophoblast glycoprotein a
chr7_+_24770873 0.85 ENSDART00000165314
ENSDARG00000103682
chr13_+_16130123 0.85 ENSDART00000170855
molybdenum cofactor sulfurase
chr5_-_63422783 0.84 ENSDART00000083684
pregnancy-associated plasma protein A, pappalysin 1b
chr2_-_44330405 0.84 ENSDART00000111246
cell adhesion molecule 3
chr3_+_40667131 0.84 ENSDART00000033713
actin related protein 2/3 complex, subunit 1B
chr15_-_25592228 0.83 ENSDART00000157498
hypoxia-inducible factor 1, alpha subunit, like
chr1_+_38669801 0.83 ENSDART00000084891
ENSDART00000148701
teneurin transmembrane protein 3
chr3_+_23621561 0.83 ENSDART00000146636
homeobox B2a
chr24_+_18804086 0.82 ENSDART00000106186
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_38669902 0.82 ENSDART00000084891
ENSDART00000148701
teneurin transmembrane protein 3
chr7_+_53485273 0.81 ENSDART00000158160
ENSDART00000163261
neogenin 1a
chr8_-_38168395 0.80 ENSDART00000155189
PDZ and LIM domain 2 (mystique)
chr21_-_27301938 0.80 ENSDART00000130632
hypoxia-inducible factor 1, alpha subunit, like 2
chr5_-_7329952 0.80 ENSDART00000162626
ENSDART00000157661
PDZ and LIM domain 5a
chr16_-_55234426 0.79 ENSDART00000078887
transmembrane protein 222a
chr4_+_26507297 0.79 ENSDART00000160652
IQ motif and Sec7 domain 3a
chr20_-_7303804 0.79 ENSDART00000100060
desmocollin 2 like
chr19_+_20194594 0.78 ENSDART00000169074
homeobox A4a
chr1_-_22867130 0.78 ENSDART00000145942
ENSDART00000077394
family with sequence similarity 184, member B
chr24_-_24306469 0.77 ENSDART00000154149
ENSDARG00000097984
chr5_-_62747914 0.77

chr3_+_23621843 0.77 ENSDART00000146636
homeobox B2a
chr19_+_20202737 0.76 ENSDART00000164677
homeobox A4a
chr22_-_29886668 0.76 ENSDART00000125017
ENSDARG00000092881
chr15_+_28269289 0.76 ENSDART00000077736
vitronectin a
chr8_-_34077790 0.76

chr8_+_5222065 0.76 ENSDART00000035676
BCL2/adenovirus E1B interacting protein 3-like a
chr3_+_37433008 0.76 ENSDART00000055225
wingless-type MMTV integration site family, member 9B
chr15_+_14048904 0.75 ENSDART00000159438
zgc:162730
chr14_+_5078937 0.74 ENSDART00000031508
ladybird homeobox 2
chr24_+_34227202 0.74 ENSDART00000105572
gastrulation brain homeobox 1
chr3_+_26015378 0.74

chr12_-_28766713 0.73 ENSDART00000148459
chromobox homolog 1b (HP1 beta homolog Drosophila)
chr9_-_30553051 0.72 ENSDART00000147030
synaptotagmin-like 5
chr5_+_64411412 0.72 ENSDART00000158484
ENSDARG00000101163
chr4_-_25496215 0.71 ENSDART00000041402
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
KN150623v1_+_577 0.71

chr21_+_2048601 0.71

chr5_-_32687349 0.71 ENSDART00000004238
ribosomal protein L7a
chr3_-_62143464 0.71 ENSDART00000155853
G protein-coupled receptor, class C, group 5, member Ba
chr18_+_23891152 0.70 ENSDART00000146490
ENSDARG00000092402
chr7_-_20201693 0.70 ENSDART00000174001
netrin 5
chr3_+_15656123 0.69 ENSDART00000055834
phosphatase, orphan 1
chr4_+_13453879 0.69 ENSDART00000145069
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr8_-_23744125 0.68 ENSDART00000141871
innate immunity activator
chr24_+_37692365 0.68

chr18_+_9228336 0.68

chr9_+_25964868 0.68 ENSDART00000147229
ENSDART00000127834
zinc finger E-box binding homeobox 2a
chr23_+_18565721 0.68

chr23_-_45646407 0.68 ENSDART00000149291
ENSDARG00000036894
chr23_-_28286971 0.67

chr22_+_20436009 0.67 ENSDART00000135984
one cut homeobox 3a
chr1_+_45843326 0.67

chr17_+_50622804 0.66 ENSDART00000049464
fermitin family member 2
chr9_-_12604260 0.66 ENSDART00000102419
insulin-like growth factor 2 mRNA binding protein 2a

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.6 GO:0050765 monocyte activation involved in immune response(GO:0002280) negative regulation of phagocytosis(GO:0050765)
1.3 3.8 GO:0032369 negative regulation of lipid transport(GO:0032369)
1.1 4.4 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.8 2.3 GO:0006600 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.6 1.9 GO:0032875 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
0.6 2.2 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) glycerol biosynthetic process from pyruvate(GO:0046327) cellular response to dexamethasone stimulus(GO:0071549)
0.5 1.6 GO:0070983 dendrite guidance(GO:0070983) regulation of homophilic cell adhesion(GO:1903385)
0.5 1.5 GO:0042730 fibrinolysis(GO:0042730)
0.5 1.9 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.5 2.8 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.4 1.3 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.4 3.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.4 2.2 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.4 1.1 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.4 1.5 GO:1990544 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.4 2.9 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.4 1.4 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.4 5.3 GO:0072554 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.3 4.0 GO:0070831 basement membrane assembly(GO:0070831)
0.3 1.6 GO:0048853 forebrain morphogenesis(GO:0048853)
0.3 1.3 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.3 2.2 GO:0090178 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.3 1.5 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 2.1 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.3 1.2 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.3 1.2 GO:0021561 facial nerve development(GO:0021561)
0.3 1.1 GO:0010939 regulation of necrotic cell death(GO:0010939) regulation of necroptotic process(GO:0060544)
0.3 1.1 GO:0044209 AMP salvage(GO:0044209)
0.3 1.1 GO:0043217 myelin maintenance(GO:0043217)
0.2 0.7 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.2 1.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 1.9 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.2 0.9 GO:1901492 regulation of lymphangiogenesis(GO:1901490) positive regulation of lymphangiogenesis(GO:1901492)
0.2 0.4 GO:0043266 regulation of potassium ion transport(GO:0043266)
0.2 1.0 GO:0098971 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971) axo-dendritic protein transport(GO:0099640)
0.2 1.9 GO:0051639 actin filament network formation(GO:0051639)
0.2 1.3 GO:0006833 water transport(GO:0006833)
0.2 1.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.2 3.6 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.2 1.7 GO:0009435 NAD biosynthetic process(GO:0009435)
0.2 0.5 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.2 1.2 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.8 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 0.9 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579)
0.1 1.3 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 1.0 GO:0090398 cellular senescence(GO:0090398)
0.1 1.2 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.1 0.6 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 0.4 GO:0019532 oxalate transport(GO:0019532)
0.1 0.4 GO:0002762 negative regulation of myeloid leukocyte differentiation(GO:0002762)
0.1 0.9 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.3 GO:0032475 otolith formation(GO:0032475)
0.1 0.4 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
0.1 0.5 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 1.4 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 0.2 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.1 0.5 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.3 GO:0015882 L-ascorbic acid transport(GO:0015882)
0.1 0.3 GO:0090594 inflammatory response to wounding(GO:0090594)
0.1 1.1 GO:0007602 phototransduction(GO:0007602)
0.1 1.8 GO:0071456 cellular response to hypoxia(GO:0071456)
0.1 0.3 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.1 0.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.6 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.1 1.6 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 1.6 GO:0007548 sex differentiation(GO:0007548)
0.1 1.0 GO:0002574 thrombocyte differentiation(GO:0002574)
0.1 2.6 GO:0060037 pharyngeal system development(GO:0060037)
0.1 1.0 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 2.4 GO:0008203 cholesterol metabolic process(GO:0008203)
0.1 1.7 GO:0006937 regulation of muscle contraction(GO:0006937)
0.1 0.7 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.1 0.4 GO:0002093 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.1 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.7 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 2.0 GO:0042742 defense response to bacterium(GO:0042742)
0.0 0.9 GO:0051283 sequestering of calcium ion(GO:0051208) release of sequestered calcium ion into cytosol(GO:0051209) regulation of sequestering of calcium ion(GO:0051282) negative regulation of sequestering of calcium ion(GO:0051283)
0.0 0.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 2.5 GO:0055113 epiboly involved in gastrulation with mouth forming second(GO:0055113)
0.0 0.2 GO:0019478 D-amino acid catabolic process(GO:0019478) D-serine catabolic process(GO:0036088) D-amino acid metabolic process(GO:0046416) D-serine metabolic process(GO:0070178)
0.0 0.9 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 1.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.5 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.0 3.7 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.1 GO:0032964 collagen biosynthetic process(GO:0032964)
0.0 0.3 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 2.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.5 GO:0060326 cell chemotaxis(GO:0060326)
0.0 0.5 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.2 GO:0009584 detection of visible light(GO:0009584)
0.0 2.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.8 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 0.7 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.0 0.7 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.6 GO:0051875 pigment granule localization(GO:0051875) establishment of pigment granule localization(GO:0051905)
0.0 0.2 GO:0021983 pituitary gland development(GO:0021983)
0.0 1.8 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 0.1 GO:0010887 cholesterol storage(GO:0010878) regulation of cholesterol storage(GO:0010885) negative regulation of cholesterol storage(GO:0010887) negative regulation of lipid storage(GO:0010888)
0.0 0.3 GO:0009409 response to cold(GO:0009409)
0.0 1.6 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 1.7 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.0 GO:0051645 Golgi localization(GO:0051645)
0.0 0.7 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.4 GO:0001756 somitogenesis(GO:0001756)
0.0 0.9 GO:0006814 sodium ion transport(GO:0006814)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 8.6 GO:0030315 T-tubule(GO:0030315)
0.5 4.0 GO:0005614 interstitial matrix(GO:0005614)
0.4 3.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.4 1.2 GO:0005577 fibrinogen complex(GO:0005577)
0.3 1.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.3 1.5 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 2.0 GO:0046930 pore complex(GO:0046930)
0.2 0.7 GO:0070062 extracellular exosome(GO:0070062)
0.1 1.0 GO:0044295 axonal growth cone(GO:0044295)
0.1 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 0.6 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.9 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 3.6 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1 1.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 5.9 GO:0030018 Z disc(GO:0030018)
0.1 0.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.2 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.5 GO:0005913 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.1 1.2 GO:0030057 desmosome(GO:0030057)
0.1 2.4 GO:0014069 postsynaptic density(GO:0014069)
0.1 0.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 1.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.5 GO:0030175 filopodium(GO:0030175)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 5.9 GO:0030424 axon(GO:0030424)
0.0 0.5 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.5 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.4 GO:0016342 catenin complex(GO:0016342)
0.0 1.0 GO:0005604 basement membrane(GO:0005604)
0.0 1.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 0.4 GO:0005844 polysome(GO:0005844)
0.0 1.0 GO:0043296 apical junction complex(GO:0043296)
0.0 0.7 GO:0022626 cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626)
0.0 0.0 GO:1990745 EARP complex(GO:1990745)
0.0 0.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.5 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0008465 glycerate dehydrogenase activity(GO:0008465)
0.6 2.2 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.5 3.8 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.4 1.8 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.4 2.0 GO:0070492 oligosaccharide binding(GO:0070492)
0.4 1.1 GO:0004001 adenosine kinase activity(GO:0004001)
0.4 1.5 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.4 2.9 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.3 1.3 GO:0019809 polyamine binding(GO:0019808) spermidine binding(GO:0019809)
0.3 3.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.3 1.5 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.2 2.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 1.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 1.3 GO:0015250 water channel activity(GO:0015250)
0.2 1.7 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.2 0.8 GO:0030151 molybdenum ion binding(GO:0030151)
0.2 8.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 1.9 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1 3.6 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 3.1 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 3.2 GO:0004707 MAP kinase activity(GO:0004707)
0.1 2.5 GO:0008143 poly(A) binding(GO:0008143)
0.1 1.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.9 GO:0005355 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.1 0.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 1.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 0.4 GO:0099528 G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.1 1.0 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 1.1 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 0.5 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 3.0 GO:0005109 frizzled binding(GO:0005109)
0.1 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.2 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.1 0.8 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 1.3 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 1.0 GO:0019894 kinesin binding(GO:0019894)
0.1 0.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.7 GO:0015026 coreceptor activity(GO:0015026)
0.1 8.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 1.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 4.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.7 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.6 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.7 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 2.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 1.4 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 18.6 GO:0001159 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 1.6 GO:0015293 symporter activity(GO:0015293)
0.0 0.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 8.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 1.8 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0034595 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.0 0.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 1.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 3.0 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 1.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 1.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 2.2 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.9 PID E2F PATHWAY E2F transcription factor network
0.0 1.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.3 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.2 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.3 2.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 2.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2 2.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 0.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.5 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.6 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.1 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives