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Results for pitx3

Z-value: 0.22

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Transcription factors associated with pitx3

Gene Symbol Gene ID Gene Info
pitx3
ENSDARG00000070069 paired-like homeodomain 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pitx3dr10_dc_chr13_-_7241422_7241494-0.048.9e-01Click!

Activity profile of pitx3 motif

Sorted Z-values of pitx3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_+_26013873 0.37 ENSDART00000043932
atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr21_+_27346176 0.15 ENSDART00000005682
actn3a
actinin alpha 3a
chr21_-_11539798 0.14 ENSDART00000144770
cast
calpastatin
chr6_-_13910679 0.12 ENSDART00000065361
etv5b
ets variant 5b
chr7_+_45748011 0.12 ENSDART00000170294
ccne1
cyclin E1
chr4_-_17226968 0.11 ENSDART00000177956
ENSDART00000177406
BX547928.1
ENSDARG00000106175
chr7_+_53143741 0.11 ENSDART00000164643
ENSDARG00000104530
ENSDARG00000104530
chr11_-_29316162 0.11 ENSDART00000163958
arhgef10la
Rho guanine nucleotide exchange factor (GEF) 10-like a
chr20_+_29685331 0.08 ENSDART00000153339
adam17b
ADAM metallopeptidase domain 17b
chr23_+_36832325 0.08

chr20_+_29685096 0.07 ENSDART00000153339
adam17b
ADAM metallopeptidase domain 17b
chr7_-_66641971 0.07

chr18_+_9228336 0.07

chr23_+_22649686 0.06 ENSDART00000146709
CR388207.1
ENSDARG00000095377
chr5_+_45822196 0.06

chr18_+_7680416 0.06 ENSDART00000132369
rabl2
RAB, member of RAS oncogene family-like 2
chr12_-_7902815 0.06 ENSDART00000088100
ank3b
ankyrin 3b
chr14_+_6117282 0.05 ENSDART00000051556
abca1b
ATP-binding cassette, sub-family A (ABC1), member 1B
chr7_-_66641207 0.05

chr7_+_45748086 0.05 ENSDART00000170294
ccne1
cyclin E1
chr19_-_39048324 0.05 ENSDART00000086717
col16a1
collagen, type XVI, alpha 1
chr5_-_16479187 0.04 ENSDART00000038740
galnt9
polypeptide N-acetylgalactosaminyltransferase 9
chr25_-_20932941 0.04 ENSDART00000138985
ENSDART00000046298
gnaia
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr3_-_26013660 0.04

chr25_+_18467034 0.04 ENSDART00000170841
cav1
caveolin 1
chr2_-_32521879 0.04 ENSDART00000056639
faim2a
Fas apoptotic inhibitory molecule 2a
chr2_-_32755182 0.04 ENSDART00000041146
nrbp2a
nuclear receptor binding protein 2a
chr17_+_777154 0.03 ENSDART00000161446
si:ch211-193k8.2
si:ch211-193k8.2
chr25_+_21735567 0.03 ENSDART00000148299
ckmt1
creatine kinase, mitochondrial 1
chr8_+_23083842 0.03 ENSDART00000025171
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr9_+_30822402 0.03

chr4_+_11465367 0.03 ENSDART00000008584
gdi2
GDP dissociation inhibitor 2
chr18_-_5822255 0.03 ENSDART00000121503
cplx3b
complexin 3b
chr21_+_1117194 0.03 ENSDART00000178294
CABZ01086137.1
ENSDARG00000107408
chr8_+_23084130 0.02 ENSDART00000025171
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr3_-_20989024 0.02 ENSDART00000129016
maza
MYC-associated zinc finger protein a (purine-binding transcription factor)
chr23_+_22649652 0.02 ENSDART00000146709
CR388207.1
ENSDARG00000095377
chr16_-_51434927 0.02 ENSDART00000148677
serpinb1l4
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 4
chr8_+_23334921 0.02 ENSDART00000085361
ENSDART00000046460
ENSDART00000145062
dnmt3ba
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr6_+_28232386 0.02 ENSDART00000163057
FP101882.1
ENSDARG00000098121
chr25_+_18467835 0.02 ENSDART00000172338
cav1
caveolin 1
chr16_-_25748690 0.02 ENSDART00000031304
derl1
derlin 1
chr6_-_12786937 0.02 ENSDART00000157139
tmbim1a
transmembrane BAX inhibitor motif containing 1a
chr7_-_29262814 0.02 ENSDART00000124028
anxa2b
annexin A2b
chr12_-_19056530 0.01

chr19_-_39048402 0.01 ENSDART00000086717
col16a1
collagen, type XVI, alpha 1
chr17_+_16038358 0.01 ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr5_+_60234640 0.01

chr13_-_22653869 0.01

chr7_+_53143890 0.01 ENSDART00000164643
ENSDARG00000104530
ENSDARG00000104530
chr1_-_40211790 0.01 ENSDART00000113087
hmx1
H6 family homeobox 1
chr7_+_45747622 0.01 ENSDART00000163991
ccne1
cyclin E1
chr6_-_54118302 0.01 ENSDART00000161059
tusc2a
tumor suppressor candidate 2a
chr2_-_48317047 0.01 ENSDART00000123040
pfkpb
phosphofructokinase, platelet b
chr24_+_17044956 0.01

chr5_-_40473026 0.01 ENSDART00000174936
pdzd2
PDZ domain containing 2
chr3_-_49104540 0.01 ENSDART00000138503
btr02
bloodthirsty-related gene family, member 2
chr25_+_18467217 0.01 ENSDART00000170841
cav1
caveolin 1
chr19_+_43928043 0.01 ENSDART00000113031
wasf2
WAS protein family, member 2
chr20_+_29685379 0.01 ENSDART00000178617
adam17b
ADAM metallopeptidase domain 17b
chr12_+_27122352 0.00 ENSDART00000133048
nbr1a
neighbor of brca1 gene 1a
chr17_+_777107 0.00 ENSDART00000161446
si:ch211-193k8.2
si:ch211-193k8.2
chr16_+_29651305 0.00 ENSDART00000124232
mcl1b
MCL1, BCL2 family apoptosis regulator b
chr21_+_5597536 0.00 ENSDART00000161235
ENSDART00000170456
shroom3
shroom family member 3
chr7_-_17527827 0.00 ENSDART00000128504
si:dkey-106g10.7
si:dkey-106g10.7

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0045933 regulation of skeletal muscle contraction(GO:0014819) positive regulation of muscle contraction(GO:0045933)
0.0 0.1 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.0 0.1 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.0 0.4 GO:0031672 A band(GO:0031672)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis