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Results for pknox1.1+pknox1.2_meis2b

Z-value: 2.04

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Transcription factors associated with pknox1.1+pknox1.2_meis2b

Gene Symbol Gene ID Gene Info
pknox1.1
ENSDARG00000018765 pbx/knotted 1 homeobox 1.1
pknox1.2
ENSDARG00000036542 pbx/knotted 1 homeobox 1.2
meis2b
ENSDARG00000077840 Meis homeobox 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
meis2bdr10_dc_chr20_-_10131480_10131649-0.837.6e-05Click!
pknox1.2dr10_dc_chr1_-_46292847_46292912-0.783.4e-04Click!
pknox1.1dr10_dc_chr9_+_19719018_19719087-0.087.6e-01Click!

Activity profile of pknox1.1+pknox1.2_meis2b motif

Sorted Z-values of pknox1.1+pknox1.2_meis2b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of pknox1.1+pknox1.2_meis2b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr20_-_28531087 9.31 ENSDART00000172133
CABZ01057122.1
ENSDARG00000105192
chr14_-_41101660 7.32 ENSDART00000003170
mid1ip1l
MID1 interacting protein 1, like
chr9_+_4382041 6.96

chr8_-_32376710 6.90 ENSDART00000098850
lipg
lipase, endothelial
chr25_+_22222388 6.53 ENSDART00000154376
cyp11a1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr5_-_12086676 5.84 ENSDART00000081494
ENSDART00000162780
vsig10
V-set and immunoglobulin domain containing 10
chr4_-_17289857 5.66 ENSDART00000178686
lrmp
lymphoid-restricted membrane protein
chr13_+_22973764 5.25 ENSDART00000110266
pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr24_+_40770039 5.23

chr17_-_36913213 5.16 ENSDART00000154981
senp6b
SUMO1/sentrin specific peptidase 6b
chr19_+_42661987 4.10 ENSDART00000102698
jtb
jumping translocation breakpoint
chr22_-_21021942 4.09 ENSDART00000133982
ssbp4
single stranded DNA binding protein 4
chr8_+_25940758 4.06 ENSDART00000140626
ENSDARG00000061023
ENSDARG00000061023
chr17_-_7635061 3.91 ENSDART00000064655
zbtb2a
zinc finger and BTB domain containing 2a
chr22_-_37899243 3.90 ENSDART00000076128
ppp1r2
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr20_-_28531019 3.58 ENSDART00000172133
CABZ01057122.1
ENSDARG00000105192
chr14_-_20940726 3.54 ENSDART00000129743
si:ch211-175m2.5
si:ch211-175m2.5
chr8_+_25940883 3.52 ENSDART00000140626
ENSDARG00000061023
ENSDARG00000061023
chr15_+_545678 3.50 ENSDART00000102275
ENSDART00000102274
ftr86
finTRIM family, member 86
chr5_-_12086593 3.28 ENSDART00000081494
ENSDART00000162780
vsig10
V-set and immunoglobulin domain containing 10
chr15_+_23592828 3.14 ENSDART00000152422
si:dkey-182i3.8
si:dkey-182i3.8
chr17_+_5680342 3.14 ENSDART00000156089
CU929322.1
ENSDARG00000096839
chr5_-_39205454 3.07 ENSDART00000133231
rasgef1ba
RasGEF domain family, member 1Ba
chr6_+_422911 2.95

chr18_+_39506453 2.94 ENSDART00000126978
acadl
acyl-CoA dehydrogenase, long chain
chr18_-_49291686 2.91 ENSDART00000174038
si:zfos-464b6.2
si:zfos-464b6.2
chr24_+_23571714 2.91 ENSDART00000080332
cops5
COP9 signalosome subunit 5
chr20_+_15072029 2.90 ENSDART00000063874
vamp4
vesicle-associated membrane protein 4
chr11_+_29299382 2.88

chr7_-_20556760 2.83 ENSDART00000143509
dnajc3b
DnaJ (Hsp40) homolog, subfamily C, member 3b
chr10_+_36752015 2.82 ENSDART00000171392
rab6a
RAB6A, member RAS oncogene family
chr20_-_46563338 2.80 ENSDART00000060702
rmdn3
regulator of microtubule dynamics 3
chr25_+_14773723 2.79 ENSDART00000035714
dnajc24
DnaJ (Hsp40) homolog, subfamily C, member 24
chr15_-_28654137 2.75 ENSDART00000156049
ssh2a
slingshot protein phosphatase 2a
chr5_-_36503296 2.70 ENSDART00000149211
il13ra2
interleukin 13 receptor, alpha 2
chr16_-_32708662 2.67 ENSDART00000133351
coq3
coenzyme Q3 methyltransferase
chr1_+_57267909 2.67 ENSDART00000152640
BX469930.2
ENSDARG00000096615
chr5_-_40524177 2.65 ENSDART00000083561
mtmr12
myotubularin related protein 12
chr20_-_35601497 2.61

chr12_-_33558248 2.59 ENSDART00000153457
tmem94
transmembrane protein 94
chr25_+_22222336 2.57 ENSDART00000154065
cyp11a1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr17_-_36913302 2.54 ENSDART00000154981
senp6b
SUMO1/sentrin specific peptidase 6b
chr10_+_45108698 2.45

chr14_-_38549466 2.44 ENSDART00000035779
zgc:101583
zgc:101583
chr3_+_16880947 2.44 ENSDART00000080854
stat3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr11_+_8142982 2.41 ENSDART00000166379
samd13
sterile alpha motif domain containing 13
chr25_+_14773447 2.39 ENSDART00000171835
dnajc24
DnaJ (Hsp40) homolog, subfamily C, member 24
chr15_+_545631 2.35 ENSDART00000102275
ENSDART00000102274
ftr86
finTRIM family, member 86
chr12_+_18794467 2.34 ENSDART00000127536
cbx7b
chromobox homolog 7b
chr20_+_34021257 2.33 ENSDART00000146292
lmx1a
LIM homeobox transcription factor 1, alpha
chr13_-_24265471 2.31 ENSDART00000016211
tbp
TATA box binding protein
chr6_+_49054117 2.30 ENSDART00000011876
sycp1
synaptonemal complex protein 1
chr4_-_20092577 2.29 ENSDART00000164410
dennd6b
DENN/MADD domain containing 6B
chr16_-_32708605 2.28 ENSDART00000133351
coq3
coenzyme Q3 methyltransferase
chr16_-_11981275 2.27

chr10_+_37556367 2.25 ENSDART00000135642
msi2a
musashi RNA-binding protein 2a
chr7_-_25991514 2.16 ENSDART00000137769
ap1s1
adaptor-related protein complex 1, sigma 1 subunit
chr11_-_24300905 2.14 ENSDART00000171004
plekhg5a
pleckstrin homology domain containing, family G (with RhoGef domain) member 5a
chr20_-_20370397 2.13 ENSDART00000009356
ppp2r5ea
protein phosphatase 2, regulatory subunit B', epsilon isoform a
chr8_-_41511380 2.11 ENSDART00000019858
golga1
golgin A1
chr24_-_20812363 2.06 ENSDART00000142080
kpna1
karyopherin alpha 1 (importin alpha 5)
chr2_+_50680126 2.01 ENSDART00000122716
ENSDARG00000090398
ENSDARG00000090398
chr3_-_22240424 2.01

chr3_-_23466232 2.00 ENSDART00000156897
ube2z
ubiquitin-conjugating enzyme E2Z
chr11_-_15886860 2.00 ENSDART00000170731
zgc:173544
zgc:173544
chr4_+_27909339 1.98 ENSDART00000100453
cerk
ceramide kinase
chr25_+_2252667 1.97 ENSDART00000172905
zmp:0000000932
zmp:0000000932
chr21_-_23009910 1.97 ENSDART00000016167
zw10
zw10 kinetochore protein
chr20_+_34021116 1.96 ENSDART00000146292
lmx1a
LIM homeobox transcription factor 1, alpha
chr2_-_45657620 1.94 ENSDART00000056357
gpsm2
G protein signaling modulator 2
chr7_-_56465369 1.93 ENSDART00000020967
csnk2a2a
casein kinase 2, alpha prime polypeptide a
chr22_-_21021984 1.93 ENSDART00000133982
ssbp4
single stranded DNA binding protein 4
chr6_-_39162916 1.92 ENSDART00000148661
stat2
signal transducer and activator of transcription 2
chr5_-_31889551 1.92 ENSDART00000168870
gpr107
G protein-coupled receptor 107
chr11_+_29295032 1.91 ENSDART00000112721
BX548000.1
ENSDARG00000079546
chr12_+_23543100 1.90 ENSDART00000111334
mtpap
mitochondrial poly(A) polymerase
chr5_-_22981395 1.90 ENSDART00000170293
si:dkeyp-20g2.1
si:dkeyp-20g2.1
chr6_+_56224631 1.89 ENSDART00000174612
ENSDART00000177824
FO834918.1
ENSDARG00000106015
chr16_-_44706998 1.88 ENSDART00000015139
dcaf13
ddb1 and cul4 associated factor 13
chr7_-_58856806 1.80 ENSDART00000159285
haus6
HAUS augmin-like complex, subunit 6
chr19_-_6215704 1.79 ENSDART00000104978
cica
capicua transcriptional repressor a
chr8_-_31374705 1.78 ENSDART00000162872
creb3l3l
cAMP responsive element binding protein 3-like 3 like
chr8_-_4704361 1.78 ENSDART00000064201
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae)
chr22_-_16351654 1.77 ENSDART00000168170
ttc39c
tetratricopeptide repeat domain 39C
chr23_-_27579257 1.76 ENSDART00000137229
asb8
ankyrin repeat and SOCS box containing 8
chr4_+_16020464 1.75 ENSDART00000144611
CR749763.5
ENSDARG00000093983
chr25_+_14773607 1.74 ENSDART00000171835
dnajc24
DnaJ (Hsp40) homolog, subfamily C, member 24
chr14_-_15777250 1.73 ENSDART00000165656
mxd3
MAX dimerization protein 3
chr1_+_22160932 1.70 ENSDART00000016488
gtf2e2
general transcription factor IIE, polypeptide 2, beta
chr19_+_1148544 1.70 ENSDART00000166088
zgc:63863
zgc:63863
chr4_+_13413303 1.69 ENSDART00000003694
cand1
cullin-associated and neddylation-dissociated 1
chr4_-_71752866 1.68 ENSDART00000143417
ENSDART00000172042
zgc:162958
zgc:162958
chr2_+_3115593 1.68 ENSDART00000160715
pik3r3a
phosphoinositide-3-kinase, regulatory subunit 3a (gamma)
chr5_+_36168475 1.68 ENSDART00000146854
mark4a
MAP/microtubule affinity-regulating kinase 4a
chr13_+_45387478 1.65 ENSDART00000019113
tmem57b
transmembrane protein 57b
chr5_+_32698516 1.65 ENSDART00000097945
usp20
ubiquitin specific peptidase 20
chr24_+_23571680 1.65 ENSDART00000080332
cops5
COP9 signalosome subunit 5
chr6_+_35811398 1.64 ENSDART00000151760
FP236809.1
ENSDARG00000096356
chr14_-_33605295 1.64 ENSDART00000168546
zdhhc24
zinc finger, DHHC-type containing 24
chr5_-_23291887 1.63 ENSDART00000099083
ENSDART00000099084
ENSDART00000147887
gbgt1l4
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr12_-_33558313 1.63 ENSDART00000111259
tmem94
transmembrane protein 94
chr14_-_44880144 1.62 ENSDART00000163543
abhd18
abhydrolase domain containing 18
chr9_+_29737843 1.60 ENSDART00000176057
rnf17
ring finger protein 17
chr21_+_347169 1.59 ENSDART00000168983
TMEM38B
transmembrane protein 38B
chr24_+_40770010 1.57

chr13_+_45387708 1.56 ENSDART00000074567
tmem57b
transmembrane protein 57b
chr3_+_61903372 1.55 ENSDART00000108945
GID4
GID complex subunit 4 homolog
chr25_+_4414838 1.55 ENSDART00000129978
pnpla2
patatin-like phospholipase domain containing 2
chr17_+_11519212 1.54

chr13_+_22973830 1.54 ENSDART00000110266
pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr10_-_25366450 1.54 ENSDART00000123820
tmem135
transmembrane protein 135
chr6_+_38775771 1.53 ENSDART00000129655
ube3a
ubiquitin protein ligase E3A
chr20_+_34091702 1.53 ENSDART00000061729
si:dkey-97o5.1
si:dkey-97o5.1
chr17_+_49995001 1.51 ENSDART00000113644
vps39
vacuolar protein sorting 39 homolog (S. cerevisiae)
chr5_+_23559435 1.50 ENSDART00000142268
gps2
G protein pathway suppressor 2
chr21_-_14735450 1.50 ENSDART00000144859
pus1
pseudouridylate synthase 1
chr15_-_20189604 1.49 ENSDART00000152355
med13b
mediator complex subunit 13b
chr23_-_14118530 1.49 ENSDART00000139406
g6pd
glucose-6-phosphate dehydrogenase
chr17_-_49994799 1.48

chr22_-_29957382 1.48 ENSDART00000019786
ENSDART00000159813
smc3
structural maintenance of chromosomes 3
chr5_-_23171454 1.47 ENSDART00000135153
TBC1D8B
TBC1 domain family member 8B
chr7_-_58856862 1.46 ENSDART00000164104
haus6
HAUS augmin-like complex, subunit 6
chr8_-_22492972 1.45

chr20_+_21491468 1.45 ENSDART00000049586
ENSDART00000024922
jag2b
jagged 2b
chr6_+_41455676 1.44 ENSDART00000007798
ENSDART00000162135
twf2a
twinfilin actin-binding protein 2a
chr12_+_18776712 1.43

chr7_-_25991876 1.43 ENSDART00000101109
ap1s1
adaptor-related protein complex 1, sigma 1 subunit
chr11_+_24583090 1.42 ENSDART00000135443
kdm5ba
lysine (K)-specific demethylase 5Ba
chr24_+_23571827 1.42 ENSDART00000080332
cops5
COP9 signalosome subunit 5
chr20_-_47576872 1.41 ENSDART00000067776
rab10
RAB10, member RAS oncogene family
chr11_+_5883229 1.38 ENSDART00000129663
dazap1
DAZ associated protein 1
chr3_-_20643874 1.38 ENSDART00000163473
ENSDART00000159457
spop
speckle-type POZ protein
chr2_+_30800532 1.37

chr25_+_18910528 1.36 ENSDART00000104420
samm50
SAMM50 sorting and assembly machinery component
chr8_-_11286308 1.35 ENSDART00000008215
pip5k1bb
phosphatidylinositol-4-phosphate 5-kinase, type I, beta b
chr15_-_20592699 1.35 ENSDART00000048423
timm50
translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
chr23_+_6652454 1.35 ENSDART00000081763
rbm38
RNA binding motif protein 38
chr8_-_41511321 1.34 ENSDART00000019858
golga1
golgin A1
chr20_+_27813565 1.33 ENSDART00000008306
zbtb1
zinc finger and BTB domain containing 1
chr8_-_25826973 1.33 ENSDART00000047008
ENSDART00000128829
efhd2
EF-hand domain family, member D2
chr25_-_1243081 1.32 ENSDART00000156062
calml4b
calmodulin-like 4b
chr8_-_37072857 1.32 ENSDART00000004041
zgc:162200
zgc:162200
chr15_-_31266460 1.31 ENSDART00000157145
ENSDART00000155473
ksr1b
kinase suppressor of ras 1b
chr3_+_17901295 1.30 ENSDART00000035531
mettl26
methyltransferase like 26
chr10_+_33629943 1.28 ENSDART00000130093
c10h21orf59
c10h21orf59 homolog (H. sapiens)
chr5_+_26537518 1.27

chr20_-_46563521 1.27 ENSDART00000060702
rmdn3
regulator of microtubule dynamics 3
chr1_+_33962885 1.26 ENSDART00000145535
gtf2f2a
general transcription factor IIF, polypeptide 2a
chr2_+_30506215 1.25 ENSDART00000115271
march6
membrane-associated ring finger (C3HC4) 6
chr7_+_71585147 1.24 ENSDART00000161344
nsun6
NOL1/NOP2/Sun domain family, member 6
chr7_-_37283707 1.24 ENSDART00000148905
ENSDART00000150229
cylda
cylindromatosis (turban tumor syndrome), a
chr4_-_20092548 1.24 ENSDART00000024647
dennd6b
DENN/MADD domain containing 6B
chr16_+_9509875 1.24 ENSDART00000162073
ENSDART00000146174
ice1
KIAA0947-like (H. sapiens)
chr19_-_31212648 1.23 ENSDART00000125893
ENSDART00000145581
trit1
tRNA isopentenyltransferase 1
chr8_-_18869085 1.22 ENSDART00000079840
rorca
RAR-related orphan receptor C a
chr14_-_33141111 1.21 ENSDART00000147059
lamp2
lysosomal-associated membrane protein 2
chr7_-_25991743 1.21 ENSDART00000137769
ap1s1
adaptor-related protein complex 1, sigma 1 subunit
chr13_+_46514282 1.21 ENSDART00000159260
CU695232.1
ENSDARG00000098286
chr4_+_15007453 1.20 ENSDART00000146156
zc3hc1
zinc finger, C3HC-type containing 1
chr6_+_41506220 1.19 ENSDART00000136538
cish
cytokine inducible SH2-containing protein
chr1_+_28379996 1.19 ENSDART00000113735
cars2
cysteinyl-tRNA synthetase 2, mitochondrial
chr11_-_24300849 1.19 ENSDART00000171004
plekhg5a
pleckstrin homology domain containing, family G (with RhoGef domain) member 5a
chr20_-_44678938 1.19 ENSDART00000148639
ubxn2a
UBX domain protein 2A
chr10_+_28273581 1.19 ENSDART00000131003
rnft1
ring finger protein, transmembrane 1
chr5_+_20418001 1.18 ENSDART00000131838
si:dkey-174n20.1
si:dkey-174n20.1
chr16_+_50489655 1.18

chr15_-_545279 1.18 ENSDART00000155472
nudt8
nudix (nucleoside diphosphate linked moiety X)-type motif 8
chr8_-_37072691 1.18 ENSDART00000004041
zgc:162200
zgc:162200
chr8_-_37072649 1.17 ENSDART00000004041
zgc:162200
zgc:162200
chr11_-_10472636 1.17 ENSDART00000081827
ect2
epithelial cell transforming 2
chr11_+_36088518 1.16

chr5_-_19631924 1.13 ENSDART00000158613
usp30
ubiquitin specific peptidase 30
chr20_+_1308632 1.13 ENSDART00000064436
tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr7_-_9628384 1.13 ENSDART00000006343
asb7
ankyrin repeat and SOCS box containing 7
chr19_+_10477101 1.13 ENSDART00000151735
necap1
NECAP endocytosis associated 1
chr24_+_25872005 1.13 ENSDART00000137851
tfr1b
transferrin receptor 1b
chr1_-_11191824 1.13 ENSDART00000163971
ENSDART00000123431
iqce
IQ motif containing E
chr5_+_25408121 1.11

chr8_-_48679386 1.11 ENSDART00000047134
clcn6
chloride channel 6
chr6_+_13766964 1.11 ENSDART00000136006
ENSDART00000009382
dnpep
aspartyl aminopeptidase
chr22_+_17188103 1.11 ENSDART00000090107
nrd1b
nardilysin b (N-arginine dibasic convertase)
chr18_-_15300493 1.10 ENSDART00000048206
tmem263
transmembrane protein 263
chr16_-_44707135 1.10 ENSDART00000015139
dcaf13
ddb1 and cul4 associated factor 13
chr11_-_43409685 1.10 ENSDART00000163843
zgc:153431
zgc:153431
chr4_-_3340315 1.09 ENSDART00000009076
pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr3_-_19890717 1.08 ENSDART00000104118
ENSDART00000170199
atxn7l3
ataxin 7-like 3
chr15_-_545179 1.08 ENSDART00000155472
nudt8
nudix (nucleoside diphosphate linked moiety X)-type motif 8
chr5_-_32698092 1.08 ENSDART00000015076
zgc:103692
zgc:103692
chr13_+_16389663 1.08

chr4_-_14916416 1.08 ENSDART00000067040
si:dkey-180p18.9
si:dkey-180p18.9
chr5_-_23291809 1.07 ENSDART00000099083
ENSDART00000099084
gbgt1l4
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr20_-_54285455 1.07 ENSDART00000074255
mgat2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr13_+_12538980 1.07 ENSDART00000010517
eif4eb
eukaryotic translation initiation factor 4eb
chr2_-_41888389 1.07

chr13_-_42548129 1.06 ENSDART00000169083
lrrfip2
leucine rich repeat (in FLII) interacting protein 2
chr6_+_33552518 1.06 ENSDART00000040334
pik3r3b
phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
chr23_-_36469779 1.06 ENSDART00000168246
spryd3
SPRY domain containing 3
chr6_+_46307828 1.05 ENSDART00000154817
si:dkeyp-67f1.1
si:dkeyp-67f1.1
chr7_+_41607231 1.05 ENSDART00000165789
ENSDART00000115090
gpt2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr21_-_13026036 1.04 ENSDART00000135623
fam219aa
family with sequence similarity 219, member Aa

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
1.9 5.7 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
1.5 8.8 GO:0019433 triglyceride catabolic process(GO:0019433)
1.0 3.1 GO:0044320 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.9 6.5 GO:0000338 protein deneddylation(GO:0000338)
0.8 2.3 GO:0051026 chiasma assembly(GO:0051026)
0.7 2.9 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.7 2.9 GO:0090161 Golgi ribbon formation(GO:0090161)
0.6 7.7 GO:0016926 protein desumoylation(GO:0016926)
0.6 6.9 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.5 3.7 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.5 2.6 GO:0033572 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.5 2.5 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.5 1.4 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.4 2.1 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.4 1.2 GO:0006929 substrate-dependent cell migration(GO:0006929)
0.4 1.5 GO:1990481 tRNA pseudouridine synthesis(GO:0031119) mRNA pseudouridine synthesis(GO:1990481)
0.4 3.6 GO:0030259 lipid glycosylation(GO:0030259)
0.3 5.2 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.3 1.0 GO:0010265 SCF complex assembly(GO:0010265)
0.3 3.7 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.3 3.8 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.3 1.6 GO:0048478 replication fork protection(GO:0048478)
0.3 0.9 GO:0009098 leucine biosynthetic process(GO:0009098)
0.3 0.8 GO:0071887 leukocyte apoptotic process(GO:0071887) regulation of leukocyte apoptotic process(GO:2000106)
0.3 1.0 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.2 5.7 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2 1.4 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.2 1.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.2 0.7 GO:0072578 neurotransmitter-gated ion channel clustering(GO:0072578)
0.2 0.9 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
0.2 1.9 GO:0006611 protein export from nucleus(GO:0006611)
0.2 0.6 GO:0002504 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.2 2.4 GO:0015693 magnesium ion transport(GO:0015693)
0.2 0.6 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.2 1.2 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.2 1.0 GO:0032289 central nervous system myelin formation(GO:0032289)
0.2 2.2 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.2 0.7 GO:0051204 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.2 1.2 GO:0045620 negative regulation of lymphocyte differentiation(GO:0045620) negative regulation of erythrocyte differentiation(GO:0045647)
0.2 1.2 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.2 2.0 GO:0050779 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.2 0.8 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.2 2.0 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) negative regulation of mitotic metaphase/anaphase transition(GO:0045841) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174)
0.2 3.9 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 1.0 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin biosynthetic process(GO:0032049)
0.2 1.8 GO:0071357 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.2 1.1 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 1.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 0.1 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1 1.8 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.1 0.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 1.6 GO:0015701 bicarbonate transport(GO:0015701)
0.1 1.2 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.1 0.4 GO:0070849 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.1 6.3 GO:0071166 ribonucleoprotein complex localization(GO:0071166)
0.1 0.5 GO:0070861 regulation of protein exit from endoplasmic reticulum(GO:0070861) positive regulation of protein exit from endoplasmic reticulum(GO:0070863) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 4.2 GO:0043534 blood vessel endothelial cell migration(GO:0043534)
0.1 0.7 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.1 0.6 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.8 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.1 1.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 4.3 GO:0000281 mitotic cytokinesis(GO:0000281)
0.1 2.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 2.3 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.1 1.2 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 1.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.7 GO:0051932 synaptic transmission, GABAergic(GO:0051932) regulation of postsynaptic membrane potential(GO:0060078)
0.1 1.7 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.7 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 3.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 0.8 GO:0032387 negative regulation of intracellular transport(GO:0032387)
0.1 0.9 GO:0042026 protein refolding(GO:0042026)
0.1 0.8 GO:0021634 optic nerve formation(GO:0021634)
0.1 2.3 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 0.3 GO:0071042 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.1 0.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.5 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 1.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 0.3 GO:0019388 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.1 1.9 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.1 0.9 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 1.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 0.6 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 0.5 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 1.1 GO:0002574 thrombocyte differentiation(GO:0002574)
0.1 3.9 GO:0051225 spindle assembly(GO:0051225)
0.1 0.6 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.1 0.7 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 0.4 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 2.2 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 0.3 GO:0038203 TORC2 signaling(GO:0038203)
0.1 1.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.2 GO:0019835 cytolysis(GO:0019835)
0.0 2.8 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 2.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.4 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.6 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.8 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.6 GO:0009086 methionine metabolic process(GO:0006555) methionine biosynthetic process(GO:0009086)
0.0 1.0 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.2 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 1.6 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 1.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 1.1 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.3 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.7 GO:0002250 adaptive immune response(GO:0002250)
0.0 0.4 GO:0033157 regulation of intracellular protein transport(GO:0033157) positive regulation of intracellular protein transport(GO:0090316)
0.0 1.1 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 2.4 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.5 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 1.0 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 1.0 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.3 GO:0003139 secondary heart field specification(GO:0003139)
0.0 0.1 GO:0034505 tooth mineralization(GO:0034505)
0.0 1.0 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.3 GO:0006400 tRNA modification(GO:0006400)
0.0 0.9 GO:0030641 regulation of cellular pH(GO:0030641)
0.0 0.2 GO:0044247 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.4 GO:0051340 regulation of ligase activity(GO:0051340) positive regulation of ligase activity(GO:0051351)
0.0 1.7 GO:0006672 ceramide metabolic process(GO:0006672)
0.0 0.5 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.6 GO:0043113 receptor clustering(GO:0043113)
0.0 0.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.5 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.0 0.4 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.1 GO:0006821 chloride transport(GO:0006821)
0.0 0.8 GO:0051051 negative regulation of transport(GO:0051051)
0.0 0.1 GO:0060036 notochord cell vacuolation(GO:0060036)
0.0 1.0 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 1.8 GO:0006413 translational initiation(GO:0006413)
0.0 1.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.4 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.3 GO:2000050 regulation of non-canonical Wnt signaling pathway(GO:2000050)
0.0 1.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 1.1 GO:0070646 protein modification by small protein removal(GO:0070646)
0.0 0.2 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.5 GO:0030048 actin filament-based movement(GO:0030048)
0.0 0.5 GO:0060215 primitive hemopoiesis(GO:0060215)
0.0 1.0 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 0.2 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.9 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 0.1 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.4 GO:0030318 melanocyte differentiation(GO:0030318)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0000801 central element(GO:0000801)
0.8 9.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.6 6.3 GO:0008180 COP9 signalosome(GO:0008180)
0.5 6.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.5 2.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.4 4.2 GO:0070652 HAUS complex(GO:0070652)
0.4 1.2 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.3 1.3 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.3 0.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 1.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.3 1.5 GO:0030893 meiotic cohesin complex(GO:0030893)
0.3 1.8 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.3 1.0 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.2 2.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.2 1.4 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.2 1.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 1.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 0.7 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 6.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 3.1 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.7 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 2.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 4.1 GO:0030496 midbody(GO:0030496)
0.1 0.8 GO:0032021 NELF complex(GO:0032021)
0.1 0.6 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 6.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 0.3 GO:0097361 CIA complex(GO:0097361)
0.1 2.5 GO:0005844 polysome(GO:0005844)
0.1 0.7 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 1.0 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.4 GO:0000814 ESCRT II complex(GO:0000814)
0.1 1.0 GO:0005869 dynactin complex(GO:0005869)
0.1 2.9 GO:0032040 small-subunit processome(GO:0032040)
0.1 6.0 GO:0048475 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.1 2.5 GO:0016528 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.1 2.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 4.0 GO:0030139 endocytic vesicle(GO:0030139)
0.1 0.5 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 1.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.3 GO:0031415 NatA complex(GO:0031415)
0.1 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 2.2 GO:0005819 spindle(GO:0005819)
0.0 0.9 GO:0043186 P granule(GO:0043186)
0.0 0.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.4 GO:0031201 SNARE complex(GO:0031201)
0.0 1.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.9 GO:0005814 centriole(GO:0005814)
0.0 0.7 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.8 GO:0016592 mediator complex(GO:0016592)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 1.8 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 1.1 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 7.0 GO:0005874 microtubule(GO:0005874)
0.0 0.4 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 1.5 GO:0000502 proteasome complex(GO:0000502)
0.0 0.6 GO:0030175 filopodium(GO:0030175)
0.0 1.8 GO:0055037 recycling endosome(GO:0055037)
0.0 0.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0000938 GARP complex(GO:0000938)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.6 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.3 GO:0000177 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.6 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.8 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 10.3 GO:0005794 Golgi apparatus(GO:0005794)
0.0 1.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.3 GO:0030425 dendrite(GO:0030425)
0.0 0.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
2.3 6.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
1.9 7.7 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
1.7 5.0 GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity(GO:0008425) quinone cofactor methyltransferase activity(GO:0030580)
1.1 6.9 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.8 6.5 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.7 2.9 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.7 2.0 GO:0001729 ceramide kinase activity(GO:0001729)
0.6 3.5 GO:0051920 peroxiredoxin activity(GO:0051920)
0.6 2.3 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.5 2.6 GO:0004998 transferrin receptor activity(GO:0004998)
0.5 1.9 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.5 3.7 GO:0034452 dynactin binding(GO:0034452)
0.4 1.3 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.4 6.9 GO:0001671 ATPase activator activity(GO:0001671)
0.4 1.6 GO:0036310 annealing helicase activity(GO:0036310)
0.4 2.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.3 0.9 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.3 0.8 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.3 0.8 GO:0030629 U6 snRNA 3'-end binding(GO:0030629) 23S rRNA (adenine(1618)-N(6))-methyltransferase activity(GO:0052907)
0.3 0.8 GO:0035174 histone serine kinase activity(GO:0035174)
0.2 2.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 1.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 1.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 4.6 GO:0051787 misfolded protein binding(GO:0051787)
0.2 0.7 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 6.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 1.3 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.2 0.6 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.2 0.6 GO:0045545 syndecan binding(GO:0045545)
0.2 0.5 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.2 0.7 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.2 1.4 GO:0034046 poly(G) binding(GO:0034046)
0.2 0.5 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.2 1.0 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.2 1.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.2 1.7 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.7 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 1.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 2.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.4 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.6 GO:0042287 MHC protein binding(GO:0042287)
0.1 0.6 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 2.1 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 1.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 1.0 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 1.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.8 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.1 0.8 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.1 3.5 GO:0019955 cytokine binding(GO:0019955)
0.1 6.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.4 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.3 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 1.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.5 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 0.7 GO:0070728 leucine binding(GO:0070728)
0.1 2.1 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.1 0.4 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 1.5 GO:0005112 Notch binding(GO:0005112)
0.1 0.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.6 GO:0043495 protein anchor(GO:0043495)
0.1 1.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 2.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 3.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.6 GO:0031419 cobalamin binding(GO:0031419)
0.1 1.3 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.4 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.1 1.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 2.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 2.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 2.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 1.2 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 3.9 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 0.7 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 2.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.6 GO:0008301 DNA binding, bending(GO:0008301)
0.0 8.2 GO:0008017 microtubule binding(GO:0008017)
0.0 0.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.4 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 7.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.2 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.0 0.6 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 4.3 GO:0016758 transferase activity, transferring hexosyl groups(GO:0016758)
0.0 1.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 0.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 1.3 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.1 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 1.1 GO:0004620 phospholipase activity(GO:0004620)
0.0 1.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 1.8 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.0 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.1 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.9 PID IL27 PATHWAY IL27-mediated signaling events
0.5 3.5 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 1.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.2 4.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 0.6 PID IL5 PATHWAY IL5-mediated signaling events
0.1 6.8 PID BCR 5PATHWAY BCR signaling pathway
0.1 1.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 1.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 1.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 0.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.3 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 2.1 PID ATM PATHWAY ATM pathway
0.1 2.3 PID PLK1 PATHWAY PLK1 signaling events
0.1 1.6 PID ATR PATHWAY ATR signaling pathway
0.1 0.8 PID AURORA A PATHWAY Aurora A signaling
0.0 1.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.4 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.5 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.2 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.5 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.5 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.1 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.5 1.8 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.4 3.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.4 5.0 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.4 7.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 3.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 2.9 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 0.8 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 1.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.6 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 4.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 0.7 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.1 1.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 0.9 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 3.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.2 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 2.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 0.6 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 2.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 3.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 1.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.1 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.9 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.5 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 5.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.4 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.6 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.2 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.6 REACTOME MEIOSIS Genes involved in Meiosis
0.0 0.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.1 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events