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Results for pknox2

Z-value: 0.70

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Transcription factors associated with pknox2

Gene Symbol Gene ID Gene Info
pknox2
ENSDARG00000055349 pbx/knotted 1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pknox2dr10_dc_chr10_-_31334198_313342210.837.4e-05Click!

Activity profile of pknox2 motif

Sorted Z-values of pknox2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of pknox2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_14822990 2.42 ENSDART00000149949
pou3f3b
POU class 3 homeobox 3b
chr20_+_28531684 2.27 ENSDART00000123387
dpf3
D4, zinc and double PHD fingers, family 3
chr18_+_29424354 2.17 ENSDART00000014703
mafa
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)
chr6_+_14823185 2.12 ENSDART00000149202
pou3f3b
POU class 3 homeobox 3b
chr11_+_27970922 1.75 ENSDART00000169360
ENSDART00000043756
ephb2b
eph receptor B2b
chr11_-_32461160 1.69 ENSDART00000155592
pcdh17
protocadherin 17
chr4_+_12932838 1.68 ENSDART00000016382
wif1
wnt inhibitory factor 1
chr12_+_36796886 1.53 ENSDART00000125900
hs3st3b1b
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b
chr10_+_26020615 1.51 ENSDART00000128292
ENSDART00000170275
ENSDART00000166164
ENSDART00000108808
frem2a
Fras1 related extracellular matrix protein 2a
chr21_-_34623741 1.50 ENSDART00000023038
dacha
dachshund a
chr2_+_3864843 1.47 ENSDART00000108964
ENSDART00000128514
egfra
epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
chr2_-_55737505 1.35 ENSDART00000059003
rx2
retinal homeobox gene 2
chr12_+_17382681 1.26 ENSDART00000020628
cyth3a
cytohesin 3a
chr3_-_36130248 1.20 ENSDART00000126588
rac3a
ras-related C3 botulinum toxin substrate 3a (rho family, small GTP binding protein Rac3)
chr18_+_24575639 1.15 ENSDART00000099463
lysmd4
LysM, putative peptidoglycan-binding, domain containing 4
chr6_-_10593395 1.13 ENSDART00000020261
chrna1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr10_+_33926312 1.12 ENSDART00000174730
BX569785.2
ENSDARG00000106629
chr22_-_23238714 1.04 ENSDART00000054807
lhx9
LIM homeobox 9
chr4_+_12932950 1.02 ENSDART00000016382
wif1
wnt inhibitory factor 1
chr21_+_17073163 0.90

chr3_-_15739545 0.89 ENSDART00000148363
cramp1
cramped chromatin regulator homolog 1
chr10_+_31701855 0.87 ENSDART00000115251
esama
endothelial cell adhesion molecule a
chr7_+_20215723 0.86 ENSDART00000173724
ENSDART00000173773
si:dkey-33c9.8
si:dkey-33c9.8
chr23_-_20402258 0.86 ENSDART00000136204
CR749762.2
ENSDARG00000093223
chr16_-_7321943 0.84 ENSDART00000149260
nt5c3a
5'-nucleotidase, cytosolic IIIA
chr16_-_543957 0.83 ENSDART00000016303
irx2a
iroquois homeobox 2a
chr4_-_16356071 0.81 ENSDART00000079521
kera
keratocan
chr19_+_41488385 0.78 ENSDART00000138687
ppp1r9a
protein phosphatase 1, regulatory subunit 9A
chr5_+_41497442 0.77 ENSDART00000171919
ENSDART00000097587
p2rx5
purinergic receptor P2X, ligand-gated ion channel, 5
chr3_-_10342940 0.76 ENSDART00000124419
BX539325.2
ENSDARG00000101154
chr5_+_15167637 0.74 ENSDART00000127015
srrm4
serine/arginine repetitive matrix 4
chr17_-_21179064 0.72

chr3_-_15739701 0.72 ENSDART00000148363
cramp1
cramped chromatin regulator homolog 1
chr14_-_32553399 0.71 ENSDART00000169380
slc25a43
solute carrier family 25, member 43
chr2_-_32575527 0.71 ENSDART00000140026
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr4_-_19027117 0.71 ENSDART00000166160
si:dkey-31f5.11
si:dkey-31f5.11
chr9_-_33518818 0.70 ENSDART00000140039
rpl8
ribosomal protein L8
chr12_-_36565562 0.70 ENSDART00000153259
si:ch211-216b21.2
si:ch211-216b21.2
chr8_-_17148743 0.68 ENSDART00000025803
pola2
polymerase (DNA directed), alpha 2
chr19_+_21783111 0.68 ENSDART00000024639
tshz1
teashirt zinc finger homeobox 1
chr19_-_27730419 0.66 ENSDART00000151047
sh3bp5lb
SH3-binding domain protein 5-like, b
chr3_+_17387551 0.66 ENSDART00000104549
hcrt
hypocretin (orexin) neuropeptide precursor
chr5_+_26537490 0.65

chr3_-_15889742 0.62 ENSDART00000143324
spsb3a
splA/ryanodine receptor domain and SOCS box containing 3a
chr5_-_40524018 0.59 ENSDART00000083561
mtmr12
myotubularin related protein 12
chr12_+_49071673 0.57

chr16_-_13704905 0.56 ENSDART00000060004
ntd5
ntl-dependent gene 5
chr23_-_19177660 0.55 ENSDART00000016901
pard6b
par-6 partitioning defective 6 homolog beta (C. elegans)
chr11_-_18004437 0.54 ENSDART00000125800
CABZ01112210.1
ENSDARG00000088766
chr25_-_21796677 0.54 ENSDART00000089642
fbxo31
F-box protein 31
chr13_+_28286826 0.53 ENSDART00000043658
slc2a15a
solute carrier family 2 (facilitated glucose transporter), member 15a
chr4_-_73683521 0.53

chr1_-_13547500 0.53 ENSDART00000044896
camk2d2
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr16_+_40625705 0.53 ENSDART00000161503
ccne2
cyclin E2
chr2_-_41873625 0.52 ENSDART00000155577
ENSDARG00000056490
ENSDARG00000056490
chr20_+_32575184 0.51 ENSDART00000145269
ostm1
osteopetrosis associated transmembrane protein 1
chr15_+_16961487 0.51 ENSDART00000154679
ypel2b
yippee-like 2b
chr16_+_1073570 0.49

chr21_-_38106145 0.48 ENSDART00000151226
klf5l
Kruppel-like factor 5 like
chr19_+_21783429 0.47 ENSDART00000024639
tshz1
teashirt zinc finger homeobox 1
chr14_+_50164568 0.47 ENSDART00000084114
nsd1a
nuclear receptor binding SET domain protein 1a
chr9_-_30463616 0.42 ENSDART00000089526
otc
ornithine carbamoyltransferase
chr12_-_21918058 0.41 ENSDART00000153187
thrab
thyroid hormone receptor alpha b
chr25_+_3884499 0.41 ENSDART00000104926
ENSDARG00000058108
ENSDARG00000058108
chr10_-_43200499 0.41 ENSDART00000171494
ssbp2
single-stranded DNA binding protein 2
chr19_-_9793494 0.40 ENSDART00000134816
slc2a3a
solute carrier family 2 (facilitated glucose transporter), member 3a
chr4_+_20901783 0.39

chr19_+_1148444 0.39 ENSDART00000166088
zgc:63863
zgc:63863
chr11_-_18004011 0.38 ENSDART00000125800
CABZ01112210.1
ENSDARG00000088766
chr23_+_34037058 0.37 ENSDART00000140666
prosc
pyridoxal phosphate binding protein
chr4_-_3215227 0.37 ENSDART00000112210
plekha5
pleckstrin homology domain containing, family A member 5
chr13_-_28133363 0.36 ENSDART00000041036
smap1
small ArfGAP 1
chr10_-_28474085 0.35

chr6_+_14823900 0.33 ENSDART00000178555
CU929521.3
ENSDARG00000108533
chr19_-_9793444 0.33 ENSDART00000134816
slc2a3a
solute carrier family 2 (facilitated glucose transporter), member 3a
chr6_-_39162845 0.32 ENSDART00000148661
stat2
signal transducer and activator of transcription 2
chr3_-_20972827 0.31 ENSDART00000129540
larsa
leucyl-tRNA synthetase a
chr20_-_47576935 0.31 ENSDART00000067776
rab10
RAB10, member RAS oncogene family
chr15_-_46484516 0.31 ENSDART00000154577
zgc:162872
zgc:162872
chr19_+_41488351 0.30 ENSDART00000138687
ppp1r9a
protein phosphatase 1, regulatory subunit 9A
chr23_+_18176720 0.30 ENSDART00000010270
mfsd4ab
major facilitator superfamily domain containing 4Ab
chr7_-_68033217 0.28

chr10_-_22988906 0.28

chr2_+_26632673 0.28 ENSDART00000017668
ptbp1a
polypyrimidine tract binding protein 1a
chr19_+_43124105 0.27 ENSDART00000136873
clasp2
cytoplasmic linker associated protein 2
chr5_+_26217533 0.27

chr16_-_52761159 0.27 ENSDART00000111869
ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr8_+_30416440 0.24 ENSDART00000012132
cbwd
COBW domain containing
chr11_-_27970634 0.24

chr19_-_25843036 0.23 ENSDART00000036854
glcci1
glucocorticoid induced 1
chr19_+_44310050 0.23 ENSDART00000168725
ENSDART00000133628
ankib1a
ankyrin repeat and IBR domain containing 1a
chr19_-_1921345 0.22 ENSDART00000004585
clptm1l
CLPTM1-like
chr7_+_69664384 0.22 ENSDART00000058763
sec24d
SEC24 homolog D, COPII coat complex component
chr5_+_31889674 0.20 ENSDART00000165417
ndor1
NADPH dependent diflavin oxidoreductase 1
chr16_+_13964949 0.20 ENSDART00000143983
zgc:174888
zgc:174888
chr24_-_12836986 0.18 ENSDART00000133166
dcaf11
ddb1 and cul4 associated factor 11
chr9_-_34410053 0.17 ENSDART00000111027
dcaf6
ddb1 and cul4 associated factor 6
chr17_-_11264425 0.17 ENSDART00000151847
arid4a
AT rich interactive domain 4A (RBP1-like)
chr22_-_21021866 0.16 ENSDART00000133982
ssbp4
single stranded DNA binding protein 4
chr21_+_26502430 0.15 ENSDART00000021121
stx5al
syntaxin 5A, like
chr17_-_14772485 0.15 ENSDART00000080401
ENSDART00000154690
si:ch211-266o15.1
si:ch211-266o15.1
chr19_-_35739052 0.15

chr23_-_4080767 0.14 ENSDART00000159780
slc9a8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr20_-_47576610 0.14 ENSDART00000067776
rab10
RAB10, member RAS oncogene family
chr5_-_34600498 0.13 ENSDART00000164396
fcho2
FCH domain only 2
chr5_+_57073554 0.13 ENSDART00000166098
ENSDART00000005090
alg9
ALG9, alpha-1,2-mannosyltransferase
chr21_+_43887079 0.12 ENSDART00000075672
sra1
steroid receptor RNA activator 1
chr5_-_13145749 0.12 ENSDART00000166957
purba
purine-rich element binding protein Ba
chr12_-_17079132 0.12 ENSDART00000020541
lipf
lipase, gastric
chr10_+_10780578 0.11 ENSDART00000170147
ENSDART00000004181
slc27a4
solute carrier family 27 (fatty acid transporter), member 4
chr7_-_56465497 0.11 ENSDART00000020967
csnk2a2a
casein kinase 2, alpha prime polypeptide a
chr6_+_49927433 0.11 ENSDART00000018523
ahcy
adenosylhomocysteinase
chr16_+_3814595 0.11 ENSDART00000174521
CABZ01088996.1
ENSDARG00000108584
chr19_-_35739013 0.11

chr10_+_20632757 0.10 ENSDART00000131819
letm2
leucine zipper-EF-hand containing transmembrane protein 2
chr5_-_13266357 0.09 ENSDART00000134064
mxd1
MAX dimerization protein 1
chr3_-_15739926 0.08 ENSDART00000148363
cramp1
cramped chromatin regulator homolog 1
chr3_-_10343029 0.08 ENSDART00000124419
BX539325.2
ENSDARG00000101154
chr5_-_13267041 0.08

chr1_+_19156170 0.07 ENSDART00000111454
ENSDARG00000080019
ENSDARG00000080019
chr23_-_6442213 0.07 ENSDART00000112667
ppp1r12b
protein phosphatase 1, regulatory subunit 12B
chr14_+_663662 0.05 ENSDART00000125969
ube2ka
ubiquitin-conjugating enzyme E2Ka (UBC1 homolog, yeast)
chr7_-_29452646 0.05 ENSDART00000112651
vps13c
vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr18_-_33832 0.05 ENSDART00000158957
ENSDART00000129125
pde8a
phosphodiesterase 8A
chr19_-_6215704 0.04 ENSDART00000104978
cica
capicua transcriptional repressor a
chr9_-_33518171 0.04 ENSDART00000160534
ENSDART00000132973
rpl8
ribosomal protein L8
chr24_-_17089437 0.00

chr7_-_66641207 0.00

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0097376 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.2 1.1 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.2 0.7 GO:0001659 temperature homeostasis(GO:0001659) sleep(GO:0030431)
0.1 0.4 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.1 0.8 GO:0033198 response to ATP(GO:0033198)
0.1 3.0 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.1 0.1 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.1 0.5 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 0.4 GO:0019627 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.1 1.5 GO:0072554 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.1 0.9 GO:0070527 platelet aggregation(GO:0070527)
0.1 2.3 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.1 2.7 GO:0048794 swim bladder development(GO:0048794)
0.1 0.7 GO:0021754 facial nucleus development(GO:0021754)
0.1 0.2 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 1.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.7 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 1.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0007343 egg activation(GO:0007343)
0.0 0.8 GO:0039014 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014) nephron tubule epithelial cell differentiation(GO:0072160)
0.0 0.3 GO:1900044 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.3 GO:0007020 microtubule nucleation(GO:0007020)
0.0 1.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 1.5 GO:0033334 fin morphogenesis(GO:0033334)
0.0 0.7 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.2 GO:1901655 cellular response to ketone(GO:1901655)
0.0 0.0 GO:0071364 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 1.2 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.0 0.5 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082)
0.0 0.8 GO:0007601 visual perception(GO:0007601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.7 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 1.5 GO:0009925 basal plasma membrane(GO:0009925)
0.1 3.0 GO:0071565 nBAF complex(GO:0071565)
0.1 0.5 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.1 0.8 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.3 GO:0045178 basal part of cell(GO:0045178)
0.0 1.1 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.7 GO:0009986 cell surface(GO:0009986)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.7 GO:0005684 U2-type spliceosomal complex(GO:0005684)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.7 GO:0005938 cell cortex(GO:0005938)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.4 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1 0.8 GO:0004931 purinergic nucleotide receptor activity(GO:0001614) extracellular ATP-gated cation channel activity(GO:0004931) nucleotide receptor activity(GO:0016502) ATP-gated ion channel activity(GO:0035381)
0.1 1.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 1.5 GO:0042562 hormone binding(GO:0042562)
0.1 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314) phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.5 GO:0030332 cyclin binding(GO:0030332)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.3 GO:0015145 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.0 0.2 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.0 0.6 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0016801 hydrolase activity, acting on ether bonds(GO:0016801)
0.0 0.7 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.7 GO:0019843 rRNA binding(GO:0019843)
0.0 0.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 2.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 0.8 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 0.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.7 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC