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Results for pparaa+pparda+ppardb

Z-value: 0.71

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Transcription factors associated with pparaa+pparda+ppardb

Gene Symbol Gene ID Gene Info
ppardb
ENSDARG00000009473 peroxisome proliferator-activated receptor delta b
pparaa
ENSDARG00000031777 peroxisome proliferator-activated receptor alpha a
pparda
ENSDARG00000044525 peroxisome proliferator-activated receptor delta a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ppardadr10_dc_chr22_+_980951_980953-0.601.3e-02Click!
ppardbdr10_dc_chr8_+_23682463_236825030.391.3e-01Click!
pparaadr10_dc_chr4_-_18660286_186603190.381.4e-01Click!

Activity profile of pparaa+pparda+ppardb motif

Sorted Z-values of pparaa+pparda+ppardb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of pparaa+pparda+ppardb

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_+_933677 6.03 ENSDART00000149528
fabp1b.1
fatty acid binding protein 1b, tandem duplicate 1
chr1_+_25157675 2.63 ENSDART00000136984
fabp2
fatty acid binding protein 2, intestinal
chr25_+_21732255 2.56 ENSDART00000027393
ckmt1
creatine kinase, mitochondrial 1
chr14_-_49115338 1.65 ENSDART00000056712
etfdh
electron-transferring-flavoprotein dehydrogenase
chr2_-_43110857 1.63 ENSDART00000098303
oc90
otoconin 90
chr13_-_37001997 1.62 ENSDART00000135510
syne2b
spectrin repeat containing, nuclear envelope 2b
chr4_-_16461748 1.58 ENSDART00000128835
wu:fc23c09
wu:fc23c09
KN149726v1_+_1094 1.50

chr12_-_5085227 1.48 ENSDART00000160729
rbp4
retinol binding protein 4, plasma
chr17_+_12254292 1.43 ENSDART00000160722
khk
ketohexokinase
chr25_+_5162045 1.39 ENSDART00000169540
ENSDARG00000101164
ENSDARG00000101164
chr25_+_22224346 1.36 ENSDART00000073566
cyp11a1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr4_-_24310846 1.21 ENSDART00000017443
celf2
cugbp, Elav-like family member 2
chr5_+_37600633 1.19 ENSDART00000100769
hsd20b2
hydroxysteroid (20-beta) dehydrogenase 2
chr13_+_28689749 1.14 ENSDART00000101653
CU639469.1
ENSDARG00000062790
chr19_+_41274734 1.14 ENSDART00000126470
zgc:85777
zgc:85777
chr23_+_44817648 1.12 ENSDART00000143688
dlg4b
discs, large homolog 4b (Drosophila)
chr23_+_2193582 1.12 ENSDART00000106336
cpeb2
cytoplasmic polyadenylation element binding protein 2
chr6_-_30876091 1.10 ENSDART00000155330
pde4ba
phosphodiesterase 4B, cAMP-specific a
chr10_-_44180588 1.00 ENSDART00000145404
crybb1
crystallin, beta B1
chr1_+_40098861 0.91 ENSDART00000147497
cpz
carboxypeptidase Z
chr20_-_53162473 0.88 ENSDART00000164460
gata4
GATA binding protein 4
chr17_+_443558 0.88 ENSDART00000171386
zgc:194887
zgc:194887
chr11_+_24720057 0.84 ENSDART00000145647
sulf2a
sulfatase 2a
chr25_+_35797357 0.81 ENSDART00000152449
CR354435.1
ENSDARG00000039547
chr8_-_12171880 0.79 ENSDART00000132824
dab2ipa
DAB2 interacting protein a
chr10_+_4717800 0.79 ENSDART00000161789
palm2
paralemmin 2
KN149978v1_-_10669 0.78 ENSDART00000175723
CABZ01068178.1
ENSDARG00000105971
chr22_+_38276148 0.75 ENSDART00000104504
si:ch211-284e20.8
si:ch211-284e20.8
chr17_-_16079935 0.73

chr19_+_32570656 0.73 ENSDART00000005255
mrpl53
mitochondrial ribosomal protein L53
chr15_-_47264693 0.71

chr12_-_31342432 0.68 ENSDART00000148603
acsl5
acyl-CoA synthetase long-chain family member 5
chr15_+_895792 0.66

chr23_-_3814291 0.66

chr8_-_12171624 0.66 ENSDART00000132824
dab2ipa
DAB2 interacting protein a
chr9_+_28301359 0.65

chr25_+_17308788 0.60 ENSDART00000164349
e2f4
E2F transcription factor 4
chr20_+_15119519 0.60 ENSDART00000039345
myoc
myocilin
chr7_-_23775835 0.59 ENSDART00000144616
dhrs4
dehydrogenase/reductase (SDR family) member 4
chr5_+_18827478 0.59 ENSDART00000089078
acacb
acetyl-CoA carboxylase beta
chr1_+_11485480 0.57 ENSDART00000132560
stra6l
STRA6-like
chr12_-_7951265 0.57

chr25_+_30701751 0.54

chr21_-_18969970 0.51 ENSDART00000080269
pgam2
phosphoglycerate mutase 2 (muscle)
chr11_+_11217547 0.51 ENSDART00000087105
myom2a
myomesin 2a
chr7_-_33878076 0.49 ENSDART00000045374
smad3a
SMAD family member 3a
chr15_+_3296905 0.48 ENSDART00000171723
foxo1a
forkhead box O1 a
chr8_-_12171755 0.46 ENSDART00000132824
dab2ipa
DAB2 interacting protein a
chr6_+_60060297 0.45 ENSDART00000178621
pck1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_+_23600656 0.43

chr2_-_39052185 0.42 ENSDART00000048838
rbp2b
retinol binding protein 2b, cellular
chr10_-_41478085 0.42 ENSDART00000009838
gpat4
glycerol-3-phosphate acyltransferase 4
chr20_+_15119754 0.42 ENSDART00000039345
myoc
myocilin
chr22_-_17570275 0.42 ENSDART00000099056
gpx4a
glutathione peroxidase 4a
chr12_-_34612758 0.41 ENSDART00000153272
bahcc1b
BAH domain and coiled-coil containing 1b
chr9_-_41982635 0.41 ENSDART00000144573
obsl1b
obscurin-like 1b
chr16_-_50024848 0.41 ENSDART00000161782
etfb
electron-transfer-flavoprotein, beta polypeptide
chr16_+_28667291 0.39 ENSDART00000018235
crot
carnitine O-octanoyltransferase
chr15_-_47264619 0.38

chr25_-_34608926 0.37 ENSDART00000130395
hist1h4l
histone 1, H4, like
chr6_-_39767452 0.36 ENSDART00000085277
pfkmb
phosphofructokinase, muscle b
chr17_+_25463178 0.36 ENSDART00000139451
aim1a
crystallin beta-gamma domain containing 1a
chr12_+_27035744 0.35 ENSDART00000025966
hoxb6b
homeobox B6b
chr16_+_5470419 0.35

chr9_+_48521741 0.34 ENSDART00000145972
ccdc173
coiled-coil domain containing 173
chr23_+_36241656 0.32 ENSDART00000011201
copz1
coatomer protein complex, subunit zeta 1
chr3_+_23621843 0.30 ENSDART00000146636
hoxb2a
homeobox B2a
chr4_-_16461881 0.27 ENSDART00000128835
wu:fc23c09
wu:fc23c09
KN149947v1_-_2715 0.26 ENSDART00000158566
ENSDARG00000101294
ENSDARG00000101294
chr9_+_28301214 0.26

chr2_+_7341600 0.24 ENSDART00000146547
ENSDARG00000078299
ENSDARG00000078299
chr22_+_25304162 0.24 ENSDART00000155836
ENSDART00000155006
si:ch211-226h8.15
si:ch211-226h8.15
chr22_-_10744909 0.22 ENSDART00000081156
timm13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr20_-_48773402 0.22 ENSDART00000161769
mgst3a
microsomal glutathione S-transferase 3a
chr13_-_37002066 0.21 ENSDART00000135510
syne2b
spectrin repeat containing, nuclear envelope 2b
chr18_+_18465885 0.21 ENSDART00000165079
siah1
siah E3 ubiquitin protein ligase 1
chr1_-_49274993 0.20 ENSDART00000050603
hadh
hydroxyacyl-CoA dehydrogenase
chr4_+_25868802 0.19

chr18_+_16755239 0.19 ENSDART00000133490
lyve1b
lymphatic vessel endothelial hyaluronic receptor 1b
chr12_+_26579286 0.19 ENSDART00000144355
arhgap12b
Rho GTPase activating protein 12b
chr15_+_494813 0.19 ENSDART00000155682
nipsnap2
nipsnap homolog 2
chr23_+_2193828 0.18 ENSDART00000106336
cpeb2
cytoplasmic polyadenylation element binding protein 2
chr20_-_27038165 0.17 ENSDART00000160827
ftr79
finTRIM family, member 79
chr15_+_28249920 0.16

chr23_-_24562107 0.16 ENSDART00000155593
tmem82
transmembrane protein 82
chr8_+_8660457 0.15 ENSDART00000137780
uxt
ubiquitously-expressed, prefoldin-like chaperone
chr8_-_24194821 0.14 ENSDART00000177464
CT025875.1
ENSDARG00000106046
chr5_-_21520111 0.14

chr10_-_41742329 0.13 ENSDART00000150213
ggt1b
gamma-glutamyltransferase 1b
chr15_+_17094877 0.11 ENSDART00000062069
plin2
perilipin 2
chr22_+_34454253 0.11 ENSDART00000156615
amigo3
adhesion molecule with Ig-like domain 3
chr6_+_28127514 0.10

chr6_+_28127444 0.09

chr18_+_12452 0.08

chr21_-_1956120 0.05 ENSDART00000165547
CABZ01045062.1
ENSDARG00000100274
chr3_+_58096720 0.04 ENSDART00000010395
ENSDART00000159755
ENSDART00000171149
uqcrc2a
ubiquinol-cytochrome c reductase core protein IIa
chr11_+_24720206 0.03 ENSDART00000145647
sulf2a
sulfatase 2a
chr15_-_29900 0.03

chr15_+_28335293 0.02 ENSDART00000152536
myo1cb
myosin Ic, paralog b
chr24_-_11365575 0.01 ENSDART00000140217
prpf4bb
pre-mRNA processing factor 4Bb

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.4 1.1 GO:0072578 neurotransmitter-gated ion channel clustering(GO:0072578)
0.3 2.6 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.3 1.9 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.3 2.1 GO:0046865 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.2 1.6 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.2 0.7 GO:1903793 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) regulation of organic acid transport(GO:0032890) positive regulation of organic acid transport(GO:0032892) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transport(GO:1903793) regulation of anion transmembrane transport(GO:1903959) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.2 0.6 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.2 0.5 GO:0048659 smooth muscle cell proliferation(GO:0048659)
0.1 1.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 1.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.9 GO:0035860 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 1.9 GO:0009746 response to carbohydrate(GO:0009743) response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.1 1.2 GO:0033555 multicellular organismal response to stress(GO:0033555)
0.1 0.9 GO:0048795 swim bladder morphogenesis(GO:0048795)
0.1 8.8 GO:0033993 response to lipid(GO:0033993)
0.1 1.0 GO:0001952 regulation of cell-matrix adhesion(GO:0001952)
0.0 1.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 1.6 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.1 GO:0030730 regulation of sequestering of triglyceride(GO:0010889) positive regulation of sequestering of triglyceride(GO:0010890) sequestering of triglyceride(GO:0030730)
0.0 0.2 GO:0006007 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.5 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.5 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.0 GO:0007601 visual perception(GO:0007601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.1 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.5 GO:0031430 M band(GO:0031430)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 1.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.9 GO:0005795 Golgi stack(GO:0005795)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 8.7 GO:0005504 fatty acid binding(GO:0005504)
0.5 1.4 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.3 2.6 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.3 1.5 GO:0034632 retinol transporter activity(GO:0034632)
0.3 1.6 GO:0048039 ubiquinone binding(GO:0048039)
0.1 1.6 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 0.4 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.4 GO:0016415 octanoyltransferase activity(GO:0016415)
0.1 0.4 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 1.3 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.5 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.1 1.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.1 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 0.6 GO:0016421 CoA carboxylase activity(GO:0016421)
0.1 0.7 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 1.2 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.1 0.2 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.1 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.0 1.6 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.5 GO:0070411 I-SMAD binding(GO:0070411)
0.0 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.2 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 0.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 0.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 0.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.4 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates