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DANIO-CODE
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Results for prdm2a
Z-value: 5.70
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Transcription factors associated with prdm2a
Network of associatons between targets according to the STRING database.
First level regulatory network of prdm2a
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_24310846 Show fit | 14.08 |
ENSDART00000017443
|
cugbp, Elav-like family member 2 |
|
| chr7_+_39173765 Show fit | 13.86 |
ENSDART00000173748
|
troponin T type 3b (skeletal, fast) |
|
| chr6_+_33556031 Show fit | 13.48 |
ENSDART00000147625
|
phosphoinositide-3-kinase, regulatory subunit 3b (gamma) |
|
| chr20_+_31366832 Show fit | 11.59 |
ENSDART00000133353
|
apolipoprotein Bb, tandem duplicate 1 |
|
| chr23_-_9556986 Show fit | 11.57 |
ENSDART00000139688
|
suppressor of glucose, autophagy associated 1 |
|
| chr13_-_49826330 Show fit | 10.95 |
ENSDART00000099475
|
nidogen 1a |
|
| chr15_-_2677200 Show fit | 10.92 |
ENSDART00000063320
|
claudin e |
|
| chr23_-_35595271 Show fit | 10.92 |
ENSDART00000164616
|
tubulin, alpha 1c |
|
| chr14_+_20809272 Show fit | 10.77 |
ENSDART00000139865
|
aldolase b, fructose-bisphosphate |
|
| chr13_-_18704185 Show fit | 10.72 |
ENSDART00000146795
|
leucine zipper, putative tumor suppressor 2a |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 22.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 22.5 | GO:0055085 | transmembrane transport(GO:0055085) |
| 1.5 | 22.4 | GO:0043551 | regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551) |
| 3.1 | 21.5 | GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) |
| 0.7 | 20.1 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.8 | 19.6 | GO:0043297 | apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830) |
| 0.3 | 18.5 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
| 0.6 | 15.3 | GO:0017144 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 0.7 | 13.9 | GO:0006942 | regulation of striated muscle contraction(GO:0006942) |
| 1.1 | 13.7 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 71.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 64.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 26.9 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.3 | 26.0 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.1 | 24.1 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 22.4 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.4 | 22.3 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 15.7 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.6 | 13.9 | GO:0005861 | troponin complex(GO:0005861) |
| 1.0 | 12.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 72.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 43.8 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.5 | 24.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.3 | 23.3 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.7 | 22.4 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.1 | 20.9 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.5 | 18.0 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.5 | 17.5 | GO:0005109 | frizzled binding(GO:0005109) |
| 1.7 | 13.9 | GO:0030172 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.1 | 13.9 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 19.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.7 | 14.1 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.4 | 13.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.5 | 8.4 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 2.1 | 6.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.4 | 5.8 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.3 | 5.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 5.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 3.8 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.5 | 12.5 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.6 | 12.0 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.1 | 11.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.7 | 10.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.6 | 10.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.7 | 9.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 8.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 1.2 | 8.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 7.8 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |