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Results for prox1a+prox2+prox3

Z-value: 1.23

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Transcription factors associated with prox1a+prox2+prox3

Gene Symbol Gene ID Gene Info
prox2
ENSDARG00000041952 prospero homeobox 2
prox1a
ENSDARG00000055158 prospero homeobox 1a
prox3
ENSDARG00000088810 prospero homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
prox1adr10_dc_chr17_-_32913432_32913509-0.853.2e-05Click!
prox1bdr10_dc_chr7_-_19688306_196884280.351.9e-01Click!

Activity profile of prox1a+prox2+prox3 motif

Sorted Z-values of prox1a+prox2+prox3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of prox1a+prox2+prox3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr21_-_32747592 5.10

chr14_+_24543399 3.34 ENSDART00000106039
arhgef37
Rho guanine nucleotide exchange factor (GEF) 37
chr24_+_40321763 3.24

chr5_+_22006830 2.60 ENSDART00000080919
rpl36a
ribosomal protein L36A
chr19_+_20404995 2.48 ENSDART00000142841
osbpl3a
oxysterol binding protein-like 3a
chr15_-_14102102 2.33 ENSDART00000139068
zgc:114130
zgc:114130
chr16_-_55211053 2.20 ENSDART00000156533
kdf1a
keratinocyte differentiation factor 1a
chr7_-_44265768 2.12 ENSDART00000149072
tk2
thymidine kinase 2, mitochondrial
chr23_+_25952724 2.08 ENSDART00000124963
pkig
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr1_-_8801877 2.07 ENSDART00000137821
micall2b
mical-like 2b
chr9_+_8990576 2.02 ENSDART00000133899
ube2al
ubiquitin conjugating enzyme E2 A, like
chr19_+_20405107 1.96 ENSDART00000151066
osbpl3a
oxysterol binding protein-like 3a
chr9_+_8990774 1.95 ENSDART00000133899
ube2al
ubiquitin conjugating enzyme E2 A, like
chr14_+_28167213 1.93 ENSDART00000157306
ENSDART00000166375
ENSDART00000167439
ENSDART00000017075
xiap
X-linked inhibitor of apoptosis
chr1_-_12575687 1.92

chr15_-_29229170 1.85 ENSDART00000138449
xaf1
XIAP associated factor 1
chr16_+_4353561 1.83 ENSDART00000060729
yrdc
yrdC N(6)-threonylcarbamoyltransferase domain containing
chr8_+_11287550 1.78 ENSDART00000115057
tjp2b
tight junction protein 2b (zona occludens 2)
chr3_-_26060787 1.76 ENSDART00000113843
ypel3
yippee-like 3
chr6_-_32424559 1.76 ENSDART00000151002
usp1
ubiquitin specific peptidase 1
chr6_-_31798839 1.75

chr12_+_6032235 1.68 ENSDART00000142418
sgms1
sphingomyelin synthase 1
chr3_-_21006698 1.62 ENSDART00000104051
cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr14_+_28167358 1.61 ENSDART00000157306
ENSDART00000166375
ENSDART00000167439
ENSDART00000017075
xiap
X-linked inhibitor of apoptosis
chr17_+_15666078 1.60 ENSDART00000156726
bach2a
BTB and CNC homology 1, basic leucine zipper transcription factor 2a
chr3_-_5523316 1.59 ENSDART00000159308
trim35-7
tripartite motif containing 35-7
chr13_-_25711537 1.52 ENSDART00000015154
papolg
poly(A) polymerase gamma
chr4_+_5187879 1.52 ENSDART00000067386
rad51ap1
RAD51 associated protein 1
chr21_-_32747544 1.47

chr3_+_22204475 1.45 ENSDART00000055676
ENSDARG00000038186
ENSDARG00000038186
chr19_+_43316957 1.43 ENSDART00000151298
arpp21
cAMP-regulated phosphoprotein, 21
chr10_-_38372418 1.43 ENSDART00000149580
nrip1b
nuclear receptor interacting protein 1b
chr2_+_7014241 1.42 ENSDART00000016607
rgs5b
regulator of G protein signaling 5b
chr4_-_20456437 1.40 ENSDART00000003621
ENSDART00000132356
sinup
siaz-interacting nuclear protein
chr5_-_36499541 1.36

chr7_+_20651600 1.36 ENSDART00000129161
wrap53
WD repeat containing, antisense to TP53
chr17_-_9903930 1.33 ENSDART00000166984
baz1a
bromodomain adjacent to zinc finger domain, 1A
chr15_-_29229135 1.32 ENSDART00000138449
xaf1
XIAP associated factor 1
chr3_-_5523243 1.27 ENSDART00000159308
trim35-7
tripartite motif containing 35-7
chr20_+_27088328 1.20 ENSDART00000012816
sel1l
sel-1 suppressor of lin-12-like (C. elegans)
chr19_-_31455278 1.19 ENSDART00000133101
ENSDART00000136213
bzw2
basic leucine zipper and W2 domains 2
chr13_+_11696495 1.14 ENSDART00000110141
sufu
suppressor of fused homolog (Drosophila)
chr15_+_32391061 1.10 ENSDART00000152513
arfip2a
ADP-ribosylation factor interacting protein 2a
chr21_+_22088080 1.08 ENSDART00000130179
cul5b
cullin 5b
chr11_-_25223594 1.07 ENSDART00000014945
hcfc1a
host cell factor C1a
chr3_+_22204569 1.06 ENSDART00000055676
ENSDARG00000038186
ENSDARG00000038186
chr7_+_20651775 1.05 ENSDART00000129161
wrap53
WD repeat containing, antisense to TP53
chr2_+_26002522 1.05 ENSDART00000051234
tnika
TRAF2 and NCK interacting kinase a
chr19_-_27811272 0.99 ENSDART00000103940
mgat1b
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase b
chr15_-_31296457 0.97 ENSDART00000008854
wsb1
WD repeat and SOCS box containing 1
chr3_-_26060702 0.96 ENSDART00000144726
ypel3
yippee-like 3
chr6_-_32424706 0.94 ENSDART00000078908
usp1
ubiquitin specific peptidase 1
chr2_+_26002426 0.94 ENSDART00000051234
tnika
TRAF2 and NCK interacting kinase a
chr4_-_20456517 0.93 ENSDART00000003621
ENSDART00000132356
sinup
siaz-interacting nuclear protein
chr15_-_31296524 0.92 ENSDART00000008854
wsb1
WD repeat and SOCS box containing 1
chr5_+_13370060 0.92 ENSDART00000160690
hk2
hexokinase 2
chr12_-_23244600 0.89 ENSDART00000170376
mpp7a
membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7)
chr1_-_8801818 0.87 ENSDART00000008682
ENSDART00000157814
micall2b
mical-like 2b
chr11_-_25224150 0.87 ENSDART00000014945
hcfc1a
host cell factor C1a
chr8_-_49356414 0.85 ENSDART00000053203
plp2
proteolipid protein 2
chr3_-_15517767 0.85 ENSDART00000115022
zgc:66474
zgc:66474
chr19_-_27811300 0.84 ENSDART00000103940
mgat1b
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase b
chr3_-_5523147 0.81 ENSDART00000159308
trim35-7
tripartite motif containing 35-7
chr19_+_43316927 0.78 ENSDART00000151298
arpp21
cAMP-regulated phosphoprotein, 21
chr16_+_51290761 0.74 ENSDART00000058290
dhdds
dehydrodolichyl diphosphate synthase
chr3_-_26060748 0.74 ENSDART00000144726
ypel3
yippee-like 3
chr13_-_12534653 0.70 ENSDART00000079594
zgc:113201
zgc:113201
chr16_+_39246663 0.68 ENSDART00000017017
zdhhc3a
zinc finger, DHHC-type containing 3a
chr12_-_18776533 0.66 ENSDART00000163582
desi1b
desumoylating isopeptidase 1b
chr18_-_44617805 0.64 ENSDART00000173095
ENSDART00000136420
spred3
sprouty-related, EVH1 domain containing 3
chr3_-_36117170 0.59 ENSDART00000158701
ENSDART00000141106
gps1
G protein pathway suppressor 1
chr5_+_13370237 0.58 ENSDART00000160690
hk2
hexokinase 2
chr6_-_32425011 0.53 ENSDART00000078908
usp1
ubiquitin specific peptidase 1
chr10_-_2686054 0.52 ENSDART00000123754
mier3a
mesoderm induction early response 1, family member 3 a
chr1_+_5464124 0.51 ENSDART00000144559
cnppd1
cyclin Pas1/PHO80 domain containing 1
chr21_-_13875945 0.37 ENSDART00000143874
akna
AT-hook transcription factor
chr1_+_58288476 0.30

chr21_-_32747483 0.27

chr18_-_34573536 0.26 ENSDART00000137101
ssr3
signal sequence receptor, gamma
chr8_-_43567869 0.26 ENSDART00000162770
ncor2
nuclear receptor corepressor 2
chr24_-_32281707 0.23 ENSDART00000151845
trdmt1
tRNA aspartic acid methyltransferase 1
chr6_+_11014565 0.22 ENSDART00000132677
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr23_+_36019942 0.20 ENSDART00000103134
ENSDART00000139319
hoxc5a
homeobox C5a
chr17_-_37247455 0.20 ENSDART00000108514
asxl2
additional sex combs like transcriptional regulator 2
chr8_+_47228598 0.12 ENSDART00000075068
mthfr
methylenetetrahydrofolate reductase (NAD(P)H)
chr7_+_6786457 0.12 ENSDART00000172421
rbm14b
RNA binding motif protein 14b
chr11_-_25223723 0.08 ENSDART00000014945
hcfc1a
host cell factor C1a
chr4_-_39946152 0.06

chr3_+_27188961 0.06

chr19_-_37921386 0.06 ENSDART00000018255
ilf2
interleukin enhancer binding factor 2
chr4_-_5904787 0.02 ENSDART00000169439
arl1
ADP-ribosylation factor-like 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0003334 keratinocyte development(GO:0003334) epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.4 2.4 GO:0030575 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576)
0.3 2.1 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 1.1 GO:1903533 regulation of protein targeting(GO:1903533)
0.3 1.8 GO:0006450 regulation of translational fidelity(GO:0006450)
0.2 1.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.2 1.6 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.2 0.6 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.1 0.7 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.1 1.8 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 1.5 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.1 2.3 GO:0001840 neural plate development(GO:0001840)
0.1 2.9 GO:0036269 swimming behavior(GO:0036269)
0.1 4.0 GO:0016574 histone ubiquitination(GO:0016574)
0.1 3.5 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.1 0.6 GO:0000338 protein deneddylation(GO:0000338)
0.1 3.2 GO:0006282 regulation of DNA repair(GO:0006282)
0.1 1.5 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.1 1.5 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 1.1 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.2 GO:0044805 late nucleophagy(GO:0044805)
0.0 2.0 GO:0032147 activation of protein kinase activity(GO:0032147)
0.0 0.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.8 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.3 GO:0030225 macrophage differentiation(GO:0030225)
0.0 3.0 GO:0006869 lipid transport(GO:0006869)
0.0 6.6 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.1 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 1.2 GO:0006338 chromatin remodeling(GO:0006338)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.0 GO:0033503 HULC complex(GO:0033503)
0.4 4.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 1.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 1.1 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.2 0.7 GO:1904423 dehydrodolichyl diphosphate synthase complex(GO:1904423)
0.1 2.4 GO:0015030 Cajal body(GO:0015030)
0.1 0.7 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 3.5 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 1.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 2.7 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 1.7 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 3.5 GO:0005730 nucleolus(GO:0005730)
0.0 0.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.4 2.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.4 1.5 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.3 1.6 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.3 2.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 1.7 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.3 3.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.2 1.5 GO:0005536 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 0.7 GO:0045547 polyprenyltransferase activity(GO:0002094) dehydrodolichyl diphosphate synthase activity(GO:0045547)
0.2 4.4 GO:0015248 sterol transporter activity(GO:0015248)
0.2 0.7 GO:0019705 protein-cysteine S-myristoyltransferase activity(GO:0019705)
0.1 4.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 3.2 GO:0101005 cysteine-type endopeptidase activity(GO:0004197) thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 1.8 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 2.3 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 6.9 GO:0008270 zinc ion binding(GO:0008270)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 1.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 0.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 3.5 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 3.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 1.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.6 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity