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Results for ptf1a

Z-value: 0.71

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Transcription factors associated with ptf1a

Gene Symbol Gene ID Gene Info
ptf1a
ENSDARG00000014479 pancreas associated transcription factor 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ptf1adr10_dc_chr2_+_29727235_29727242-0.692.8e-03Click!

Activity profile of ptf1a motif

Sorted Z-values of ptf1a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ptf1a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_45182378 2.24 ENSDART00000161815
polm
polymerase (DNA directed), mu
chr22_+_22413803 1.62 ENSDART00000147825
kif14
kinesin family member 14
chr22_-_20670164 1.58 ENSDART00000169077
org
oogenesis-related gene
chr25_+_33787063 1.49

chr23_-_32267833 1.40

chr3_+_17728616 1.37 ENSDART00000167953
dnajc7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr4_+_48372465 1.26

chr11_-_15886860 1.25 ENSDART00000170731
zgc:173544
zgc:173544
chr11_-_27715592 1.08 ENSDART00000168338
ece1
endothelin converting enzyme 1
chr10_+_16914003 1.01 ENSDART00000177906
UNC13B
unc-13 homolog B
chr7_-_41532268 0.99 ENSDART00000016105
ENSDART00000138800
vps35
vacuolar protein sorting 35 homolog (S. cerevisiae)
chr9_+_188749 0.96 ENSDART00000172946
rrp1
ribosomal RNA processing 1
chr11_-_27580252 0.91 ENSDART00000121847
cstf1
cleavage stimulation factor, 3' pre-RNA, subunit 1
chr7_+_15479700 0.90

chr23_+_39231080 0.82

chr15_+_35076414 0.81 ENSDART00000165210
zgc:66024
zgc:66024
chr22_-_36721626 0.76 ENSDART00000017188
ENSDART00000124698
ncl
nucleolin
chr22_+_22413878 0.76 ENSDART00000147825
kif14
kinesin family member 14
chr24_+_39631194 0.70 ENSDART00000013894
dcun1d3
defective in cullin neddylation 1 domain containing 3
chr15_+_32053944 0.66 ENSDART00000175828
brca2
breast cancer 2, early onset
chr17_-_51729568 0.66 ENSDART00000157244
exd2
exonuclease 3'-5' domain containing 2
chr7_+_71658178 0.65

chr15_-_46594821 0.64 ENSDART00000045110
chd
chordin
chr17_-_51729707 0.63 ENSDART00000157244
exd2
exonuclease 3'-5' domain containing 2
chr7_+_71658255 0.63

chr5_-_47419494 0.63 ENSDART00000078401
tmem161b
transmembrane protein 161B
chr17_+_21458177 0.62 ENSDART00000155309
pla2g4f.2
phospholipase A2, group IVF, tandem duplicate 2
chr19_-_44154954 0.61 ENSDART00000151309
ppt1
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr5_-_32290272 0.58 ENSDART00000007512
pole3
polymerase (DNA directed), epsilon 3 (p17 subunit)
chr18_-_18952992 0.56 ENSDART00000100458
si:dkey-73n10.1
si:dkey-73n10.1
chr7_+_41532360 0.55 ENSDART00000174333
orc6
origin recognition complex, subunit 6
chr9_+_188598 0.54 ENSDART00000162764
rrp1
ribosomal RNA processing 1
chr5_-_47419466 0.53 ENSDART00000078401
tmem161b
transmembrane protein 161B
chr3_+_32802124 0.53 ENSDART00000112742
nbr1b
neighbor of brca1 gene 1b
chr24_+_39630741 0.53 ENSDART00000132939
dcun1d3
defective in cullin neddylation 1 domain containing 3
chr11_-_28508152 0.52

chr18_-_2954175 0.51 ENSDART00000166382
clns1a
chloride channel, nucleotide-sensitive, 1A
chr18_+_50921419 0.50 ENSDART00000058468
ENSDART00000008696
cttn
cortactin
chr8_-_1586037 0.49 ENSDART00000142703
CU694486.1
ENSDARG00000091948
chr15_+_12504537 0.48 ENSDART00000168011
tmprss4a
transmembrane protease, serine 4a
chr3_+_32802899 0.47

chr19_-_44154669 0.46 ENSDART00000147328
ppt1
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr15_+_2512287 0.45 ENSDART00000035939
ENSDART00000157845
panx1a
pannexin 1a
chr18_+_5260404 0.44 ENSDART00000150992
wdr59
WD repeat domain 59
chr17_-_14443647 0.43 ENSDART00000039438
jkamp
jnk1/mapk8-associated membrane protein
chr3_+_37507573 0.43 ENSDART00000075039
gosr2
golgi SNAP receptor complex member 2
chr7_+_15197911 0.43 ENSDART00000046542
igf1rb
insulin-like growth factor 1b receptor
chr22_-_26231695 0.43 ENSDART00000142821
ccdc130
coiled-coil domain containing 130
chr7_+_28906011 0.42 ENSDART00000008096
aph1b
APH1B gamma secretase subunit
chr5_-_47419401 0.42 ENSDART00000078401
tmem161b
transmembrane protein 161B
chr8_-_18849529 0.42 ENSDART00000100491
sh3gl1b
SH3-domain GRB2-like 1b
chr5_-_32290231 0.42 ENSDART00000007512
pole3
polymerase (DNA directed), epsilon 3 (p17 subunit)
chr7_+_15479520 0.41

chr15_+_12504492 0.39 ENSDART00000168011
tmprss4a
transmembrane protease, serine 4a
chr15_+_12504756 0.39 ENSDART00000169894
tmprss4a
transmembrane protease, serine 4a
chr22_-_36721592 0.39 ENSDART00000130171
ncl
nucleolin
chr5_+_44538762 0.39 ENSDART00000172702
ENSDART00000136002
smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_-_16893974 0.38 ENSDART00000124627
strap
serine/threonine kinase receptor associated protein
chr5_+_44208458 0.38

chr13_+_24467302 0.38 ENSDART00000158949
AL831745.3
ENSDARG00000101436
chr7_+_69212246 0.36 ENSDART00000159799
ctdnep1b
CTD nuclear envelope phosphatase 1b
KN150589v1_-_6303 0.35

chr25_+_33787029 0.34

chr6_-_7094468 0.32

chr7_+_69211965 0.32 ENSDART00000028064
ctdnep1b
CTD nuclear envelope phosphatase 1b
chr11_-_27580123 0.31 ENSDART00000121847
cstf1
cleavage stimulation factor, 3' pre-RNA, subunit 1
chr22_-_26231606 0.30 ENSDART00000060888
ccdc130
coiled-coil domain containing 130
chr19_-_12293162 0.30 ENSDART00000142077
znf706
zinc finger protein 706
chr6_-_10677028 0.30 ENSDART00000036456
cycsb
cytochrome c, somatic b
chr2_-_23331500 0.29 ENSDART00000146497
mllt1b
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1b
chr7_-_41531991 0.29 ENSDART00000174058
vps35
vacuolar protein sorting 35 homolog (S. cerevisiae)
chr18_+_17548213 0.29 ENSDART00000144960
nup93
nucleoporin 93
chr6_+_54350379 0.26 ENSDART00000153704
anks1ab
ankyrin repeat and sterile alpha motif domain containing 1Ab
chr10_-_15090551 0.26 ENSDART00000038401
ENSDART00000155674
si:ch211-95j8.2
si:ch211-95j8.2
chr8_-_53553764 0.25 ENSDART00000157521
actr8
ARP8 actin related protein 8 homolog
chr5_-_47419195 0.25 ENSDART00000078401
tmem161b
transmembrane protein 161B
chr7_+_69212144 0.24 ENSDART00000159799
ctdnep1b
CTD nuclear envelope phosphatase 1b
chr15_+_1569864 0.23 ENSDART00000056765
smc4
structural maintenance of chromosomes 4
chr3_+_61960035 0.22 ENSDART00000097312
sco1
SCO1 cytochrome c oxidase assembly protein
chr12_-_3904030 0.21 ENSDART00000134292
ENSDARG00000021154
ENSDARG00000021154
chr5_-_47419154 0.21 ENSDART00000078401
tmem161b
transmembrane protein 161B
chr24_+_16402587 0.21 ENSDART00000164319
sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr15_+_46093261 0.20

chr1_-_28146457 0.19 ENSDART00000110270
ENSDART00000170797
pwp2h
PWP2 periodic tryptophan protein homolog (yeast)
chr8_+_16722505 0.18 ENSDART00000133514
elovl7a
ELOVL fatty acid elongase 7a
chr18_-_2954048 0.17 ENSDART00000166382
clns1a
chloride channel, nucleotide-sensitive, 1A
chr15_-_35075545 0.17 ENSDART00000006288
dhx16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr1_-_5387933 0.15 ENSDART00000138891
ENSDART00000176913
pard3ba
par-3 family cell polarity regulator beta a
chr16_+_35952050 0.15 ENSDART00000162411
sh3d21
SH3 domain containing 21
chr5_+_37497105 0.13

chr12_-_9094888 0.13 ENSDART00000066471
adam8b
ADAM metallopeptidase domain 8b
chr18_-_1745485 0.12

chr15_-_2556119 0.11 ENSDART00000047013
srprb
signal recognition particle receptor, B subunit
chr5_-_47419233 0.11 ENSDART00000078401
tmem161b
transmembrane protein 161B
chr3_-_36117170 0.11 ENSDART00000158701
ENSDART00000141106
gps1
G protein pathway suppressor 1
chr15_-_1569267 0.10 ENSDART00000133943
ift80
intraflagellar transport 80 homolog (Chlamydomonas)
KN150262v1_+_4307 0.10

chr6_-_7094523 0.09

chr14_+_49180737 0.08

chr14_+_49180922 0.07

chr13_+_8735 0.06 ENSDART00000168769
ENSDART00000165772
ENSDARG00000103415
ENSDARG00000103415
chr18_-_19501985 0.06 ENSDART00000090413
snapc5
small nuclear RNA activating complex, polypeptide 5
chr16_-_25748643 0.06 ENSDART00000132136
derl1
derlin 1
chr5_+_57073554 0.05 ENSDART00000166098
ENSDART00000005090
alg9
ALG9, alpha-1,2-mannosyltransferase
chr8_-_1201388 0.05 ENSDART00000150064
cdc14b
cell division cycle 14B
chr14_-_29498646 0.05

chr8_+_36467811 0.05 ENSDART00000098701
slc7a4
solute carrier family 7, member 4
chr3_+_61960120 0.05 ENSDART00000097312
sco1
SCO1 cytochrome c oxidase assembly protein
chr10_+_45213266 0.05 ENSDART00000166945
nudcd3
NudC domain containing 3
chr21_-_2033162 0.05

chr7_+_49391403 0.04 ENSDART00000131210
rassf7b
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr18_-_5260386 0.04 ENSDART00000027115
nob1
NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
chr1_+_25773300 0.03 ENSDART00000011809
uso1
USO1 vesicle transport factor
chr23_+_1721822 0.03 ENSDART00000149545
tgm1
transglutaminase 1, K polypeptide
chr7_+_15197937 0.02 ENSDART00000046542
igf1rb
insulin-like growth factor 1b receptor
chr18_-_5822255 0.01 ENSDART00000121503
cplx3b
complexin 3b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.9 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 0.5 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.1 1.2 GO:0009303 rRNA transcription(GO:0009303)
0.1 2.2 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 1.1 GO:0016486 peptide hormone processing(GO:0016486)
0.1 0.7 GO:0008585 female gonad development(GO:0008585)
0.1 1.1 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 1.2 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.1 0.3 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.4 GO:0007220 Notch receptor processing(GO:0007220)
0.1 0.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.7 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.6 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.2 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.4 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 1.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.1 GO:0000338 protein deneddylation(GO:0000338)
0.0 2.4 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.3 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0034709 methylosome(GO:0034709)
0.2 1.0 GO:0008623 CHRAC(GO:0008623)
0.1 0.9 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 1.3 GO:0030904 retromer complex(GO:0030904)
0.1 1.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 0.5 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 0.5 GO:0005921 gap junction(GO:0005921)
0.1 0.4 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.7 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 2.4 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.5 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.3 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.2 0.5 GO:0005243 gap junction channel activity(GO:0005243)
0.1 2.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.2 GO:0097602 cullin family protein binding(GO:0097602)
0.1 1.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.4 GO:0043560 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.0 1.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 2.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.3 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 1.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 0.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 1.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.2 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 0.7 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 1.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 0.4 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.1 0.5 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.0 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs