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Results for rest
Z-value: 3.70
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Transcription factors associated with rest
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rest | dr10_dc_chr14_-_51717514_51717624 | -0.14 | 6.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of rest
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_30858769 Show fit | 25.09 |
ENSDART00000131285
|
myelin transcription factor 1a |
|
| chr20_+_35010140 Show fit | 14.23 |
ENSDART00000172001
|
synaptosomal-associated protein, 25a |
|
| chr12_+_24221087 Show fit | 13.61 |
ENSDART00000088178
|
neurexin 1a |
|
| chr1_+_16983775 Show fit | 12.98 |
ENSDART00000030665
|
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 |
|
| chr1_+_10036098 Show fit | 12.55 |
ENSDART00000139387
|
ATPase, Na+/K+ transporting, beta 1b polypeptide |
|
| chr4_-_5294280 Show fit | 11.82 |
ENSDART00000178921
|
si:ch211-214j24.9 |
|
| chr25_-_22541525 Show fit | 11.73 |
ENSDART00000073583
|
immunoglobulin superfamily containing leucine-rich repeat 2 |
|
| chr12_+_28252623 Show fit | 11.49 |
ENSDART00000066294
|
cyclin-dependent kinase 5, regulatory subunit 1b (p35) |
|
| chr21_+_6829161 Show fit | 10.27 |
ENSDART00000037265
|
olfactomedin 1b |
|
| chr25_-_31452381 Show fit | 10.02 |
ENSDART00000028338
|
secretory carrier membrane protein 5a |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 39.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 25.1 | GO:1904888 | cranial skeletal system development(GO:1904888) |
| 1.7 | 20.7 | GO:0016082 | synaptic vesicle priming(GO:0016082) |
| 2.9 | 14.4 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.1 | 13.4 | GO:0002040 | sprouting angiogenesis(GO:0002040) |
| 3.2 | 13.0 | GO:1990544 | intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544) |
| 3.2 | 12.8 | GO:0003210 | cardiac atrium formation(GO:0003210) |
| 0.8 | 12.6 | GO:0014059 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.7 | 12.5 | GO:0036376 | cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436) |
| 0.2 | 12.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 53.8 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 44.0 | GO:0016021 | integral component of membrane(GO:0016021) intrinsic component of membrane(GO:0031224) |
| 0.1 | 40.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 33.0 | GO:0005886 | plasma membrane(GO:0005886) |
| 1.5 | 20.7 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 1.4 | 14.4 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 14.2 | GO:0045202 | synapse(GO:0045202) |
| 0.0 | 13.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 12.8 | GO:0005576 | extracellular region(GO:0005576) |
| 1.6 | 12.5 | GO:1904949 | sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 25.1 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 24.3 | GO:0046872 | metal ion binding(GO:0046872) |
| 0.9 | 20.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 3.6 | 14.4 | GO:0005326 | neurotransmitter transporter activity(GO:0005326) |
| 0.0 | 13.7 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012) |
| 1.0 | 13.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 3.2 | 13.0 | GO:0005471 | ATP:ADP antiporter activity(GO:0005471) |
| 1.6 | 12.8 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.5 | 12.6 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 3.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 0.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.0 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.1 | 9.5 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.5 | 8.5 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.5 | 7.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.9 | 4.5 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.5 | 4.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.5 | 3.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |