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Results for rest

Z-value: 3.70

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Transcription factors associated with rest

Gene Symbol Gene ID Gene Info
rest
ENSDARG00000103046 Danio rerio RE1-silencing transcription factor (rest), mRNA.

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
restdr10_dc_chr14_-_51717514_51717624-0.146.0e-01Click!

Activity profile of rest motif

Sorted Z-values of rest motif

Network of associatons between targets according to the STRING database.

First level regulatory network of rest

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr23_-_30858769 25.09 ENSDART00000131285
myt1a
myelin transcription factor 1a
chr20_+_35010140 14.23 ENSDART00000172001
snap25a
synaptosomal-associated protein, 25a
chr12_+_24221087 13.61 ENSDART00000088178
nrxn1a
neurexin 1a
chr1_+_16983775 12.98 ENSDART00000030665
slc25a4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr1_+_10036098 12.55 ENSDART00000139387
atp1b1b
ATPase, Na+/K+ transporting, beta 1b polypeptide
chr4_-_5294280 11.82 ENSDART00000178921
SNAP91 (1 of many)
si:ch211-214j24.9
chr25_-_22541525 11.73 ENSDART00000073583
islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr12_+_28252623 11.49 ENSDART00000066294
cdk5r1b
cyclin-dependent kinase 5, regulatory subunit 1b (p35)
chr21_+_6829161 10.27 ENSDART00000037265
olfm1b
olfactomedin 1b
chr25_-_31452381 10.02 ENSDART00000028338
scamp5a
secretory carrier membrane protein 5a
chr10_+_21850059 9.79 ENSDART00000164634
ENSDART00000172513
pcdh1g32
protocadherin 1 gamma 32
chr9_-_35106146 9.53 ENSDART00000139608
ENSDART00000100728
ENSDART00000123005
upf3a
UPF3 regulator of nonsense transcripts homolog A (yeast)
chr13_+_781725 8.48 ENSDART00000129866
pcsk2
proprotein convertase subtilisin/kexin type 2
chr13_+_23152038 8.44 ENSDART00000171676
khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr6_+_41257803 8.35 ENSDART00000042683
cadpsb
Ca2+-dependent activator protein for secretion b
chr18_+_36825511 7.97 ENSDART00000098958
ttc9b
tetratricopeptide repeat domain 9B
chr14_-_2274883 7.95 ENSDART00000128659
pcdh2ab10
protocadherin 2 alpha b 10
chr2_+_57369722 7.89 ENSDART00000129811
onecut3b
one cut homeobox 3b
chr23_-_45356039 7.75 ENSDART00000067630
ENSDARG00000039901
ENSDARG00000039901
chr7_+_23636549 7.69 ENSDART00000045479
syt4
synaptotagmin IV
chr5_-_25493792 7.66 ENSDART00000010199
fam219ab
family with sequence similarity 219, member Ab
chr7_+_31608828 7.63 ENSDART00000138491
mybpc3
myosin binding protein C, cardiac
chr25_+_34745872 7.59 ENSDART00000003494
slc17a6a
solute carrier family 17 (vesicular glutamate transporter), member 6a
chr25_+_4909062 7.44 ENSDART00000170049
parvb
parvin, beta
chr20_-_54669179 7.43

chr2_-_28154388 7.26 ENSDART00000161864
zgc:123035
zgc:123035
chr23_+_35660991 7.19 ENSDART00000047082
gdap1l1
ganglioside induced differentiation associated protein 1-like 1
chr15_+_24277664 6.89 ENSDART00000155502
sez6b
seizure related 6 homolog b
chr3_+_33209227 6.82 ENSDART00000128786
pyya
peptide YYa
chr7_-_32562435 6.78 ENSDART00000099872
ENSDART00000099871
ENSDART00000147554
slc17a6b
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr10_+_23052796 6.77 ENSDART00000138955
si:dkey-175g6.2
si:dkey-175g6.2
chr9_-_27838603 6.70

chr17_-_12231165 6.49 ENSDART00000080927
snap25b
synaptosomal-associated protein, 25b
chr12_-_1931281 6.16 ENSDART00000005676
ENSDART00000127937
sox9a
SRY (sex determining region Y)-box 9a
chr9_-_30073641 6.06

chr6_-_42143595 6.06 ENSDART00000085472
grm2a
glutamate receptor, metabotropic 2a
chr20_+_38821682 6.02 ENSDART00000015095
uts1
urotensin 1
chr6_-_43094573 5.95 ENSDART00000084389
lrrn1
leucine rich repeat neuronal 1
chr5_+_43365449 5.93 ENSDART00000113502
TMEM8B
si:dkey-84j12.1
chr23_+_36648211 5.84

chr14_-_31918174 5.72 ENSDART00000052949
fgf13a
fibroblast growth factor 13a
chr4_-_5293599 5.56 ENSDART00000177099
SNAP91 (1 of many)
si:ch211-214j24.9
chr10_+_21630540 5.53

chr3_+_56008829 5.52

chr14_-_2155141 5.51 ENSDART00000106691
pcdh2g6
protocadherin 2 gamma 6
chr21_+_11375961 5.45 ENSDART00000158936
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr11_+_35896325 5.44 ENSDART00000163330
grm2b
glutamate receptor, metabotropic 2b
chr14_-_2175076 5.36 ENSDART00000110937
CT573264.3
ENSDARG00000079424
chr14_-_2179471 5.29 ENSDART00000157401
pcdh2g1
protocadherin 2 gamma 1
chr7_+_31608878 5.17 ENSDART00000099789
mybpc3
myosin binding protein C, cardiac
chr2_+_56705456 5.05

chr19_-_4769990 5.00

chr5_+_71028018 4.98 ENSDART00000164893
ENSDART00000159658
ENSDART00000097164
ENSDART00000124939
ENSDART00000171230
LHX3
LIM homeobox 3
chr7_+_39957385 4.97 ENSDART00000052222
ptprn2
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr5_-_29150278 4.72 ENSDART00000051474
barhl1a
BarH-like homeobox 1a
chr11_-_25962291 4.61

chr19_-_42674928 4.59 ENSDART00000102697
cart4
cocaine- and amphetamine-regulated transcript 4
chr20_+_5511996 4.53

chr19_+_27133834 4.36 ENSDART00000134455
zgc:100906
zgc:100906
chr1_+_33510660 4.27 ENSDART00000147201
slc5a7a
solute carrier family 5 (sodium/choline cotransporter), member 7a
chr6_+_10214270 4.25 ENSDART00000090874
kcnh7
potassium channel, voltage gated eag related subfamily H, member 7
chr18_+_29010470 4.17 ENSDART00000018685
syt9a
synaptotagmin IXa
chr20_+_27121126 4.17 ENSDART00000126919
ENSDART00000016014
chga
chromogranin A
chr2_-_5864098 3.83 ENSDART00000133851
nyap2b
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2b
chr13_+_23152160 3.80 ENSDART00000101134
khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr21_+_6829352 3.74 ENSDART00000146371
olfm1b
olfactomedin 1b
chr3_-_59179368 3.67 ENSDART00000100327
nptx1l
neuronal pentraxin 1 like
chr3_-_26073923 3.62 ENSDART00000103748
gdpd3a
glycerophosphodiester phosphodiesterase domain containing 3a
chr15_+_43535893 3.57

chr15_-_22212082 3.57 ENSDART00000159116
scn3b
sodium channel, voltage-gated, type III, beta
chr3_-_38603604 3.52 ENSDART00000165823
si:ch211-198m17.1
si:ch211-198m17.1
chr14_-_2159010 3.30 ENSDART00000158928
pcdh2g16
protocadherin 2 gamma 16
chr20_+_45837841 2.97 ENSDART00000113454
chgb
chromogranin B
chr17_-_23235070 2.96

chr14_-_2162867 2.76 ENSDART00000159262
pcdh2g3
protocadherin 2 gamma 3
chr5_+_43365528 2.59 ENSDART00000113502
TMEM8B
si:dkey-84j12.1
chr11_+_19618349 2.56 ENSDART00000157394
cadpsa
Ca2+-dependent activator protein for secretion a
chr6_+_19680394 2.54

chr7_+_16978182 2.53

chr7_+_16977286 2.45 ENSDART00000097982
slc6a5
solute carrier family 6 (neurotransmitter transporter), member 5
chr14_-_2349346 2.13 ENSDART00000130712
pcdh2aa15
protocadherin 2 alpha a 15
chr7_+_16977507 2.04 ENSDART00000097982
slc6a5
solute carrier family 6 (neurotransmitter transporter), member 5
chr9_-_51251505 1.81 ENSDART00000162278
CABZ01053748.1
ENSDARG00000100870
chr14_-_2114123 1.60 ENSDART00000111335
pcdh2g13
protocadherin 2 gamma 13
chr6_+_43905694 1.54 ENSDART00000006435
gpr27
G protein-coupled receptor 27
chr20_-_31028201 1.48 ENSDART00000146376
acat2
acetyl-CoA acetyltransferase 2
chr14_-_2166955 1.47 ENSDART00000169201
pcdh2g16
protocadherin 2 gamma 16
chr4_+_344355 1.46 ENSDART00000142225
ENSDART00000163436
tmem181
transmembrane protein 181
chr11_+_39631586 1.43 ENSDART00000173280
camta1b
calmodulin binding transcription activator 1b
chr23_+_20714105 1.07 ENSDART00000054691
uba1
ubiquitin-like modifier activating enzyme 1
chr10_-_30006277 1.05 ENSDART00000099983
bsx
brain-specific homeobox
chr10_+_21609883 0.96

chr17_+_19610407 0.84 ENSDART00000104895
rgs7a
regulator of G protein signaling 7a
chr3_+_34690823 0.83

chr1_+_54233842 0.82 ENSDART00000089603
golga7ba
golgin A7 family, member Ba
chr18_+_29010525 0.74 ENSDART00000018685
syt9a
synaptotagmin IXa
chr3_-_13771322 0.73 ENSDART00000159177
ENSDART00000165174
si:dkey-61n16.5
si:dkey-61n16.5
chr21_-_17446442 0.45

chr3_-_26073676 0.38 ENSDART00000169123
gdpd3a
glycerophosphodiester phosphodiesterase domain containing 3a
chr18_-_44617805 0.30 ENSDART00000173095
ENSDART00000136420
spred3
sprouty-related, EVH1 domain containing 3
chr12_+_19183576 0.22 ENSDART00000066391
csnk1e
casein kinase 1, epsilon
chr25_-_31452269 0.20 ENSDART00000028338
scamp5a
secretory carrier membrane protein 5a
chr10_-_26775840 0.14 ENSDART00000020096
fgf13b
fibroblast growth factor 13b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 13.0 GO:1990544 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
3.2 12.8 GO:0003210 cardiac atrium formation(GO:0003210)
2.9 14.4 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
2.2 10.9 GO:1990504 dense core granule exocytosis(GO:1990504)
1.7 20.7 GO:0016082 synaptic vesicle priming(GO:0016082)
1.6 11.5 GO:0035881 amacrine cell differentiation(GO:0035881)
1.2 3.6 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
1.2 5.9 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
1.1 4.5 GO:0043092 amino acid import(GO:0043090) L-amino acid import(GO:0043092)
1.0 4.2 GO:0046888 negative regulation of hormone secretion(GO:0046888)
1.0 11.5 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
0.9 5.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.9 6.2 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.9 4.3 GO:0008291 neuromuscular synaptic transmission(GO:0007274) acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.9 6.0 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.8 12.6 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.8 8.5 GO:0016486 peptide hormone processing(GO:0016486)
0.7 12.5 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.5 6.8 GO:0007631 feeding behavior(GO:0007631)
0.5 10.2 GO:1903307 positive regulation of calcium ion-dependent exocytosis(GO:0045956) positive regulation of regulated secretory pathway(GO:1903307)
0.3 39.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 7.4 GO:0097581 lamellipodium assembly(GO:0030032) lamellipodium organization(GO:0097581)
0.3 9.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.2 1.1 GO:0021982 pineal gland development(GO:0021982)
0.2 11.1 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.2 12.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 13.4 GO:0002040 sprouting angiogenesis(GO:0002040)
0.1 25.1 GO:1904888 cranial skeletal system development(GO:1904888)
0.1 0.3 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.1 4.3 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 3.5 GO:0007043 cell-cell junction assembly(GO:0007043)
0.1 2.8 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 1.5 GO:0042593 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.0 1.5 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.8 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 5.0 GO:0006470 protein dephosphorylation(GO:0006470)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 4.2 GO:0042583 chromaffin granule(GO:0042583)
1.8 5.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.6 12.5 GO:1904949 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
1.5 20.7 GO:0031083 BLOC-1 complex(GO:0031083)
1.4 14.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.8 10.9 GO:0098978 glutamatergic synapse(GO:0098978)
0.7 4.9 GO:0031045 dense core granule(GO:0031045)
0.6 3.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.6 10.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 4.3 GO:0043204 perikaryon(GO:0043204)
0.2 5.9 GO:0030175 filopodium(GO:0030175)
0.2 7.9 GO:0030141 secretory granule(GO:0030141)
0.1 7.4 GO:0030027 lamellipodium(GO:0030027)
0.1 0.8 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 40.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 8.5 GO:0043005 neuron projection(GO:0043005)
0.0 13.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 14.2 GO:0045202 synapse(GO:0045202)
0.0 6.0 GO:0031012 extracellular matrix(GO:0031012)
0.0 33.0 GO:0005886 plasma membrane(GO:0005886)
0.0 6.6 GO:0005730 nucleolus(GO:0005730)
0.0 12.8 GO:0005576 extracellular region(GO:0005576)
0.0 44.0 GO:0016021 integral component of membrane(GO:0016021) intrinsic component of membrane(GO:0031224)
0.0 53.8 GO:0005634 nucleus(GO:0005634)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.5 GO:0098988 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
3.6 14.4 GO:0005326 neurotransmitter transporter activity(GO:0005326)
3.2 13.0 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
1.6 12.8 GO:0032036 myosin heavy chain binding(GO:0032036)
1.4 5.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.0 13.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.9 20.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.9 3.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.9 4.3 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.8 5.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.8 7.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.7 12.5 GO:0001671 ATPase activator activity(GO:0001671)
0.7 12.2 GO:0008143 poly(A) binding(GO:0008143)
0.5 12.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.5 1.5 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.4 4.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.4 9.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.2 6.0 GO:0005179 hormone activity(GO:0005179)
0.1 4.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 1.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 8.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 39.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 5.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 25.1 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 6.2 GO:0003682 chromatin binding(GO:0003682)
0.0 13.7 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 7.4 GO:0003779 actin binding(GO:0003779)
0.0 1.4 GO:0003690 double-stranded DNA binding(GO:0003690)
0.0 1.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 24.3 GO:0046872 metal ion binding(GO:0046872)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 3.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5 7.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.5 4.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.5 3.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 8.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.4 13.0 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 9.5 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex