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Results for rfx3_rfx1a_rfx2

Z-value: 2.45

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Transcription factors associated with rfx3_rfx1a_rfx2

Gene Symbol Gene ID Gene Info
ENSDARG00000014550 regulatory factor X, 3 (influences HLA class II expression)
ENSDARG00000005883 regulatory factor X, 1a (influences HLA class II expression)
ENSDARG00000013575 regulatory factor X, 2 (influences HLA class II expression)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx2dr10_dc_chr8_-_20106132_20106149-0.862.1e-05Click!
rfx1adr10_dc_chr3_-_19050721_190507950.702.4e-03Click!
rfx3dr10_dc_chr10_-_625501_6256650.204.6e-01Click!

Activity profile of rfx3_rfx1a_rfx2 motif

Sorted Z-values of rfx3_rfx1a_rfx2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of rfx3_rfx1a_rfx2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr24_-_475010 15.93 ENSDART00000108762
vesicular, overexpressed in cancer, prosurvival protein 1
chr16_-_9978112 7.96 ENSDART00000149312
neurocalcin delta a
chr8_+_21163236 7.55 ENSDART00000091307
collagen, type II, alpha 1a
chr2_+_57995336 7.10

chr5_-_70948223 7.05 ENSDART00000013404
adenylate kinase 1
chr23_+_35609887 6.86 ENSDART00000179393
tubulin, alpha 1b
chr13_-_13163676 6.48 ENSDART00000125883
ENSDART00000013534
fibroblast growth factor receptor 3
chr16_-_45103102 5.88 ENSDART00000058384
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr2_-_30675594 5.25 ENSDART00000087270
catenin (cadherin-associated protein), delta 2b
chr7_-_57796486 5.20 ENSDART00000043984
ankyrin 2b, neuronal
chr25_+_25358457 4.52 ENSDART00000112330
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr22_+_16511562 4.49

chr11_+_6118409 4.30 ENSDART00000027666
nuclear receptor subfamily 2, group F, member 6b
chr9_+_53736715 4.26 ENSDART00000003310
SRY (sex determining region Y)-box 21b
chr21_-_15833030 4.23 ENSDART00000080693
LIM homeobox 5
chr3_+_60637167 4.16 ENSDART00000157772
forkhead box J1a
chr8_-_49356479 4.12 ENSDART00000053203
proteolipid protein 2
chr17_-_10682357 4.09 ENSDART00000064597
lectin, galactoside binding soluble 3b
chr14_-_25279835 3.95 ENSDART00000163669
complexin 2
chr6_-_8501230 3.87 ENSDART00000143956
caveolae associated protein 2b
chr21_+_25034997 3.80 ENSDART00000167523
DIX domain containing 1b
chr21_-_1600125 3.70 ENSDART00000066621
vitelline membrane outer layer 1 homolog b
chr15_+_47316316 3.69 ENSDART00000063835
orthodenticle homolog 5
chr13_-_13163801 3.61 ENSDART00000156968
fibroblast growth factor receptor 3
chr21_-_43806271 3.56 ENSDART00000138710
PDZ and LIM domain 4
chr8_+_2428689 3.53 ENSDART00000081325
dynein, light chain, LC8-type 1
chr6_+_13833991 3.52

chr10_+_5693933 3.50 ENSDART00000159769
peptidylglycine alpha-amidating monooxygenase
chr2_-_26872047 3.42 ENSDART00000138693
si:ch211-106k21.5
chr1_-_10122492 3.31 ENSDART00000139749
ENSDARG00000087107
chr25_+_36878565 3.29 ENSDART00000157596
RIC3 acetylcholine receptor chaperone b
chr25_-_2485276 3.17 ENSDART00000154889
ENSDART00000155027
ENSDARG00000096850
chr12_-_36191048 3.15 ENSDART00000177986
centrosomal protein 131
chr9_-_56292487 3.11 ENSDART00000151720
si:ch211-39i22.1
chr13_-_31339870 3.11 ENSDART00000076574
reticulon 1a
chr2_-_43110857 3.08 ENSDART00000098303
otoconin 90
chr22_+_2921305 3.05 ENSDART00000143258
centrosomal protein 19
chr21_+_26660833 3.02 ENSDART00000004109
guanine nucleotide binding protein (G protein), gamma 3
chr19_-_5142310 2.99 ENSDART00000130062
chromodomain helicase DNA binding protein 4a
chr9_-_16845777 2.98 ENSDART00000160273
ENSDARG00000102261
chr17_+_8831186 2.97 ENSDART00000109573
A kinase (PRKA) anchor protein 6
chr16_-_29593569 2.95 ENSDART00000150028
one cut domain, family member, like
chr4_-_376986 2.89 ENSDART00000067482
ENSDART00000160718
dynein, light chain, Tctex-type 1
chr14_+_4489377 2.89 ENSDART00000041468
adaptor-related protein complex 1 associated regulatory protein
chr2_+_35745559 2.85 ENSDART00000002094
ankyrin repeat domain 45
chr8_+_2260519 2.80 ENSDART00000136743
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr7_-_28278286 2.79 ENSDART00000113313
suppression of tumorigenicity 5
chr9_-_6949104 2.76 ENSDART00000059092
transmembrane protein 182a
chr1_-_55554518 2.76 ENSDART00000019573
zgc:65894
chr16_+_49796978 2.71 ENSDART00000157100
ubiquitin-conjugating enzyme E2E 2
chr5_-_22675495 2.70 ENSDART00000161883
si:dkey-114c15.5
chr7_+_49628680 2.66 ENSDART00000007487
APAF1 interacting protein
chr24_-_38928988 2.62 ENSDART00000063231
noggin 2
chr8_+_7740132 2.62 ENSDART00000171325
transcription factor binding to IGHM enhancer 3a
chr21_+_11410738 2.58 ENSDART00000146701
si:dkey-184p9.7
chr9_-_44487895 2.56 ENSDART00000110411
ceramide kinase-like
chr15_-_45229713 2.52

KN150001v1_+_19561 2.52

chr6_+_52212513 2.50 ENSDART00000025940
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a
chr15_+_1187249 2.50 ENSDART00000152638
ENSDART00000152466
myeloid leukemia factor 1
chr12_+_25509394 2.50 ENSDART00000077157
SIX homeobox 3b
chr5_+_38963156 2.48 ENSDART00000097872
si:ch211-57h10.1
chr24_+_17125429 2.48 ENSDART00000017605
sperm associated antigen 6
chr3_+_54489642 2.44 ENSDART00000114443
si:ch211-74m13.3
chr3_-_12087518 2.44 ENSDART00000081374
cilia and flagella associated protein 70
chr8_-_34077790 2.43

chr16_-_24697750 2.40 ENSDART00000163305
FXYD domain containing ion transport regulator 6 like
chr19_-_28382815 2.38 ENSDART00000110016
ubiquitin-conjugating enzyme E2Q family-like 1
chr3_-_49242655 2.37 ENSDART00000142200
ENSDART00000139524
ADP-ribosylation factor-like 16
chr10_+_22759607 2.36

chr19_-_40599163 2.35 ENSDART00000150972
EF-hand calcium binding domain 1
chr2_+_6214792 2.35 ENSDART00000153916
fizzy/cell division cycle 20 related 1b
chr21_+_22386643 2.34 ENSDART00000133190
calcyphosine-like b
chr16_+_10974655 2.33

chr15_-_18226612 2.32 ENSDART00000012064
PIH1 domain containing 2
chr13_+_1051015 2.31 ENSDART00000033528
tumor necrosis factor, alpha-induced protein 3
chr24_-_2918801 2.31 ENSDART00000164776
family with sequence similarity 69, member C
chr4_+_12618485 2.30 ENSDART00000112860
LIM domain only 3
chr7_+_40183670 2.27 ENSDART00000173916
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr17_+_52024610 2.27

chr20_+_4120302 2.26 ENSDART00000159837
cnksr family member 3
chr22_+_38028979 2.24 ENSDART00000165078
ENSDART00000159906
ENSDARG00000100625
chr16_-_31835463 2.24 ENSDART00000148389
chromodomain helicase DNA binding protein 4b
chr1_-_44942144 2.23 ENSDART00000044057
septin 3
chr25_+_32114076 2.19 ENSDART00000156145
S-phase cyclin A-associated protein in the ER
chr25_-_25641897 2.18 ENSDART00000166308
calcium and integrin binding family member 2
chr24_-_38215159 2.15

chr3_-_34208423 2.14 ENSDART00000151634
trinucleotide repeat containing 6C1
chr13_+_33115704 2.11 ENSDART00000141912
NADH dehydrogenase (ubiquinone) complex I, assembly factor 1
chr21_-_21477423 2.10 ENSDART00000164076
poliovirus receptor-related 3b
chr5_-_57250212 2.09 ENSDART00000023262
si:dkey-27p23.3
chr2_-_56224858 2.07 ENSDART00000060745
ubiquitin A-52 residue ribosomal protein fusion product 1
chr21_+_27427785 2.07 ENSDART00000113061
Bardet-Biedl syndrome 1
chr17_-_24666272 2.05 ENSDART00000105457
MORN repeat containing 2
chr2_+_294913 2.05 ENSDART00000130999
zgc:113452
chr16_+_24717056 2.04 ENSDART00000157237
si:dkey-56f14.7
chr16_-_33976031 2.02 ENSDART00000110743
dynein, axonemal, light intermediate chain 1
chr11_+_6118322 2.02 ENSDART00000165031
nuclear receptor subfamily 2, group F, member 6b
chr3_+_49277125 1.99 ENSDART00000161724
growth arrest-specific 7a
chr23_+_21453261 1.99 ENSDART00000089379
intermediate filament family orphan 2a
chr3_+_31813888 1.98 ENSDART00000114957
zgc:193811
chr16_+_9141325 1.98

chr5_-_54026450 1.96 ENSDART00000159009
sperm associated antigen 8
chr13_-_252864 1.93

chr8_-_15267816 1.93 ENSDART00000137923
spermatogenesis associated 6
chr15_-_44029439 1.91

chr8_+_26502828 1.90 ENSDART00000046863
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl
chr14_+_23220869 1.89 ENSDART00000112930
si:ch211-221f10.2
chr19_-_10324632 1.87 ENSDART00000148073
shisa family member 7
chr19_-_34328673 1.87 ENSDART00000164563
engulfment and cell motility 1 (ced-12 homolog, C. elegans)
chr18_+_35198982 1.86 ENSDART00000127379
cilia and flagella associated protein 45
chr10_-_43200499 1.85 ENSDART00000171494
single-stranded DNA binding protein 2
chr6_-_33039029 1.84 ENSDART00000156211
adenylate cyclase activating polypeptide 1b (pituitary) receptor type I
chr7_+_9726412 1.83 ENSDART00000173155
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr10_-_36738730 1.83 ENSDART00000139097
DnaJ (Hsp40) homolog, subfamily B, member 13
chr20_+_32646617 1.82

chr25_+_13635079 1.82 ENSDART00000161012
coiled-coil domain containing 135
chr21_-_22520832 1.81 ENSDART00000167230
cilia and flagella associated protein 53
chr1_-_44942047 1.81 ENSDART00000044057
septin 3
chr13_-_36577270 1.80 ENSDART00000044357
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr21_-_22672597 1.80 ENSDART00000140032
ENSDART00000136993
si:dkeyp-69c1.9
chr2_+_47864913 1.80

chr23_+_23559246 1.79 ENSDART00000172214
agrin
chr6_+_8956398 1.79 ENSDART00000150916
ENSDARG00000071159
chr2_-_42784609 1.77

chr12_+_33261056 1.76 ENSDART00000124982
coiled-coil domain containing 57
chr6_-_29297541 1.76 ENSDART00000078630
NME/NM23 family member 7
chr13_+_32987105 1.73 ENSDART00000085719
si:ch211-10a23.2
chr9_-_3700395 1.73 ENSDART00000102900
Sp5 transcription factor a
chr8_+_54058732 1.72

chr21_+_142265 1.71

chr23_+_22350713 1.71 ENSDART00000130375
RAP1 GTPase activating protein
chr6_+_47425082 1.69 ENSDART00000171087
si:ch211-286o17.1
chr23_-_26150495 1.68 ENSDART00000126299
GDP dissociation inhibitor 1
chr5_-_54954988 1.68 ENSDART00000142912
heterogeneous nuclear ribonucleoprotein K, like
chr6_-_2089453 1.67 ENSDART00000022179
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr4_-_5643440 1.67 ENSDART00000010903
radial spoke head 9 homolog
chr19_-_9553977 1.67 ENSDART00000045565
vesicle-associated membrane protein 1
chr10_-_17274395 1.66 ENSDART00000135679
RAB36, member RAS oncogene family
chr15_-_21003820 1.66 ENSDART00000152371
ubiquitin specific peptidase 2a
chr7_+_890752 1.65 ENSDART00000111531
ependymin-like 1
chr18_-_39491932 1.62 ENSDART00000122930
secretogranin III
chr1_+_54231447 1.61 ENSDART00000145652
golgin A7 family, member Ba
chr10_+_31336284 1.61 ENSDART00000140988
transmembrane protein 218
chr11_+_36215554 1.61 ENSDART00000128245
low density lipoprotein receptor class A domain containing 2
KN150503v1_-_598 1.60 ENSDART00000174608
ENSDARG00000108333
chr7_-_33994315 1.60 ENSDART00000173596
si:ch211-98n17.5
chr19_+_46647893 1.59 ENSDART00000162785
ENSDART00000171251
ENSDART00000164938
mitogen-activated protein kinase 15
chr23_-_28766019 1.56 ENSDART00000078141
RIB43A domain with coiled-coils 1
chr11_+_14373731 1.55 ENSDART00000161879
ENSDARG00000099220
chr14_+_11151485 1.54 ENSDART00000169202
si:ch211-153b23.5
chr9_+_17779858 1.53 ENSDART00000013111
diacylglycerol kinase, eta
chr21_+_22792068 1.52 ENSDART00000151109
si:rp71-1p14.7
chr8_+_18584936 1.52 ENSDART00000089161
ENSDARG00000062021
chr17_-_29102320 1.50 ENSDART00000104204
forkhead box G1a
chr5_-_7901538 1.50 ENSDART00000159718
sperm flagellar 2
chr23_-_20026717 1.49 ENSDART00000153828
ATPase, Ca++ transporting, plasma membrane 3b
chr14_-_2728708 1.48 ENSDART00000031211
bicaudal C homolog 2
chr25_+_34340139 1.47 ENSDART00000061996
transmembrane protein 231
chr3_-_15475774 1.47 ENSDART00000136890
ENSDARG00000090026
chr6_+_102073 1.46 ENSDART00000151209
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr22_-_2921219 1.45 ENSDART00000092991
phosphatidylinositol glycan anchor biosynthesis, class X
chr5_-_56981925 1.45

chr13_-_6089739 1.44 ENSDART00000159052
si:zfos-1056e6.1
chr20_-_47680305 1.43 ENSDART00000023058
EF-hand domain (C-terminal) containing 1
chr24_+_33697332 1.43

chr8_+_50499355 1.43

chr19_+_1106964 1.42 ENSDART00000165516
cilia and flagella associated protein 20
chr13_+_49527181 1.40 ENSDART00000176643
ENSDARG00000106801
chr25_-_14573221 1.40

chr17_-_53234493 1.39

chr4_-_19027117 1.38 ENSDART00000166160
si:dkey-31f5.11
chr6_+_15635738 1.38 ENSDART00000128939
IQ motif containing with AAA domain 1
chr13_+_11305781 1.36

chr10_+_9576710 1.36 ENSDART00000080843
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8
chr12_+_6065116 1.36 ENSDART00000139054
sphingomyelin synthase 1
chr2_+_54218444 1.34 ENSDART00000161221
calcyphosine-like a
chr20_+_52653111 1.34 ENSDART00000057980
tissue specific transplantation antigen P35B
chr21_+_17920229 1.33 ENSDART00000080431
dynein, axonemal, intermediate chain 1, paralog 2
chr6_+_29297594 1.32 ENSDART00000112099
zgc:172121
chr25_-_3521512 1.31 ENSDART00000171863
ENSDART00000166363
si:ch211-272n13.3
chr4_+_5515028 1.31 ENSDART00000027304
mitogen-activated protein kinase 12b
KN149841v1_+_6400 1.31 ENSDART00000179534
ENSDARG00000108002
chr23_-_2027166 1.28 ENSDART00000127443
PR domain containing 5
chr25_-_211879 1.28 ENSDART00000021614
SRSF protein kinase 2
chr20_+_40869520 1.27 ENSDART00000144401
TBC1 domain family, member 32
chr24_-_37792982 1.25 ENSDART00000078828
ENSDART00000131342
ankyrin repeat and sterile alpha motif domain containing 3
chr13_-_31340029 1.25 ENSDART00000076574
reticulon 1a
chr1_+_2074153 1.24 ENSDART00000058877
RAP2A, member of RAS oncogene family b
chr23_+_22408855 1.24 ENSDART00000147696
RAP1 GTPase activating protein
chr21_-_32403403 1.24 ENSDART00000076974
glutamine-fructose-6-phosphate transaminase 2
chr10_-_29858525 1.24 ENSDART00000088605
intraflagellar transport 46 homolog (Chlamydomonas)
chr3_-_22699157 1.24 ENSDART00000055659
cytochrome b561
chr2_-_2456819 1.23 ENSDART00000013794
ENSDART00000082155
ENSDART00000169871
ENSDART00000167202
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr21_-_28883441 1.22 ENSDART00000132884
CXXC finger protein 5a
chr1_-_30546026 1.21 ENSDART00000085370
potassium voltage-gated channel, KQT-like subfamily, member 5b
chr4_+_76581339 1.21 ENSDART00000174203
zgc:113921
chr6_+_48138737 1.21

chr1_+_2154115 1.21 ENSDART00000141036
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr10_+_6009364 1.20 ENSDART00000163680
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
1.3 6.5 GO:0036371 protein localization to T-tubule(GO:0036371)
1.3 7.6 GO:0006172 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
1.1 3.2 GO:0007288 sperm axoneme assembly(GO:0007288)
1.0 4.0 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
1.0 5.8 GO:0060295 regulation of cilium beat frequency(GO:0003356) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.9 2.8 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.9 2.7 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine(GO:0019284)
0.9 3.5 GO:1902176 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176)
0.8 2.3 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.8 2.3 GO:1990168 protein K29-linked deubiquitination(GO:0035523) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) protein K33-linked deubiquitination(GO:1990168)
0.7 2.2 GO:0007638 mechanosensory behavior(GO:0007638)
0.6 3.2 GO:0090317 negative regulation of intracellular protein transport(GO:0090317)
0.5 2.6 GO:0060845 lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
0.5 2.5 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.5 2.5 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.5 2.9 GO:1900024 regulation of substrate adhesion-dependent cell spreading(GO:1900024)
0.5 2.8 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.4 3.1 GO:1903963 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.4 3.5 GO:0030033 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.4 4.9 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.4 2.3 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.4 7.8 GO:0030199 collagen fibril organization(GO:0030199)
0.4 4.7 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.3 1.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.3 1.2 GO:0032486 Rap protein signal transduction(GO:0032486)
0.3 1.2 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.3 10.1 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.3 1.8 GO:0030317 sperm motility(GO:0030317)
0.3 1.2 GO:0045337 farnesyl diphosphate biosynthetic process(GO:0045337)
0.3 1.8 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.3 0.9 GO:1902855 nonmotile primary cilium assembly(GO:0035058) regulation of nonmotile primary cilium assembly(GO:1902855)
0.3 0.8 GO:0060855 venous endothelial cell migration involved in lymph vessel development(GO:0060855)
0.2 0.9 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.2 0.9 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.2 3.0 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.2 1.0 GO:0036158 outer dynein arm assembly(GO:0036158)
0.2 0.6 GO:0003245 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.2 0.9 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.2 1.1 GO:0008210 estrogen biosynthetic process(GO:0006703) estrogen metabolic process(GO:0008210)
0.2 0.5 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.2 1.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 1.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.2 4.3 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.2 1.8 GO:0002934 desmosome organization(GO:0002934)
0.2 1.8 GO:0043584 nose development(GO:0043584)
0.1 2.8 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 1.7 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 0.6 GO:2001032 positive regulation of double-strand break repair via homologous recombination(GO:1905168) regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1 2.6 GO:0001649 osteoblast differentiation(GO:0001649)
0.1 1.3 GO:0006555 methionine metabolic process(GO:0006555) methionine biosynthetic process(GO:0009086)
0.1 2.1 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.7 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 2.4 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 0.5 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.1 0.5 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520) regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.1 0.8 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.1 1.8 GO:0006541 glutamine metabolic process(GO:0006541)
0.1 2.5 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 2.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.9 GO:0046471 cardiolipin metabolic process(GO:0032048) phosphatidylglycerol metabolic process(GO:0046471)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.1 GO:1903429 regulation of cell maturation(GO:1903429)
0.1 2.2 GO:0003341 cilium movement(GO:0003341)
0.1 0.5 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.1 6.0 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
0.1 3.7 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.1 1.7 GO:0035675 neuromast hair cell development(GO:0035675)
0.1 1.0 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.4 GO:1904086 regulation of epiboly involved in gastrulation with mouth forming second(GO:1904086)
0.1 0.6 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.1 0.7 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.1 0.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 2.3 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 0.1 GO:1903306 negative regulation of calcium ion-dependent exocytosis(GO:0045955) negative regulation of regulated secretory pathway(GO:1903306)
0.1 0.8 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
0.1 1.2 GO:0003094 glomerular filtration(GO:0003094)
0.1 1.8 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 0.2 GO:0061011 hepatic duct development(GO:0061011)
0.1 0.6 GO:0051013 microtubule severing(GO:0051013)
0.1 1.8 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 4.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 1.0 GO:1990798 pancreas regeneration(GO:1990798)
0.1 0.2 GO:0045682 regulation of epidermis development(GO:0045682)
0.1 0.5 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.1 1.9 GO:0006909 phagocytosis(GO:0006909)
0.1 3.1 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.1 1.1 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 0.3 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.1 0.2 GO:0001881 receptor recycling(GO:0001881)
0.1 0.6 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 0.8 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 0.2 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 0.3 GO:0043279 response to nicotine(GO:0035094) response to alkaloid(GO:0043279)
0.0 1.6 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.4 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 1.1 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 1.3 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.6 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.6 GO:0060173 limb development(GO:0060173)
0.0 0.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.5 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 2.1 GO:0033334 fin morphogenesis(GO:0033334)
0.0 1.3 GO:0060536 cartilage morphogenesis(GO:0060536)
0.0 1.8 GO:0021854 hypothalamus development(GO:0021854)
0.0 1.2 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.3 GO:0051597 response to methylmercury(GO:0051597)
0.0 0.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 11.7 GO:0000226 microtubule cytoskeleton organization(GO:0000226)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.0 GO:1904355 positive regulation of telomere maintenance(GO:0032206) regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355)
0.0 1.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.2 GO:0071357 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 1.3 GO:0048332 mesoderm morphogenesis(GO:0048332)
0.0 7.6 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 1.3 GO:0007050 cell cycle arrest(GO:0007050)
0.0 1.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.7 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 0.1 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.0 2.4 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.4 GO:0007398 ectoderm development(GO:0007398)
0.0 0.4 GO:0039021 pronephric glomerulus development(GO:0039021)
0.0 0.1 GO:0036372 opsin transport(GO:0036372)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.2 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 1.0 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 1.5 GO:0030903 notochord development(GO:0030903)
0.0 0.1 GO:0097205 renal filtration(GO:0097205)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.3 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.5 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 2.6 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 2.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.8 GO:0009306 protein secretion(GO:0009306)
0.0 0.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.6 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 2.3 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.1 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.0 GO:0046546 development of primary male sexual characteristics(GO:0046546) male sex differentiation(GO:0046661)
0.0 1.5 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.1 GO:0032094 response to food(GO:0032094)
0.0 0.1 GO:0019320 hexose catabolic process(GO:0019320) galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.7 GO:0007131 reciprocal meiotic recombination(GO:0007131)
0.0 0.3 GO:1902667 regulation of axon guidance(GO:1902667)
0.0 0.9 GO:0022900 electron transport chain(GO:0022900)
0.0 0.9 GO:0032880 regulation of protein localization(GO:0032880)
0.0 0.7 GO:0007269 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.0 0.7 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 2.8 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 1.0 GO:0044782 cilium organization(GO:0044782)
0.0 2.3 GO:0030041 actin filament polymerization(GO:0030041)
0.0 0.1 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.5 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.7 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.2 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.0 2.0 GO:0060070 canonical Wnt signaling pathway(GO:0060070)
0.0 0.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0097224 sperm connecting piece(GO:0097224)
0.8 4.1 GO:0001772 immunological synapse(GO:0001772)
0.6 2.5 GO:0005858 axonemal dynein complex(GO:0005858)
0.6 1.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.6 4.0 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.6 2.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.5 1.5 GO:0097225 sperm midpiece(GO:0097225)
0.5 2.3 GO:0097255 R2TP complex(GO:0097255)
0.5 6.5 GO:0030315 T-tubule(GO:0030315)
0.4 2.7 GO:0044447 axoneme part(GO:0044447)
0.3 3.5 GO:0034451 centriolar satellite(GO:0034451)
0.3 3.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 3.0 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.3 4.0 GO:0043195 terminal bouton(GO:0043195)
0.2 1.9 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 0.9 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 1.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.2 1.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.6 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.6 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 7.8 GO:0005581 collagen trimer(GO:0005581)
0.1 1.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 3.9 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 20.7 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.1 3.6 GO:0031941 filamentous actin(GO:0031941)
0.1 0.4 GO:0098894 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1 1.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.5 GO:1990246 uniplex complex(GO:1990246)
0.1 1.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 1.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 2.2 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 0.9 GO:0060170 ciliary membrane(GO:0060170)
0.1 0.4 GO:0036126 sperm flagellum(GO:0036126)
0.1 3.1 GO:0000922 spindle pole(GO:0000922)
0.1 0.4 GO:0031526 brush border membrane(GO:0031526)
0.1 3.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.1 GO:0008305 integrin complex(GO:0008305)
0.1 0.8 GO:0014704 intercalated disc(GO:0014704)
0.1 3.6 GO:0014069 postsynaptic density(GO:0014069)
0.1 0.4 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.0 GO:0030057 desmosome(GO:0030057)
0.1 0.3 GO:0002102 podosome(GO:0002102)
0.1 0.6 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.3 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 9.7 GO:0043235 receptor complex(GO:0043235)
0.0 3.0 GO:0045111 intermediate filament(GO:0005882) intermediate filament cytoskeleton(GO:0045111)
0.0 11.0 GO:0005874 microtubule(GO:0005874)
0.0 2.0 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.5 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 10.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.0 4.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 10.2 GO:0005576 extracellular region(GO:0005576)
0.0 1.0 GO:0030425 dendrite(GO:0030425)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.5 GO:0030018 Z disc(GO:0030018)
0.0 0.5 GO:0001726 ruffle(GO:0001726)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.9 2.8 GO:0008384 IkappaB kinase activity(GO:0008384)
0.9 3.5 GO:0016842 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) amidine-lyase activity(GO:0016842)
0.9 8.7 GO:0004017 adenylate kinase activity(GO:0004017)
0.6 10.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 1.6 GO:0018812 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.5 3.5 GO:0001727 lipid kinase activity(GO:0001727)
0.4 1.2 GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360) L-glutamine aminotransferase activity(GO:0070548)
0.4 5.7 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 1.3 GO:0045503 dynein light chain binding(GO:0045503)
0.3 4.6 GO:0005080 protein kinase C binding(GO:0005080)
0.3 3.4 GO:0004623 phospholipase A2 activity(GO:0004623)
0.3 1.5 GO:0034632 retinol transporter activity(GO:0034632)
0.3 3.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.3 3.6 GO:0015464 acetylcholine receptor activity(GO:0015464)
0.3 1.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.3 5.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.3 3.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.2 2.9 GO:0019894 kinesin binding(GO:0019894)
0.2 2.6 GO:0001972 retinoic acid binding(GO:0001972)
0.2 1.4 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 10.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 3.1 GO:0038191 neuropilin binding(GO:0038191)
0.2 2.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 2.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 1.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 1.2 GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 1.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 5.7 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.2 4.0 GO:0042805 actinin binding(GO:0042805)
0.2 1.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 2.3 GO:0043236 laminin binding(GO:0043236)
0.2 0.7 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.2 1.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 0.5 GO:0030331 estrogen receptor binding(GO:0030331)
0.2 1.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.6 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.8 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 7.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 2.8 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.1 GO:0031386 protein tag(GO:0031386)
0.1 0.5 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 1.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.1 GO:0022842 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.1 0.6 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 2.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 1.9 GO:0017022 myosin binding(GO:0017022)
0.1 6.3 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 0.4 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.2 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.1 0.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 1.7 GO:0016208 AMP binding(GO:0016208)
0.1 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.1 4.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.8 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.1 1.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 3.4 GO:0045296 cadherin binding(GO:0045296)
0.1 0.2 GO:0030623 U5 snRNA binding(GO:0030623)
0.1 0.4 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 0.7 GO:0017046 peptide hormone binding(GO:0017046)
0.1 2.6 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 4.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.2 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.0 GO:0051087 chaperone binding(GO:0051087)
0.0 1.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 1.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.5 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 14.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 3.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.3 GO:0060090 binding, bridging(GO:0060090)
0.0 2.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 1.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 3.8 GO:0051015 actin filament binding(GO:0051015)
0.0 24.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.7 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 1.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.4 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 3.8 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.1 GO:0043015 gamma-tubulin binding(GO:0043015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.3 0.8 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.3 6.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.2 10.4 PID FGF PATHWAY FGF signaling pathway
0.1 2.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 1.9 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 1.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 2.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 2.2 PID LKB1 PATHWAY LKB1 signaling events
0.1 1.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 2.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 10.1 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.6 1.7 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.5 4.9 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.5 7.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4 2.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.4 6.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.4 3.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.4 4.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3 2.8 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.3 5.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 0.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 0.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 1.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.9 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 0.7 REACTOME BILE ACID AND BILE SALT METABOLISM Genes involved in Bile acid and bile salt metabolism
0.1 1.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.7 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME SIGNALING BY FGFR1 MUTANTS Genes involved in Signaling by FGFR1 mutants
0.0 0.4 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)