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Results for rfx5

Z-value: 0.43

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Transcription factors associated with rfx5

Gene Symbol Gene ID Gene Info
rfx5
ENSDARG00000063258 regulatory factor X, 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx5dr10_dc_chr19_-_7576069_7576133-0.775.2e-04Click!

Activity profile of rfx5 motif

Sorted Z-values of rfx5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of rfx5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_-_28004606 1.51 ENSDART00000121643
si:dkeyp-46h3.2
si:dkeyp-46h3.2
chr13_+_22691356 1.08 ENSDART00000144094
dna2
DNA replication helicase/nuclease 2
chr10_-_36149719 0.90

chr13_+_22691251 0.80 ENSDART00000144094
dna2
DNA replication helicase/nuclease 2
chr12_+_14046373 0.73

chr17_+_15527923 0.58 ENSDART00000148443
marcksb
myristoylated alanine-rich protein kinase C substrate b
chr18_-_3455211 0.53 ENSDART00000163762
dcun1d5
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
chr13_+_22691194 0.52 ENSDART00000109798
dna2
DNA replication helicase/nuclease 2
chr13_-_17729510 0.51 ENSDART00000170583
march8
membrane-associated ring finger (C3HC4) 8
chr13_+_31586338 0.51 ENSDART00000034745
prkcha
protein kinase C, eta, a
chr13_+_16389616 0.49

chr13_+_16389663 0.47

chr20_-_29961589 0.47 ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr1_+_5527701 0.47 ENSDART00000145378
fastkd2
FAST kinase domains 2
chr6_-_25065823 0.45 ENSDART00000167259
znf326
zinc finger protein 326
chr1_+_499061 0.38 ENSDART00000108579
blzf1
basic leucine zipper nuclear factor 1
chr6_-_25065745 0.37 ENSDART00000165170
znf326
zinc finger protein 326
chr17_+_15527861 0.37 ENSDART00000148443
marcksb
myristoylated alanine-rich protein kinase C substrate b
chr19_+_7082199 0.35 ENSDART00000110366
zbtb22b
zinc finger and BTB domain containing 22b
chr7_+_25778794 0.35 ENSDART00000173611
si:dkey-6n21.12
si:dkey-6n21.12
chr11_-_18637646 0.30 ENSDART00000156276
pfkfb2b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr21_-_5731575 0.29 ENSDART00000172650
wu:fj64h06
wu:fj64h06
chr15_-_20189097 0.28 ENSDART00000152355
med13b
mediator complex subunit 13b
chr16_-_47366405 0.27 ENSDART00000169697
mios
missing oocyte, meiosis regulator, homolog (Drosophila)
chr3_+_13780104 0.27 ENSDART00000164179
syce2
synaptonemal complex central element protein 2
chr19_-_42847112 0.26 ENSDART00000086961
vps45
vacuolar protein sorting 45 homolog (S. cerevisiae)
chr7_+_61938347 0.25 ENSDART00000025308
tbc1d19
TBC1 domain family, member 19
chr18_-_3455306 0.25 ENSDART00000166841
ENSDART00000161197
dcun1d5
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
chr13_+_25394 0.25 ENSDART00000102511
ENSDART00000159546
cfap36
cilia and flagella associated protein 36
chr13_-_10488076 0.23 ENSDART00000160561
si:ch73-54n14.2
si:ch73-54n14.2
chr17_+_26785230 0.23 ENSDART00000023470
pgrmc2
progesterone receptor membrane component 2
chr7_+_39393052 0.22 ENSDART00000146171
zgc:158564
zgc:158564
chr8_-_22252628 0.22 ENSDART00000121513
nphp4
nephronophthisis 4
chr15_-_20189405 0.21 ENSDART00000152355
med13b
mediator complex subunit 13b
chr1_+_22583970 0.21 ENSDART00000036448
lias
lipoic acid synthetase
chr5_+_31541677 0.21 ENSDART00000041504
tescb
tescalcin b
chr8_-_11039536 0.20 ENSDART00000143844
dennd2c
DENN/MADD domain containing 2C
chr1_+_499101 0.20 ENSDART00000108579
blzf1
basic leucine zipper nuclear factor 1
chr6_-_53391354 0.19 ENSDART00000155483
si:ch211-161c3.6
si:ch211-161c3.6
chr23_+_41935781 0.19 ENSDART00000171885
scp2b
sterol carrier protein 2b
chr13_+_30939809 0.19 ENSDART00000110560
si:ch211-223a10.1
si:ch211-223a10.1
chr6_-_25065773 0.18 ENSDART00000165170
znf326
zinc finger protein 326
chr18_-_35861482 0.17 ENSDART00000088488
opa3
optic atrophy 3
chr7_-_54752472 0.17 ENSDART00000172394
ENSDART00000170637
tpcn2
two pore segment channel 2
chr7_-_54752678 0.17 ENSDART00000172394
ENSDART00000170637
tpcn2
two pore segment channel 2
chr2_+_47885621 0.17

chr10_-_16069787 0.16 ENSDART00000122540
aldh7a1
aldehyde dehydrogenase 7 family, member A1
chr16_-_38407365 0.16

chr8_-_11039421 0.16 ENSDART00000143844
dennd2c
DENN/MADD domain containing 2C
chr6_-_54340370 0.15 ENSDART00000156501
zgc:101577
zgc:101577
chr21_+_1084935 0.14

chr7_-_54752565 0.12 ENSDART00000172394
ENSDART00000170637
tpcn2
two pore segment channel 2
chr10_-_8476067 0.10 ENSDART00000108643
tctn1
tectonic family member 1
chr15_+_1801642 0.09 ENSDART00000168250
cul3b
cullin 3b
chr13_+_9036533 0.09 ENSDART00000109126
alms1
Alstrom syndrome protein 1
chr17_-_24420654 0.08

chr4_+_13651618 0.08 ENSDART00000110370
nrcama
neuronal cell adhesion molecule a
chr10_+_36148811 0.07 ENSDART00000086490
smyd4
SET and MYND domain containing 4
chr3_+_13780013 0.05 ENSDART00000164179
syce2
synaptonemal complex central element protein 2
chr7_+_29592486 0.05 ENSDART00000134068
tln2a
talin 2a
chr1_+_33471274 0.04 ENSDART00000046094
arl6
ADP-ribosylation factor-like 6
chr20_+_36779159 0.03 ENSDART00000130513
ncoa1
nuclear receptor coactivator 1
chr22_-_121198 0.03

chr2_+_16505452 0.02 ENSDART00000045933
sh3glb1b
SH3-domain GRB2-like endophilin B1b
chr8_-_36585594 0.02 ENSDART00000047912
ENSDART00000127435
gpkow
G patch domain and KOW motifs
chr7_+_29592666 0.01 ENSDART00000134068
tln2a
talin 2a
chr19_-_42847182 0.01 ENSDART00000086961
vps45
vacuolar protein sorting 45 homolog (S. cerevisiae)
chr7_+_29592358 0.01 ENSDART00000167286
tln2a
talin 2a
chr1_-_499082 0.00 ENSDART00000144406
ENSDART00000031635
ercc5
excision repair cross-complementation group 5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0071932 replication fork reversal(GO:0071932)
0.3 0.9 GO:2001284 epithelial cell morphogenesis involved in gastrulation(GO:0003381) BMP secretion(GO:0038055) positive regulation of BMP secretion(GO:1900144) regulation of BMP secretion(GO:2001284)
0.1 0.4 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.1 0.5 GO:2000290 regulation of myotome development(GO:2000290)
0.1 0.3 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.1 0.5 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.1 0.2 GO:0030728 ovulation(GO:0030728)
0.1 0.8 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.2 GO:0032367 intracellular cholesterol transport(GO:0032367) positive regulation of lipid transport(GO:0032370)
0.0 0.3 GO:0007130 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.0 0.2 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.6 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 1.0 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.0 0.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.3 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.0 0.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0005760 gamma DNA polymerase complex(GO:0005760)
0.3 1.0 GO:0044609 DBIRD complex(GO:0044609)
0.1 0.3 GO:0000801 central element(GO:0000801)
0.0 0.3 GO:0001650 fibrillar center(GO:0001650)
0.0 0.4 GO:0097546 ciliary base(GO:0097546)
0.0 0.9 GO:0032432 actin filament bundle(GO:0032432)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base(GO:0016890)
0.1 0.4 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.5 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.8 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.0 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.3 GO:0001047 core promoter sequence-specific DNA binding(GO:0001046) core promoter binding(GO:0001047)
0.0 0.5 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo