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Results for runx3

Z-value: 0.55

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Transcription factors associated with runx3

Gene Symbol Gene ID Gene Info
runx3
ENSDARG00000052826 RUNX family transcription factor 3

Activity profile of runx3 motif

Sorted Z-values of runx3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of runx3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_50066633 2.11

chr6_-_9346394 1.42 ENSDART00000144335
cyp27c1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr5_+_26829686 1.15 ENSDART00000087894
zgc:153409
zgc:153409
chr23_+_358044 1.14 ENSDART00000114000
zgc:101663
zgc:101663
chr14_-_3264798 1.11 ENSDART00000171601
im:7150988
im:7150988
chr8_+_17148864 1.04 ENSDART00000140531
dimt1l
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr15_-_20532537 0.96 ENSDART00000018514
dlc
deltaC
chr9_+_37331936 0.92 ENSDART00000024555
gli2a
GLI family zinc finger 2a
chr5_+_68889557 0.89 ENSDART00000160171
CT978957.3
ENSDARG00000103717
chr9_-_20562293 0.75 ENSDART00000113418
igsf3
immunoglobulin superfamily, member 3
chr11_-_40255633 0.71 ENSDART00000172819
miip
migration and invasion inhibitory protein
chr16_+_23516127 0.71 ENSDART00000004679
icn
ictacalcin
chr19_-_5464238 0.69 ENSDART00000105806
cyt1
type I cytokeratin, enveloping layer
chr14_-_16171165 0.68 ENSDART00000089021
canx
calnexin
chr4_-_71353374 0.59

chr19_-_24859287 0.59 ENSDART00000163763
thbs3b
thrombospondin 3b
chr16_+_28819826 0.58 ENSDART00000103340
s100v1
S100 calcium binding protein V1
chr12_+_18622682 0.57 ENSDART00000153456
mkl1b
megakaryoblastic leukemia (translocation) 1b
chr4_-_689860 0.55

chr8_-_18868986 0.54 ENSDART00000079840
rorca
RAR-related orphan receptor C a
chr2_-_56224858 0.52 ENSDART00000060745
uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr3_-_25239180 0.48 ENSDART00000055491
smurf2
SMAD specific E3 ubiquitin protein ligase 2
chr22_+_10728099 0.47 ENSDART00000145551
tmprss9
transmembrane protease, serine 9
KN150099v1_-_34647 0.46 ENSDART00000157438
nudt12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr11_-_17620732 0.46 ENSDART00000154627
eogt
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr12_+_28795950 0.44 ENSDART00000076572
rnf40
ring finger protein 40
chr3_-_45237479 0.43 ENSDART00000160923
si:ch73-167f10.1
si:ch73-167f10.1
chr22_+_11490729 0.42 ENSDART00000063147
sgsh
N-sulfoglucosamine sulfohydrolase (sulfamidase)
chr5_-_33611896 0.41

chr1_+_49894685 0.41 ENSDART00000020412
pkd2
polycystic kidney disease 2
chr14_-_223462 0.39

chr4_+_689631 0.38

chr13_-_31516518 0.38 ENSDART00000172375
ENSDART00000125987
ENSDART00000143903
ENSDART00000158719
six4a
SIX homeobox 4a
chr20_-_43448899 0.36 ENSDART00000152888
mllt4a
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4a
chr8_+_17148832 0.35 ENSDART00000140531
dimt1l
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr16_+_41110126 0.35 ENSDART00000141130
scap
SREBF chaperone
chr18_+_35198982 0.34 ENSDART00000127379
cfap45
cilia and flagella associated protein 45
KN149797v1_-_53588 0.34

chr6_+_54146669 0.32 ENSDART00000061735
nudt3b
nudix (nucleoside diphosphate linked moiety X)-type motif 3b
chr9_-_23936295 0.29 ENSDART00000165907
ndufa10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10
chr21_-_43020159 0.27 ENSDART00000065097
dpysl3
dihydropyrimidinase-like 3
chr3_-_25238896 0.26 ENSDART00000055491
smurf2
SMAD specific E3 ubiquitin protein ligase 2
chr18_-_50527399 0.26 ENSDART00000033591
cd276
CD276 molecule
chr24_-_14068113 0.26 ENSDART00000130825
xkr9
XK, Kell blood group complex subunit-related family, member 9
chr2_-_7375138 0.26 ENSDART00000146434
zgc:153115
zgc:153115
chr12_-_151380 0.23

chr12_+_28795771 0.23 ENSDART00000076342
rnf40
ring finger protein 40
chr20_-_34767188 0.23 ENSDART00000033325
slc25a24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr10_+_45301543 0.22 ENSDART00000172621
ogdhb
oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide)
chr8_-_17148743 0.21 ENSDART00000025803
pola2
polymerase (DNA directed), alpha 2
chr3_-_3589844 0.21 ENSDART00000140482
ENSDARG00000079723
ENSDARG00000079723
chr12_+_46867586 0.21 ENSDART00000008312
fam53b
family with sequence similarity 53, member B
chr17_-_37247505 0.21 ENSDART00000108514
asxl2
additional sex combs like transcriptional regulator 2
chr13_+_30190977 0.20

chr7_+_25587183 0.19 ENSDART00000148780
mtmr1a
myotubularin related protein 1a
chr13_-_31516399 0.19 ENSDART00000172375
ENSDART00000125987
ENSDART00000143903
ENSDART00000158719
six4a
SIX homeobox 4a
chr2_-_195129 0.18 ENSDART00000126704
zgc:113518
zgc:113518
chr16_+_35917621 0.18

chr9_+_34339522 0.16 ENSDART00000078051
gpr161
G protein-coupled receptor 161
chr18_+_16997001 0.16 ENSDART00000147377
si:ch211-218c6.8
si:ch211-218c6.8
chr20_-_14116800 0.16 ENSDART00000152429
si:ch211-22i13.2
si:ch211-22i13.2
chr16_-_7310925 0.14 ENSDART00000149030
nt5c3a
5'-nucleotidase, cytosolic IIIA
chr12_+_20578266 0.13 ENSDART00000016099
ENSDARG00000043818
ENSDARG00000043818
chr20_-_34767302 0.12 ENSDART00000033325
slc25a24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr24_-_14567403 0.08 ENSDART00000131830
jph1a
junctophilin 1a
chr2_-_52792076 0.08 ENSDART00000097716
zgc:136336
zgc:136336
chr20_-_48677794 0.07 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr17_+_37363572 0.06 ENSDART00000157122
elmsan1b
ELM2 and Myb/SANT-like domain containing 1b
chr19_+_2659309 0.05 ENSDART00000162293
si:ch73-345f18.3
si:ch73-345f18.3
chr1_+_54233842 0.05 ENSDART00000089603
golga7ba
golgin A7 family, member Ba
chr25_-_21796677 0.04 ENSDART00000089642
fbxo31
F-box protein 31
KN150703v1_-_47289 0.03 ENSDART00000168391
CABZ01081752.1
ENSDARG00000099245
chr16_+_51597530 0.03

chr18_-_895821 0.02 ENSDART00000172518
cox5ab
cytochrome c oxidase subunit Vab
chr5_+_23555868 0.01 ENSDART00000124379
gabarapa
GABA(A) receptor-associated protein a
chr15_+_37688139 0.01 ENSDART00000076066
lin37
lin-37 DREAM MuvB core complex component
chr16_+_51597409 0.00

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0048855 post-embryonic morphogenesis(GO:0009886) post-embryonic foregut morphogenesis(GO:0048618) hypophysis morphogenesis(GO:0048850) diencephalon morphogenesis(GO:0048852) adenohypophysis morphogenesis(GO:0048855)
0.2 0.5 GO:0072526 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
0.1 1.0 GO:0061056 arterial endothelial cell differentiation(GO:0060842) sclerotome development(GO:0061056)
0.1 0.4 GO:0097704 regulation of collagen metabolic process(GO:0010712) regulation of collagen biosynthetic process(GO:0032965) regulation of multicellular organismal metabolic process(GO:0044246) response to oscillatory fluid shear stress(GO:0097702) cellular response to oscillatory fluid shear stress(GO:0097704)
0.1 0.7 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.3 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 0.3 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 0.4 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 1.4 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.3 GO:1901910 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.6 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.5 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.2 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.3 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.7 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 1.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.4 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 1.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.4 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.1 GO:0060221 retinal rod cell differentiation(GO:0060221)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.7 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.7 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.3 1.4 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2 1.4 GO:0019841 retinol binding(GO:0019841)
0.2 0.5 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.5 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 1.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.4 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 1.0 GO:0005112 Notch binding(GO:0005112) PDZ domain binding(GO:0030165)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.3 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.5 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID BMP PATHWAY BMP receptor signaling
0.0 0.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1