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Results for rx3

Z-value: 1.28

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Transcription factors associated with rx3

Gene Symbol Gene ID Gene Info
rx3
ENSDARG00000052893 retinal homeobox gene 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rx3dr10_dc_chr21_+_10663517_10663526-0.721.5e-03Click!

Activity profile of rx3 motif

Sorted Z-values of rx3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of rx3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr18_-_40718244 6.11 ENSDART00000077577
si:ch211-132b12.8
si:ch211-132b12.8
chr11_-_44539778 5.42 ENSDART00000161846
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr8_+_45326435 4.87 ENSDART00000134161
pabpc1l
poly(A) binding protein, cytoplasmic 1-like
chr10_-_34058331 4.82 ENSDART00000046599
zar1l
zygote arrest 1-like
chr13_-_6875290 4.71

chr24_+_12689711 4.56 ENSDART00000114762
nanog
nanog homeobox
chr24_-_14446593 4.19

chr17_+_16038358 4.02 ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr10_-_21404605 3.86 ENSDART00000125167
avd
avidin
chr24_+_19270877 3.24

chr1_-_18118467 2.97 ENSDART00000142026
si:dkey-167i21.2
si:dkey-167i21.2
chr18_-_43890836 2.90 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr2_+_6341404 2.72 ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr21_-_32027717 2.68 ENSDART00000131651
ENSDARG00000073961
ENSDARG00000073961
chr20_-_23527234 2.57 ENSDART00000004625
zar1
zygote arrest 1
chr24_+_12689887 2.51 ENSDART00000114762
nanog
nanog homeobox
chr10_-_32550351 2.46 ENSDART00000129395
uvrag
UV radiation resistance associated gene
chr19_+_39689450 2.44

chr17_+_16038103 2.43 ENSDART00000155005
si:ch73-204p21.2
si:ch73-204p21.2
chr4_+_4825461 2.31 ENSDART00000150309
ptprz1b
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr24_-_24999240 2.28 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr14_-_8634381 2.11 ENSDART00000129030
zgc:153681
zgc:153681
chr12_-_33256671 2.07 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr14_+_23420053 1.94 ENSDART00000006373
ndfip1
Nedd4 family interacting protein 1
chr10_+_6925373 1.93 ENSDART00000128866
ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr6_-_19556029 1.90 ENSDART00000136019
ppp1r12c
protein phosphatase 1, regulatory subunit 12C
chr12_-_33256754 1.86 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr9_-_35824470 1.73 ENSDART00000140356
zp2l1
zona pellucida glycoprotein 2, like 1
chr16_+_42567707 1.70 ENSDART00000166640
si:ch211-215k15.5
si:ch211-215k15.5
chr1_+_18118735 1.69 ENSDART00000078610
slc25a51a
solute carrier family 25, member 51a
chr25_-_13394261 1.68 ENSDART00000056721
ldhd
lactate dehydrogenase D
chr20_-_29961498 1.63 ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr22_-_21873054 1.62

chr1_+_35253862 1.60 ENSDART00000139636
zgc:152968
zgc:152968
chr12_-_33257026 1.59 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr12_+_33257120 1.57

chr20_-_29961589 1.54 ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr6_+_40925259 1.52 ENSDART00000002728
ENSDART00000145153
eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr18_+_20571460 1.47 ENSDART00000151990
wee2
WEE1 homolog 2 (S. pombe)
chr12_-_33256599 1.44 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr18_+_8362265 1.43 ENSDART00000092053
chkb
choline kinase beta
chr10_-_2944190 1.40 ENSDART00000132526
marveld2a
MARVEL domain containing 2a
chr8_-_44247277 1.40

chr2_-_15656155 1.37 ENSDART00000015655
tecrl2b
trans-2,3-enoyl-CoA reductase-like 2b
chr13_-_24778226 1.32

chr18_+_20571400 1.25 ENSDART00000151990
wee2
WEE1 homolog 2 (S. pombe)
chr11_-_44539726 1.21 ENSDART00000173360
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr14_+_23419864 1.17 ENSDART00000006373
ndfip1
Nedd4 family interacting protein 1
chr6_-_19556121 1.16 ENSDART00000136019
ppp1r12c
protein phosphatase 1, regulatory subunit 12C
chr13_-_24778352 1.14

chr6_-_19556328 1.12 ENSDART00000074256
ppp1r12c
protein phosphatase 1, regulatory subunit 12C
chr12_+_22459218 1.08 ENSDART00000171725
capgb
capping protein (actin filament), gelsolin-like b
chr13_-_24778261 1.08

KN150040v1_-_6426 1.01

chr15_-_37037547 1.01

chr22_-_551324 1.01

chr6_+_59580554 1.01

chr20_-_37910887 1.00 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr5_+_6391432 0.95 ENSDART00000170564
ENSDART00000086666
stpg2
sperm-tail PG-rich repeat containing 2
chr8_+_45326523 0.95 ENSDART00000145011
pabpc1l
poly(A) binding protein, cytoplasmic 1-like
chr12_+_22459177 0.93 ENSDART00000171725
capgb
capping protein (actin filament), gelsolin-like b
chr20_+_35176069 0.90

chr2_+_6341345 0.89 ENSDART00000058256
zp3b
zona pellucida glycoprotein 3b
chr24_+_16402587 0.83 ENSDART00000164319
sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr15_-_43402935 0.77 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
KN150040v1_+_6648 0.73

chr24_-_24999348 0.73 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr24_-_24999290 0.73 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr22_-_21872864 0.72 ENSDART00000158501
gna11a
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr16_+_42567668 0.71 ENSDART00000166640
si:ch211-215k15.5
si:ch211-215k15.5
chr24_-_14447655 0.69

chr8_-_25015215 0.68 ENSDART00000170511
nfyal
nuclear transcription factor Y, alpha, like
chr18_+_20571785 0.67 ENSDART00000040074
wee2
WEE1 homolog 2 (S. pombe)
chr14_-_6901783 0.66 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b
chr16_-_42105636 0.66 ENSDART00000102798
zp3d.2
zona pellucida glycoprotein 3d tandem duplicate 2
chr24_+_12689972 0.66 ENSDART00000114762
nanog
nanog homeobox
chr4_+_4825628 0.65 ENSDART00000150309
ptprz1b
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr24_-_14446522 0.62

chr14_+_8634323 0.61 ENSDART00000159920
rps6kal
ribosomal protein S6 kinase a, like
chr17_+_8642373 0.59 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr9_-_50304120 0.58 ENSDART00000161648
ENSDART00000168514
scn1a
sodium channel, voltage-gated, type I, alpha
chr24_-_14447519 0.56

chr3_+_32234155 0.56 ENSDART00000155967
ap2a1
adaptor-related protein complex 2, alpha 1 subunit
chr9_-_50304152 0.50 ENSDART00000161648
ENSDART00000168514
scn1a
sodium channel, voltage-gated, type I, alpha
chr10_+_6925975 0.50

chr5_-_54492042 0.49 ENSDART00000158007
CU467961.1
ENSDARG00000078270
chr12_+_22459371 0.48 ENSDART00000171725
capgb
capping protein (actin filament), gelsolin-like b
chr11_-_29520809 0.47 ENSDART00000079117
plekha3
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr17_+_8642428 0.45 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr18_+_8362131 0.44 ENSDART00000092053
chkb
choline kinase beta
chr17_-_41000670 0.43 ENSDART00000124715
si:dkey-16j16.4
si:dkey-16j16.4
chr11_+_34259003 0.41

chr16_-_42105733 0.40 ENSDART00000102798
zp3d.2
zona pellucida glycoprotein 3d tandem duplicate 2
chr6_+_59580339 0.38

chr17_+_8642686 0.32 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr14_+_23419894 0.30 ENSDART00000006373
ndfip1
Nedd4 family interacting protein 1
chr2_+_50873843 0.28

chr24_+_12690117 0.27 ENSDART00000114762
nanog
nanog homeobox
chr7_-_68229115 0.26

chr5_-_66441778 0.25 ENSDART00000168245
rps6ka4
ribosomal protein S6 kinase, polypeptide 4
chr13_-_25689369 0.24 ENSDART00000077612
rel
v-rel avian reticuloendotheliosis viral oncogene homolog
chr20_-_29961621 0.17 ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr22_+_20141311 0.17

chr1_+_35253821 0.13 ENSDART00000179634
zgc:152968
zgc:152968
chr22_-_20141216 0.13 ENSDART00000128023
btbd2a
BTB (POZ) domain containing 2a
chr2_-_22162431 0.11 ENSDART00000135230
chd7
chromodomain helicase DNA binding protein 7
chr10_-_2944221 0.08 ENSDART00000132526
marveld2a
MARVEL domain containing 2a

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.0 GO:0043622 cortical microtubule organization(GO:0043622)
0.7 3.4 GO:0060631 regulation of meiosis I(GO:0060631)
0.4 6.6 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.3 4.7 GO:2000344 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2 1.9 GO:0061458 gonad development(GO:0008406) reproductive structure development(GO:0048608) reproductive system development(GO:0061458)
0.2 1.4 GO:0034063 stress granule assembly(GO:0034063)
0.1 1.5 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 3.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 7.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 2.4 GO:0051014 actin filament severing(GO:0051014)
0.1 0.5 GO:0035627 ceramide transport(GO:0035627)
0.1 3.3 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800) positive regulation of proteolysis involved in cellular protein catabolic process(GO:1903052)
0.1 3.4 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.1 1.4 GO:0031297 replication fork processing(GO:0031297)
0.1 0.6 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0 1.4 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.3 GO:0016572 histone phosphorylation(GO:0016572)
0.0 1.5 GO:0007605 sensory perception of sound(GO:0007605)
0.0 3.7 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.7 GO:0001508 action potential(GO:0001508)
0.0 2.9 GO:0017148 negative regulation of translation(GO:0017148)
0.0 1.2 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.1 GO:0048798 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.0 4.8 GO:0006412 translation(GO:0006412)
0.0 0.2 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0061689 tricellular tight junction(GO:0061689)
0.3 3.7 GO:0045180 basal cortex(GO:0045180)
0.2 6.6 GO:0000421 autophagosome membrane(GO:0000421)
0.2 7.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.4 GO:0035101 FACT complex(GO:0035101)
0.1 1.9 GO:0043186 P granule(GO:0043186)
0.1 0.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 2.5 GO:0001726 ruffle(GO:0001726)
0.0 3.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.3 GO:0000151 ubiquitin ligase complex(GO:0000151)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.6 GO:1903231 mRNA binding involved in posttranscriptional gene silencing(GO:1903231)
1.0 7.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.8 3.9 GO:0009374 biotin binding(GO:0009374)
0.6 1.7 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.5 5.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.4 3.4 GO:0050699 WW domain binding(GO:0050699)
0.4 3.6 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 1.1 GO:0032190 acrosin binding(GO:0032190)
0.1 0.5 GO:0035620 ceramide transporter activity(GO:0035620) sphingolipid transporter activity(GO:0046624) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.1 3.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 6.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 0.7 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 3.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 3.3 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.6 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 8.0 GO:0042802 identical protein binding(GO:0042802)
0.0 4.2 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 1.4 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 3.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.7 GO:0004527 exonuclease activity(GO:0004527)
0.0 1.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.5 GO:0000149 SNARE binding(GO:0000149)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.4 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 1.9 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import