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Results for rxraa+rxrba+rxrbb+rxrgb

Z-value: 0.50

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Transcription factors associated with rxraa+rxrba+rxrbb+rxrgb

Gene Symbol Gene ID Gene Info
rxrbb
ENSDARG00000002006 retinoid x receptor, beta b
rxrgb
ENSDARG00000004697 retinoid X receptor, gamma b
rxraa
ENSDARG00000057737 retinoid X receptor, alpha a
rxrba
ENSDARG00000078954 retinoid x receptor, beta a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rxrgbdr10_dc_chr20_+_33972327_339723540.665.6e-03Click!
rxraadr10_dc_chr21_+_17731439_177316760.621.0e-02Click!
rxrbbdr10_dc_chr16_+_18729942_187300540.342.0e-01Click!
rxrbadr10_dc_chr19_-_7354071_73541760.039.2e-01Click!

Activity profile of rxraa+rxrba+rxrbb+rxrgb motif

Sorted Z-values of rxraa+rxrba+rxrbb+rxrgb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of rxraa+rxrba+rxrbb+rxrgb

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_+_933677 1.49 ENSDART00000149528
fabp1b.1
fatty acid binding protein 1b, tandem duplicate 1
chr1_+_25157675 1.47 ENSDART00000136984
fabp2
fatty acid binding protein 2, intestinal
chr3_+_39425125 1.29 ENSDART00000146867
aldoaa
aldolase a, fructose-bisphosphate, a
chr13_-_39033893 1.18 ENSDART00000045434
col9a1b
collagen, type IX, alpha 1b
chr5_-_1325831 0.91

chr6_-_13654186 0.76 ENSDART00000150102
ENSDART00000041269
cryba2a
crystallin, beta A2a
chr16_+_29716279 0.74 ENSDART00000137153
tmod4
tropomodulin 4 (muscle)
chr25_+_21732255 0.69 ENSDART00000027393
ckmt1
creatine kinase, mitochondrial 1
chr16_+_24697776 0.68

chr11_+_11217547 0.66 ENSDART00000087105
myom2a
myomesin 2a
chr15_-_35563367 0.66

chr11_-_42096921 0.63

chr5_-_21520111 0.62

chr17_-_31642673 0.60 ENSDART00000030448
vsx2
visual system homeobox 2
chr19_-_19290260 0.57

chr17_+_443558 0.54 ENSDART00000171386
zgc:194887
zgc:194887
chr15_+_9321225 0.54 ENSDART00000055554
slc37a4a
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr19_-_22983970 0.52 ENSDART00000160153
pleca
plectin a
chr15_+_3296905 0.52 ENSDART00000171723
foxo1a
forkhead box O1 a
chr21_-_26459113 0.51 ENSDART00000157255
cd248b
CD248 molecule, endosialin b
chr16_-_24697750 0.50 ENSDART00000163305
fxyd6l
FXYD domain containing ion transport regulator 6 like
chr11_-_23079615 0.49 ENSDART00000125024
golt1a
golgi transport 1A
chr22_+_26543146 0.48

chr22_-_23641813 0.48 ENSDART00000159622
cfh
complement factor H
chr13_-_39033849 0.47 ENSDART00000045434
col9a1b
collagen, type IX, alpha 1b
chr20_+_23643050 0.46 ENSDART00000168690
palld
palladin, cytoskeletal associated protein
chr9_+_33167554 0.46 ENSDART00000007630
nhlh2
nescient helix loop helix 2
chr6_+_60060297 0.43 ENSDART00000178621
pck1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr18_-_48498261 0.42 ENSDART00000146346
kcnj1a.6
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6
chr12_-_31342432 0.42 ENSDART00000148603
acsl5
acyl-CoA synthetase long-chain family member 5
chr1_+_23093114 0.42

chr8_+_29751639 0.41

chr24_-_21027589 0.40 ENSDART00000154259
atp6v1ab
ATPase, H+ transporting, lysosomal, V1 subunit Ab
chr7_+_36267647 0.39 ENSDART00000173653
chd9
chromodomain helicase DNA binding protein 9
chr16_-_46678676 0.38 ENSDART00000131485
ENSDART00000122584
ENSDART00000132926
tmem176l.2
transmembrane protein 176l.2
chr4_-_16461748 0.38 ENSDART00000128835
wu:fc23c09
wu:fc23c09
chr21_-_45852590 0.36 ENSDART00000169816
galnt10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr5_-_47519273 0.36

chr12_-_30897542 0.34 ENSDART00000145967
tcf7l2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr19_+_177005 0.33 ENSDART00000111580
tmem65
transmembrane protein 65
chr3_-_18642744 0.33 ENSDART00000134208
hagh
hydroxyacylglutathione hydrolase
chr2_-_49060868 0.32

chr16_-_23882488 0.31 ENSDART00000077834
rps27.2
ribosomal protein S27, isoform 2
chr9_-_41982635 0.30 ENSDART00000144573
obsl1b
obscurin-like 1b
chr22_+_34454253 0.30 ENSDART00000156615
amigo3
adhesion molecule with Ig-like domain 3
chr19_-_22984081 0.30 ENSDART00000160153
pleca
plectin a
chr5_+_24569070 0.30 ENSDART00000012268
mrpl41
mitochondrial ribosomal protein L41
chr12_-_30897752 0.28 ENSDART00000145967
tcf7l2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr13_-_37001997 0.28 ENSDART00000135510
syne2b
spectrin repeat containing, nuclear envelope 2b
chr22_-_17570275 0.28 ENSDART00000099056
gpx4a
glutathione peroxidase 4a
chr9_-_48152388 0.28

chr1_+_11485480 0.27 ENSDART00000132560
stra6l
STRA6-like
chr5_-_3562233 0.27 ENSDART00000143250
si:ch1073-189o9.1
si:ch1073-189o9.1
chr2_-_32572545 0.27 ENSDART00000056641
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr5_-_63031745 0.26

chr17_-_16079935 0.25

chr6_+_40953885 0.24 ENSDART00000156660
patz1
POZ (BTB) and AT hook containing zinc finger 1
chr13_-_22713071 0.24 ENSDART00000142738
pbld
phenazine biosynthesis like protein domain containing
chr22_+_26991665 0.24 ENSDART00000112826
tmem186
transmembrane protein 186
chr24_+_13780553 0.23 ENSDART00000138119
ENSDART00000134221
eya1
EYA transcriptional coactivator and phosphatase 1
chr16_-_1479139 0.22 ENSDART00000036348
sim1a
single-minded family bHLH transcription factor 1a
chr15_+_6870469 0.19

chr13_-_41420815 0.19 ENSDART00000163331
ENSDART00000164732
pcdh15a
protocadherin-related 15a
chr5_-_27394386 0.19 ENSDART00000171611
ppp3cca
protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr17_-_45750643 0.19 ENSDART00000074873
arf6b
ADP-ribosylation factor 6b
chr9_+_33167471 0.18 ENSDART00000007630
nhlh2
nescient helix loop helix 2
chr17_-_45750693 0.18 ENSDART00000074873
arf6b
ADP-ribosylation factor 6b
chr23_-_45074750 0.17 ENSDART00000148669
si:ch73-269m23.5
si:ch73-269m23.5
chr25_-_34608926 0.17 ENSDART00000130395
hist1h4l
histone 1, H4, like
chr6_+_28127514 0.17

chr18_+_38793474 0.16 ENSDART00000059208
fam214a
family with sequence similarity 214, member A
chr8_+_7974156 0.16

chr6_+_28127444 0.15

chr23_+_28450814 0.15 ENSDART00000014983
zgc:153867
zgc:153867
chr13_+_21695882 0.15 ENSDART00000165150
zswim8
zinc finger, SWIM-type containing 8
KN150477v1_+_13133 0.14

chr23_+_37535830 0.14

chr2_-_56896934 0.14 ENSDART00000164086
slc25a42
solute carrier family 25, member 42
chr5_-_55745987 0.13 ENSDART00000083079
acaca
acetyl-CoA carboxylase alpha
chr9_+_28301359 0.12

chr4_+_2725218 0.12 ENSDART00000007638
bcap29
B-cell receptor-associated protein 29
chr23_+_8862155 0.11 ENSDART00000132992
sox18
SRY (sex determining region Y)-box 18
chr17_-_9774006 0.11 ENSDART00000149640
egln3
egl-9 family hypoxia-inducible factor 3
chr7_+_7261692 0.11 ENSDART00000102629
nit1
nitrilase 1
chr13_+_45843567 0.10 ENSDART00000005195
ENSDART00000074547
bsdc1
BSD domain containing 1
chr7_-_23775835 0.09 ENSDART00000144616
dhrs4
dehydrogenase/reductase (SDR family) member 4
chr13_+_45843396 0.09 ENSDART00000005195
ENSDART00000074547
bsdc1
BSD domain containing 1
chr9_-_30752583 0.09

chr24_-_7558008 0.08 ENSDART00000093163
galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr2_+_23600656 0.08

chr1_+_49894685 0.07 ENSDART00000020412
pkd2
polycystic kidney disease 2
chr10_-_30006277 0.07 ENSDART00000099983
bsx
brain-specific homeobox
chr9_-_29769100 0.07 ENSDART00000140876
cenpj
centromere protein J
chr7_-_41116672 0.06 ENSDART00000051679
prkdc
protein kinase, DNA-activated, catalytic polypeptide
chr6_+_12972934 0.05 ENSDART00000036927
ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr12_+_26579396 0.04 ENSDART00000144355
arhgap12b
Rho GTPase activating protein 12b
chr16_+_28667291 0.04 ENSDART00000018235
crot
carnitine O-octanoyltransferase
chr19_-_22984023 0.03 ENSDART00000160153
pleca
plectin a
chr17_+_28664644 0.02

chr25_-_34635697 0.02 ENSDART00000113870
ENSDARG00000075379
ENSDARG00000075379
chr15_+_36355348 0.01

chr25_+_20021806 0.01 ENSDART00000104304
bpgm
2,3-bisphosphoglycerate mutase
chr21_+_302452 0.00 ENSDART00000151613
lhfpl2a
lipoma HMGIC fusion partner-like 2a
chr6_+_12972739 0.00 ENSDART00000036927
ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0048659 smooth muscle cell proliferation(GO:0048659)
0.2 0.6 GO:0010226 response to lithium ion(GO:0010226)
0.1 0.4 GO:1903959 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) regulation of organic acid transport(GO:0032890) positive regulation of organic acid transport(GO:0032892) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transport(GO:1903793) regulation of anion transmembrane transport(GO:1903959) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.1 0.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.4 GO:0071549 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) glycerol biosynthetic process from pyruvate(GO:0046327) cellular response to dexamethasone stimulus(GO:0071549)
0.1 0.7 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 1.3 GO:0030388 thigmotaxis(GO:0001966) fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.3 GO:0009438 methylglyoxal metabolic process(GO:0009438)
0.1 0.2 GO:0035776 pronephric proximal tubule development(GO:0035776)
0.1 0.9 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.0 0.6 GO:0061074 regulation of neural retina development(GO:0061074)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.3 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.0 0.5 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 3.5 GO:0033993 response to lipid(GO:0033993)
0.0 0.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.3 GO:0061337 cardiac conduction(GO:0061337)
0.0 0.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.1 GO:0044246 regulation of collagen metabolic process(GO:0010712) regulation of collagen biosynthetic process(GO:0032965) regulation of multicellular organismal metabolic process(GO:0044246) response to oscillatory fluid shear stress(GO:0097702) cellular response to oscillatory fluid shear stress(GO:0097704)
0.0 0.3 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0061511 centriole elongation(GO:0061511)
0.0 0.4 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.1 GO:0021982 pineal gland development(GO:0021982)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.4 GO:0010107 potassium ion import(GO:0010107) potassium ion import across plasma membrane(GO:1990573)
0.0 0.8 GO:0007601 visual perception(GO:0007601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.9 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.7 GO:0031430 M band(GO:0031430)
0.0 0.2 GO:0032420 stereocilium(GO:0032420)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.7 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.0 GO:0005504 fatty acid binding(GO:0005504)
0.2 0.5 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 1.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.4 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 0.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.7 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.9 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.2 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0016421 CoA carboxylase activity(GO:0016421)
0.0 0.1 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.0 GO:0016415 octanoyltransferase activity(GO:0016415)
0.0 0.6 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 0.6 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins