ISMARA results: si:ch1073-357b18.4

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Results for si:ch1073-357b18.4

Z-value: 4.36

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Transcription factors associated with si:ch1073-357b18.4

Gene Symbol	Gene ID	Gene Info
si_ch1073-357b18.4 NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000096602	si_ch1073-357b18.4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
si:ch1073-357b18.4	dr10_dc_chr12_-_280962_281088	0.68	3.8e-03	Click!

Activity profile of si:ch1073-357b18.4 motif

Sorted Z-values of si:ch1073-357b18.4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of si:ch1073-357b18.4

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Promoter	Score	Transcript	Gene	Gene Info
chr16_+_24063849 Show fit	13.57	ENSDART00000135084	apoa2 NCBI UniProt ZFIN ENSEMBL Google Show fit	apolipoprotein A-II
chr25_-_32344881 Show fit	13.07	ENSDART00000012862	isl2a NCBI UniProt ZFIN ENSEMBL Google Show fit	ISL LIM homeobox 2a
chr19_-_5441932 Show fit	12.80	ENSDART00000105034	cyt1l NCBI UniProt ZFIN ENSEMBL Google Show fit	type I cytokeratin, enveloping layer, like
chr17_+_19479310 Show fit	11.19	ENSDART00000077804	slc22a15 NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 22, member 15
chr22_-_37414940 Show fit	10.87	ENSDART00000104493	sox2 NCBI UniProt ZFIN ENSEMBL Google Show fit	SRY (sex determining region Y)-box 2
chr9_-_47041677 Show fit	9.49	ENSDART00000054137	igfbp5b NCBI UniProt ZFIN ENSEMBL Google Show fit	insulin-like growth factor binding protein 5b
chr6_-_39315024 Show fit	9.41	ENSDART00000012644	krt4 NCBI UniProt ZFIN ENSEMBL Google Show fit	keratin 4
chr2_+_22324846 Show fit	9.31	ENSDART00000044371	tox NCBI UniProt ZFIN ENSEMBL Google Show fit	thymocyte selection-associated high mobility group box
chr25_-_30845998 Show fit	8.82	ENSDART00000027661	myod1 NCBI UniProt ZFIN ENSEMBL Google Show fit	myogenic differentiation 1
chr14_-_24463906 Show fit	8.61	ENSDART00000126199	slit3 NCBI UniProt ZFIN ENSEMBL Google Show fit	slit homolog 3 (Drosophila)

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	26.0	GO:0006357	regulation of transcription from RNA polymerase II promoter(GO:0006357)
0.1	17.2	GO:0045944	positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
2.4	14.1	GO:0003311	pancreatic D cell differentiation(GO:0003311)
0.1	13.6	GO:0000280	nuclear division(GO:0000280)
2.6	13.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
1.3	12.7	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.9	12.3	GO:0036302	atrioventricular canal development(GO:0036302)
0.4	11.8	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
1.2	11.0	GO:0060114	vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
2.2	10.9	GO:0021982	pineal gland development(GO:0021982)

Showing 1 to 10 of 147 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	125.4	GO:0005634	nucleus(GO:0005634)
0.0	67.5	GO:0016021	integral component of membrane(GO:0016021)
0.1	46.6	GO:0005615	extracellular space(GO:0005615)
0.6	42.1	GO:0005882	intermediate filament(GO:0005882)
0.1	27.2	GO:0000785	chromatin(GO:0000785)
0.1	20.2	GO:0005576	extracellular region(GO:0005576)
0.0	18.5	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	17.9	GO:0043005	neuron projection(GO:0043005)
0.2	14.3	GO:0005795	Golgi stack(GO:0005795)
0.1	13.3	GO:0005759	mitochondrial matrix(GO:0005759)

Showing 1 to 10 of 52 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	118.0	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1	39.4	GO:0005198	structural molecule activity(GO:0005198)
0.1	29.5	GO:0051015	actin filament binding(GO:0051015)
1.6	14.5	GO:0048495	Roundabout binding(GO:0048495)
2.1	14.4	GO:0070888	E-box binding(GO:0070888)
0.0	14.0	GO:0003712	transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
1.3	13.4	GO:0008327	methyl-CpG binding(GO:0008327)
1.3	12.7	GO:0031995	insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0	12.1	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.2	10.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)

Showing 1 to 10 of 102 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	18.9	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.4	14.6	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	11.0	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.4	10.8	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	9.5	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	9.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	8.3	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	6.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	6.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	3.8	PID CERAMIDE PATHWAY	Ceramide signaling pathway

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	16.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.7	14.2	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.7	14.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.7	13.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
2.8	11.2	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.2	10.6	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.5	8.6	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
1.0	7.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	5.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	3.8	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism

Showing 1 to 10 of 34 entries

Results for si:ch1073-357b18.4

Z-value: 4.36

Motif logo

Transcription factors associated with si:ch1073-357b18.4

Activity-expression correlation:

Activity profile of si:ch1073-357b18.4 motif

Sorted Z-values of si:ch1073-357b18.4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of si:ch1073-357b18.4

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: