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Results for si:ch73-386h18.1+si:dkey-56d12.4+zfhx3+zfhx4

Z-value: 0.45

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Transcription factors associated with si:ch73-386h18.1+si:dkey-56d12.4+zfhx3+zfhx4

Gene Symbol Gene ID Gene Info
si_dkey-56d12.4
ENSDARG00000070845 si_dkey-56d12.4
si_ch73-386h18.1
ENSDARG00000073944 si_ch73-386h18.1
zfhx4
ENSDARG00000075542 zinc finger homeobox 4
zfhx3
ENSDARG00000103057 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zfhx4dr10_dc_chr24_-_23174888_231749750.572.2e-02Click!

Activity profile of si:ch73-386h18.1+si:dkey-56d12.4+zfhx3+zfhx4 motif

Sorted Z-values of si:ch73-386h18.1+si:dkey-56d12.4+zfhx3+zfhx4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of si:ch73-386h18.1+si:dkey-56d12.4+zfhx3+zfhx4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_28753020 1.16 ENSDART00000155815
nova2
neuro-oncological ventral antigen 2
chr5_+_31745031 0.91 ENSDART00000147132
c9
complement component 9
chr7_-_26035308 0.77 ENSDART00000131906
zgc:77439
zgc:77439
chr4_+_9668755 0.71 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr16_-_42990753 0.70 ENSDART00000149317
hfe2
hemochromatosis type 2
chr23_+_21546553 0.69 ENSDART00000142921
si:ch73-21g5.7
si:ch73-21g5.7
chr1_-_13547500 0.63 ENSDART00000044896
camk2d2
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr6_-_32362232 0.61 ENSDART00000140004
angptl3
angiopoietin-like 3
chr20_-_9107294 0.60 ENSDART00000140792
OMA1
OMA1 zinc metallopeptidase
chr2_+_51087570 0.59

chr25_+_24193604 0.58 ENSDART00000083407
b4galnt4a
beta-1,4-N-acetyl-galactosaminyl transferase 4a
chr11_+_23522743 0.54 ENSDART00000121874
nfasca
neurofascin homolog (chicken) a
chr1_-_25600988 0.53 ENSDART00000160381
cxxc4
CXXC finger 4
chr22_+_20695983 0.50 ENSDART00000171321
si:dkey-211f22.5
si:dkey-211f22.5
chr5_-_44229464 0.50 ENSDART00000019104
fbp2
fructose-1,6-bisphosphatase 2
chr11_-_42096921 0.49

chr4_-_5294280 0.48 ENSDART00000178921
SNAP91 (1 of many)
si:ch211-214j24.9
chr8_+_15216833 0.48 ENSDART00000141185
slc5a9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr19_+_14669633 0.47 ENSDART00000022076
fam46bb
family with sequence similarity 46, member Bb
chr23_+_24557956 0.45

chr25_-_35094733 0.43 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr16_+_28449134 0.42 ENSDART00000059044
itga8
integrin, alpha 8
chr3_+_49277125 0.40 ENSDART00000161724
gas7a
growth arrest-specific 7a
chr2_+_21067708 0.39 ENSDART00000148400
ENSDART00000021168
rxrga
retinoid x receptor, gamma a
chr21_-_39132283 0.39 ENSDART00000065143
unc119b
unc-119 homolog b (C. elegans)
chr5_+_29578638 0.39 ENSDART00000134624
adamts15a
ADAM metallopeptidase with thrombospondin type 1 motif, 15a
chr9_+_21340251 0.37 ENSDART00000133903
hao2
hydroxyacid oxidase 2 (long chain)
chr24_-_38758093 0.36

chr3_-_5318206 0.35 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr20_-_38714872 0.34 ENSDART00000050474
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr12_+_27035744 0.34 ENSDART00000025966
hoxb6b
homeobox B6b
chr20_-_25582221 0.34 ENSDART00000157559
si:dkey-183n20.15
si:dkey-183n20.15
chr5_+_36332564 0.33 ENSDART00000037879
crx
cone-rod homeobox
chr12_-_19029801 0.33 ENSDART00000057124
tefa
thyrotrophic embryonic factor a
chr3_+_40028301 0.32 ENSDART00000011568
syngr3a
synaptogyrin 3a
chr24_-_2453987 0.31 ENSDART00000093331
rreb1a
ras responsive element binding protein 1a
chr16_-_9785057 0.30 ENSDART00000113724
mal2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr2_+_51087643 0.30

chr21_-_20728623 0.29 ENSDART00000135940
ENSDART00000002231
ghrb
growth hormone receptor b
KN150001v1_+_14939 0.28

chr23_-_20402258 0.28 ENSDART00000136204
CR749762.2
ENSDARG00000093223
chr1_+_44137376 0.28 ENSDART00000083127
ENSDART00000162779
kdm2aa
lysine (K)-specific demethylase 2Aa
chr2_+_29265967 0.28 ENSDART00000099157
cdh18a
cadherin 18, type 2a
chr17_-_22047445 0.27 ENSDART00000156872
ttbk1b
tau tubulin kinase 1b
chr22_-_23641813 0.27 ENSDART00000159622
cfh
complement factor H
chr11_+_43136945 0.26

chr24_-_21325777 0.25 ENSDART00000109848
atp8a2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr24_+_14569372 0.24 ENSDART00000134475
gdap1
ganglioside induced differentiation associated protein 1
chr6_-_40061147 0.23 ENSDART00000103240
uroc1
urocanate hydratase 1
chr8_+_18800414 0.23 ENSDART00000160732
mpnd
MPN domain containing
chr24_-_24306469 0.23 ENSDART00000154149
BX323067.1
ENSDARG00000097984
chr22_+_13862110 0.20 ENSDART00000105711
sh3bp4a
SH3-domain binding protein 4a
chr9_+_2001849 0.19 ENSDART00000082329
evx2
even-skipped homeobox 2
chr5_+_3721680 0.19 ENSDART00000140537
dhrs11a
dehydrogenase/reductase (SDR family) member 11a
chr3_-_27989221 0.19 ENSDART00000151143
rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr7_+_42124857 0.17 ENSDART00000004120
adamts18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr20_+_31173383 0.17 ENSDART00000136255
otofa
otoferlin a
chr18_+_1353857 0.16 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr15_+_28753150 0.16 ENSDART00000060244
nova2
neuro-oncological ventral antigen 2
chr14_-_24814149 0.16 ENSDART00000158108
si:rp71-1d10.8
si:rp71-1d10.8
KN150001v1_+_15017 0.15

chr4_+_14659537 0.15

chr17_+_8642428 0.14 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr12_-_36191048 0.13 ENSDART00000177986
cep131
centrosomal protein 131
chr12_-_34621359 0.13

chr23_-_19577146 0.13 ENSDART00000143288
asb14b
ankyrin repeat and SOCS box containing 14b
chr25_-_35094522 0.13 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr23_+_44007440 0.12 ENSDART00000113757
ENSDARG00000076011
ENSDARG00000076011
chr2_-_27953540 0.11 ENSDART00000040555
tgs1
trimethylguanosine synthase 1
chr8_-_12253026 0.11 ENSDART00000091612
dab2ipa
DAB2 interacting protein a
chr3_-_27989425 0.11 ENSDART00000151143
rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr4_-_22617898 0.11 ENSDART00000131402
golgb1
golgin B1
chr18_+_29971911 0.11 ENSDART00000146431
ENSDART00000099285
atmin
ATM interactor
chr1_-_32825274 0.10 ENSDART00000075632
creb1a
cAMP responsive element binding protein 1a
chr15_+_29842298 0.10

chr9_+_31204464 0.10

chr14_-_3836967 0.10 ENSDART00000055817
ENSDARG00000038270
ENSDARG00000038270
chr24_+_26183653 0.10 ENSDART00000003884
mynn
myoneurin
chr11_-_26578973 0.09

chr2_-_22173254 0.09 ENSDART00000137538
rab2a
RAB2A, member RAS oncogene family
chr25_+_34410545 0.08 ENSDART00000073441
sntb2
syntrophin, beta 2
chr7_-_40734662 0.08 ENSDART00000013785
insig1
insulin induced gene 1
chr21_+_13053889 0.08 ENSDART00000102256
spna2
spectrin alpha 2
chr10_-_11303185 0.08 ENSDART00000146727
ptbp3
polypyrimidine tract binding protein 3
chr1_+_53353287 0.08 ENSDART00000012104
dla
deltaA
chr17_+_9152727 0.07

chr6_+_30469823 0.07 ENSDART00000121492
FP236735.1
ENSDARG00000087805
chr19_-_41882385 0.06

chr10_+_45056951 0.06 ENSDART00000158553
ENSDARG00000101143
ENSDARG00000101143
chr10_-_8238422 0.05 ENSDART00000129467
dhx29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
chr17_+_8642373 0.04 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr10_-_42302932 0.04 ENSDART00000076693
ENSDART00000073631
stambpa
STAM binding protein a
chr1_-_22160662 0.04 ENSDART00000054386
qdprb1
quinoid dihydropteridine reductase b1
chr22_-_38493856 0.03 ENSDART00000168676
soul4
heme-binding protein soul4
chr11_-_44738307 0.02 ENSDART00000167540
afmid
arylformamidase
chr13_+_45387478 0.02 ENSDART00000019113
tmem57b
transmembrane protein 57b
chr9_-_8035360 0.02

chr1_-_9426640 0.01

chr8_+_21974863 0.01

chr16_+_24818799 0.01 ENSDART00000155217
si:dkey-79d12.4
si:dkey-79d12.4
chr3_+_34513 0.01

chr3_-_27989329 0.01 ENSDART00000151143
rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0055091 negative regulation of phospholipase activity(GO:0010519) phospholipid homeostasis(GO:0055091)
0.2 0.9 GO:0006958 humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)
0.1 0.3 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 0.2 GO:0052805 imidazole-containing compound metabolic process(GO:0052803) imidazole-containing compound catabolic process(GO:0052805)
0.1 0.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.5 GO:0019226 transmission of nerve impulse(GO:0019226)
0.1 0.3 GO:0045056 transcytosis(GO:0045056)
0.0 0.2 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.3 GO:0060416 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.2 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.3 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 0.1 GO:0090317 negative regulation of intracellular protein transport(GO:0090317)
0.0 0.3 GO:0007530 sex determination(GO:0007530)
0.0 0.4 GO:0032526 response to retinoic acid(GO:0032526)
0.0 1.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0055016 hypochord development(GO:0055016)
0.0 0.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.8 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.2 GO:0031297 replication fork processing(GO:0031297)
0.0 0.2 GO:0061462 protein localization to lysosome(GO:0061462)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.3 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.2 GO:0035101 FACT complex(GO:0035101)
0.0 0.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.4 GO:0008305 integrin complex(GO:0008305)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.2 0.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.3 GO:0004903 growth hormone receptor activity(GO:0004903)
0.1 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.5 GO:0005355 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.1 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.5 GO:0050308 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.4 GO:0010181 FMN binding(GO:0010181)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0070122 isopeptidase activity(GO:0070122)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.7 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.5 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing