Project

DANIO-CODE

Navigation
Downloads

Results for six4a+six4b

Z-value: 0.88

Motif logo

logo of

Transcription factors associated with six4a+six4b

Gene Symbol Gene ID Gene Info
six4a
ENSDARG00000004695 SIX homeobox 4a
six4b
ENSDARG00000031983 SIX homeobox 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
six4adr10_dc_chr13_-_31516399_315164430.775.5e-04Click!
six4bdr10_dc_chr20_+_20585136_205852150.674.2e-03Click!

Activity profile of six4a+six4b motif

Sorted Z-values of six4a+six4b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of six4a+six4b

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr19_-_11113032 2.76 ENSDART00000027598
tpm3
tropomyosin 3
chr7_-_26035308 2.18 ENSDART00000131906
zgc:77439
zgc:77439
chr2_+_24649130 2.17 ENSDART00000078972
fitm1
fat storage-inducing transmembrane protein 1
chr23_+_36002332 2.01 ENSDART00000103139
hoxc8a
homeobox C8a
chr16_-_17439735 1.61 ENSDART00000144392
zyx
zyxin
chr21_-_43020159 1.57 ENSDART00000065097
dpysl3
dihydropyrimidinase-like 3
chr24_+_36045759 1.46 ENSDART00000173322
obscnb
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b
chr4_-_16356071 1.41 ENSDART00000079521
kera
keratocan
chr13_-_22877318 1.39 ENSDART00000057638
ENSDART00000171778
hk1
hexokinase 1
KN150642v1_+_9419 1.35 ENSDART00000159069
atoh1b
atonal bHLH transcription factor 1b
chr2_+_33352680 1.34 ENSDART00000126135
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr2_+_43619752 1.25 ENSDART00000142078
ENSDART00000098265
ENSDART00000098267
nrp1b
neuropilin 1b
chr12_+_22605268 1.24

chr2_+_11973282 1.20 ENSDART00000057268
greb1l
growth regulation by estrogen in breast cancer-like
chr23_-_19898781 1.19 ENSDART00000144027
ENSDART00000139425
haus7
HAUS augmin-like complex, subunit 7
chr17_+_7438152 1.16 ENSDART00000130625
si:dkeyp-110a12.4
si:dkeyp-110a12.4
chr19_+_10412345 1.15 ENSDART00000143930
tmem238a
transmembrane protein 238a
chr11_+_15935769 1.12 ENSDART00000158824
ctbs
chitobiase, di-N-acetyl-
chr10_-_44509732 1.10

chr16_-_24646282 1.09 ENSDART00000126274
si:ch211-79k12.2
si:ch211-79k12.2
chr23_+_2597825 1.07 ENSDART00000159039
ENSDARG00000089986
ENSDARG00000089986
chr14_-_6822151 1.04 ENSDART00000171311
si:ch73-43g23.1
si:ch73-43g23.1
chr9_+_27939731 1.02 ENSDART00000125303
rab5b
RAB5B, member RAS oncogene family
chr16_+_21436660 1.00 ENSDART00000145886
osbpl3b
oxysterol binding protein-like 3b
chr2_+_29507819 0.99

chr10_+_44509370 0.96

chr11_+_40385236 0.94 ENSDART00000173156
slc45a1
solute carrier family 45, member 1
chr8_+_49582361 0.93 ENSDART00000108613
rasef
RAS and EF-hand domain containing
chr7_+_58397256 0.93 ENSDART00000049264
sdr16c5b
short chain dehydrogenase/reductase family 16C, member 5b
chr10_+_33956052 0.90

chr2_-_11879076 0.86 ENSDART00000145108
ENSDARG00000039203
ENSDARG00000039203
chr2_+_50892294 0.86 ENSDART00000018150
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr12_+_22605229 0.85

chr7_-_26035541 0.84 ENSDART00000057288
zgc:77439
zgc:77439
chr10_+_12559022 0.81 ENSDART00000159853
FQ311890.1
ENSDARG00000102794
chr2_-_32575527 0.81 ENSDART00000140026
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr2_-_40170303 0.80 ENSDART00000165602
epha4a
eph receptor A4a
chr16_+_14135089 0.79

chr17_-_31041977 0.79 ENSDART00000104307
eml1
echinoderm microtubule associated protein like 1
chr6_-_40660116 0.71 ENSDART00000154359
ppil1
peptidylprolyl isomerase (cyclophilin)-like 1
chr22_+_34454253 0.71 ENSDART00000156615
amigo3
adhesion molecule with Ig-like domain 3
chr25_-_15117843 0.69 ENSDART00000031499
wt1a
wilms tumor 1a
chr1_+_37033111 0.68 ENSDART00000139448
GALNTL6
polypeptide N-acetylgalactosaminyltransferase like 6
chr2_-_30787161 0.66 ENSDART00000131230
rgs20
regulator of G protein signaling 20
chr3_-_54352640 0.66 ENSDART00000128041
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr20_+_27792255 0.65 ENSDART00000153299
si:dkey-1h6.8
si:dkey-1h6.8
chr3_-_35425227 0.61 ENSDART00000010944
dctn5
dynactin 5
chr14_-_40454194 0.60 ENSDART00000166621
ef1
E74-like factor 1 (ets domain transcription factor)
chr8_-_43938411 0.59

chr3_+_18249890 0.59 ENSDART00000110842
rps2
ribosomal protein S2
chr6_-_35326559 0.59 ENSDART00000114960
nos1apa
nitric oxide synthase 1 (neuronal) adaptor protein a
chr21_+_29190291 0.56 ENSDART00000013641
adra1ba
adrenoceptor alpha 1Ba
chr22_+_4750764 0.52 ENSDART00000106156
mydgf
myeloid-derived growth factor
chr2_-_21008962 0.51 ENSDART00000114546
dusp12
dual specificity phosphatase 12
chr4_-_71046688 0.51 ENSDART00000161800
CABZ01054391.1
ENSDARG00000104152
chr10_-_36738730 0.50 ENSDART00000139097
dnajb13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr10_+_248929 0.50

chr7_+_73604595 0.49 ENSDART00000109316
zgc:173587
zgc:173587
chr16_+_14135138 0.48

chr6_+_49584462 0.46 ENSDART00000103357
vapb
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr9_+_48521741 0.44 ENSDART00000145972
ccdc173
coiled-coil domain containing 173
chr2_+_43619953 0.43 ENSDART00000142078
ENSDART00000098265
ENSDART00000098267
nrp1b
neuropilin 1b
chr15_+_11798993 0.40 ENSDART00000163844
si:dkey-31c13.1
si:dkey-31c13.1
chr17_-_42778156 0.37 ENSDART00000140549
nkx2.2a
NK2 homeobox 2a
chr2_+_43620000 0.36 ENSDART00000142078
ENSDART00000098265
ENSDART00000098267
nrp1b
neuropilin 1b
chr6_+_13273286 0.36 ENSDART00000032331
gmppab
GDP-mannose pyrophosphorylase Ab
chr13_-_5423165 0.35

chr15_+_17924364 0.35

chr18_+_19430014 0.33 ENSDART00000025107
map2k1
mitogen-activated protein kinase kinase 1
chr25_-_20835675 0.32

chr9_+_41072345 0.32 ENSDART00000141548
hibch
3-hydroxyisobutyryl-CoA hydrolase
chr4_-_22798521 0.29 ENSDART00000002851
ENSDART00000123801
ENSDART00000130409
kdm7aa
lysine (K)-specific demethylase 7Aa
chr7_+_39089755 0.28 ENSDART00000173481
acp2
acid phosphatase 2, lysosomal
chr18_-_26912259 0.25 ENSDART00000147735
si:dkey-24l11.2
si:dkey-24l11.2
chr2_-_43886373 0.24 ENSDART00000138947
kif5ba
kinesin family member 5B, a
chr20_+_26196386 0.23 ENSDART00000139350
syne1a
spectrin repeat containing, nuclear envelope 1a
chr15_+_17924404 0.23

chr8_-_23591082 0.22 ENSDART00000025024
slc38a5b
solute carrier family 38, member 5b
chr6_+_32478052 0.21

chr17_+_28532738 0.20

chr18_+_5616238 0.18 ENSDART00000163629
dut
deoxyuridine triphosphatase
chr2_+_54075496 0.18 ENSDART00000166013
abhd8a
abhydrolase domain containing 8a
chr11_-_10867153 0.17 ENSDART00000091901
psmd14
proteasome 26S subunit, non-ATPase 14
chr17_+_7437994 0.16 ENSDART00000130625
si:dkeyp-110a12.4
si:dkeyp-110a12.4
chr3_-_20972827 0.15 ENSDART00000129540
larsa
leucyl-tRNA synthetase a
chr9_-_27939140 0.15 ENSDART00000064156
tbccd1
TBCC domain containing 1
chr12_-_31369772 0.15 ENSDART00000066578
tectb
tectorin beta
chr6_+_41448993 0.15 ENSDART00000029553
rsg1
REM2 and RAB-like small GTPase 1
chr19_+_16160028 0.12 ENSDART00000144376
gmeb1
glucocorticoid modulatory element binding protein 1
chr24_-_26157275 0.10 ENSDART00000130696
myeov2
myeloma overexpressed 2
chr1_+_34823754 0.09

chr4_-_16356247 0.09 ENSDART00000079521
kera
keratocan
chr5_+_42307434 0.07

chr3_+_1328162 0.06 ENSDART00000132817
si:ch1073-322p19.1
si:ch1073-322p19.1
chr9_-_41072032 0.05 ENSDART00000066424
pofut2
protein O-fucosyltransferase 2
chr2_-_11879220 0.05 ENSDART00000145108
ENSDARG00000039203
ENSDARG00000039203
chr9_-_35073289 0.03 ENSDART00000011163
asmtl
acetylserotonin O-methyltransferase-like
chr14_-_6822444 0.03 ENSDART00000171311
si:ch73-43g23.1
si:ch73-43g23.1
chr12_-_18839808 0.02 ENSDART00000172574
ep300a
E1A binding protein p300 a
chr7_-_30353264 0.01 ENSDART00000173828
rnf111
ring finger protein 111
chr17_+_7438085 0.01 ENSDART00000130625
si:dkeyp-110a12.4
si:dkeyp-110a12.4
chr7_+_17923953 0.00 ENSDART00000109171
rce1a
Ras converting CAAX endopeptidase 1a

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.4 1.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.3 2.0 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.3 1.3 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.3 1.3 GO:0099565 chemical synaptic transmission, postsynaptic(GO:0099565)
0.2 0.6 GO:0010460 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.2 0.7 GO:0061032 visceral serous pericardium development(GO:0061032) glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.1 0.4 GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion(GO:0061400)
0.1 0.4 GO:0008347 glial cell migration(GO:0008347)
0.1 1.4 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.1 0.8 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.1 2.8 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.1 0.8 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.2 GO:0032329 serine transport(GO:0032329) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.1 0.3 GO:0006574 valine catabolic process(GO:0006574)
0.1 2.0 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.1 0.4 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.1 0.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.2 GO:0051645 Golgi localization(GO:0051645)
0.0 0.2 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971) axo-dendritic protein transport(GO:0099640)
0.0 3.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 1.3 GO:1990266 neutrophil migration(GO:1990266)
0.0 0.5 GO:0001938 positive regulation of endothelial cell proliferation(GO:0001938)
0.0 1.6 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.5 GO:0007601 visual perception(GO:0007601)
0.0 1.0 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.5 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 1.2 GO:0007098 centrosome cycle(GO:0007098)
0.0 0.5 GO:0036269 swimming behavior(GO:0036269)
0.0 1.5 GO:0030239 myofibril assembly(GO:0030239)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0031430 M band(GO:0031430)
0.1 1.2 GO:0070652 HAUS complex(GO:0070652)
0.1 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.8 GO:0071564 npBAF complex(GO:0071564)
0.0 1.6 GO:0030426 growth cone(GO:0030426)
0.0 2.8 GO:0005884 actin filament(GO:0005884)
0.0 1.6 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.6 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 1.0 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.8 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.4 1.1 GO:0004568 chitinase activity(GO:0004568)
0.2 1.4 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 2.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.2 1.6 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.2 0.9 GO:0008506 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 1.6 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.6 GO:0004936 alpha-adrenergic receptor activity(GO:0004936) alpha1-adrenergic receptor activity(GO:0004937)
0.1 0.4 GO:0004475 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
0.1 0.3 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.5 GO:0033149 FFAT motif binding(GO:0033149)
0.1 1.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 1.0 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.3 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 0.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 3.0 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.6 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.7 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 1.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.3 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 1.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 1.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.2 2.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.4 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.3 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.7 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex