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Results for smad1_si:dkey-222b8.1+smad4a+smad4b_smad2

Z-value: 1.02

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Transcription factors associated with smad1_si:dkey-222b8.1+smad4a+smad4b_smad2

Gene Symbol Gene ID Gene Info
ENSDARG00000027199 SMAD family member 1
ENSDARG00000012649 SMAD family member 4b
ENSDARG00000045094 si_dkey-222b8.1
ENSDARG00000075226 SMAD family member 4a
ENSDARG00000006389 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
smad2dr10_dc_chr10_-_14971565_14971593-0.837.7e-05Click!
smad1dr10_dc_chr1_-_35196892_351969700.775.3e-04Click!
SMAD4 (1 of many)dr10_dc_chr5_+_6308337_63084150.712.0e-03Click!
smad4adr10_dc_chr10_+_573116_573138-0.601.4e-02Click!

Activity profile of smad1_si:dkey-222b8.1+smad4a+smad4b_smad2 motif

Sorted Z-values of smad1_si:dkey-222b8.1+smad4a+smad4b_smad2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of smad1_si:dkey-222b8.1+smad4a+smad4b_smad2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr9_+_52872108 6.02 ENSDART00000157453
ENSDART00000163684
NME/NM23 family member 8
chr23_-_39956151 3.61 ENSDART00000115330
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr5_-_65349550 2.86 ENSDART00000164228
notch-regulated ankyrin repeat protein b
chr20_+_18263793 2.69 ENSDART00000011287
aquaporin 4
chr18_-_44914637 2.31 ENSDART00000169636
si:ch211-71n6.4
chr15_+_40161311 2.28 ENSDART00000063783
integral membrane protein 2Ca
chr6_+_7936632 2.17 ENSDART00000146106
nuclear factor, interleukin 3 regulated, member 5
chr16_-_38117896 2.02 ENSDART00000114266
pleckstrin homology domain containing, family O member 1b
chr17_-_21260319 1.87 ENSDART00000166524
heat shock protein 12A
chr12_-_9256949 1.85 ENSDART00000003805
parathyroid hormone 1 receptor b
chr4_-_4923982 1.70 ENSDART00000103293
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr2_-_52202004 1.69 ENSDART00000165350
ENSDARG00000098957
chr10_-_10059864 1.68 ENSDART00000132375
spermatid perinuclear RNA binding protein
chr24_+_40625215 1.67

chr10_+_20406765 1.60 ENSDART00000080395
golgin A7
KN150142v1_-_9787 1.56 ENSDART00000166321
ENSDART00000170296
ENSDARG00000100534
chr13_-_349685 1.46 ENSDART00000159803
HEAT repeat containing 5B
chr18_+_49230636 1.44 ENSDART00000167609
ENSDART00000135026
ENSDART00000171618
si:ch211-136a13.1
chr1_+_25717717 1.40 ENSDART00000112263
Rho guanine nucleotide exchange factor (GEF) 38
chr19_+_26838851 1.39 ENSDART00000136244
natriuretic peptide receptor 1a
chr12_-_17590507 1.36 ENSDART00000010144
parvalbumin 2
chr25_+_31547276 1.33 ENSDART00000090727
dual oxidase
chr19_-_41482388 1.32 ENSDART00000111982
sarcoglycan, epsilon
chr20_-_16022816 1.31 ENSDART00000152828
family with sequence similarity 20, member B (H. sapiens)
chr21_-_7703717 1.27 ENSDART00000158852
EGF-like-domain, multiple 7
chr23_+_29981525 1.23 ENSDART00000035755
dishevelled segment polarity protein 1a
chr8_+_7882144 1.21

chr19_-_33123724 1.20 ENSDART00000004034
hippocalcin
chr18_+_618393 1.18 ENSDART00000159464
neural precursor cell expressed, developmentally down-regulated 4a
chr25_+_222244 1.17 ENSDART00000155344
ENSDARG00000073905
chr25_+_7000082 1.16

chr12_-_5470187 1.12 ENSDART00000159784
ABI family, member 3b
chr21_+_17073163 1.10

chr15_+_28370102 1.05 ENSDART00000175860
myosin Ic, paralog b
chr23_+_41015697 1.03 ENSDART00000115161
RALBP1 associated Eps domain containing 2
chr6_+_7936373 1.03 ENSDART00000146106
nuclear factor, interleukin 3 regulated, member 5
chr5_+_6054781 1.03 ENSDART00000060532
zgc:110796
chr20_-_31524559 1.01 ENSDART00000007735
uronyl-2-sulfotransferase
chr14_+_6239755 1.00 ENSDART00000097214
ADAM metallopeptidase domain 19b
chr3_+_32394653 0.98 ENSDART00000150897
si:ch73-367p23.2
chr5_+_34397578 0.98 ENSDART00000043341
forkhead box D1
chr22_+_38837247 0.97 ENSDART00000144318
anosmin 1b
chr25_-_3766929 0.97 ENSDART00000043172
transmembrane protein 258
chr10_+_25304728 0.97 ENSDART00000100438
RAB38b, member of RAS oncogene family
chr5_-_37850885 0.95 ENSDART00000136428
ENSDART00000112487
cholinergic receptor, nicotinic, epsilon
chr22_-_520129 0.93 ENSDART00000001201
bystin-like
chr4_+_22959458 0.90 ENSDART00000036531
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr21_-_3301751 0.89 ENSDART00000009740
SMAD family member 7
chr2_+_33474083 0.84 ENSDART00000056657
zgc:113531
chr23_+_157661 0.84

chr23_+_36832325 0.83

chr3_+_25888520 0.83 ENSDART00000135389
FAD-dependent oxidoreductase domain containing 2
chr25_+_31746643 0.83 ENSDART00000162636
tight junction protein 1b
chr19_-_44223619 0.82 ENSDART00000160879
kelch-like family member 43
chr8_+_26273354 0.82 ENSDART00000053463
monoglyceride lipase
chr8_-_17480730 0.82 ENSDART00000100667
v-ski avian sarcoma viral oncogene homolog a
chr11_+_39768718 0.78 ENSDART00000130278
si:dkey-264d12.1
chr24_+_40974634 0.77

chr5_-_37851313 0.77 ENSDART00000136428
ENSDART00000112487
cholinergic receptor, nicotinic, epsilon
chr12_-_4033069 0.77 ENSDART00000042200
aldolase a, fructose-bisphosphate, b
chr25_-_30818836 0.75 ENSDART00000156828
proline rich 33
chr10_-_43506501 0.75 ENSDART00000146660
hyaluronan and proteoglycan link protein 1b
chr14_-_26999410 0.74 ENSDART00000159727
protocadherin 11
chr19_-_5464238 0.74 ENSDART00000105806
type I cytokeratin, enveloping layer
chr4_-_25869361 0.74 ENSDART00000128968
nuclear receptor subfamily 2, group C, member 1
chr21_+_45227200 0.73 ENSDART00000155681
ENSDART00000157136
transcription factor 7 (T-cell specific, HMG-box)
chr3_+_16115532 0.73

chr8_-_12365342 0.72 ENSDART00000113286
PHD finger protein 19
chr19_-_2939818 0.72

chr23_-_27226280 0.72 ENSDART00000141305
si:dkey-157g16.6
chr9_+_3147601 0.71 ENSDART00000135619
finTRIM family, member 52, pseudogene
chr19_-_47897712 0.70

chr18_+_23004984 0.70 ENSDART00000171871
core-binding factor, beta subunit
chr10_-_20489955 0.68 ENSDART00000159672
lysyl oxidase-like 2a
chr1_+_1657493 0.66 ENSDART00000103850
ATPase, Na+/K+ transporting, alpha 1a polypeptide, tandem duplicate 3
chr4_-_26333625 0.66 ENSDART00000170709
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr25_+_30535271 0.66

chr20_-_31524614 0.65 ENSDART00000007735
uronyl-2-sulfotransferase
chr14_+_9115745 0.65 ENSDART00000123652
high mobility group nucleosome binding domain 6
chr13_+_48324283 0.65 ENSDART00000177067
ENSDARG00000107321
chr9_+_42112576 0.64 ENSDART00000130434
ENSDART00000007058
collagen type XVIII alpha 1 chain a
chr24_+_38371710 0.63 ENSDART00000105672
myosin binding protein C, fast type b
chr13_+_45843567 0.62 ENSDART00000005195
ENSDART00000074547
BSD domain containing 1
chr2_-_59531831 0.61 ENSDART00000168568
ENSDARG00000100128
chr16_-_8749368 0.61 ENSDART00000162988
cordon-bleu WH2 repeat protein
chr21_+_5887486 0.61 ENSDART00000048399
solute carrier family 4 (sodium bicarbonate cotransporter), member 4b
chr4_+_10065500 0.61 ENSDART00000026492
filamin C, gamma b (actin binding protein 280)
chr22_-_11106940 0.61 ENSDART00000016873
ATPase, H+ transporting, lysosomal accessory protein 2
chr13_+_23065500 0.61 ENSDART00000158370
sorbin and SH3 domain containing 1
chr20_+_34497817 0.60 ENSDART00000061632
family with sequence similarity 129, member Aa
chr16_+_24045774 0.58 ENSDART00000133484
apolipoprotein Eb
chr23_+_2101659 0.58

chr5_-_71340996 0.58 ENSDART00000162526
SET and MYND domain containing 1a
chr15_+_34131126 0.57 ENSDART00000169487
von Willebrand factor D and EGF domains
chr8_+_28493742 0.57 ENSDART00000053782
scratch family zinc finger 2
KN150670v1_-_72156 0.56

chr11_-_23151247 0.56

chr19_-_325337 0.56 ENSDART00000147635
glycerol-3-phosphate dehydrogenase 1c
chr7_-_72127164 0.56 ENSDART00000176069
ENSDARG00000106736
chr10_+_4874841 0.54 ENSDART00000165942
paralemmin 2
chr7_-_25623974 0.54 ENSDART00000173602
CD99 molecule-like 2
chr2_-_7693224 0.54 ENSDART00000167019
wu:fc46h12
chr8_-_38357549 0.54 ENSDART00000129597
sorbin and SH3 domain containing 3
chr9_-_33584190 0.53 ENSDART00000138844
calcium/calmodulin-dependent serine protein kinase a
chr2_+_49358871 0.53 ENSDART00000179089
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba
chr3_+_24067387 0.53 ENSDART00000055609
activating transcription factor 4b
chr21_-_26459113 0.52 ENSDART00000157255
CD248 molecule, endosialin b
chr4_-_18606513 0.52 ENSDART00000049061
cyclin-dependent kinase inhibitor 1Ba
chr21_+_43674754 0.52 ENSDART00000136025
trimethyllysine hydroxylase, epsilon
chr23_-_5429419 0.52 ENSDART00000159105
ENSDARG00000101435
chr12_+_23717554 0.51 ENSDART00000152997
supervillin a
chr19_-_33123907 0.51 ENSDART00000004034
hippocalcin
chr11_-_2107054 0.51 ENSDART00000173031
homeobox C6b
chr23_-_27226387 0.50 ENSDART00000141305
si:dkey-157g16.6
chr3_-_53304694 0.50 ENSDART00000073930
notch 3
chr10_+_33926312 0.49 ENSDART00000174730
ENSDARG00000106629
chr19_+_41966252 0.49 ENSDART00000169193
si:ch211-57n23.4
chr17_-_14663139 0.49 ENSDART00000037371
protein phosphatase 1, regulatory subunit 13Ba
chr14_-_46648563 0.49

chr16_-_26258657 0.48 ENSDART00000157787
lipase, hormone-sensitive b
chr17_+_33481064 0.48 ENSDART00000077581
synaptosomal-associated protein 23.2
chr6_-_4369754 0.48

chr6_+_7936576 0.48 ENSDART00000146106
nuclear factor, interleukin 3 regulated, member 5
chr25_-_30856032 0.48 ENSDART00000067028
zgc:172145
chr4_-_74907755 0.47 ENSDART00000132323
finTRIM family, member 51
chr7_+_40183670 0.47 ENSDART00000173916
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr2_-_31037043 0.47 ENSDART00000087026
elastin microfibril interfacer 2a
chr1_-_50513645 0.47 ENSDART00000047851
jagged 1a
chr10_-_44117211 0.46 ENSDART00000009134
septin 5b
chr13_-_49826330 0.46 ENSDART00000099475
nidogen 1a
chr6_+_6333766 0.46 ENSDART00000140827
B-cell CLL/lymphoma 11Ab
chr8_+_47644421 0.45 ENSDART00000139096
si:ch211-251b21.1
chr24_-_36287207 0.45 ENSDART00000065338
PAK1 interacting protein 1
chr3_-_36704626 0.45 ENSDART00000055237
receptor (G protein-coupled) activity modifying protein 2
chr6_-_9964616 0.45

chr6_-_39311711 0.45

chr10_+_18994733 0.45 ENSDART00000146517
dihydropyrimidinase-like 2b
chr12_+_30538113 0.45 ENSDART00000179355
thrombospondin 2b
chr19_+_2162466 0.45

chr23_-_15442032 0.45 ENSDART00000082060
ENSDARG00000078145
chr3_+_14238188 0.45 ENSDART00000165452
ENSDART00000171726
transmembrane protein 56b
chr14_-_9114872 0.44 ENSDART00000081158
SH3 domain binding glutamate-rich protein like
chr5_+_34397618 0.44 ENSDART00000043341
forkhead box D1
chr9_-_21420106 0.44 ENSDART00000102147
popeye domain containing 2
chr13_+_45843396 0.43 ENSDART00000005195
ENSDART00000074547
BSD domain containing 1
chr14_-_12001505 0.43 ENSDART00000171136
myotilin
chr9_+_51693805 0.43 ENSDART00000132896
fibroblast activation protein, alpha
chr21_-_11539798 0.43 ENSDART00000144770
calpastatin
chr23_+_36007936 0.42 ENSDART00000128533
homeo box C3a
chr24_-_41448993 0.42 ENSDART00000041349
crystallin, gamma N2
chr1_-_29669484 0.42 ENSDART00000164202
insulin-like growth factor 2 mRNA binding protein 2b
chr6_+_41466199 0.42 ENSDART00000177439
twinfilin actin-binding protein 2a
chr18_-_44135616 0.42 ENSDART00000087339
cell adhesion associated, oncogene regulated
chr17_+_22082952 0.42 ENSDART00000047772
mal, T-cell differentiation protein
chr9_+_308260 0.41 ENSDART00000163474
SH3 and cysteine rich domain 3
chr5_-_34397435 0.41 ENSDART00000170684
basic transcription factor 3
chr20_+_35010140 0.41 ENSDART00000172001
synaptosomal-associated protein, 25a
chr7_+_23778570 0.41 ENSDART00000121837
embryonal Fyn-associated substrate
chr23_-_42775849 0.41 ENSDART00000149944
glutathione peroxidase 7
chr23_-_34970838 0.41 ENSDART00000087219
ENSDARG00000061272
chr13_-_25067585 0.41 ENSDART00000159585
adenosine kinase a
chr6_+_47845002 0.41 ENSDART00000140943
peptidyl arginine deiminase, type II
chr23_+_45020761 0.41 ENSDART00000159104
ATPase, Na+/K+ transporting, beta 2a polypeptide
chr15_-_8333117 0.40 ENSDART00000061351
tumor necrosis factor receptor superfamily, member 19
chr3_+_34064081 0.40

chr2_-_59047356 0.40

chr21_+_44749057 0.40 ENSDART00000084780
ring finger protein 121
chr5_+_27298136 0.40 ENSDART00000098604
ADAM metallopeptidase domain 28
chr25_-_6501787 0.39 ENSDART00000112782
chondroitin sulfate proteoglycan 4
chr6_-_8126955 0.39 ENSDART00000132412
acid phosphatase 5a, tartrate resistant
chr4_+_57435 0.39 ENSDART00000169187
protein tyrosine phosphatase, receptor type, O
chr7_+_34417030 0.39 ENSDART00000108473
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr9_+_54692834 0.39

chr8_-_19364689 0.39 ENSDART00000014183
collagen beta(1-O)galactosyltransferase 2
KN150495v1_-_20497 0.39

chr1_-_50513873 0.39 ENSDART00000137172
jagged 1a
chr1_-_50066633 0.39

chr21_+_28459490 0.39 ENSDART00000138236
cytochrome c oxidase subunit VIIIA (ubiquitous)
chr8_-_40231417 0.38 ENSDART00000162020
lysine (K)-specific demethylase 2Ba
chr25_-_32344881 0.38 ENSDART00000012862
ISL LIM homeobox 2a
chr20_-_7303804 0.38 ENSDART00000100060
desmocollin 2 like
chr5_-_25866099 0.38 ENSDART00000144035
armadillo repeat gene deleted in velocardiofacial syndrome b
chr9_+_24089828 0.38 ENSDART00000127859
tripartite motif containing 63b
chr6_-_39315024 0.38 ENSDART00000012644
keratin 4
chr2_+_55888093 0.38 ENSDART00000146160
lysyl oxidase-like 5b
chr3_-_39313029 0.38 ENSDART00000156123
ENSDARG00000097747
chr19_+_12663944 0.37 ENSDART00000151508
low density lipoprotein receptor class A domain containing 4a
chr16_+_74373 0.37

chr15_+_32963784 0.37 ENSDART00000167739
doublecortin-like kinase 1b
chr5_+_44316830 0.37

chr5_-_30324182 0.37 ENSDART00000153909
spinster homolog 2 (Drosophila)
chr20_-_47123598 0.37 ENSDART00000100320
DNA (cytosine-5-)-methyltransferase 3 alpha a
chr6_+_170792 0.37

chr8_+_10267246 0.37 ENSDART00000159312
ENSDART00000160766
Pim-1 proto-oncogene, serine/threonine kinase
chr2_-_42279180 0.37 ENSDART00000047055
tripartite motif containing 55a
chr16_+_29277783 0.37 ENSDART00000149569
ENSDARG00000095906
chr1_+_4704661 0.36 ENSDART00000040204
tubulin, alpha 8 like 2
chr2_-_21323717 0.36 ENSDART00000113384
LYR motif containing 4
chr11_-_2524674 0.36 ENSDART00000114079
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr20_-_26142897 0.36 ENSDART00000140255
si:dkey-12h9.6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0042985 negative regulation of glycoprotein biosynthetic process(GO:0010561) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) negative regulation of glycoprotein metabolic process(GO:1903019)
0.4 1.3 GO:0042554 superoxide anion generation(GO:0042554)
0.4 2.0 GO:1901739 regulation of myoblast fusion(GO:1901739)
0.4 2.7 GO:0006833 water transport(GO:0006833)
0.3 3.3 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.2 1.4 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.2 0.7 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.2 0.8 GO:0086065 atrial cardiac muscle cell action potential(GO:0086014) cell-cell signaling involved in cardiac conduction(GO:0086019) atrial cardiac muscle cell to AV node cell signaling(GO:0086026) cell communication involved in cardiac conduction(GO:0086065) atrial cardiac muscle cell to AV node cell communication(GO:0086066)
0.2 0.6 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.2 0.6 GO:0071831 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.2 0.8 GO:0016264 gap junction assembly(GO:0016264)
0.2 1.8 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.2 1.2 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.2 0.7 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.2 1.3 GO:0061337 cardiac conduction(GO:0061337)
0.1 0.7 GO:0033151 V(D)J recombination(GO:0033151)
0.1 0.3 GO:0035474 selective angioblast sprouting(GO:0035474)
0.1 0.3 GO:0070527 platelet aggregation(GO:0070527)
0.1 0.4 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045)
0.1 1.4 GO:0098508 endothelial to hematopoietic transition(GO:0098508)
0.1 0.4 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.1 0.5 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.5 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 0.9 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.8 GO:0002093 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.6 GO:0010990 SMAD protein complex assembly(GO:0007183) regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991) negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.6 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.1 0.3 GO:0007508 larval development(GO:0002164) larval heart development(GO:0007508)
0.1 0.4 GO:0010656 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.1 0.4 GO:0070296 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) sarcoplasmic reticulum calcium ion transport(GO:0070296) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.1 0.3 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.4 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.1 0.4 GO:0018158 peptidyl-lysine oxidation(GO:0018057) protein oxidation(GO:0018158)
0.1 0.4 GO:0090299 regulation of neural crest formation(GO:0090299)
0.1 3.6 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.1 0.4 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.1 0.8 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.1 0.3 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.1 0.3 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.1 0.4 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.9 GO:0030240 skeletal muscle thin filament assembly(GO:0030240) skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.4 GO:1903069 neuronal action potential(GO:0019228) regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903069)
0.1 0.3 GO:0044209 AMP salvage(GO:0044209)
0.1 0.3 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.1 0.3 GO:0035989 tendon development(GO:0035989)
0.1 0.9 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 0.3 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.1 0.3 GO:1904969 bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
0.1 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to ciliary membrane(GO:1903441)
0.1 0.5 GO:0051013 microtubule severing(GO:0051013)
0.1 0.2 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 0.5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 1.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.4 GO:0045453 bone resorption(GO:0045453)
0.1 0.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 1.1 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 0.2 GO:1902895 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.1 0.9 GO:0032438 melanosome organization(GO:0032438)
0.1 1.0 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.1 1.3 GO:0051014 actin filament severing(GO:0051014)
0.1 0.3 GO:0034650 cortisol metabolic process(GO:0034650)
0.1 0.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.1 GO:0045299 otolith mineralization(GO:0045299)
0.1 0.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.4 GO:2000480 regulation of cAMP-dependent protein kinase activity(GO:2000479) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.3 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 1.0 GO:0030878 thyroid gland development(GO:0030878)
0.1 0.2 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.1 0.6 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.6 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.6 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.2 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.0 0.2 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.3 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.4 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.2 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.0 0.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 1.1 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0070166 enamel mineralization(GO:0070166) amelogenesis(GO:0097186)
0.0 0.5 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.5 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.6 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.1 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.0 0.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.2 GO:0019878 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.4 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.2 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.3 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249) positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.7 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 1.1 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.2 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.7 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.0 GO:0061036 positive regulation of cartilage development(GO:0061036)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.2 GO:0051031 tRNA transport(GO:0051031)
0.0 0.3 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.0 0.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.3 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.0 0.2 GO:0032288 myelin assembly(GO:0032288)
0.0 0.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 1.6 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.4 GO:0031269 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 1.6 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.1 GO:0061011 hepatic duct development(GO:0061011)
0.0 0.1 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 1.0 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 1.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.8 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.1 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.2 GO:0002698 negative regulation of immune effector process(GO:0002698)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.5 GO:0061009 intrahepatic bile duct development(GO:0035622) common bile duct development(GO:0061009)
0.0 0.3 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 0.5 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 0.2 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.2 GO:0035284 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.4 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.2 GO:0001952 regulation of cell-matrix adhesion(GO:0001952)
0.0 0.1 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.0 1.0 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772) thiamine diphosphate metabolic process(GO:0042357) thiamine-containing compound metabolic process(GO:0042723)
0.0 0.2 GO:0032261 purine nucleotide salvage(GO:0032261)
0.0 0.3 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.1 GO:0032475 otolith formation(GO:0032475)
0.0 0.2 GO:0061055 myotome development(GO:0061055)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.2 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.2 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.0 0.0 GO:2000136 cell proliferation involved in heart morphogenesis(GO:0061323) regulation of cell proliferation involved in heart morphogenesis(GO:2000136)
0.0 0.2 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.0 0.1 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.1 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.2 GO:0006188 IMP biosynthetic process(GO:0006188) 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.3 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.0 0.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.5 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.1 GO:0090398 cellular senescence(GO:0090398)
0.0 0.3 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.0 0.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.2 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.2 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.4 GO:0021587 cerebellum morphogenesis(GO:0021587)
0.0 0.5 GO:0045765 regulation of angiogenesis(GO:0045765)
0.0 0.2 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.2 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.1 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.1 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 1.1 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.1 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.1 GO:0003313 heart rudiment development(GO:0003313)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.8 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.4 GO:0001570 vasculogenesis(GO:0001570)
0.0 0.2 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.4 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.0 1.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.0 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.7 GO:0007601 visual perception(GO:0007601)
0.0 0.1 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.3 GO:0030641 regulation of cellular pH(GO:0030641)
0.0 0.1 GO:2000142 regulation of transcription initiation from RNA polymerase II promoter(GO:0060260) regulation of DNA-templated transcription, initiation(GO:2000142)
0.0 0.2 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
0.0 0.2 GO:0061386 closure of optic fissure(GO:0061386)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 1.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 1.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 0.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 0.6 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.2 0.5 GO:0008352 katanin complex(GO:0008352)
0.1 0.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.4 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 1.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.3 GO:0031362 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.1 0.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.5 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1 0.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.5 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.2 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 0.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.2 GO:1902560 GMP reductase complex(GO:1902560)
0.1 0.9 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.7 GO:0030057 desmosome(GO:0030057)
0.1 0.6 GO:0031430 M band(GO:0031430)
0.1 0.4 GO:0098533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.1 3.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 0.3 GO:0005883 neurofilament(GO:0005883)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.7 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.8 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.0 1.1 GO:0005902 microvillus(GO:0005902)
0.0 0.1 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.2 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 0.1 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.0 0.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0030315 T-tubule(GO:0030315)
0.0 2.1 GO:0030018 Z disc(GO:0030018)
0.0 0.3 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 1.5 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0005921 gap junction(GO:0005921)
0.0 0.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) cytochrome complex(GO:0070069)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.0 GO:0001726 ruffle(GO:0001726)
0.0 0.3 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.9 GO:0005604 basement membrane(GO:0005604)
0.0 0.4 GO:0042383 sarcolemma(GO:0042383)
0.0 0.2 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.2 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.0 0.5 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0043204 perikaryon(GO:0043204)
0.0 0.3 GO:0031941 filamentous actin(GO:0031941)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)
0.0 1.0 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.0 GO:0009986 cell surface(GO:0009986)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.6 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 5.8 GO:0030054 cell junction(GO:0030054)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.6 GO:0005581 collagen trimer(GO:0005581)
0.0 7.2 GO:0005615 extracellular space(GO:0005615)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.2 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0044447 axoneme part(GO:0044447)
0.0 0.0 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.0 GO:0016586 RSC complex(GO:0016586)
0.0 0.0 GO:1990072 TRAPPIII protein complex(GO:1990072)
0.0 0.1 GO:0002178 palmitoyltransferase complex(GO:0002178)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.4 2.7 GO:0015250 water channel activity(GO:0015250)
0.4 1.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174) superoxide-generating NADPH oxidase activity(GO:0016175)
0.3 3.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 0.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 1.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.2 1.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 0.5 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.4 GO:0004001 adenosine kinase activity(GO:0004001)
0.1 0.4 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 0.5 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.3 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1 0.6 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1 0.9 GO:0008199 ferric iron binding(GO:0008199)
0.1 0.4 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.1 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.5 GO:0005112 Notch binding(GO:0005112)
0.1 0.2 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 1.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.3 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.1 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.7 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.2 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 0.5 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.9 GO:0070411 I-SMAD binding(GO:0070411)
0.1 0.2 GO:0001729 ceramide kinase activity(GO:0001729)
0.1 0.4 GO:0036122 BMP binding(GO:0036122)
0.1 0.2 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 1.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.9 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 1.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.4 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.5 GO:0030291 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 0.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.5 GO:0015026 coreceptor activity(GO:0015026)
0.0 2.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 1.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.5 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.9 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.6 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.2 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.4 GO:0030552 cAMP binding(GO:0030552)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 2.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.6 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.3 GO:0005109 frizzled binding(GO:0005109)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.2 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.2 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.2 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0016918 retinal binding(GO:0016918)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.1 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.2 GO:0031704 apelin receptor binding(GO:0031704)
0.0 0.1 GO:0060182 apelin receptor activity(GO:0060182)
0.0 0.9 GO:0032451 demethylase activity(GO:0032451)
0.0 0.4 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.7 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.6 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.0 0.8 GO:0046332 SMAD binding(GO:0046332)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0047710 bis(5'-adenosyl)-triphosphatase activity(GO:0047710)
0.0 0.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.0 GO:0016859 cis-trans isomerase activity(GO:0016859)
0.0 0.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 1.8 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.7 GO:0045296 cadherin binding(GO:0045296)
0.0 1.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 9.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.1 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.0 GO:0004953 icosanoid receptor activity(GO:0004953)
0.0 0.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0008320 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.0 0.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.2 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.1 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.8 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.1 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 4.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 1.1 PID ALK1 PATHWAY ALK1 signaling events
0.1 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.4 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.7 PID INSULIN PATHWAY Insulin Pathway
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 1.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 0.9 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 0.3 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.5 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.7 REACTOME AQUAPORIN MEDIATED TRANSPORT Genes involved in Aquaporin-mediated transport
0.1 0.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 0.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 2.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME BILE ACID AND BILE SALT METABOLISM Genes involved in Bile acid and bile salt metabolism
0.0 0.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.5 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.3 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.0 0.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.1 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.2 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation