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Results for sox18

Z-value: 0.73

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Transcription factors associated with sox18

Gene Symbol Gene ID Gene Info
sox18
ENSDARG00000058598 SRY-box transcription factor 18

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox18dr10_dc_chr23_+_8862155_8862175-0.665.3e-03Click!

Activity profile of sox18 motif

Sorted Z-values of sox18 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of sox18

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_1522439 1.41 ENSDART00000175566
CABZ01085702.1
ENSDARG00000106927
chr9_-_46614763 1.37 ENSDART00000009790
cx43.4
connexin 43.4
chr19_+_15536640 1.20 ENSDART00000098970
lin28a
lin-28 homolog A (C. elegans)
chr14_-_23980261 0.89 ENSDART00000054243
dpf2l
D4, zinc and double PHD fingers family 2, like
chr4_+_13413303 0.89 ENSDART00000003694
cand1
cullin-associated and neddylation-dissociated 1
chr14_+_29932533 0.88 ENSDART00000017122
asah1a
N-acylsphingosine amidohydrolase (acid ceramidase) 1a
chr14_+_6122803 0.87 ENSDART00000149783
ENSDART00000148461
abca1b
ATP-binding cassette, sub-family A (ABC1), member 1B
chr7_-_24724911 0.85 ENSDART00000173791
rcor2
REST corepressor 2
chr16_-_39291647 0.85 ENSDART00000171342
tmem42a
transmembrane protein 42a
chr6_+_7916307 0.84

chr4_-_13974345 0.83 ENSDART00000067177
ENSDART00000144127
prickle1b
prickle homolog 1b
chr14_-_23980060 0.81 ENSDART00000054243
dpf2l
D4, zinc and double PHD fingers family 2, like
chr20_+_34814623 0.77 ENSDART00000034252
pnocb
prepronociceptin b
chr17_+_25828037 0.77

chr5_-_15971338 0.75 ENSDART00000110437
piwil2
piwi-like RNA-mediated gene silencing 2
chr7_+_24543671 0.74 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr16_+_31871645 0.73 ENSDART00000045210
mlf2
myeloid leukemia factor 2
chr15_+_29795467 0.71 ENSDART00000099958
zgc:153372
zgc:153372
chr11_+_17849608 0.71 ENSDART00000020283
rpusd4
RNA pseudouridylate synthase domain containing 4
chr6_+_49054117 0.71 ENSDART00000011876
sycp1
synaptonemal complex protein 1
chr9_-_6861630 0.71

chr21_-_34809442 0.70 ENSDART00000029708
zgc:56585
zgc:56585
chr14_+_37205204 0.69 ENSDART00000173192
pcdh1b
protocadherin 1b
chr24_+_9335316 0.65 ENSDART00000132688
si:ch211-285f17.1
si:ch211-285f17.1
chr5_-_23697487 0.62 ENSDART00000013309
sox19a
SRY (sex determining region Y)-box 19a
chr1_+_45015350 0.60 ENSDART00000143363
si:ch211-214c7.4
si:ch211-214c7.4
chr13_+_40689102 0.57 ENSDART00000016960
prkg1a
protein kinase, cGMP-dependent, type Ia
chr18_+_35253031 0.53

chr25_+_34555948 0.53 ENSDART00000111706
si:dkey-108k21.14
si:dkey-108k21.14
chr10_+_16071124 0.52 ENSDART00000065036
phax
phosphorylated adaptor for RNA export
chr9_+_45193290 0.52 ENSDART00000176175
retsatl
retinol saturase (all-trans-retinol 13,14-reductase) like
chr25_-_34599241 0.52 ENSDART00000156727
si:dkey-108k21.21
si:dkey-108k21.21
chr14_-_35060298 0.51 ENSDART00000129676
lsm11
LSM11, U7 small nuclear RNA associated
chr7_+_22582619 0.50 ENSDART00000148502
clcn5b
chloride channel, voltage-sensitive 5b
chr14_+_6655541 0.49 ENSDART00000148447
hnrnpaba
heterogeneous nuclear ribonucleoprotein A/Ba
chr8_+_23705243 0.48 ENSDART00000142395
mkrn4
makorin, ring finger protein, 4
chr7_+_22582561 0.47 ENSDART00000148502
clcn5b
chloride channel, voltage-sensitive 5b
chr19_+_10742387 0.45 ENSDART00000091813
ago3b
argonaute RISC catalytic component 3b
chr14_+_6122901 0.44 ENSDART00000149783
ENSDART00000148461
abca1b
ATP-binding cassette, sub-family A (ABC1), member 1B
chr2_-_48069574 0.44 ENSDART00000056306
ftr24
finTRIM family, member 24
chr3_+_25868700 0.44 ENSDART00000024316
mcm5
minichromosome maintenance complex component 5
chr14_+_8437594 0.42

chr3_-_25246452 0.41 ENSDART00000177576
kpna2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chr22_+_24532560 0.38 ENSDART00000169847
wdr47b
WD repeat domain 47b
chr14_+_6656015 0.38 ENSDART00000148394
hnrnpaba
heterogeneous nuclear ribonucleoprotein A/Ba
chr2_+_31959127 0.37 ENSDART00000132113
otulinb
OTU deubiquitinase with linear linkage specificity b
chr12_-_33256934 0.37 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr21_+_10152870 0.37

chr21_-_4901827 0.36 ENSDART00000067733
zgc:77838
zgc:77838
chr23_-_33692244 0.36

chr4_+_46917725 0.36

chr25_+_34556009 0.36 ENSDART00000111706
si:dkey-108k21.14
si:dkey-108k21.14
chr23_-_10810190 0.35 ENSDART00000140745
eif4e3
eukaryotic translation initiation factor 4E family member 3
chr22_+_24532479 0.35 ENSDART00000169847
wdr47b
WD repeat domain 47b
chr14_+_6122644 0.34 ENSDART00000149783
ENSDART00000148461
abca1b
ATP-binding cassette, sub-family A (ABC1), member 1B
chr25_-_22821132 0.34

chr2_-_32279019 0.34 ENSDART00000159843
ENSDART00000056621
ENSDART00000039717
ENSDART00000145704
fam49ba
family with sequence similarity 49, member Ba
chr16_-_42015364 0.33 ENSDART00000136742
BX649388.1
ENSDARG00000091933
chr24_-_31257458 0.32 ENSDART00000158808
cnn3a
calponin 3, acidic a
chr2_-_10173776 0.32 ENSDART00000137924
zgc:55943
zgc:55943
chr7_-_24724452 0.31 ENSDART00000173791
rcor2
REST corepressor 2
chr11_+_17849528 0.31 ENSDART00000020283
rpusd4
RNA pseudouridylate synthase domain containing 4
chr4_+_13413119 0.29 ENSDART00000003694
cand1
cullin-associated and neddylation-dissociated 1
chr21_+_28710269 0.29 ENSDART00000014058
zgc:100829
zgc:100829
chr10_-_8083196 0.28 ENSDART00000059017
nfkbil1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr1_+_48790583 0.28 ENSDART00000124833
pdcd11
programmed cell death 11
chr8_-_24772008 0.27 ENSDART00000111617
rbm15
RNA binding motif protein 15
chr3_-_25246374 0.27 ENSDART00000077538
kpna2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chr19_+_10742344 0.27 ENSDART00000091813
ago3b
argonaute RISC catalytic component 3b
chr5_-_67580755 0.26 ENSDART00000169350
ENSDARG00000098655
ENSDARG00000098655
chr8_+_53202474 0.25

chr4_-_70349899 0.25

chr17_+_33862300 0.24

chr8_+_17148864 0.24 ENSDART00000140531
dimt1l
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr3_+_25868480 0.24 ENSDART00000024316
mcm5
minichromosome maintenance complex component 5
chr11_-_28367400 0.23 ENSDART00000065853
dhrs3b
dehydrogenase/reductase (SDR family) member 3b
chr24_+_9335428 0.23 ENSDART00000132688
si:ch211-285f17.1
si:ch211-285f17.1
chr21_-_43176006 0.23 ENSDART00000148630
hspa4a
heat shock protein 4a
chr24_-_31257591 0.23 ENSDART00000158808
cnn3a
calponin 3, acidic a
chr10_+_11439845 0.22 ENSDART00000064210
cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr18_-_21759421 0.22 ENSDART00000079253
pskh1
protein serine kinase H1
chr16_+_22949379 0.22 ENSDART00000137783
flad1
flavin adenine dinucleotide synthetase 1
chr14_+_6655894 0.21 ENSDART00000148394
hnrnpaba
heterogeneous nuclear ribonucleoprotein A/Ba
chr10_+_22921629 0.21 ENSDART00000057291
arrb2a
arrestin, beta 2a
chr12_+_19078444 0.21

chr15_+_29795509 0.21 ENSDART00000099958
zgc:153372
zgc:153372
chr17_+_51593393 0.19 ENSDART00000004379
nol10
nucleolar protein 10
chr12_-_35004566 0.17 ENSDART00000153034
si:ch73-127m5.2
si:ch73-127m5.2
chr4_-_29167253 0.17 ENSDART00000160579
CR388132.2
ENSDARG00000101782
chr9_+_32496059 0.17 ENSDART00000078513
mob4
MOB family member 4, phocein
chr16_+_22949494 0.16 ENSDART00000137783
flad1
flavin adenine dinucleotide synthetase 1
chr8_+_53202445 0.15

chr3_-_23340407 0.15 ENSDART00000113135
ENSDART00000166068
msl1a
male-specific lethal 1 homolog a (Drosophila)
chr2_+_31959275 0.15 ENSDART00000132113
otulinb
OTU deubiquitinase with linear linkage specificity b
chr8_+_14120357 0.14 ENSDART00000080832
si:dkey-6n6.2
si:dkey-6n6.2
chr9_+_56880744 0.14

chr24_+_20228016 0.14 ENSDART00000139989
plcd1a
phospholipase C, delta 1a
chr9_-_33975936 0.12 ENSDART00000140779
fundc1
FUN14 domain containing 1
chr17_+_50484982 0.11 ENSDART00000075150
bmp4
bone morphogenetic protein 4
chr11_-_43409685 0.11 ENSDART00000163843
zgc:153431
zgc:153431
chr2_+_31959316 0.10 ENSDART00000132113
otulinb
OTU deubiquitinase with linear linkage specificity b
chr9_+_37945009 0.09 ENSDART00000100592
pdia5
protein disulfide isomerase family A, member 5
chr5_+_39066924 0.09 ENSDART00000085388
bmp3
bone morphogenetic protein 3
chr17_-_14772485 0.08 ENSDART00000080401
ENSDART00000154690
si:ch211-266o15.1
si:ch211-266o15.1
chr2_-_28244864 0.08 ENSDART00000137542
zgc:163121
zgc:163121
chr11_-_27260783 0.08

chr24_-_40968527 0.07 ENSDART00000172617
smyhc1
slow myosin heavy chain 1
chr17_+_48929046 0.07 ENSDART00000171615
CU499333.1
ENSDARG00000103628
chr1_-_49967146 0.07 ENSDART00000015591
ppm1k
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr9_-_43015354 0.06

chr14_-_35060332 0.06 ENSDART00000129676
lsm11
LSM11, U7 small nuclear RNA associated
chr5_-_12706568 0.05 ENSDART00000051666
ppm1f
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr9_+_45031009 0.05 ENSDART00000002633
frzb
frizzled-related protein
chr23_-_10810264 0.04 ENSDART00000013768
eif4e3
eukaryotic translation initiation factor 4E family member 3
chr8_+_23704956 0.04 ENSDART00000132734
mkrn4
makorin, ring finger protein, 4
chr5_-_23013841 0.04 ENSDART00000137655
stag2a
stromal antigen 2a
KN150118v1_-_40245 0.04

chr5_-_30104184 0.03 ENSDART00000016709
ift22
intraflagellar transport 22 homolog (Chlamydomonas)
chr13_-_44926708 0.03 ENSDART00000130467
ENSDART00000074791
ENSDART00000136679
chp1
calcineurin-like EF-hand protein 1
chr2_+_21527785 0.02 ENSDART00000136498
si:dkey-29d8.3
si:dkey-29d8.3
chr24_-_24578984 0.02 ENSDART00000012399
armc1
armadillo repeat containing 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0010265 SCF complex assembly(GO:0010265)
0.2 0.7 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.2 0.7 GO:0051026 chiasma assembly(GO:0051026)
0.2 0.9 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.2 0.5 GO:0006408 snRNA export from nucleus(GO:0006408)
0.1 1.2 GO:0033700 phospholipid efflux(GO:0033700)
0.1 1.0 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.1 0.4 GO:0046443 FAD biosynthetic process(GO:0006747) FAD metabolic process(GO:0046443) flavin adenine dinucleotide metabolic process(GO:0072387) flavin adenine dinucleotide biosynthetic process(GO:0072388)
0.1 0.8 GO:0021754 facial nucleus development(GO:0021754)
0.1 0.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.6 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.2 GO:0043393 G-protein coupled receptor internalization(GO:0002031) regulation of protein binding(GO:0043393)
0.1 0.7 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.4 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.7 GO:0072091 regulation of stem cell proliferation(GO:0072091)
0.0 0.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.2 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.1 GO:0035122 embryonic medial fin morphogenesis(GO:0035122)
0.0 0.2 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 1.2 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.0 GO:0006821 chloride transport(GO:0006821)
0.0 0.3 GO:0034112 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.0 0.7 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.6 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0000801 central element(GO:0000801)
0.1 0.7 GO:0071546 pi-body(GO:0071546)
0.1 0.6 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.4 GO:0005845 mRNA cap binding complex(GO:0005845)
0.1 1.7 GO:0071565 nBAF complex(GO:0071565)
0.1 0.7 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.8 GO:0043679 axon terminus(GO:0043679)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 1.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.4 GO:0000786 nucleosome(GO:0000786)
0.0 0.5 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0030791 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.2 0.9 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
0.2 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 0.6 GO:0030553 cGMP-dependent protein kinase activity(GO:0004692) cGMP binding(GO:0030553)
0.2 0.7 GO:0034584 piRNA binding(GO:0034584)
0.1 0.7 GO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA(GO:0090624)
0.1 0.4 GO:0003919 FMN adenylyltransferase activity(GO:0003919)
0.1 1.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.0 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.8 GO:0031628 opioid receptor binding(GO:0031628)
0.1 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.7 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.7 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.2 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 1.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.6 GO:0017069 snRNA binding(GO:0017069)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.5 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 1.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis