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Results for sox5

Z-value: 2.57

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Transcription factors associated with sox5

Gene Symbol Gene ID Gene Info
ENSDARG00000011582 SRY-box transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox5dr10_dc_chr4_-_17066886_170669930.989.8e-12Click!

Activity profile of sox5 motif

Sorted Z-values of sox5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of sox5

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr15_+_28753020 7.83 ENSDART00000155815
neuro-oncological ventral antigen 2
chr22_-_37417903 7.06 ENSDART00000149948
ENSDARG00000095844
chr8_-_40231417 6.63 ENSDART00000162020
lysine (K)-specific demethylase 2Ba
chr5_+_34857986 6.61 ENSDART00000141239
ER lipid raft associated 2
chr10_+_33227967 6.27 ENSDART00000159666
myosin, light chain 10, regulatory
chr8_+_21163236 5.82 ENSDART00000091307
collagen, type II, alpha 1a
chr8_-_16223730 5.52 ENSDART00000057590
DMRT-like family A2
chr24_-_24306469 5.07 ENSDART00000154149
ENSDARG00000097984
chr7_+_47014195 4.98 ENSDART00000114669
dpy-19-like 3 (C. elegans)
chr16_-_7525980 4.94 ENSDART00000017445
PR domain containing 1a, with ZNF domain
chr14_+_38445969 4.86 ENSDART00000164440
si:ch211-195b11.3
chr18_+_16257606 4.78 ENSDART00000142584
ALX homeobox 1
chr22_-_27082972 4.68 ENSDART00000077411
chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)
chr20_-_35343242 4.62 ENSDART00000113294
frizzled class receptor 3a
chr1_-_34921848 4.61 ENSDART00000142154
Fras1 related extracellular matrix 3
chr5_+_6054781 4.61 ENSDART00000060532
zgc:110796
chr7_-_50827308 4.56 ENSDART00000121574
collagen, type IV, alpha 6
chr17_-_39237265 4.54 ENSDART00000050534
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr11_-_41357639 4.50 ENSDART00000055709
hairy-related 2
chr19_-_22184035 4.50

chr24_-_6617860 4.36 ENSDART00000166216
Rho GTPase activating protein 21a
chr13_-_22641001 4.36

chr21_-_35806638 4.24 ENSDART00000172245
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr23_-_15442032 4.21 ENSDART00000082060
ENSDARG00000078145
chr18_+_40364675 4.18 ENSDART00000098791
ENSDART00000049171
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr24_+_9605832 4.16 ENSDART00000131891
transmembrane protein 108
chr25_+_14411153 4.03 ENSDART00000015681
developing brain homeobox 1b
chr5_+_17120453 4.01

chr7_-_38590391 3.99 ENSDART00000037361
ENSDART00000173629
ENSDART00000173953
PHD finger protein 21Aa
chr6_+_47845002 3.99 ENSDART00000140943
peptidyl arginine deiminase, type II
chr9_-_34129128 3.91

chr5_-_24509021 3.87 ENSDART00000177338
ENSDART00000177557
ENSDART00000177478
EMI domain containing 1
chr13_+_11913290 3.82 ENSDART00000079398
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_26406720 3.79 ENSDART00000078563
neurogenin 1
chr14_+_34683602 3.77 ENSDART00000172171
early B-cell factor 1a
chr21_+_28465617 3.73 ENSDART00000140229
OTU deubiquitinase, ubiquitin aldehyde binding 1a
chr16_+_28819826 3.69 ENSDART00000103340
S100 calcium binding protein V1
chr6_+_42821679 3.67 ENSDART00000046498
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr11_+_27027209 3.63 ENSDART00000113707
fibulin 2
chr13_-_36996246 3.62 ENSDART00000133242
spectrin repeat containing, nuclear envelope 2b
chr13_-_22901327 3.61 ENSDART00000056523
hexokinase domain containing 1
chr3_-_31672763 3.49 ENSDART00000028270
glial fibrillary acidic protein
chr16_+_23172295 3.45 ENSDART00000167518
ENSDART00000161087
ephrin-A3b
chr8_+_23071884 3.44 ENSDART00000063075
zgc:100920
chr21_-_25704662 3.27 ENSDART00000101211
claudin h
chr13_-_24779651 3.27 ENSDART00000077775
K(lysine) acetyltransferase 6B
chr21_+_20734431 3.25 ENSDART00000079732
3-oxoacid CoA transferase 1b
chr9_-_22528568 3.21 ENSDART00000134805
crystallin, gamma M2d1
chr13_+_11912981 3.21 ENSDART00000158244
guanine nucleotide binding protein (G protein), gamma 2
chr11_-_23206021 3.20 ENSDART00000032844
pleckstrin homology domain containing, family A member 6
chr19_+_48582114 3.19 ENSDART00000157424
ENSDARG00000098777
chr10_+_21850059 3.18 ENSDART00000164634
ENSDART00000172513
protocadherin 1 gamma 32
chr13_-_25067585 3.11 ENSDART00000159585
adenosine kinase a
chr23_-_18972097 3.10 ENSDART00000133826
ENSDARG00000057403
chr16_+_5625301 3.09

chr13_+_11305846 3.08

chr19_-_7069920 3.07 ENSDART00000145741
zinc finger protein 384 like
chr3_-_30027552 3.04 ENSDART00000103502
si:ch211-152f23.5
chr1_-_37990863 3.02 ENSDART00000132402
glycoprotein M6Ab
chr25_+_24152717 3.01 ENSDART00000064646
transmembrane protein 86A
chr16_+_29558320 2.98 ENSDART00000011497
cathepsin K
chr9_-_31467299 2.96 ENSDART00000022204
zic family member 5 (odd-paired homolog, Drosophila)
chr7_-_58427369 2.91 ENSDART00000149347
coiled-coil-helix-coiled-coil-helix domain containing 7
chr19_-_34508557 2.91 ENSDART00000160495
si:dkey-184p18.2
chr12_-_26314881 2.86 ENSDART00000178687
myozenin 1b
chr15_-_20297270 2.82 ENSDART00000123910
protein phosphatase 1, regulatory (inhibitor) subunit 14Ab
chr23_-_10747605 2.81

chr2_+_22196971 2.78 ENSDART00000140012
carbonic anhydrase VIII
chr6_-_44282665 2.78 ENSDART00000157215
PDZ domain containing RING finger 3b
chr24_+_21395671 2.76 ENSDART00000091529
WAS protein family, member 3b
chr20_-_47521258 2.74

chr23_+_35984675 2.74 ENSDART00000053295
homeobox C10a
chr11_-_25222937 2.69

chr19_-_2486568 2.68 ENSDART00000012791
sp8 transcription factor a
chr18_-_14868444 2.66 ENSDART00000045232
metastasis suppressor 1-like a
chr25_-_20994084 2.64 ENSDART00000154765
proline rich 5a (renal)
chr7_-_52283383 2.62 ENSDART00000165649
transcription factor 12
chr7_-_33080261 2.58 ENSDART00000114041
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr24_-_20513975 2.58 ENSDART00000127923
natural killer cell triggering receptor
chr16_+_10427961 2.57 ENSDART00000055380
tubulin, beta 5
chr11_-_42934175 2.57 ENSDART00000172929
spectrin, beta, non-erythrocytic 1
chr7_+_65532390 2.57 ENSDART00000156683
ENSDARG00000097673
chr6_-_8075384 2.56 ENSDART00000129674
solute carrier family 44 (choline transporter), member 2
chr16_+_19926776 2.56 ENSDART00000149901
ENSDART00000052927
twist family bHLH transcription factor 1b
chr13_-_20387917 2.54 ENSDART00000167916
ENSDART00000165310
ENSDART00000168955
gdnf family receptor alpha 1a
chr10_+_31358236 2.54 ENSDART00000145562
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr9_+_4188263 2.49 ENSDART00000164543
kalirin RhoGEF kinase a
chr8_-_40231354 2.48 ENSDART00000162020
lysine (K)-specific demethylase 2Ba
chr1_+_8605984 2.46 ENSDART00000055009
Unc4.1 homeobox (C. elegans)
chr24_-_36938495 2.45 ENSDART00000112694
family with sequence similarity 171, member A2b
chr23_-_5751064 2.44 ENSDART00000067351
troponin T type 2a (cardiac)
chr18_+_40365208 2.42 ENSDART00000167134
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr24_-_6048914 2.38 ENSDART00000146830
ENSDART00000021981
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr9_+_33167554 2.38 ENSDART00000007630
nescient helix loop helix 2
chr12_-_1931281 2.36 ENSDART00000005676
ENSDART00000127937
SRY (sex determining region Y)-box 9a
chr11_-_6051096 2.35 ENSDART00000147761
vessel-specific 1
chr19_+_44373777 2.35 ENSDART00000051712
GATA zinc finger domain containing 1
chr19_+_5399813 2.33 ENSDART00000145749
si:dkeyp-113d7.1
chr20_+_20287015 2.32 ENSDART00000002507
ras homolog family member J
chr7_+_26980284 2.29 ENSDART00000173962
SRY (sex determining region Y)-box 6
chr1_-_29885008 2.29 ENSDART00000018827
dachshund c
chr2_-_50638153 2.27 ENSDART00000108900
contactin associated protein-like 2b
chr23_+_20936419 2.27 ENSDART00000129992
paired box 7b
chr5_-_40310798 2.27 ENSDART00000133183
poly (ADP-ribose) polymerase family, member 8
chr19_-_32931355 2.24 ENSDART00000103410
zinc finger and BTB domain containing 8B
chr1_-_15972040 2.24 ENSDART00000040434
N-acylsphingosine amidohydrolase (acid ceramidase) 1b
chr13_+_1051015 2.24 ENSDART00000033528
tumor necrosis factor, alpha-induced protein 3
chr17_-_52735250 2.22

chr6_+_43429115 2.20 ENSDART00000056457
microphthalmia-associated transcription factor a
chr22_-_15576473 2.19 ENSDART00000036075
tropomyosin 4a
chr17_-_1599376 2.16 ENSDART00000034216
ENSDART00000158837
dynein, cytoplasmic 1, heavy chain 1
chr10_+_33935945 2.15

chr17_+_34854673 2.15

chr4_-_6558919 2.12 ENSDART00000142087
forkhead box P2
chr10_+_38582701 2.07 ENSDART00000144329
alkaline ceramidase 3
chr14_+_34683695 2.04 ENSDART00000170631
early B-cell factor 1a
chr8_+_23704956 2.03 ENSDART00000132734
makorin, ring finger protein, 4
chr11_+_6809190 2.03 ENSDART00000104289
RAB3A, member RAS oncogene family, b
chr19_-_31996936 2.02 ENSDART00000052183
zgc:111986
chr19_-_31754505 2.02 ENSDART00000040810
ADP-ribosylation factor-like 4ab
chr11_+_37345024 1.97 ENSDART00000077496
heterochromatin protein 1, binding protein 3
chr5_-_40310638 1.96 ENSDART00000133183
poly (ADP-ribose) polymerase family, member 8
chr7_-_52574822 1.95 ENSDART00000172951
microtubule-associated protein 1Aa
chr9_+_24198112 1.92 ENSDART00000148226
melanophilin b
chr9_-_10561062 1.91 ENSDART00000175269
thrombospondin, type I, domain containing 7Ba
chr4_-_17960341 1.90 ENSDART00000144956
ankyrin repeat and sterile alpha motif domain containing 1B
KN149760v1_-_29067 1.89

chr23_+_18796386 1.88 ENSDART00000137438
myosin, heavy chain 7B, cardiac muscle, beta b
chr23_+_20936374 1.88 ENSDART00000129992
paired box 7b
chr13_+_30190977 1.87

chr3_+_47826386 1.87 ENSDART00000003338
unkempt family zinc finger-like
chr8_+_20456215 1.85 ENSDART00000036630
zgc:101100
chr20_-_35343057 1.84 ENSDART00000113294
frizzled class receptor 3a
chr22_-_20317201 1.84 ENSDART00000161610
transcription factor 3b
chr21_+_17073163 1.83

chr13_+_30546398 1.83

chr6_-_41087828 1.81 ENSDART00000028217
serine/arginine-rich splicing factor 3a
chr3_+_52745202 1.81 ENSDART00000104683
pre-B-cell leukemia transcription factor 4
chr25_-_28691412 1.79 ENSDART00000067066
poly (ADP-ribose) polymerase family, member 6b
chr21_-_27164751 1.79 ENSDART00000065402
zgc:77262
chr8_-_12171624 1.78 ENSDART00000132824
DAB2 interacting protein a
chr8_+_7655655 1.78 ENSDART00000170184
FYVE, RhoGEF and PH domain containing 1
chr19_-_7069850 1.77 ENSDART00000145741
zinc finger protein 384 like
chr21_-_20728623 1.74 ENSDART00000135940
ENSDART00000002231
growth hormone receptor b
chr1_+_45102814 1.71

chr2_+_22196842 1.69 ENSDART00000140012
carbonic anhydrase VIII
chr8_+_39525254 1.67

chr16_-_28921444 1.66 ENSDART00000078543
synaptotagmin XIb
chr2_+_3125365 1.66 ENSDART00000164308
ENSDART00000167649
phosphoinositide-3-kinase, regulatory subunit 3a (gamma)
KN150129v1_-_30546 1.66

chr24_-_28166614 1.65 ENSDART00000167861
cytochrome c oxidase subunit IV isoform 1, like
chr17_-_52735615 1.65

chr17_+_28690237 1.64 ENSDART00000126967
striatin, calmodulin binding protein 3
chr5_-_40310702 1.64 ENSDART00000133183
poly (ADP-ribose) polymerase family, member 8
chr7_-_68033217 1.62

chr23_-_3816492 1.59 ENSDART00000136394
high mobility group AT-hook 1a
chr17_-_21422311 1.59 ENSDART00000167094
ventral anterior homeobox 1
chr11_-_3846064 1.55 ENSDART00000161426
GATA binding protein 2a
chr25_-_36760720 1.51 ENSDART00000111862
low density lipoprotein receptor class A domain containing 3
chr19_+_20189224 1.51 ENSDART00000163611
homeobox A4a
chr9_-_22371512 1.51 ENSDART00000101809
crystallin, gamma M2d6
chr9_+_49961721 1.49

chr24_-_8589800 1.47

chr22_-_20316908 1.47 ENSDART00000165667
transcription factor 3b
chr13_-_8268681 1.46 ENSDART00000045086
protein kinase C, epsilon b
chr11_-_30971376 1.45 ENSDART00000170700
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing b
chr17_+_19003200 1.42

chr11_-_40415291 1.41

chr19_+_5399877 1.41 ENSDART00000145749
si:dkeyp-113d7.1
chr25_+_7147666 1.40 ENSDART00000104712
high mobility group 20A
chr11_+_26138359 1.39 ENSDART00000087652
copine I
chr6_-_43679553 1.39 ENSDART00000150128
forkhead box P1b
chr18_+_14725148 1.38 ENSDART00000146128
URI1, prefoldin-like chaperone
chr21_+_27241416 1.37

chr14_-_30467807 1.36 ENSDART00000173262
protease, serine, 23
chr9_-_22324699 1.36 ENSDART00000175417
ENSDART00000101902
crystallin, gamma M2d8
chr5_-_45219030 1.36

chr17_-_35330764 1.35 ENSDART00000063437
ADAM metallopeptidase domain 17a
chr23_-_33728344 1.34 ENSDART00000146180
cysteine-serine-rich nuclear protein 2
chr5_+_64159481 1.33 ENSDART00000073953
leucine rich repeat containing 8 family, member Ab
chr21_-_25704793 1.31 ENSDART00000101211
claudin h
chr8_+_13069277 1.31 ENSDART00000138433
integrin, beta 4
chr5_+_32680990 1.30 ENSDART00000146223
surfeit 1
chr18_+_6692267 1.30

chr23_+_35819758 1.30 ENSDART00000049551
retinoic acid receptor gamma a
chr3_-_41944723 1.30 ENSDART00000083111
tweety family member 3a
chr2_+_31974269 1.27 ENSDART00000012413
ANKH inorganic pyrophosphate transport regulator b
chr23_-_32231333 1.27 ENSDART00000000876
nuclear receptor subfamily 4, group A, member 1
chr3_+_24003840 1.26 ENSDART00000156204
si:ch211-246i5.5
chr13_-_20388016 1.25 ENSDART00000167916
ENSDART00000165310
ENSDART00000168955
gdnf family receptor alpha 1a
chr3_-_35472632 1.25 ENSDART00000055269
guanine nucleotide binding protein (G protein), gamma 13b
chr13_-_40286013 1.24 ENSDART00000150091
ENSDART00000057094
NK2 homeobox 3
chr4_-_6558687 1.24 ENSDART00000150774
forkhead box P2
chr5_+_61335845 1.24 ENSDART00000166482
ENSDART00000050884
ENSDART00000163909
selenoprotein W, 1
chr17_-_33336706 1.19 ENSDART00000040346
EFR3 homolog Ba (S. cerevisiae)
chr12_+_26530620 1.19 ENSDART00000046959
Rho GTPase activating protein 12b
chr8_+_30654957 1.18 ENSDART00000138750
adenosine A2a receptor a
chr13_+_22165699 1.17

chr25_-_20993989 1.15

chr23_+_36019989 1.15 ENSDART00000103134
ENSDART00000139319
homeobox C5a

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 GO:0097535 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
1.6 4.8 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
1.4 4.2 GO:0097484 dendrite extension(GO:0097484)
1.4 5.5 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
1.3 5.1 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
1.2 4.7 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.9 3.8 GO:0021516 dorsal spinal cord development(GO:0021516)
0.9 4.7 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.8 3.2 GO:0046950 cellular ketone body metabolic process(GO:0046950) ketone body metabolic process(GO:1902224)
0.8 3.1 GO:0044209 AMP salvage(GO:0044209)
0.8 4.5 GO:0007405 neuroblast proliferation(GO:0007405)
0.7 2.2 GO:0071947 protein K29-linked deubiquitination(GO:0035523) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) protein K33-linked deubiquitination(GO:1990168)
0.6 6.5 GO:0021754 facial nucleus development(GO:0021754)
0.6 6.6 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.5 4.9 GO:0051155 positive regulation of striated muscle cell differentiation(GO:0051155)
0.5 3.7 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.5 1.5 GO:1902893 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.5 2.0 GO:0099558 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.5 1.4 GO:0001961 positive regulation of cytokine-mediated signaling pathway(GO:0001961) positive regulation of response to cytokine stimulus(GO:0060760)
0.4 2.2 GO:0097264 self proteolysis(GO:0097264)
0.4 2.6 GO:0038203 TORC2 signaling(GO:0038203)
0.4 7.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.4 3.4 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.4 1.1 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.4 3.0 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.4 1.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.3 4.4 GO:0045471 response to ethanol(GO:0045471)
0.3 8.1 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.3 1.0 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.3 5.9 GO:0030199 collagen fibril organization(GO:0030199)
0.3 1.8 GO:0003232 bulbus arteriosus development(GO:0003232)
0.3 1.8 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.3 5.5 GO:0021984 adenohypophysis development(GO:0021984)
0.3 2.6 GO:0090259 regulation of retinal ganglion cell axon guidance(GO:0090259)
0.3 4.5 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.3 7.0 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.3 0.8 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.3 4.6 GO:0071711 basement membrane organization(GO:0071711)
0.2 1.7 GO:0060396 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.2 1.0 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954) positive regulation of Rac protein signal transduction(GO:0035022)
0.2 2.8 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 2.1 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.2 1.4 GO:0003160 endocardium morphogenesis(GO:0003160)
0.2 3.8 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.2 1.2 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784) regulation of type B pancreatic cell proliferation(GO:0061469)
0.2 2.7 GO:0097178 ruffle assembly(GO:0097178)
0.2 1.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 5.0 GO:0036269 swimming behavior(GO:0036269)
0.2 3.7 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.2 1.0 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.2 1.7 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.2 4.2 GO:0015696 ammonium transport(GO:0015696)
0.2 1.3 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.2 2.2 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.2 1.8 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.1 3.4 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.1 6.8 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.1 0.8 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.1 1.0 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 2.0 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.1 8.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 5.9 GO:0021515 cell differentiation in spinal cord(GO:0021515)
0.1 1.7 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 3.0 GO:0009612 response to mechanical stimulus(GO:0009612)
0.1 3.8 GO:0048484 enteric nervous system development(GO:0048484)
0.1 2.6 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 0.9 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.1 2.7 GO:0048570 notochord morphogenesis(GO:0048570)
0.1 0.8 GO:0034063 stress granule assembly(GO:0034063)
0.1 6.1 GO:0007601 visual perception(GO:0007601)
0.1 1.8 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.1 2.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 2.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 0.3 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.1 0.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 4.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 0.8 GO:0021884 forebrain neuron development(GO:0021884)
0.1 1.3 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 2.2 GO:0030318 melanocyte differentiation(GO:0030318)
0.1 0.5 GO:0042551 neuron maturation(GO:0042551)
0.1 0.6 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 1.1 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.1 1.5 GO:0003094 glomerular filtration(GO:0003094)
0.1 2.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.5 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 1.8 GO:0043242 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) negative regulation of protein complex disassembly(GO:0043242) actin filament capping(GO:0051693) negative regulation of protein depolymerization(GO:1901880)
0.0 4.5 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 1.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.3 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.8 GO:0030032 lamellipodium assembly(GO:0030032) lamellipodium organization(GO:0097581)
0.0 0.4 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 1.2 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 0.2 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.0 2.6 GO:0031101 fin regeneration(GO:0031101)
0.0 0.3 GO:0051932 synaptic transmission, GABAergic(GO:0051932) regulation of postsynaptic membrane potential(GO:0060078)
0.0 0.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 3.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.3 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.5 GO:0060840 artery development(GO:0060840)
0.0 0.2 GO:0022011 myelination in peripheral nervous system(GO:0022011)
0.0 0.5 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 1.9 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 1.3 GO:0006821 chloride transport(GO:0006821)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 1.1 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.3 GO:0051289 protein homotetramerization(GO:0051289)
0.0 0.6 GO:0007254 JNK cascade(GO:0007254)
0.0 2.0 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 0.5 GO:1901653 cellular response to peptide hormone stimulus(GO:0071375) cellular response to peptide(GO:1901653)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.6 GO:0098644 complex of collagen trimers(GO:0098644)
0.6 4.5 GO:0044295 axonal growth cone(GO:0044295)
0.6 7.0 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.6 1.7 GO:0070195 growth hormone receptor complex(GO:0070195)
0.6 3.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.4 1.8 GO:0008091 spectrin(GO:0008091)
0.3 0.8 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 1.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 2.8 GO:0031209 SCAR complex(GO:0031209)
0.2 7.3 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.6 GO:0031932 TORC2 complex(GO:0031932)
0.2 5.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 1.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 5.1 GO:0044420 basement membrane(GO:0005604) extracellular matrix component(GO:0044420)
0.1 0.5 GO:0043083 synaptic cleft(GO:0043083)
0.1 2.4 GO:0005861 troponin complex(GO:0005861)
0.1 5.9 GO:0005581 collagen trimer(GO:0005581)
0.1 1.0 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 2.2 GO:0030286 dynein complex(GO:0030286)
0.1 4.2 GO:0014069 postsynaptic density(GO:0014069)
0.1 5.4 GO:0031674 I band(GO:0031674)
0.1 0.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.6 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.8 GO:0008305 integrin complex(GO:0008305)
0.1 2.9 GO:0016459 myosin complex(GO:0016459)
0.1 4.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.5 GO:0005882 intermediate filament(GO:0005882)
0.0 0.8 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.0 GO:0043025 neuronal cell body(GO:0043025)
0.0 4.5 GO:0070382 exocytic vesicle(GO:0070382)
0.0 5.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 4.1 GO:0016607 nuclear speck(GO:0016607)
0.0 1.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 8.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 5.9 GO:0000785 chromatin(GO:0000785)
0.0 1.3 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 13.3 GO:0005576 extracellular region(GO:0005576)
0.0 2.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 6.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.5 GO:0042383 sarcolemma(GO:0042383)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
1.0 3.1 GO:0004001 adenosine kinase activity(GO:0004001)
0.9 4.3 GO:0017040 ceramidase activity(GO:0017040)
0.8 3.2 GO:0008410 CoA-transferase activity(GO:0008410)
0.8 3.0 GO:0016803 ether hydrolase activity(GO:0016803)
0.7 2.9 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.7 8.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.6 1.7 GO:0004903 growth hormone receptor activity(GO:0004903)
0.5 3.8 GO:0070888 E-box binding(GO:0070888)
0.5 4.7 GO:0008009 chemokine activity(GO:0008009) chemokine receptor binding(GO:0042379)
0.5 2.6 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.5 3.7 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.4 2.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.4 1.3 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.4 1.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 6.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 4.7 GO:0038191 neuropilin binding(GO:0038191)
0.3 1.8 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 2.8 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.3 2.4 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.3 3.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 0.8 GO:0008126 acetylesterase activity(GO:0008126)
0.3 7.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 1.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 1.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 3.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 4.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 8.1 GO:0032452 histone demethylase activity(GO:0032452)
0.2 2.8 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 6.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 4.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 11.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 3.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 3.0 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 1.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.2 5.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.2 6.6 GO:0015485 cholesterol binding(GO:0015485)
0.2 2.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 2.6 GO:0016018 cyclosporin A binding(GO:0016018)
0.2 1.1 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 4.9 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 4.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 6.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 4.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 1.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 1.4 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 0.3 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 3.0 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 1.8 GO:0005178 integrin binding(GO:0005178)
0.1 2.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.0 GO:0098631 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.1 1.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 1.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 44.0 GO:0001159 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 1.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 11.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.7 GO:0017022 myosin binding(GO:0017022)
0.0 0.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.9 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 1.0 GO:0005179 hormone activity(GO:0005179)
0.0 4.5 GO:0005543 phospholipid binding(GO:0005543)
0.0 8.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 5.6 GO:0003779 actin binding(GO:0003779)
0.0 5.6 GO:1990837 sequence-specific double-stranded DNA binding(GO:1990837)
0.0 0.9 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 1.0 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 3.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.9 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.8 GO:0005125 cytokine activity(GO:0005125)
0.0 1.1 GO:0003714 transcription corepressor activity(GO:0003714)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.3 2.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 5.5 NABA COLLAGENS Genes encoding collagen proteins
0.2 12.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 1.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 5.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.2 PID CD40 PATHWAY CD40/CD40L signaling
0.1 4.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 3.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID BMP PATHWAY BMP receptor signaling
0.0 0.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.0 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.6 3.0 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.3 2.6 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.3 2.4 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.3 1.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 5.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 2.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 0.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 0.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 1.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 0.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 2.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.9 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 2.6 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation