ISMARA results: sp1

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Results for sp1

Z-value: 4.19

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Transcription factors associated with sp1

Gene Symbol	Gene ID	Gene Info
sp1 NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000088347	sp1 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sp1	dr10_dc_chr11_-_28193_28230	-0.69	2.9e-03	Click!

Activity profile of sp1 motif

Sorted Z-values of sp1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of sp1

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Promoter	Score	Transcript	Gene	Gene Info
chr20_+_33391554 Show fit	14.47	ENSDART00000024104	mycn NCBI UniProt ZFIN ENSEMBL Google Show fit	MYCN proto-oncogene, bHLH transcription factor
chr13_+_11913290 Show fit	12.65	ENSDART00000079398	gng2 NCBI UniProt ZFIN ENSEMBL Google Show fit	guanine nucleotide binding protein (G protein), gamma 2
chr16_-_46799406 Show fit	11.61	ENSDART00000115244	MEX3A NCBI UniProt ZFIN ENSEMBL Google Show fit	mex-3 RNA binding family member A
chr5_-_43896815 Show fit	10.95	ENSDART00000110076	gas1a NCBI UniProt ZFIN ENSEMBL Google Show fit	growth arrest-specific 1a
chr18_-_41660821 Show fit	10.64	ENSDART00000024087	fzd9b NCBI UniProt ZFIN ENSEMBL Google Show fit	frizzled class receptor 9b
chr3_+_22412059 Show fit	10.39
chr19_-_32214978 Show fit	10.04	ENSDART00000103640	hey1 NCBI UniProt ZFIN ENSEMBL Google Show fit	hes-related family bHLH transcription factor with YRPW motif 1
chr16_+_46327528 Show fit	9.80	ENSDART00000040769	nr2f5 NCBI UniProt ZFIN ENSEMBL Google Show fit	nuclear receptor subfamily 2, group F, member 5
chr10_+_4094568 Show fit	9.71	ENSDART00000114533	mn1a NCBI UniProt ZFIN ENSEMBL Google Show fit	meningioma 1a
chr22_+_13862110 Show fit	9.46	ENSDART00000105711	sh3bp4a NCBI UniProt ZFIN ENSEMBL Google Show fit	SH3-domain binding protein 4a

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	28.8	GO:0048010	vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.6	22.9	GO:0050772	positive regulation of axonogenesis(GO:0050772)
0.5	21.9	GO:0007050	cell cycle arrest(GO:0007050)
0.2	20.9	GO:0043062	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
1.0	17.1	GO:0032526	response to retinoic acid(GO:0032526)
0.3	16.2	GO:0035567	non-canonical Wnt signaling pathway(GO:0035567)
0.7	15.1	GO:0030878	thyroid gland development(GO:0030878)
0.1	13.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
4.4	13.1	GO:0070587	regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
1.8	12.3	GO:0021628	olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)

Showing 1 to 10 of 302 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	86.0	GO:0016021	integral component of membrane(GO:0016021)
0.1	51.6	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	49.2	GO:0005615	extracellular space(GO:0005615)
0.5	38.1	GO:0005882	intermediate filament(GO:0005882)
0.2	32.5	GO:0043235	receptor complex(GO:0043235)
0.2	21.1	GO:0030424	axon(GO:0030424)
1.9	20.7	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
0.4	19.7	GO:0042641	actomyosin(GO:0042641)
0.3	17.6	GO:0005581	collagen trimer(GO:0005581)
0.3	15.6	GO:0005871	kinesin complex(GO:0005871)

Showing 1 to 10 of 113 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	90.1	GO:0046983	protein dimerization activity(GO:0046983)
0.0	51.0	GO:0000976	transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.5	30.4	GO:0005201	extracellular matrix structural constituent(GO:0005201)
1.4	24.7	GO:0005112	Notch binding(GO:0005112)
0.1	24.1	GO:0003779	actin binding(GO:0003779)
0.3	23.6	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.3	22.9	GO:0042802	identical protein binding(GO:0042802)
1.7	20.7	GO:0031681	G-protein beta-subunit binding(GO:0031681)
1.1	20.6	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.3	18.4	GO:0045296	cadherin binding(GO:0045296)

Showing 1 to 10 of 229 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	22.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.6	20.9	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.8	17.7	NABA COLLAGENS	Genes encoding collagen proteins
0.4	14.7	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.3	9.2	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.3	9.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.3	8.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.7	8.1	PID IL27 PATHWAY	IL27-mediated signaling events
0.5	7.6	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.2	7.4	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta

Showing 1 to 10 of 54 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	23.0	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5	16.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.6	14.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.5	14.3	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.6	12.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.9	12.1	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.3	12.1	REACTOME AMYLOIDS	Genes involved in Amyloids
1.2	11.8	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.1	10.0	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	10.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation

Showing 1 to 10 of 83 entries

Results for sp1

Z-value: 4.19

Motif logo

Transcription factors associated with sp1

Activity-expression correlation:

Activity profile of sp1 motif

Sorted Z-values of sp1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of sp1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: