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Results for sp2
Z-value: 1.93
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Transcription factors associated with sp2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| sp2 | dr10_dc_chr11_-_12024136_12024158 | 0.84 | 4.5e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of sp2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_2401636 Show fit | 6.06 |
ENSDART00000013506
|
zona pellucida glycoprotein 3, tandem duplicate 2 |
|
| chr20_+_34088917 Show fit | 5.90 |
ENSDART00000061744
|
zona pellucida glycoprotein 3a, tandem duplicate 1 |
|
| chr17_-_2396632 Show fit | 5.84 |
ENSDART00000074181
|
zona pellucida glycoprotein 3, tandem duplicate 2 |
|
| chr18_+_14308032 Show fit | 5.55 |
|
|
|
| chr25_+_22222388 Show fit | 5.44 |
ENSDART00000154376
|
cytochrome P450, family 11, subfamily A, polypeptide 1 |
|
| chr16_-_52847564 Show fit | 5.36 |
ENSDART00000147236
|
antizyme inhibitor 1a |
|
| chr22_+_818795 Show fit | 5.11 |
ENSDART00000003325
|
DENN/MADD domain containing 2Db |
|
| chr15_+_25554119 Show fit | 4.82 |
ENSDART00000162482
|
zgc:152863 |
|
| chr20_+_34084660 Show fit | 4.18 |
ENSDART00000061751
|
zona pellucida glycoprotein 3a, tandem duplicate 2 |
|
| chr17_-_45021393 Show fit | 4.15 |
|
|
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 23.2 | GO:0060046 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 1.8 | 8.8 | GO:0010922 | positive regulation of phosphatase activity(GO:0010922) positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
| 2.9 | 8.6 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
| 2.5 | 7.5 | GO:1902267 | polyamine transport(GO:0015846) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269) |
| 1.0 | 7.3 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.5 | 6.9 | GO:0046716 | muscle cell cellular homeostasis(GO:0046716) |
| 0.1 | 6.4 | GO:0071559 | transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560) |
| 0.9 | 5.4 | GO:0000103 | sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 0.0 | 5.3 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.3 | 4.4 | GO:0032958 | inositol phosphate biosynthetic process(GO:0032958) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.5 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 12.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.5 | 8.8 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 7.3 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 5.7 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 1.3 | 3.8 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.1 | 3.8 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 3.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 3.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 3.4 | GO:0043296 | apical junction complex(GO:0043296) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 23.2 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 2.9 | 8.6 | GO:0016713 | cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713) |
| 2.5 | 7.5 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 0.2 | 7.3 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.1 | 7.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 2.1 | 6.3 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) type I transforming growth factor beta receptor binding(GO:0034713) |
| 0.9 | 5.4 | GO:0004779 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.1 | 4.6 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.4 | 4.4 | GO:0000828 | inositol hexakisphosphate kinase activity(GO:0000828) |
| 0.3 | 3.8 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 7.3 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.2 | 6.9 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 4.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 2.5 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 2.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 2.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.2 | 1.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 0.7 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 8.6 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.4 | 7.3 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.2 | 4.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 4.2 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.2 | 2.8 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 2.8 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.4 | 2.7 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 1.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 1.7 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.2 | 1.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |