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DANIO-CODE

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Results for sp2

Z-value: 1.93

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Transcription factors associated with sp2

Gene Symbol Gene ID Gene Info
sp2
ENSDARG00000076763 sp2 transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sp2dr10_dc_chr11_-_12024136_120241580.844.5e-05Click!

Activity profile of sp2 motif

Sorted Z-values of sp2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of sp2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_-_2401636 6.06 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr20_+_34088917 5.90 ENSDART00000061744
zp3a.1
zona pellucida glycoprotein 3a, tandem duplicate 1
chr17_-_2396632 5.84 ENSDART00000074181
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr18_+_14308032 5.55

chr25_+_22222388 5.44 ENSDART00000154376
cyp11a1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr16_-_52847564 5.36 ENSDART00000147236
azin1a
antizyme inhibitor 1a
chr22_+_818795 5.11 ENSDART00000003325
dennd2db
DENN/MADD domain containing 2Db
chr15_+_25554119 4.82 ENSDART00000162482
zgc:152863
zgc:152863
chr20_+_34084660 4.18 ENSDART00000061751
zp3a.2
zona pellucida glycoprotein 3a, tandem duplicate 2
chr17_-_45021393 4.15

chr20_-_44678938 4.09 ENSDART00000148639
ubxn2a
UBX domain protein 2A
chr16_-_39655528 3.78 ENSDART00000146301
tgfbr2b
transforming growth factor beta receptor 2b
chr3_+_51430252 3.77 ENSDART00000159493
baiap2a
BAI1-associated protein 2a
chr5_-_29480173 3.70 ENSDART00000140049
bco2a
beta-carotene oxygenase 2a
chr16_+_25344257 3.58 ENSDART00000058938
fbxo32
F-box protein 32
chr8_-_37989930 3.34

chr22_+_866803 3.33 ENSDART00000140588
stk38b
serine/threonine kinase 38b
chr19_+_26756510 3.28 ENSDART00000013497
mylipa
myosin regulatory light chain interacting protein a
chr15_-_43283562 3.26 ENSDART00000110352
ap1s3a
adaptor-related protein complex 1, sigma 3 subunit, a
chr25_+_22222336 3.12 ENSDART00000154065
cyp11a1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr21_+_28710341 3.06 ENSDART00000014058
zgc:100829
zgc:100829
chr19_-_27185558 3.05 ENSDART00000043776
ENSDART00000168777
ENSDART00000159489
prrc2a
proline-rich coiled-coil 2A
chr7_+_13742576 3.03

chr11_+_33154781 3.03

chr14_-_47125993 3.02 ENSDART00000124925
si:ch211-235e9.8
si:ch211-235e9.8
chr21_+_21242470 2.97 ENSDART00000148346
itpkca
inositol-trisphosphate 3-kinase Ca
chr24_+_41991604 2.86

chr17_-_23689233 2.85 ENSDART00000124661
papss2a
3'-phosphoadenosine 5'-phosphosulfate synthase 2a
chr18_+_46153484 2.77 ENSDART00000015034
blvrb
biliverdin reductase B
chr3_-_36298676 2.71 ENSDART00000157950
rogdi
rogdi homolog (Drosophila)
chr7_+_1337856 2.71 ENSDART00000050687
lpcat4
lysophosphatidylcholine acyltransferase 4
chr2_-_56848527 2.65 ENSDART00000164330
CU634008.1
ENSDARG00000100430
chr3_+_29338315 2.65 ENSDART00000103592
fam83fa
family with sequence similarity 83, member Fa
chr3_+_16692138 2.61 ENSDART00000023985
zgc:153952
zgc:153952
chr13_-_31267133 2.59 ENSDART00000008287
pgam1a
phosphoglycerate mutase 1a
chr12_-_17370920 2.56 ENSDART00000130735
minpp1b
multiple inositol-polyphosphate phosphatase 1b
chr16_-_39655605 2.52 ENSDART00000146301
tgfbr2b
transforming growth factor beta receptor 2b
chr20_-_194135 2.50 ENSDART00000064546
si:ch211-241j12.3
si:ch211-241j12.3
chr7_+_71263100 2.49 ENSDART00000100396
ppp1r15a
protein phosphatase 1, regulatory subunit 15A
chr23_+_30971404 2.48 ENSDART00000146859
cables2a
Cdk5 and Abl enzyme substrate 2a
chr19_+_14132374 2.44 ENSDART00000164696
tmem222b
transmembrane protein 222b
chr3_+_25776714 2.43 ENSDART00000170324
tom1
target of myb1 membrane trafficking protein
chr24_+_9898743 2.42 ENSDART00000144186
pou6f2
POU class 6 homeobox 2
chr10_+_15644868 2.41 ENSDART00000139259
zfand5b
zinc finger, AN1-type domain 5b
chr6_-_12687107 2.40 ENSDART00000155360
CU639412.1
ENSDARG00000096929
chr18_+_27095471 2.39 ENSDART00000125326
ENSDART00000098334
ppp1r15b
protein phosphatase 1, regulatory subunit 15B
chr20_-_14885722 2.38 ENSDART00000160481
suco
SUN domain containing ossification factor
chr18_-_26732762 2.36 ENSDART00000142043
malt3
MALT paracaspase 3
chr6_+_3174047 2.33 ENSDART00000160290
st3gal3a
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr10_+_33439121 2.33 ENSDART00000063662
mdh2
malate dehydrogenase 2, NAD (mitochondrial)
chr25_+_4508802 2.29 ENSDART00000021120
pgghg
protein-glucosylgalactosylhydroxylysine glucosidase
chr18_-_35861482 2.27 ENSDART00000088488
opa3
optic atrophy 3
chr2_+_25212281 2.26 ENSDART00000078838
rab3aa
RAB3A, member RAS oncogene family, a
chr5_-_12242927 2.24 ENSDART00000137705
lztr1
leucine-zipper-like transcription regulator 1
chr7_-_45579815 2.22 ENSDART00000170224
shcbp1
SHC SH2-domain binding protein 1
KN150460v1_-_33517 2.22

chr7_+_13742622 2.15

chr16_-_52847642 2.13 ENSDART00000147236
azin1a
antizyme inhibitor 1a
chr19_+_14132473 2.13 ENSDART00000164696
tmem222b
transmembrane protein 222b
chr10_-_625501 2.12 ENSDART00000041236
ENSDART00000144882
rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr11_-_16261061 2.11 ENSDART00000115085
lrig1
leucine-rich repeats and immunoglobulin-like domains 1
chr16_+_25344184 2.10 ENSDART00000058938
fbxo32
F-box protein 32
chr21_+_37760978 2.09 ENSDART00000145828
pgk1
phosphoglycerate kinase 1
chr18_-_35485549 2.08 ENSDART00000141023
itpkcb
inositol-trisphosphate 3-kinase Cb
chr5_+_60677040 2.08 ENSDART00000009507
gatsl2
GATS protein-like 2
chr12_-_23244600 2.08 ENSDART00000170376
mpp7a
membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7)
chr6_+_41506220 2.07 ENSDART00000136538
cish
cytokine inducible SH2-containing protein
chr23_+_30971437 2.06 ENSDART00000146859
cables2a
Cdk5 and Abl enzyme substrate 2a
chr22_-_26537845 2.05

chr19_-_44161951 2.03 ENSDART00000058491
ppt1
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr6_+_41506350 1.99 ENSDART00000136538
cish
cytokine inducible SH2-containing protein
KN149861v1_-_6089 1.99

chr7_+_73635687 1.96 ENSDART00000160288
FP236812.6
Histone H2B 1/2
chr10_+_18953503 1.93 ENSDART00000030205
bnip3lb
BCL2/adenovirus E1B interacting protein 3-like b
chr16_+_9822930 1.90 ENSDART00000164103
ecm1b
extracellular matrix protein 1b
chr12_+_46641510 1.89 ENSDART00000008009
trim16
tripartite motif containing 16
chr4_-_5786680 1.88 ENSDART00000039987
pgm3
phosphoglucomutase 3
chr14_+_25950244 1.87 ENSDART00000113804
ENSDART00000159054
CCDC69
coiled-coil domain containing 69
chr7_+_54811566 1.86 ENSDART00000073549
snai3
snail family zinc finger 3
KN149861v1_-_5655 1.86

chr7_+_71262845 1.85 ENSDART00000100396
ppp1r15a
protein phosphatase 1, regulatory subunit 15A
chr9_-_54359431 1.84 ENSDART00000171986
cog3
component of oligomeric golgi complex 3
chr13_-_17729510 1.83 ENSDART00000170583
march8
membrane-associated ring finger (C3HC4) 8
chr3_+_48607256 1.81 ENSDART00000168449
raver1
ribonucleoprotein, PTB-binding 1
chr20_+_791374 1.81 ENSDART00000137135
mei4
meiosis-specific, MEI4 homolog (S. cerevisiae)
chr3_+_16692090 1.79 ENSDART00000023985
zgc:153952
zgc:153952
chr7_+_54811485 1.79 ENSDART00000073549
snai3
snail family zinc finger 3
chr14_+_11803542 1.77 ENSDART00000121913
kctd12b
potassium channel tetramerisation domain containing 12b
chr25_+_16259634 1.77 ENSDART00000136454
tead1a
TEA domain family member 1a
chr18_-_35861412 1.75 ENSDART00000088488
opa3
optic atrophy 3
chr18_+_27095398 1.74 ENSDART00000125326
ENSDART00000098334
ppp1r15b
protein phosphatase 1, regulatory subunit 15B
chr6_+_25271735 1.74 ENSDART00000159978
ENSDART00000161545
ENSDART00000160978
ccbl2
cysteine conjugate-beta lyase 2
chr16_-_17678748 1.74 ENSDART00000017142
m6pr
mannose-6-phosphate receptor (cation dependent)
chr11_-_40239946 1.71 ENSDART00000165394
si:dkeyp-61b2.1
si:dkeyp-61b2.1
chr17_+_16600773 1.70

chr15_-_25158558 1.68 ENSDART00000142609
exo5
exonuclease 5
chr22_-_111800 1.68 ENSDART00000163198
ENSDART00000168678
capzb
capping protein (actin filament) muscle Z-line, beta
chr7_+_73635733 1.67 ENSDART00000160288
FP236812.6
Histone H2B 1/2
chr21_+_28710424 1.67 ENSDART00000014058
zgc:100829
zgc:100829
chr21_+_28710269 1.65 ENSDART00000014058
zgc:100829
zgc:100829
chr6_+_41506446 1.62 ENSDART00000140108
cish
cytokine inducible SH2-containing protein
chr6_+_41506504 1.62 ENSDART00000084861
cish
cytokine inducible SH2-containing protein
chr13_-_11888944 1.59 ENSDART00000125430
pprc1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr2_-_6139833 1.58 ENSDART00000147509
si:ch211-284b7.3
si:ch211-284b7.3
chr14_+_28239200 1.58 ENSDART00000125362
hmmr
hyaluronan-mediated motility receptor (RHAMM)
chr17_-_6797833 1.56 ENSDART00000109228
zbtb24
zinc finger and BTB domain containing 24
chr19_+_1298795 1.55 ENSDART00000113368
RNF5
ring finger protein 5
chr16_-_2632781 1.54 ENSDART00000148543
cdcp1a
CUB domain containing protein 1a
chr10_-_43874646 1.50 ENSDART00000025366
cetn3
centrin 3
chr13_-_26668719 1.50 ENSDART00000139264
vrk2
vaccinia related kinase 2
chr8_+_23144448 1.50 ENSDART00000063057
dnajc5aa
DnaJ (Hsp40) homolog, subfamily C, member 5aa
chr19_-_48327666 1.49

chr17_+_44642582 1.48 ENSDART00000153773
cipca
CLOCK-interacting pacemaker a
chr16_+_9823111 1.47 ENSDART00000164103
ecm1b
extracellular matrix protein 1b
chr22_-_20378023 1.47 ENSDART00000010048
map2k2a
mitogen-activated protein kinase kinase 2a
chr12_-_37274632 1.47 ENSDART00000152951
cdc42ep4b
CDC42 effector protein (Rho GTPase binding) 4b
chr20_-_14885768 1.46 ENSDART00000160481
suco
SUN domain containing ossification factor
chr16_-_54303076 1.46

chr15_-_25158683 1.46 ENSDART00000129154
exo5
exonuclease 5
chr8_-_37989415 1.45 ENSDART00000067809
rab11fip1a
RAB11 family interacting protein 1 (class I) a
chr9_+_22866612 1.45 ENSDART00000131429
ENSDART00000080005
itgb5
integrin, beta 5
chr23_-_33396673 1.43

chr19_+_2834491 1.42 ENSDART00000112414
rapgef5a
Rap guanine nucleotide exchange factor (GEF) 5a
chr13_-_44671682 1.40 ENSDART00000099984
glo1
glyoxalase 1
chr15_-_25499679 1.40 ENSDART00000112079
tlcd2
TLC domain containing 2
chr8_-_37989317 1.39 ENSDART00000067809
rab11fip1a
RAB11 family interacting protein 1 (class I) a
chr20_+_36917979 1.39 ENSDART00000153085
heca
hdc homolog, cell cycle regulator
chr20_+_46837436 1.38 ENSDART00000145294
ENSDARG00000022260
ENSDARG00000022260
chr17_-_23689380 1.38 ENSDART00000124661
papss2a
3'-phosphoadenosine 5'-phosphosulfate synthase 2a
chr14_+_25950198 1.37 ENSDART00000113804
ENSDART00000159054
CCDC69
coiled-coil domain containing 69
chr9_-_9754243 1.33 ENSDART00000092884
lrrc58b
leucine rich repeat containing 58b
chr13_+_969851 1.32 ENSDART00000139560
ppp3r1a
protein phosphatase 3, regulatory subunit B, alpha a
chr4_+_71390404 1.30 ENSDART00000174116
zgc:152938
zgc:152938
chr23_-_14118530 1.30 ENSDART00000139406
g6pd
glucose-6-phosphate dehydrogenase
chr5_-_34664282 1.29 ENSDART00000114981
ENSDART00000051279
ptcd2
pentatricopeptide repeat domain 2
chr7_+_38690837 1.29 ENSDART00000173565
dgkza
diacylglycerol kinase, zeta a
chr10_+_37556367 1.29 ENSDART00000135642
msi2a
musashi RNA-binding protein 2a
chr22_-_5888816 1.28 ENSDART00000141373
si:rp71-36a1.1
si:rp71-36a1.1
chr19_+_26756595 1.25 ENSDART00000013497
mylipa
myosin regulatory light chain interacting protein a
chr19_-_8849482 1.25 ENSDART00000170416
si:ch73-350k19.1
si:ch73-350k19.1
chr16_+_25344336 1.25 ENSDART00000058938
fbxo32
F-box protein 32
chr16_+_41065840 1.25 ENSDART00000124543
dek
DEK proto-oncogene
chr12_-_9094888 1.24 ENSDART00000066471
adam8b
ADAM metallopeptidase domain 8b
chr11_+_19208363 1.23 ENSDART00000165906
prickle2b
prickle homolog 2b
chr5_+_25474996 1.22 ENSDART00000098473
klf9
Kruppel-like factor 9
chr17_-_23689317 1.22 ENSDART00000124661
papss2a
3'-phosphoadenosine 5'-phosphosulfate synthase 2a
chr9_-_705001 1.22 ENSDART00000147092
cflarb
CASP8 and FADD-like apoptosis regulator b
chr3_+_14349244 1.21 ENSDART00000162853
tmem205
transmembrane protein 205
KN150289v1_-_7882 1.20

chr15_+_29460803 1.20 ENSDART00000155198
gdpd5b
glycerophosphodiester phosphodiesterase domain containing 5b
chr17_-_2401568 1.20 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr12_+_17370986 1.19

chr16_-_52090636 1.19 ENSDART00000155308
FO704712.1
ENSDARG00000063300
chr13_-_44885278 1.19 ENSDART00000159021
khdrbs1a
KH domain containing, RNA binding, signal transduction associated 1a
chr20_+_54525159 1.18 ENSDART00000160409
arf6a
ADP-ribosylation factor 6a
chr3_+_35682529 1.17 ENSDART00000075903
crlf3
cytokine receptor-like factor 3
chr12_-_4596004 1.16 ENSDART00000160617
prr12a
proline rich 12a
chr25_+_18910528 1.13 ENSDART00000104420
samm50
SAMM50 sorting and assembly machinery component
chr9_+_24014550 1.13 ENSDART00000138470
ints6
integrator complex subunit 6
chr3_-_36298866 1.10 ENSDART00000162875
rogdi
rogdi homolog (Drosophila)
chr17_-_2544896 1.10 ENSDART00000109582
spata7
spermatogenesis associated 7
chr2_+_26002522 1.09 ENSDART00000051234
tnika
TRAF2 and NCK interacting kinase a
chr12_-_14172962 1.09 ENSDART00000158399
avl9
AVL9 homolog (S. cerevisiase)
chr20_+_46837276 1.07 ENSDART00000145294
ENSDARG00000022260
ENSDARG00000022260
chr16_+_9822879 1.07 ENSDART00000164103
ecm1b
extracellular matrix protein 1b
chr13_-_37043725 1.06

chr14_+_32924455 1.06 ENSDART00000075187
pdzd11
PDZ domain containing 11
chr7_+_37978605 1.06 ENSDART00000150158
si:dkey-78a14.4
si:dkey-78a14.4
chr3_+_35682500 1.06 ENSDART00000075903
crlf3
cytokine receptor-like factor 3
chr22_-_3740362 1.04

chr25_+_3381632 1.03 ENSDART00000157777
zgc:153293
zgc:153293
chr8_-_41271389 1.02 ENSDART00000170332
pop5
POP5 homolog, ribonuclease P/MRP subunit
chr21_-_43402921 1.02 ENSDART00000166530
ccni2
cyclin I family, member 2
chr12_+_31379514 1.02 ENSDART00000153390
gpam
glycerol-3-phosphate acyltransferase, mitochondrial
chr12_-_17370608 1.01 ENSDART00000012421
ENSDART00000138766
minpp1b
multiple inositol-polyphosphate phosphatase 1b
chr15_-_5912917 1.00

chr4_+_248611 0.99

chr9_-_54359465 0.98 ENSDART00000171986
cog3
component of oligomeric golgi complex 3
chr7_+_6630115 0.97

chr13_+_48475352 0.97 ENSDART00000165051
CU651669.1
ENSDARG00000101069
chr20_-_1248089 0.96 ENSDART00000027119
lats1
large tumor suppressor kinase 1
chr21_+_15505169 0.96 ENSDART00000011318
smarcb1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr13_-_42598533 0.95 ENSDART00000160472
capn1a
calpain 1, (mu/I) large subunit a
chr7_+_22521055 0.95 ENSDART00000146801
rbm4.3
RNA binding motif protein 4.3
chr19_+_7072033 0.93 ENSDART00000158758
ENSDART00000160482
kifc1
kinesin family member C1
chr20_+_32321484 0.93 ENSDART00000147448
sesn1
sestrin 1
chr5_+_31179228 0.93 ENSDART00000098163
slc25a25b
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25b
chr5_+_22632955 0.93 ENSDART00000178821
prps1a
phosphoribosyl pyrophosphate synthetase 1A
chr17_+_44642465 0.92 ENSDART00000153773
cipca
CLOCK-interacting pacemaker a
chr8_+_2398268 0.91 ENSDART00000133938
ENSDART00000002764
polb
polymerase (DNA directed), beta
chr13_-_11888896 0.91 ENSDART00000125430
pprc1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr4_+_19545425 0.91 ENSDART00000140028
lrrc4.1
leucine rich repeat containing 4.1
chr17_-_52233071 0.90

chr22_+_866633 0.88 ENSDART00000140588
stk38b
serine/threonine kinase 38b
chr12_-_14173331 0.88 ENSDART00000158399
avl9
AVL9 homolog (S. cerevisiase)
chr5_-_12586284 0.86 ENSDART00000051664
ypel1
yippee-like 1
chr20_+_791328 0.86 ENSDART00000137135
mei4
meiosis-specific, MEI4 homolog (S. cerevisiae)
chr20_-_43889302 0.85 ENSDART00000004601
laptm4a
lysosomal protein transmembrane 4 alpha
chr5_+_2440622 0.85 ENSDART00000169404
hspa5
heat shock protein 5
chr15_-_44581550 0.85

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.6 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
2.5 7.5 GO:1902267 polyamine transport(GO:0015846) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269)
1.8 8.8 GO:0010922 positive regulation of phosphatase activity(GO:0010922) positive regulation of phosphoprotein phosphatase activity(GO:0032516)
1.4 23.2 GO:0060046 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
1.2 3.7 GO:0016121 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
1.0 7.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.9 5.4 GO:0000103 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.8 2.4 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.6 1.9 GO:0045822 negative regulation of heart contraction(GO:0045822) negative regulation of blood circulation(GO:1903523)
0.6 2.3 GO:0048790 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.5 3.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.5 6.9 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.5 3.8 GO:0046850 regulation of bone remodeling(GO:0046850)
0.5 3.8 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249) positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.5 1.4 GO:0055091 phospholipid homeostasis(GO:0055091)
0.4 2.1 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.4 1.1 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.3 2.3 GO:0006108 malate metabolic process(GO:0006108)
0.3 0.9 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.3 4.1 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.3 3.7 GO:0008089 anterograde axonal transport(GO:0008089)
0.3 4.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.2 4.4 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.2 0.7 GO:0039535 cytoplasmic pattern recognition receptor signaling pathway in response to virus(GO:0039528) RIG-I signaling pathway(GO:0039529) regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039531) regulation of RIG-I signaling pathway(GO:0039535) cellular response to virus(GO:0098586)
0.2 1.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 1.7 GO:0006622 protein targeting to lysosome(GO:0006622)
0.2 2.1 GO:0050796 regulation of insulin secretion(GO:0050796)
0.2 2.1 GO:0031269 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.2 0.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 1.3 GO:1902743 regulation of lamellipodium assembly(GO:0010591) regulation of lamellipodium organization(GO:1902743)
0.2 1.0 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.2 2.0 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 1.2 GO:0036010 protein localization to endosome(GO:0036010)
0.1 1.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.8 GO:0042026 protein refolding(GO:0042026)
0.1 1.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 0.4 GO:0070849 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.1 0.6 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.1 1.5 GO:0097499 protein localization to nonmotile primary cilium(GO:0097499)
0.1 1.0 GO:0003139 secondary heart field specification(GO:0003139)
0.1 0.9 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 3.1 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 1.0 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 2.0 GO:0046651 mononuclear cell proliferation(GO:0032943) T cell proliferation(GO:0042098) lymphocyte proliferation(GO:0046651) leukocyte proliferation(GO:0070661)
0.1 2.6 GO:0050879 multicellular organismal movement(GO:0050879) musculoskeletal movement(GO:0050881)
0.1 6.4 GO:0071559 transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.1 1.8 GO:0035329 hippo signaling(GO:0035329)
0.1 0.8 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.1 1.5 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.1 1.6 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.1 2.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 0.7 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.3 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.1 0.9 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 0.7 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 0.7 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1 0.2 GO:0046655 folic acid metabolic process(GO:0046655)
0.0 1.1 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.1 GO:0010586 miRNA metabolic process(GO:0010586)
0.0 0.5 GO:0090148 membrane fission(GO:0090148)
0.0 2.6 GO:0006096 glycolytic process(GO:0006096)
0.0 1.2 GO:0051904 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 1.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.1 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.0 1.2 GO:2000779 regulation of double-strand break repair(GO:2000779)
0.0 0.5 GO:0014812 muscle cell migration(GO:0014812)
0.0 2.8 GO:0045055 regulated exocytosis(GO:0045055)
0.0 0.2 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 0.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.8 GO:0007338 single fertilization(GO:0007338)
0.0 0.5 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 1.7 GO:0032147 activation of protein kinase activity(GO:0032147)
0.0 5.3 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.7 GO:0051014 actin filament severing(GO:0051014)
0.0 0.2 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.2 GO:0030073 insulin secretion(GO:0030073)
0.0 2.2 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 0.9 GO:0060972 left/right pattern formation(GO:0060972)
0.0 2.4 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 1.2 GO:0003401 axis elongation(GO:0003401)
0.0 0.2 GO:0015961 diadenosine polyphosphate metabolic process(GO:0015959) diadenosine polyphosphate catabolic process(GO:0015961)
0.0 0.9 GO:0090307 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.0 1.4 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.7 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.5 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 2.3 GO:0031099 regeneration(GO:0031099)
0.0 0.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.6 GO:0001841 neural tube formation(GO:0001841)
0.0 0.7 GO:0016575 histone deacetylation(GO:0016575)
0.0 2.7 GO:0006644 phospholipid metabolic process(GO:0006644)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0043291 RAVE complex(GO:0043291)
1.1 3.3 GO:0000800 lateral element(GO:0000800)
0.5 8.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 0.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 1.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 2.8 GO:0017119 Golgi transport complex(GO:0017119)
0.2 1.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.2 1.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.2 0.5 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.2 1.0 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 7.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.9 GO:0061700 GATOR2 complex(GO:0061700)
0.1 1.1 GO:0032039 integrator complex(GO:0032039)
0.1 20.5 GO:0031012 extracellular matrix(GO:0031012)
0.1 3.8 GO:0030175 filopodium(GO:0030175)
0.1 1.0 GO:0035060 brahma complex(GO:0035060)
0.1 3.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 5.7 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.7 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.3 GO:0005844 polysome(GO:0005844)
0.0 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 1.5 GO:0008305 integrin complex(GO:0008305)
0.0 0.5 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.1 GO:1990879 CST complex(GO:1990879)
0.0 1.7 GO:0001726 ruffle(GO:0001726)
0.0 3.4 GO:0043296 apical junction complex(GO:0043296)
0.0 3.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.3 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 1.5 GO:0005930 axoneme(GO:0005930)
0.0 0.2 GO:0035859 Seh1-associated complex(GO:0035859)
0.0 1.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.8 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.9 GO:0072686 mitotic spindle(GO:0072686)
0.0 12.4 GO:0005739 mitochondrion(GO:0005739)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.6 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
2.6 23.2 GO:0035804 structural constituent of egg coat(GO:0035804)
2.5 7.5 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
2.1 6.3 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026) type I transforming growth factor beta receptor binding(GO:0034713)
1.2 3.7 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
1.2 3.6 GO:0034417 bisphosphoglycerate 3-phosphatase activity(GO:0034417)
0.9 5.4 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.8 3.1 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.8 2.3 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.6 2.3 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.4 2.6 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.4 4.4 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.3 2.1 GO:0043531 ADP binding(GO:0043531)
0.3 1.1 GO:0033204 ribonuclease P RNA binding(GO:0033204)
0.3 1.1 GO:0008022 protein C-terminus binding(GO:0008022)
0.3 3.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 0.8 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.2 1.7 GO:0005537 mannose binding(GO:0005537)
0.2 7.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 0.9 GO:0051499 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.2 0.9 GO:0042287 MHC protein binding(GO:0042287)
0.2 0.7 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.2 1.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 1.0 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.2 1.0 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 2.3 GO:0015926 glucosidase activity(GO:0015926)
0.1 0.3 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.1 1.9 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 1.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 2.0 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.9 GO:0070728 leucine binding(GO:0070728)
0.1 0.7 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 1.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.7 GO:0008143 poly(A) binding(GO:0008143)
0.1 1.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.2 GO:0047710 bis(5'-adenosyl)-triphosphatase activity(GO:0047710)
0.1 7.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 4.6 GO:0043130 ubiquitin binding(GO:0043130)
0.1 1.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.6 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.7 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 3.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.6 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.8 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.7 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.7 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 2.4 GO:0030276 clathrin binding(GO:0030276)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.9 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.5 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.1 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 1.2 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 2.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.2 GO:0015248 sterol transporter activity(GO:0015248)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.2 1.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 6.9 PID FOXO PATHWAY FoxO family signaling
0.1 4.1 PID BMP PATHWAY BMP receptor signaling
0.1 0.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.1 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.5 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 0.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 2.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 2.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 8.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.4 2.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.4 7.3 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.2 2.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 1.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 0.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 4.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 4.2 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 0.9 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 0.7 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 0.6 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 0.7 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 0.9 REACTOME KINESINS Genes involved in Kinesins
0.1 1.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 2.8 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 1.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events