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DANIO-CODE
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Results for spi2
Z-value: 2.48
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Transcription factors associated with spi2
Network of associatons between targets according to the STRING database.
First level regulatory network of spi2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_46426385 Show fit | 6.70 |
ENSDART00000141331
|
si:ch73-59c19.1 |
|
| chr2_-_38305602 Show fit | 6.44 |
ENSDART00000061677
|
si:ch211-14a17.6 |
|
| chr12_+_13053552 Show fit | 5.86 |
ENSDART00000124799
|
si:ch211-103b1.2 |
|
| chr9_+_8429700 Show fit | 5.24 |
ENSDART00000144373
|
zgc:153499 |
|
| chr23_+_25062876 Show fit | 4.96 |
ENSDART00000145307
ENSDART00000172299 |
Rho GTPase activating protein 4a |
|
| chr2_+_30199024 Show fit | 4.88 |
ENSDART00000004903
|
retinol dehydrogenase 10b |
|
| chr5_-_15971338 Show fit | 4.78 |
ENSDART00000110437
|
piwi-like RNA-mediated gene silencing 2 |
|
| chr13_-_18564182 Show fit | 4.71 |
ENSDART00000176809
|
sideroflexin 3 |
|
| chr19_-_11486056 Show fit | 4.66 |
ENSDART00000109889
ENSDART00000172065 |
heat shock factor binding protein 1 like 1 |
|
| chr13_+_22973764 Show fit | 4.48 |
ENSDART00000110266
|
phosphoinositide-3-kinase adaptor protein 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 10.1 | GO:2000480 | regulation of cAMP-dependent protein kinase activity(GO:2000479) negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 9.8 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.9 | 8.9 | GO:0070525 | tRNA threonylcarbamoyladenosine metabolic process(GO:0070525) |
| 0.8 | 8.1 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 2.1 | 6.4 | GO:0070370 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 0.4 | 6.4 | GO:0035803 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.3 | 6.3 | GO:0006896 | Golgi to vacuole transport(GO:0006896) |
| 0.4 | 6.2 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.4 | 5.8 | GO:0030011 | maintenance of cell polarity(GO:0030011) maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.1 | 5.7 | GO:0030336 | negative regulation of cell migration(GO:0030336) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.0 | GO:0005764 | lysosome(GO:0005764) |
| 1.3 | 8.9 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 0.2 | 8.7 | GO:0005811 | lipid particle(GO:0005811) |
| 1.1 | 7.4 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.0 | 6.0 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 5.8 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.4 | 5.2 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 5.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.5 | 4.9 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.7 | 4.8 | GO:0071546 | pi-body(GO:0071546) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 10.1 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 8.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.0 | 8.1 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.1 | 7.2 | GO:0101005 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.3 | 6.9 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 6.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.4 | 6.4 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 6.4 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.3 | 6.3 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 6.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 5.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 4.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 3.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 2.6 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 2.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 2.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 2.2 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.2 | 1.9 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.4 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.8 | 5.8 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.3 | 5.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.4 | 5.4 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.2 | 4.7 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.2 | 4.7 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.2 | 4.5 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.3 | 4.1 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.5 | 3.9 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 3.9 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |