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Results for srebf2

Z-value: 1.28

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Transcription factors associated with srebf2

Gene Symbol Gene ID Gene Info
srebf2
ENSDARG00000063438 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
srebf2dr10_dc_chr3_+_1338347_13385470.758.2e-04Click!

Activity profile of srebf2 motif

Sorted Z-values of srebf2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of srebf2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_24747855 3.82 ENSDART00000111686
fhdc1
FH2 domain containing 1
chr16_-_29229687 3.66 ENSDART00000132589
mef2d
myocyte enhancer factor 2d
chr9_-_7560915 3.42 ENSDART00000081553
desma
desmin a
chr7_+_25649559 3.24 ENSDART00000026295
arrb2b
arrestin, beta 2b
chr21_+_28408329 3.21 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr7_+_39130411 3.09 ENSDART00000144750
tnni2b.1
troponin I type 2b (skeletal, fast), tandem duplicate 1
chr9_+_907908 3.08 ENSDART00000144114
dbi
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr13_-_33268447 2.99 ENSDART00000103628
btbd6a
BTB (POZ) domain containing 6a
chr10_+_4874841 2.80 ENSDART00000165942
palm2
paralemmin 2
chr22_-_13139894 2.75 ENSDART00000105762
ahr2
aryl hydrocarbon receptor 2
chr21_-_18969970 2.74 ENSDART00000080269
pgam2
phosphoglycerate mutase 2 (muscle)
chr21_-_1716495 2.55 ENSDART00000151049
onecut2
one cut homeobox 2
chr9_+_19087329 2.40 ENSDART00000110457
crfb1
cytokine receptor family member b1
chr3_-_60866373 2.32 ENSDART00000112043
cacng4b
calcium channel, voltage-dependent, gamma subunit 4b
chr13_-_2259405 2.29 ENSDART00000166456
elovl5
ELOVL fatty acid elongase 5
chr6_-_34974860 2.27 ENSDART00000113097
hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
chr2_+_19546837 2.26 ENSDART00000163137
elovl1a
ELOVL fatty acid elongase 1a
chr12_-_22888090 1.89 ENSDART00000111801
ENSDART00000149474
mkxa
mohawk homeobox a
chr23_-_20332076 1.87 ENSDART00000147326
lamb2
laminin, beta 2 (laminin S)
chr6_-_15630912 1.80 ENSDART00000063665
ackr3b
atypical chemokine receptor 3b
KN150108v1_+_18276 1.79

chr7_-_29811734 1.78 ENSDART00000075600
tspan3b
tetraspanin 3b
chr16_+_1302842 1.76

chr15_+_30276801 1.73 ENSDART00000047248
ENSDART00000123937
nlk2
nemo-like kinase, type 2
chr11_-_1792616 1.65

chr17_-_6580876 1.64 ENSDART00000157125
vsnl1b
visinin-like 1b
chr23_-_7740845 1.53 ENSDART00000172451
plagl2
pleiomorphic adenoma gene-like 2
chr3_-_35671276 1.51 ENSDART00000150911
caskin1
CASK interacting protein 1
chr4_-_44105748 1.47 ENSDART00000150621
znf1137
zinc finger protein 1137
chr16_-_204751 1.30

chr4_+_632652 1.27 ENSDART00000171138
xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr20_-_27412546 1.25 ENSDART00000148361
asb2a.1
ankyrin repeat and SOCS box containing 2a, tandem duplicate 1
chr9_-_30553051 1.24 ENSDART00000147030
sytl5
synaptotagmin-like 5
chr13_+_21695882 1.22 ENSDART00000165150
zswim8
zinc finger, SWIM-type containing 8
chr19_-_46058123 1.14

chr1_-_20132900 1.06 ENSDART00000054472
tll1
tolloid-like 1
chr24_-_28150352 1.05 ENSDART00000145290
bcl2a
B-cell CLL/lymphoma 2a
chr3_+_23590779 1.04 ENSDART00000012470
hoxb4a
homeobox B4a
chr25_-_4296732 1.01

chr7_+_44106327 0.99 ENSDART00000108766
ENSDART00000111441
cdh5
cadherin 5
chr5_+_36431907 0.99 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr5_+_36431824 0.99 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr6_+_51676410 0.97 ENSDART00000151565
fam65c
family with sequence similarity 65, member C
chr24_-_3445036 0.95 ENSDART00000143723
idi1
isopentenyl-diphosphate delta isomerase 1
chr1_-_9256864 0.92 ENSDART00000041849
tmem8a
transmembrane protein 8A
chr8_+_20589483 0.90 ENSDART00000088668
nfic
nuclear factor I/C
chr3_-_47356049 0.86 ENSDART00000155324
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr23_-_18131105 0.85 ENSDART00000173102
zgc:92287
zgc:92287
chr24_-_3445303 0.85 ENSDART00000143723
idi1
isopentenyl-diphosphate delta isomerase 1
chr8_-_26942548 0.81 ENSDART00000099214
slc16a1b
solute carrier family 16 (monocarboxylate transporter), member 1b
chr16_-_29229755 0.76 ENSDART00000132589
mef2d
myocyte enhancer factor 2d
chr1_-_29885008 0.73 ENSDART00000018827
dachc
dachshund c
chr12_-_34358536 0.73 ENSDART00000111717
fscn2b
fascin actin-bundling protein 2b, retinal
chr5_-_14990023 0.70

chr12_+_19262722 0.67 ENSDART00000078266
rsl1d1
ribosomal L1 domain containing 1
chr10_+_4874800 0.64 ENSDART00000165942
palm2
paralemmin 2
chr5_+_35913418 0.55 ENSDART00000013590
wnt11
wingless-type MMTV integration site family, member 11
chr1_+_13342678 0.43

chr2_-_23330863 0.42

chr10_+_22066137 0.40 ENSDART00000143461
npm1a
nucleophosmin 1a (nucleolar phosphoprotein B23, numatrin)
chr3_+_1338347 0.37 ENSDART00000092690
ENSDART00000165395
srebf2
sterol regulatory element binding transcription factor 2
chr9_-_29687072 0.37 ENSDART00000060246
dnajc3a
DnaJ (Hsp40) homolog, subfamily C, member 3a
chr19_-_10277398 0.31 ENSDART00000091707
dbpa
D site albumin promoter binding protein a
chr25_-_17271146 0.30 ENSDART00000064591
cyp2x6
cytochrome P450, family 2, subfamily X, polypeptide 6
chr20_+_38955797 0.28

chr20_-_7186902 0.27 ENSDART00000012247
dhcr24
24-dehydrocholesterol reductase
chr2_+_34155114 0.25 ENSDART00000137170
dars2
aspartyl-tRNA synthetase 2, mitochondrial
chr1_+_8873083 0.17 ENSDART00000111131
elfn1b
extracellular leucine-rich repeat and fibronectin type III domain containing 1b
chr5_-_13844114 0.17

chr11_-_3266080 0.12 ENSDART00000154314
prph
peripherin
chr23_-_18131038 0.11 ENSDART00000173385
zgc:92287
zgc:92287
chr5_+_35913494 0.02 ENSDART00000013590
wnt11
wingless-type MMTV integration site family, member 11

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0002031 G-protein coupled receptor internalization(GO:0002031) regulation of protein binding(GO:0043393)
0.8 2.3 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.7 2.7 GO:0042698 ovarian follicle development(GO:0001541) ovulation cycle process(GO:0022602) ovulation cycle(GO:0042698)
0.6 3.4 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.5 1.8 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
0.5 1.8 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.4 4.4 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.3 1.0 GO:0001955 blood vessel maturation(GO:0001955)
0.3 3.2 GO:0044247 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.3 1.3 GO:0051031 tRNA transport(GO:0051031)
0.2 2.3 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.2 0.8 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.2 1.9 GO:0070831 basement membrane assembly(GO:0070831)
0.1 2.3 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.1 3.1 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 1.9 GO:0045445 myoblast differentiation(GO:0045445)
0.1 2.3 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.4 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.1 2.7 GO:0007520 myoblast fusion(GO:0007520)
0.1 1.1 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 2.4 GO:0051607 defense response to virus(GO:0051607)
0.1 0.4 GO:0010884 positive regulation of lipid storage(GO:0010884)
0.1 0.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 1.7 GO:0030901 midbrain development(GO:0030901)
0.0 0.7 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.2 GO:1902667 regulation of axon guidance(GO:1902667)
0.0 0.8 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.7 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.6 GO:0060037 pharyngeal system development(GO:0060037)
0.0 3.0 GO:0050767 regulation of neurogenesis(GO:0050767)
0.0 0.2 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.2 2.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 1.9 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 2.7 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 3.1 GO:0005861 troponin complex(GO:0005861)
0.1 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 3.4 GO:0030018 Z disc(GO:0030018)
0.0 4.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.0 GO:0016342 catenin complex(GO:0016342)
0.0 1.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.7 GO:0030686 90S preribosome(GO:0030686)
0.0 1.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.5 2.7 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.3 1.8 GO:0019957 C-C chemokine binding(GO:0019957)
0.3 1.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 4.6 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 1.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 3.1 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 2.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 1.7 GO:0004707 MAP kinase activity(GO:0004707)
0.1 2.4 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 1.9 GO:0005178 integrin binding(GO:0005178)
0.0 2.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.3 GO:0000049 tRNA binding(GO:0000049)
0.0 0.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 2.3 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 0.4 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.0 GO:0045296 cadherin binding(GO:0045296)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 5.9 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.7 GO:0030674 protein binding, bridging(GO:0030674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 4.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 1.0 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 2.0 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 4.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 2.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 2.0 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 4.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation