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Results for srfa+srfb
Z-value: 3.12
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Transcription factors associated with srfa+srfb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| srfa | dr10_dc_chr22_+_35113233_35113370 | 0.84 | 5.4e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of srfa+srfb
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_53286155 Show fit | 16.95 |
ENSDART00000139625
|
actin, alpha 1a, skeletal muscle |
|
| chr7_+_29680967 Show fit | 15.65 |
ENSDART00000173540
|
alpha-tropomyosin |
|
| chr20_-_9992898 Show fit | 14.87 |
ENSDART00000080664
|
zgc:86709 |
|
| chr5_-_31708933 Show fit | 14.37 |
ENSDART00000123003
|
myosin, heavy polypeptide 1.1, skeletal muscle |
|
| chr5_-_31674204 Show fit | 14.24 |
ENSDART00000122889
|
myosin, heavy polypeptide 1.3, skeletal muscle |
|
| chr14_-_21039158 Show fit | 14.01 |
ENSDART00000054460
|
early growth response 1 |
|
| chr13_+_24148599 Show fit | 13.50 |
ENSDART00000058629
|
actin, alpha 1b, skeletal muscle |
|
| chr5_+_36487425 Show fit | 12.42 |
ENSDART00000049900
|
transgelin 2 |
|
| chr20_-_29517770 Show fit | 12.28 |
ENSDART00000147464
|
ryanodine receptor 3 |
|
| chr11_+_6118409 Show fit | 10.66 |
ENSDART00000027666
|
nuclear receptor subfamily 2, group F, member 6b |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 43.0 | GO:0006936 | muscle contraction(GO:0006936) |
| 2.8 | 19.4 | GO:0030195 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 2.6 | 18.3 | GO:0072132 | mesenchyme morphogenesis(GO:0072132) |
| 3.6 | 17.8 | GO:0060845 | lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845) |
| 0.1 | 17.1 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 0.0 | 16.8 | GO:0006468 | protein phosphorylation(GO:0006468) |
| 1.5 | 16.4 | GO:0055011 | atrial cardiac muscle cell differentiation(GO:0055011) |
| 0.7 | 15.3 | GO:0001757 | somite specification(GO:0001757) |
| 0.6 | 15.2 | GO:0051209 | release of sequestered calcium ion into cytosol(GO:0051209) |
| 0.4 | 14.0 | GO:0032922 | circadian regulation of gene expression(GO:0032922) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 42.5 | GO:0005884 | actin filament(GO:0005884) |
| 0.8 | 40.8 | GO:0016459 | myosin complex(GO:0016459) |
| 2.8 | 35.9 | GO:0005869 | dynactin complex(GO:0005869) |
| 1.3 | 24.2 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 16.1 | GO:0005576 | extracellular region(GO:0005576) |
| 2.5 | 15.2 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.1 | 13.9 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.5 | 10.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.5 | 6.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 6.6 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 43.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.3 | 40.8 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 38.7 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.4 | 31.2 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.1 | 18.2 | GO:0003779 | actin binding(GO:0003779) |
| 1.6 | 17.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 2.5 | 15.2 | GO:0048763 | ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763) |
| 0.3 | 14.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.5 | 14.0 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.3 | 13.0 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 17.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 1.2 | 17.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 1.4 | 13.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.4 | 6.4 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 3.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 3.6 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 2.3 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 1.4 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.6 | 14.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.6 | 13.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.6 | 12.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 7.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 2.1 | 6.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.8 | 2.5 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 2.3 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.1 | 1.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 1.2 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |