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Results for tbr1a+tbr1b+tbx21

Z-value: 1.21

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Transcription factors associated with tbr1a+tbr1b+tbx21

Gene Symbol Gene ID Gene Info
tbx21
ENSDARG00000004473 T-box transcription factor 21
tbr1b
ENSDARG00000004712 T-box brain transcription factor 1b
tbr1a
ENSDARG00000076259 T-box brain transcription factor 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tbr1bdr10_dc_chr9_-_51975919_519759270.078.0e-01Click!
tbr1adr10_dc_chr11_-_10844854_10844877-0.068.2e-01Click!

Activity profile of tbr1a+tbr1b+tbx21 motif

Sorted Z-values of tbr1a+tbr1b+tbx21 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of tbr1a+tbr1b+tbx21

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr23_+_23305483 7.79 ENSDART00000126479
plekhn1
pleckstrin homology domain containing, family N member 1
chr17_+_26946957 4.62 ENSDART00000114215
grhl3
grainyhead-like transcription factor 3
chr5_+_26925238 3.78 ENSDART00000051491
sfrp1a
secreted frizzled-related protein 1a
chr2_-_53772219 3.00 ENSDART00000037557
admp
anti-dorsalizing morphogenic protein
chr3_-_23513177 2.93 ENSDART00000078425
eve1
even-skipped-like1
chr10_-_44619365 2.44 ENSDART00000085556
hip1ra
huntingtin interacting protein 1 related a
chr11_-_11925832 2.35

chr13_+_14845093 2.33 ENSDART00000011520
noto
notochord homeobox
chr25_+_31547276 2.28 ENSDART00000090727
duox
dual oxidase
chr2_+_11973282 2.10 ENSDART00000057268
greb1l
growth regulation by estrogen in breast cancer-like
chr7_+_23799153 1.97

chr11_-_11591394 1.92 ENSDART00000142208
zgc:110712
zgc:110712
chr13_-_50299643 1.88 ENSDART00000170527
vent
ventral expressed homeobox
chr13_-_50299821 1.87 ENSDART00000170527
vent
ventral expressed homeobox
chr20_-_43826667 1.85 ENSDART00000100637
mixl1
Mix paired-like homeobox
chr15_-_1625846 1.84 ENSDART00000081875
nnr
nanor
chr14_-_5510157 1.78 ENSDART00000131820
kazald2
Kazal-type serine peptidase inhibitor domain 2
chr7_-_58523645 1.71

chr25_-_31547164 1.65 ENSDART00000110180
duox2
dual oxidase 2
chr14_+_37206949 1.54

chr21_-_3548719 1.54 ENSDART00000137844
atp8b1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr10_-_44619155 1.49 ENSDART00000085556
hip1ra
huntingtin interacting protein 1 related a
chr1_-_51862897 1.42 ENSDART00000136469
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr7_+_56076854 1.42

chr3_-_44113070 1.39 ENSDART00000160717
znf750
zinc finger protein 750
chr17_-_8155740 1.32 ENSDART00000064678
lft2
lefty2
chr14_+_46419051 1.26 ENSDART00000112377
map1lc3cl
microtubule-associated protein 1 light chain 3 gamma, like
chr24_-_38899781 1.17 ENSDART00000112318
ntn2
netrin 2
chr12_-_34786844 1.17 ENSDART00000027379
bicral
BRD4 interacting chromatin remodeling complex associated protein like
chr17_-_20264762 1.11

chr21_+_43204049 1.11 ENSDART00000151748
aff4
AF4/FMR2 family, member 4
chr10_+_37139869 1.09 ENSDART00000132162
vezf1a
vascular endothelial zinc finger 1a
chr7_+_6814828 1.08 ENSDART00000001649
actn3b
actinin alpha 3b
chr5_+_66693263 1.08 ENSDART00000142156
sebox
SEBOX homeobox
chr11_+_27970922 1.07 ENSDART00000169360
ENSDART00000043756
ephb2b
eph receptor B2b
chr14_-_5510256 1.05 ENSDART00000131820
kazald2
Kazal-type serine peptidase inhibitor domain 2
chr24_-_18775146 1.04 ENSDART00000144244
cpa6
carboxypeptidase A6
chr22_-_4414254 1.01 ENSDART00000114465
zgc:195170
zgc:195170
chr25_+_29631947 0.99 ENSDART00000154849
ENSDARG00000029431
ENSDARG00000029431
chr8_+_1122000 0.97 ENSDART00000127252
slc35d2
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
chr19_+_1356824 0.97 ENSDART00000081779
zdhhc3b
zinc finger, DHHC-type containing 3b
chr2_-_53771952 0.96 ENSDART00000037557
admp
anti-dorsalizing morphogenic protein
chr13_-_2868061 0.95

chr10_-_1933874 0.95 ENSDART00000101023
tdgf1
teratocarcinoma-derived growth factor 1
chr5_-_68055794 0.92 ENSDART00000136605
si:ch211-283h6.4
si:ch211-283h6.4
chr6_-_20625494 0.88

chr16_-_6298105 0.80

chr9_-_22140954 0.78 ENSDART00000146528
lmo7a
LIM domain 7a
chr7_+_15065241 0.78 ENSDART00000045385
mespba
mesoderm posterior ba
chr8_+_39630018 0.74 ENSDART00000125880
ENSDARG00000086589
ENSDARG00000086589
chr21_+_20974216 0.74 ENSDART00000079692
ndr1
nodal-related 1
chr7_+_53484981 0.71 ENSDART00000158160
ENSDART00000163261
neo1a
neogenin 1a
chr12_+_25509394 0.71 ENSDART00000077157
six3b
SIX homeobox 3b
chr17_+_26946875 0.70 ENSDART00000114215
grhl3
grainyhead-like transcription factor 3
chr17_-_20264870 0.69

chr22_-_3134876 0.68 ENSDART00000159580
lmnb2
lamin B2
chr9_-_22141138 0.65 ENSDART00000146528
lmo7a
LIM domain 7a
chr18_-_7580225 0.64 ENSDART00000133541
si:dkey-30c15.2
si:dkey-30c15.2
chr19_-_35642440 0.64 ENSDART00000167853
ENSDART00000054274
macf1a
microtubule-actin crosslinking factor 1a
chr25_-_16547149 0.63 ENSDART00000104110
slc25a18
solute carrier family 25 (glutamate carrier), member 18
chr1_-_51863187 0.62 ENSDART00000004233
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr10_+_18994733 0.60 ENSDART00000146517
dpysl2b
dihydropyrimidinase-like 2b
chr9_-_43178744 0.60

chr22_-_37468331 0.60 ENSDART00000160940
SOX2OT_exon1
SOX2 overlapping transcript exon 1
chr5_-_68055590 0.58 ENSDART00000136605
si:ch211-283h6.4
si:ch211-283h6.4
chr23_+_23305376 0.58 ENSDART00000126479
plekhn1
pleckstrin homology domain containing, family N member 1
chr6_+_56157608 0.57 ENSDART00000149665
tfap2c
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr12_-_5628248 0.55 ENSDART00000105884
itga3b
integrin, alpha 3b
chr2_-_42510909 0.53 ENSDART00000144274
si:dkey-7l6.3
si:dkey-7l6.3
chr25_-_10930008 0.52 ENSDART00000156846
mespbb
mesoderm posterior bb
chr16_+_14817799 0.49 ENSDART00000137912
col14a1a
collagen, type XIV, alpha 1a
chr23_-_35392359 0.48 ENSDART00000166167
fam110c
family with sequence similarity 110, member C
chr25_+_29631901 0.45 ENSDART00000154849
ENSDARG00000029431
ENSDARG00000029431
chr3_-_19050721 0.44 ENSDART00000131503
rfx1a
regulatory factor X, 1a (influences HLA class II expression)
chr17_+_1058137 0.44

chr3_-_25683205 0.43 ENSDART00000169706
ntn1b
netrin 1b
chr3_-_22240424 0.42

chr7_+_53485273 0.39 ENSDART00000158160
ENSDART00000163261
neo1a
neogenin 1a
chr9_-_43072092 0.39 ENSDART00000125953
ttn.1
titin, tandem duplicate 1
chr11_-_25019165 0.38 ENSDART00000130477
ENSDART00000079578
snai1a
snail family zinc finger 1a
chr3_-_32471212 0.38 ENSDART00000150997
si:ch73-248e21.7
si:ch73-248e21.7
chr12_+_9664920 0.36 ENSDART00000091489
ppp1r9bb
protein phosphatase 1, regulatory subunit 9Bb
KN150131v1_+_59098 0.34 ENSDART00000175590
CABZ01064941.1
ENSDARG00000106550
chr14_+_33382973 0.33 ENSDART00000132488
apln
apelin
chr17_+_38307512 0.33 ENSDART00000005296
nkx2.9
NK2 transcription factor related, locus 9 (Drosophila)
chr15_-_29079613 0.33 ENSDART00000060018
dharma
dharma
chr18_+_18874077 0.32 ENSDART00000091094
pllp
plasmolipin
chr5_+_50266345 0.31 ENSDART00000092938
col4a3bpa
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
chr19_-_22894525 0.31 ENSDART00000090679
pleca
plectin a
chr11_-_25019298 0.30 ENSDART00000130477
ENSDART00000079578
snai1a
snail family zinc finger 1a
chr5_+_68055760 0.30 ENSDART00000061406
usp39
ubiquitin specific peptidase 39
chr8_+_28377022 0.29 ENSDART00000158788
klhl12
kelch-like family member 12
chr1_+_46537108 0.28

chr20_-_38546922 0.28 ENSDART00000136303
itpkb
inositol-trisphosphate 3-kinase B
chr18_+_14725148 0.28 ENSDART00000146128
uri1
URI1, prefoldin-like chaperone
chr22_-_14103803 0.28 ENSDART00000062902
ENSDARG00000042857
ENSDARG00000042857
chr16_+_14817718 0.27 ENSDART00000027982
col14a1a
collagen, type XIV, alpha 1a
chr13_-_2868197 0.27

chr5_+_68055581 0.26 ENSDART00000061406
usp39
ubiquitin specific peptidase 39
chr24_-_18775194 0.26 ENSDART00000106188
cpa6
carboxypeptidase A6
chr3_-_23513293 0.24 ENSDART00000140264
eve1
even-skipped-like1
chr7_+_28896401 0.24 ENSDART00000076345
slc38a8b
solute carrier family 38, member 8b
chr6_+_32107019 0.23 ENSDART00000155710
BX664614.2
ENSDARG00000097944
chr4_-_19992951 0.23 ENSDART00000169248
drd4-rs
dopamine receptor D4 related sequence
chr10_-_13158018 0.21 ENSDART00000164568
musk
muscle, skeletal, receptor tyrosine kinase
chr14_-_43174431 0.21 ENSDART00000113697
ENSDART00000173396
eif4ea
eukaryotic translation initiation factor 4ea
chr24_-_34794856 0.20 ENSDART00000171009
ENSDART00000170046
ctnna1
catenin (cadherin-associated protein), alpha 1
chr21_+_26690161 0.19 ENSDART00000065392
calm3b
calmodulin 3b (phosphorylase kinase, delta)
chr18_+_14725283 0.19 ENSDART00000146128
uri1
URI1, prefoldin-like chaperone
chr3_+_42380497 0.19 ENSDART00000163579
si:dkey-43p13.5
si:dkey-43p13.5
chr5_+_29578638 0.18 ENSDART00000134624
adamts15a
ADAM metallopeptidase with thrombospondin type 1 motif, 15a
KN150214v1_-_155944 0.17

chr14_+_5078937 0.17 ENSDART00000031508
lbx2
ladybird homeobox 2
chr11_+_6648811 0.17 ENSDART00000172061
CR381534.1
ENSDARG00000098564
chr23_+_20522512 0.16 ENSDART00000137294
slc35c2
solute carrier family 35 (GDP-fucose transporter), member C2
chr18_+_23891068 0.16 ENSDART00000146490
BX569787.1
ENSDARG00000092402
chr21_-_151485 0.16

chr21_+_15613081 0.16 ENSDART00000065772
ddt
D-dopachrome tautomerase
chr11_-_11591351 0.15 ENSDART00000142208
zgc:110712
zgc:110712
chr21_-_151444 0.14

chr6_-_49674729 0.13 ENSDART00000112226
apcdd1l
adenomatosis polyposis coli down-regulated 1-like
chr21_-_1412006 0.13

chr15_-_16047125 0.13 ENSDART00000166583
synrg
synergin, gamma
chr18_+_23891152 0.12 ENSDART00000146490
BX569787.1
ENSDARG00000092402
chr19_-_35642784 0.10 ENSDART00000167853
ENSDART00000054274
macf1a
microtubule-actin crosslinking factor 1a
chr5_-_39136238 0.10 ENSDART00000127123
rasgef1ba
RasGEF domain family, member 1Ba
chr19_+_4940844 0.09

chr12_-_34787076 0.09 ENSDART00000027379
bicral
BRD4 interacting chromatin remodeling complex associated protein like
chr7_-_58524285 0.08 ENSDART00000171095
sox32
SRY (sex determining region Y)-box 32
chr2_-_55879949 0.07 ENSDART00000140309
cplx4c
complexin 4c
chr3_+_43010408 0.04 ENSDART00000169061
CU138533.1
ENSDARG00000099842
chr17_-_28690941 0.04 ENSDART00000135752
ap4s1
adaptor-related protein complex 4, sigma 1 subunit
chr11_-_27970634 0.03

chr11_+_24491822 0.03 ENSDART00000087740
ENSDARG00000070571
ENSDARG00000070571
chr2_+_44718147 0.01 ENSDART00000098132
klhl24a
kelch-like family member 24a
chr3_+_31468838 0.00 ENSDART00000076640
ccdc43
coiled-coil domain containing 43
chr8_-_25586350 0.00 ENSDART00000005906
stk38a
serine/threonine kinase 38a
chr18_+_35994461 0.00

chr20_-_43826581 0.00 ENSDART00000100637
mixl1
Mix paired-like homeobox

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 2.3 GO:0048327 axial mesodermal cell differentiation(GO:0048321) axial mesodermal cell fate commitment(GO:0048322) axial mesodermal cell fate specification(GO:0048327)
2.1 8.4 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.8 2.3 GO:0042554 superoxide anion generation(GO:0042554)
0.6 6.9 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661)
0.6 5.3 GO:0060325 face morphogenesis(GO:0060325)
0.6 4.0 GO:0060063 Spemann organizer formation at the embryonic shield(GO:0060063)
0.3 0.3 GO:0048320 axial mesoderm formation(GO:0048320)
0.3 1.3 GO:0097101 blood vessel endothelial cell fate specification(GO:0097101)
0.2 0.7 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.2 3.9 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 4.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.6 GO:0048855 hypophysis morphogenesis(GO:0048850) diencephalon morphogenesis(GO:0048852) adenohypophysis morphogenesis(GO:0048855)
0.1 0.3 GO:0042756 drinking behavior(GO:0042756)
0.1 1.3 GO:0003128 heart field specification(GO:0003128) specification of organ identity(GO:0010092)
0.1 0.6 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.1 0.4 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.1 1.3 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.2 GO:0051350 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclic nucleotide metabolic process(GO:0030800) negative regulation of cyclic nucleotide biosynthetic process(GO:0030803) negative regulation of nucleotide biosynthetic process(GO:0030809) negative regulation of cAMP metabolic process(GO:0030815) negative regulation of cAMP biosynthetic process(GO:0030818) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350) negative regulation of purine nucleotide biosynthetic process(GO:1900372)
0.1 0.7 GO:0060061 developmental induction(GO:0031128) Spemann organizer formation(GO:0060061)
0.1 0.8 GO:0070831 basement membrane assembly(GO:0070831)
0.1 0.7 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.1 1.1 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.2 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.1 0.4 GO:0048769 sarcomerogenesis(GO:0048769)
0.1 0.6 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 2.0 GO:0001706 endoderm formation(GO:0001706)
0.0 0.6 GO:0014034 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.0 0.2 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 1.1 GO:0007492 endoderm development(GO:0007492)
0.0 0.3 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.8 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.2 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 2.6 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.2 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.3 GO:0021514 ventral spinal cord interneuron differentiation(GO:0021514)
0.0 1.4 GO:0008544 epidermis development(GO:0008544)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.4 3.6 GO:0005614 interstitial matrix(GO:0005614)
0.2 0.7 GO:0032019 mitochondrial cloud(GO:0032019)
0.1 1.1 GO:0032783 ELL-EAF complex(GO:0032783)
0.1 4.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.3 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.9 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 11.5 GO:0005615 extracellular space(GO:0005615)
0.0 7.9 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.5 GO:0008305 integrin complex(GO:0008305)
0.0 0.2 GO:0005845 mRNA cap binding complex(GO:0005845)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 8.4 GO:1901612 cardiolipin binding(GO:1901612)
0.8 2.3 GO:0016175 NAD(P)H oxidase activity(GO:0016174) superoxide-generating NADPH oxidase activity(GO:0016175)
0.3 1.0 GO:0005461 UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.3 3.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 1.3 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.2 0.6 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 2.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.7 GO:0070698 type I activin receptor binding(GO:0070698)
0.1 1.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.6 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 3.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.2 GO:0099528 G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.1 0.3 GO:0031704 apelin receptor binding(GO:0031704)
0.1 4.0 GO:0005125 cytokine activity(GO:0005125)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 3.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.3 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.4 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases