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Results for tbx3a+tbx3b

Z-value: 0.70

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Transcription factors associated with tbx3a+tbx3b

Gene Symbol Gene ID Gene Info
tbx3a
ENSDARG00000002216 T-box transcription factor 3a
tbx3b
ENSDARG00000061509 T-box transcription factor 3b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tbx3adr10_dc_chr5_-_71539823_71539910-0.693.0e-03Click!
tbx3bdr10_dc_chr5_+_26312951_26312966-0.601.4e-02Click!

Activity profile of tbx3a+tbx3b motif

Sorted Z-values of tbx3a+tbx3b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of tbx3a+tbx3b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_-_18664720 2.11 ENSDART00000108627
snx10a
sorting nexin 10a
chr18_+_17545564 1.85 ENSDART00000061007
mt2
metallothionein 2
chr14_-_14353451 1.52 ENSDART00000170355
ENSDART00000159888
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr13_+_33331767 1.47 ENSDART00000177841
zgc:136302
zgc:136302
chr3_+_37648476 1.31 ENSDART00000151506
si:dkey-260c8.8
si:dkey-260c8.8
chr2_-_39026651 1.30 ENSDART00000114085
si:ch211-119o8.6
si:ch211-119o8.6
chr7_-_32598812 1.22

chr10_+_15066791 1.21 ENSDART00000140084
si:dkey-88l16.5
si:dkey-88l16.5
chr3_+_37648665 1.18 ENSDART00000151506
si:dkey-260c8.8
si:dkey-260c8.8
chr17_-_53241446 1.14

chr8_-_49227232 1.13

chr13_+_8508786 1.10 ENSDART00000059321
epcam
epithelial cell adhesion molecule
chr18_-_21759723 1.09 ENSDART00000079253
pskh1
protein serine kinase H1
chr7_-_21571924 1.05 ENSDART00000166446
BX005336.1
ENSDARG00000102693
chr19_-_18664670 1.02 ENSDART00000108627
snx10a
sorting nexin 10a
chr23_-_27318392 1.02

chr18_-_21759831 0.98 ENSDART00000079253
pskh1
protein serine kinase H1
chr22_-_25015224 0.92 ENSDART00000015512
polr3f
polymerase (RNA) III (DNA directed) polypeptide F
chr3_-_44466637 0.88 ENSDART00000169923
ndel1b
nudE neurodevelopment protein 1-like 1b
chr25_+_32419008 0.88

chr7_-_21572054 0.87 ENSDART00000166446
BX005336.1
ENSDARG00000102693
chr15_-_5913264 0.82 ENSDART00000155156
ENSDART00000155971
si:ch73-281n10.2
si:ch73-281n10.2
chr2_-_21780380 0.80 ENSDART00000144587
plcd1b
phospholipase C, delta 1b
chr18_-_50439653 0.78 ENSDART00000151038
CU862078.1
ENSDARG00000096262
chr21_+_25651637 0.76 ENSDART00000125709
si:dkey-17e16.17
si:dkey-17e16.17
chr21_-_34938261 0.68 ENSDART00000023838
lipia
lipase, member Ia
chr23_-_43396787 0.67

chr13_+_849563 0.66

chr25_-_35094522 0.65 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr18_-_40923017 0.64 ENSDART00000098878
polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr18_-_7138350 0.63 ENSDART00000003748
cfap161
cilia and flagella associated protein 161
chr1_+_52686620 0.62 ENSDART00000176087
tbc1d9
TBC1 domain family, member 9 (with GRAM domain)
chr17_-_53241366 0.62 ENSDART00000171082
exd1
exonuclease 3'-5' domain containing 1
chr23_-_27318468 0.60

chr5_-_19987344 0.59 ENSDART00000144232
ficd
FIC domain containing
chr6_-_32099929 0.59 ENSDART00000150934
alg6
asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)
chr5_+_2429397 0.58

chr1_+_52686770 0.56 ENSDART00000143909
tbc1d9
TBC1 domain family, member 9 (with GRAM domain)
chr9_-_45104857 0.54 ENSDART00000131252
zgc:66484
zgc:66484
chr14_-_14353487 0.54 ENSDART00000172241
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr8_+_7815256 0.53 ENSDART00000165575
cxxc1a
CXXC finger protein 1a
KN150380v1_-_10405 0.50 ENSDART00000168535
CABZ01048453.1
ENSDARG00000104434
chr4_-_5766814 0.48 ENSDART00000021753
ccnc
cyclin C
chr10_+_15066970 0.48 ENSDART00000140084
si:dkey-88l16.5
si:dkey-88l16.5
chr5_+_29203411 0.48 ENSDART00000134900
usf1l
upstream transcription factor 1, like
chr16_+_32230379 0.47 ENSDART00000084009
zufsp
zinc finger with UFM1-specific peptidase domain
chr17_-_43725091 0.46

chr15_-_24007305 0.44 ENSDART00000002824
appbp2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr18_-_7138171 0.44 ENSDART00000149122
cfap161
cilia and flagella associated protein 161
chr9_-_29510914 0.43 ENSDART00000122602
pth2r
parathyroid hormone 2 receptor
chr10_+_15066654 0.43 ENSDART00000135667
si:dkey-88l16.5
si:dkey-88l16.5
chr16_+_32230439 0.42 ENSDART00000084009
zufsp
zinc finger with UFM1-specific peptidase domain
chr18_-_7138309 0.42 ENSDART00000003748
cfap161
cilia and flagella associated protein 161
chr2_+_21527785 0.41 ENSDART00000136498
si:dkey-29d8.3
si:dkey-29d8.3
chr14_+_3409236 0.40 ENSDART00000158416
fnta
farnesyltransferase, CAAX box, alpha
chr3_-_26211047 0.40 ENSDART00000087196
zgc:153240
zgc:153240
chr15_-_23588004 0.40 ENSDART00000078396
hmbsb
hydroxymethylbilane synthase, b
chr13_+_30033024 0.39 ENSDART00000040926
eif4ebp2
eukaryotic translation initiation factor 4E binding protein 2
chr15_-_5912917 0.37

chr15_-_1800095 0.35 ENSDART00000149980
bud23
BUD23, rRNA methyltransferase and ribosome maturation factor
chr16_-_47366405 0.34 ENSDART00000169697
mios
missing oocyte, meiosis regulator, homolog (Drosophila)
chr4_-_18786577 0.34 ENSDART00000141187
def6c
differentially expressed in FDCP 6c homolog
chr4_+_15007453 0.31 ENSDART00000146156
zc3hc1
zinc finger, C3HC-type containing 1
chr12_-_26400022 0.30 ENSDART00000153361
si:dkey-287g12.6
si:dkey-287g12.6
chr24_-_38758093 0.29

chr25_+_3521763 0.29 ENSDART00000160017
CABZ01058261.1
ENSDARG00000099194
chr11_-_205744 0.29 ENSDART00000172775
tegt
testis enhanced gene transcript (BAX inhibitor 1)
chr8_+_15213743 0.25 ENSDART00000063717
ENSDARG00000043402
ENSDARG00000043402
chr18_-_7138414 0.24 ENSDART00000003748
cfap161
cilia and flagella associated protein 161
chr22_+_39098205 0.24 ENSDART00000002826
gmppb
GDP-mannose pyrophosphorylase B
chr7_+_56171081 0.23 ENSDART00000073596
ENSDART00000123273
ist1
increased sodium tolerance 1 homolog (yeast)
chr1_+_24960066 0.20 ENSDART00000054235
plrg1
pleiotropic regulator 1
chr18_-_40923158 0.19 ENSDART00000098878
polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr16_-_14697143 0.19 ENSDART00000012479
dscc1
DNA replication and sister chromatid cohesion 1
chr15_-_24007488 0.18 ENSDART00000002824
appbp2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr1_-_2305324 0.17 ENSDART00000152555
ggact.3
gamma-glutamylamine cyclotransferase, tandem duplicate 3
chr24_-_9146200 0.17 ENSDART00000153817
CU459174.1
ENSDARG00000097146
chr2_+_42155813 0.17 ENSDART00000143562
gbp2
guanylate binding protein 2
chr15_-_1800139 0.16 ENSDART00000093074
bud23
BUD23, rRNA methyltransferase and ribosome maturation factor
chr23_-_19905270 0.15 ENSDART00000054479
haus7
HAUS augmin-like complex, subunit 7
chr19_+_9293058 0.15 ENSDART00000146218
ndufv1
NADH dehydrogenase (ubiquinone) flavoprotein 1
chr8_-_49227143 0.15

chr2_-_41722058 0.14 ENSDART00000022643
znf622
zinc finger protein 622
chr17_+_8018808 0.13 ENSDART00000131200
myct1b
myc target 1b
chr10_+_20222743 0.13 ENSDART00000167008
ppp3ccb
protein phosphatase 3, catalytic subunit, gamma isozyme, b
chr25_+_32419062 0.12

chr10_-_15090551 0.10 ENSDART00000038401
ENSDART00000155674
si:ch211-95j8.2
si:ch211-95j8.2
chr7_-_20211716 0.09 ENSDART00000078192
cnpy4
canopy4
chr17_+_24585915 0.08 ENSDART00000082193
zmpste24
zinc metallopeptidase, STE24 homolog
chr10_-_35164761 0.08 ENSDART00000049633
zgc:110006
zgc:110006
chr15_-_24007354 0.08 ENSDART00000002824
appbp2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr15_+_31956131 0.07

chr3_-_13311188 0.07 ENSDART00000080807
fbxw9
F-box and WD repeat domain containing 9
chr4_-_16002407 0.07 ENSDART00000125389
mest
mesoderm specific transcript
chr20_+_53772078 0.06 ENSDART00000126983
myh6
myosin, heavy chain 6, cardiac muscle, alpha
chr8_+_7815304 0.06 ENSDART00000165575
cxxc1a
CXXC finger protein 1a
chr24_-_26334771 0.05 ENSDART00000079984
ENSDART00000136871
rpl22l1
ribosomal protein L22-like 1
chr21_-_27158568 0.04 ENSDART00000065401
zgc:110782
zgc:110782
chr20_+_53772470 0.04 ENSDART00000126983
myh6
myosin, heavy chain 6, cardiac muscle, alpha
chr12_-_26323696 0.02

chr10_+_26691086 0.02 ENSDART00000079174
htatsf1
HIV-1 Tat specific factor 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0070986 left/right axis specification(GO:0070986)
0.3 1.8 GO:0043536 positive regulation of blood vessel endothelial cell migration(GO:0043536) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.2 0.9 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.2 0.5 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
0.1 0.8 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 0.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.2 GO:0034088 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.1 0.4 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.1 2.1 GO:0001878 response to yeast(GO:0001878)
0.0 0.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.2 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 1.1 GO:0048920 posterior lateral line neuromast primordium migration(GO:0048920)
0.0 0.1 GO:0055004 atrial cardiac myofibril assembly(GO:0055004)
0.0 0.9 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.5 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.3 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.0 0.2 GO:0007032 endosome organization(GO:0007032)
0.0 0.2 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043516)
0.0 1.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.4 GO:0031514 motile cilium(GO:0031514)
0.0 0.6 GO:0043186 P granule(GO:0043186)
0.0 0.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0000974 Prp19 complex(GO:0000974)
0.0 1.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.0 GO:0005813 centrosome(GO:0005813)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 0.5 GO:0046592 polyamine oxidase activity(GO:0046592)
0.1 0.5 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 0.7 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.4 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.1 0.2 GO:0004475 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
0.1 0.4 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 1.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.6 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.6 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 3.1 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.6 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 1.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.9 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 0.8 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.8 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.4 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events