ISMARA results: tead3a+tead3b

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Results for tead3a+tead3b

Z-value: 6.25

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Transcription factors associated with tead3a+tead3b

Gene Symbol	Gene ID	Gene Info
tead3b NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000063649	TEA domain family member 3 b
tead3a NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000074321	TEA domain family member 3 a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tead3b	dr10_dc_chr6_+_54568649_54568723	0.55	2.6e-02	Click!

Activity profile of tead3a+tead3b motif

Sorted Z-values of tead3a+tead3b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of tead3a+tead3b

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Promoter	Score	Transcript	Gene	Gene Info
chr20_-_29148810 Show fit	22.40	ENSDART00000140350	thbs1b NCBI UniProt ZFIN ENSEMBL Google Show fit	thrombospondin 1b
chr2_-_10555152 Show fit	21.77	ENSDART00000150166	gng12a NCBI UniProt ZFIN ENSEMBL Google Show fit	guanine nucleotide binding protein (G protein), gamma 12a
chr6_+_15141723 Show fit	20.74	ENSDART00000128090	ecrg4b NCBI UniProt ZFIN ENSEMBL Google Show fit	esophageal cancer related gene 4b
chr1_+_53286155 Show fit	17.03	ENSDART00000139625	acta1a NCBI UniProt ZFIN ENSEMBL Google Show fit	actin, alpha 1a, skeletal muscle
chr3_-_16387246 Show fit	16.46	ENSDART00000133907	eps8l1 NCBI UniProt ZFIN ENSEMBL Google Show fit	eps8-like1
chr9_+_21466934 Show fit	14.50	ENSDART00000139620	lats2 NCBI UniProt ZFIN ENSEMBL Google Show fit	large tumor suppressor kinase 2
chr5_-_70948223 Show fit	14.35	ENSDART00000013404	ak1 NCBI UniProt ZFIN ENSEMBL Google Show fit	adenylate kinase 1
chr6_-_39315024 Show fit	14.29	ENSDART00000012644	krt4 NCBI UniProt ZFIN ENSEMBL Google Show fit	keratin 4
chr13_+_22545318 Show fit	14.13	ENSDART00000143312	zgc:193505 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:193505
chr13_-_46292762 Show fit	14.10	ENSDART00000149125	fgfr2 NCBI UniProt ZFIN ENSEMBL Google Show fit	fibroblast growth factor receptor 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.6	37.1	GO:0033278	cell proliferation in midbrain(GO:0033278)
0.2	27.8	GO:0009952	anterior/posterior pattern specification(GO:0009952)
0.8	27.5	GO:0045103	intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.2	27.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6	22.4	GO:2000181	negative regulation of angiogenesis(GO:0016525) negative regulation of blood vessel morphogenesis(GO:2000181)
1.3	20.8	GO:0061300	cerebellum vasculature development(GO:0061300)
2.7	18.8	GO:0072132	mesenchyme morphogenesis(GO:0072132)
3.1	18.5	GO:0030104	water homeostasis(GO:0030104)
0.1	18.5	GO:0007186	G-protein coupled receptor signaling pathway(GO:0007186)
6.1	18.3	GO:0015670	carbon dioxide transport(GO:0015670)

Showing 1 to 10 of 178 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	68.4	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	65.2	GO:0005615	extracellular space(GO:0005615)
0.3	60.3	GO:0043235	receptor complex(GO:0043235)
2.4	26.8	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
1.2	25.5	GO:0045095	keratin filament(GO:0045095)
0.3	20.9	GO:0030018	Z disc(GO:0030018)
0.3	20.7	GO:0016324	apical plasma membrane(GO:0016324)
1.1	20.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.3	19.9	GO:0005581	collagen trimer(GO:0005581)
1.4	18.8	GO:0005869	dynactin complex(GO:0005869)

Showing 1 to 10 of 70 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	70.7	GO:0051015	actin filament binding(GO:0051015)
0.1	67.4	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1	29.1	GO:0005509	calcium ion binding(GO:0005509)
1.8	28.0	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
1.4	27.3	GO:0004089	carbonate dehydratase activity(GO:0004089)
2.2	26.8	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.1	24.4	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1	24.1	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.2	22.5	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.8	22.4	GO:0050840	extracellular matrix binding(GO:0050840)

Showing 1 to 10 of 124 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	28.0	PID FGF PATHWAY	FGF signaling pathway
2.5	27.7	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.4	18.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	15.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.5	14.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	12.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	11.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.7	10.8	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.2	10.0	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.2	8.2	PID AR PATHWAY	Coregulation of Androgen receptor activity

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.7	28.0	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.8	16.7	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
2.0	16.4	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
1.0	15.6	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
2.2	15.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.9	14.5	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.4	12.5	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4	11.9	REACTOME G1 PHASE	Genes involved in G1 Phase
1.2	8.5	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
1.9	7.4	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB

Showing 1 to 10 of 38 entries

Results for tead3a+tead3b

Z-value: 6.25

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Transcription factors associated with tead3a+tead3b

Activity-expression correlation:

Activity profile of tead3a+tead3b motif

Sorted Z-values of tead3a+tead3b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of tead3a+tead3b

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: