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Results for tfap2a+tfap2c

Z-value: 0.29

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Transcription factors associated with tfap2a+tfap2c

Gene Symbol Gene ID Gene Info
tfap2c
ENSDARG00000040606 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
tfap2a
ENSDARG00000059279 transcription factor AP-2 alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2adr10_dc_chr24_-_8589388_85893930.467.5e-02Click!
tfap2cdr10_dc_chr6_+_56163589_561636400.351.8e-01Click!

Activity profile of tfap2a+tfap2c motif

Sorted Z-values of tfap2a+tfap2c motif

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2a+tfap2c

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_+_17451381 0.48 ENSDART00000167602
spaca4l
sperm acrosome associated 4 like
chr11_-_5793 0.45

chr23_-_27226280 0.35 ENSDART00000141305
si:dkey-157g16.6
si:dkey-157g16.6
chr7_-_33994315 0.31 ENSDART00000173596
si:ch211-98n17.5
si:ch211-98n17.5
chr23_-_27226387 0.27 ENSDART00000141305
si:dkey-157g16.6
si:dkey-157g16.6
chr10_-_5135388 0.26 ENSDART00000108587
sec31a
SEC31 homolog A, COPII coat complex component
chr19_-_5452918 0.26 ENSDART00000105004
krt17
keratin 17
chr14_-_27703812 0.25 ENSDART00000054115
tsc22d3
TSC22 domain family, member 3
chr5_-_62116975 0.24 ENSDART00000144469
adora2b
adenosine A2b receptor
chr23_-_27721250 0.23 ENSDART00000059974
wnt10b
wingless-type MMTV integration site family, member 10b
chr13_-_28543929 0.21 ENSDART00000122754
ENSDART00000057574
nt5c2a
5'-nucleotidase, cytosolic IIa
chr18_+_34205362 0.18 ENSDART00000130831
gmps
guanine monophosphate synthase
chr5_-_37851313 0.18 ENSDART00000136428
ENSDART00000112487
chrne
cholinergic receptor, nicotinic, epsilon
chr6_-_19928053 0.18 ENSDART00000161257
plxnb1b
plexin b1b
chr16_-_7876036 0.18 ENSDART00000113483
trim71
tripartite motif containing 71, E3 ubiquitin protein ligase
chr23_-_27721202 0.17 ENSDART00000059974
wnt10b
wingless-type MMTV integration site family, member 10b
chr25_+_35855292 0.17 ENSDART00000152801
ankrd27
ankyrin repeat domain 27 (VPS9 domain)
chr8_+_39525254 0.14

chr1_+_45782078 0.14 ENSDART00000166028
mcf2la
mcf.2 cell line derived transforming sequence-like a
chr3_+_26113393 0.13 ENSDART00000103733
atad5a
ATPase family, AAA domain containing 5a
chr16_-_5243402 0.13 ENSDART00000131876
ttk
ttk protein kinase
chr14_-_46476712 0.13 ENSDART00000173209
ENSDART00000164837
ehd1a
EH-domain containing 1a
chr14_-_46477165 0.13 ENSDART00000173209
ENSDART00000164837
ehd1a
EH-domain containing 1a
chr23_-_21288972 0.12 ENSDART00000143206
megf6a
multiple EGF-like-domains 6a
chr21_+_3556841 0.12

chr3_-_55073857 0.12 ENSDART00000082944
dock6
dedicator of cytokinesis 6
chr14_+_14501263 0.11 ENSDART00000169235
fhdc2
FH2 domain containing 2
chr21_-_39013447 0.11 ENSDART00000114885
aldh3a2b
aldehyde dehydrogenase 3 family, member A2b
chr3_+_26113651 0.11 ENSDART00000103734
atad5a
ATPase family, AAA domain containing 5a
chr24_+_31437128 0.11 ENSDART00000172335
cpne3
copine III
chr1_+_15855776 0.11 ENSDART00000048855
mtus1b
microtubule associated tumor suppressor 1b
chr20_-_3873641 0.11 ENSDART00000113132
gnpat
glyceronephosphate O-acyltransferase
chr19_-_5453469 0.11 ENSDART00000105004
krt17
keratin 17
chr7_+_32422659 0.11 ENSDART00000121972
slc39a13
solute carrier family 39 (zinc transporter), member 13
chr17_+_25503946 0.11

chr20_-_20412830 0.10 ENSDART00000114779
ENSDARG00000079369
ENSDARG00000079369
chr25_-_5039781 0.09

chr11_+_37639045 0.08 ENSDART00000111157
si:ch211-112f3.4
si:ch211-112f3.4
chr11_+_31061296 0.08 ENSDART00000088093
sipa1l2
signal-induced proliferation-associated 1 like 2
chr20_-_2708593 0.08 ENSDART00000145730
akirin2
akirin 2
chr4_-_21745163 0.08 ENSDART00000139962
pawr
PRKC, apoptosis, WT1, regulator
chr5_+_61136704 0.07 ENSDART00000113508
hnrnpul1l
heterogeneous nuclear ribonucleoprotein U-like 1 like
chr25_-_4376129 0.07

chr19_+_24741199 0.07 ENSDART00000090081
sema4ab
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
chr14_-_29498646 0.07

chr16_+_24697776 0.06

chr17_+_8765158 0.06

chr10_-_210681 0.06 ENSDART00000059476
psmg1
proteasome (prosome, macropain) assembly chaperone 1
chr10_+_5135537 0.06 ENSDART00000132627
ENSDART00000082295
zgc:113274
zgc:113274
chr3_+_34716635 0.06 ENSDART00000055263
itga3a
integrin, alpha 3a
chr1_+_25773300 0.05 ENSDART00000011809
uso1
USO1 vesicle transport factor
chr14_-_46476881 0.05 ENSDART00000173209
ENSDART00000164837
ehd1a
EH-domain containing 1a
chr14_-_549816 0.04 ENSDART00000168951
fgf2
fibroblast growth factor 2
chr8_+_48953831 0.04 ENSDART00000132035
rer1
retention in endoplasmic reticulum sorting receptor 1
chr3_-_56969897 0.03

chr19_-_30923513 0.03 ENSDART00000088760
bag6l
BCL2-associated athanogene 6, like
chr16_-_24697750 0.03 ENSDART00000163305
fxyd6l
FXYD domain containing ion transport regulator 6 like
chr10_+_44847446 0.03

chr7_-_15004167 0.02 ENSDART00000030009
ENSDARG00000023868
ENSDARG00000023868
chr3_-_40407003 0.02

chr8_+_48953644 0.02 ENSDART00000132035
rer1
retention in endoplasmic reticulum sorting receptor 1
chr20_-_2708686 0.02 ENSDART00000145730
akirin2
akirin 2
chr20_-_2708839 0.02 ENSDART00000152120
akirin2
akirin 2
chr3_-_26675055 0.02 ENSDART00000143710
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr20_-_15181042 0.01 ENSDART00000175585
prrc2c
proline-rich coiled-coil 2C
chr18_-_15582896 0.01 ENSDART00000172690
ENSDART00000159915
ppfibp1b
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr19_+_24741351 0.01 ENSDART00000090081
sema4ab
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
chr8_-_10966975 0.01 ENSDART00000020116
trim33
tripartite motif containing 33
chr5_-_37850885 0.01 ENSDART00000136428
ENSDART00000112487
chrne
cholinergic receptor, nicotinic, epsilon
chr10_+_40330533 0.01

chr4_-_16356071 0.00 ENSDART00000079521
kera
keratocan
chr3_+_34716733 0.00 ENSDART00000055263
itga3a
integrin, alpha 3a
chr20_-_34389652 0.00 ENSDART00000144705
ENSDART00000020389
hmcn1
hemicentin 1
chr2_-_22173254 0.00 ENSDART00000137538
rab2a
RAB2A, member RAS oncogene family

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0010586 miRNA metabolic process(GO:0010586)
0.0 0.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.1 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.0 0.5 GO:0007286 spermatid development(GO:0007286)
0.0 0.2 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 0.2 GO:0035587 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.2 GO:0045022 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.2 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0048211 Golgi vesicle docking(GO:0048211)
0.0 0.2 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0004675 transmembrane receptor protein serine/threonine kinase activity(GO:0004675)
0.0 0.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.0 0.0 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)