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Results for tfap2b

Z-value: 0.37

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Transcription factors associated with tfap2b

Gene Symbol Gene ID Gene Info
tfap2b
ENSDARG00000012667 transcription factor AP-2 beta

Activity profile of tfap2b motif

Sorted Z-values of tfap2b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_-_92920 0.77 ENSDART00000099074
si:zfos-411a11.2
si:zfos-411a11.2
chr15_-_104331 0.72 ENSDART00000164323
ENSDART00000161218
cyp2y3
cytochrome P450, family 2, subfamily Y, polypeptide 3
chr11_-_18818010 0.51

chr1_-_48900185 0.48 ENSDART00000113072
zgc:163136
zgc:163136
chr21_-_30378764 0.37 ENSDART00000136247
grpel2
GrpE-like 2, mitochondrial
chr4_-_29817874 0.36

chr4_-_62271066 0.31 ENSDART00000162955
znf1091
zinc finger protein 1091
chr16_-_21238288 0.28 ENSDART00000139737
cbx3b
chromobox homolog 3b
chr11_-_9479592 0.26 ENSDART00000175829
CU179643.1
ENSDARG00000086489
chr11_-_9479689 0.24 ENSDART00000175829
CU179643.1
ENSDARG00000086489
chr10_-_5135388 0.24 ENSDART00000108587
sec31a
SEC31 homolog A, COPII coat complex component
chr7_+_40879017 0.23

chr1_-_39177682 0.22 ENSDART00000035739
tmem134
transmembrane protein 134
chr17_-_26849495 0.22 ENSDART00000153590
si:dkey-221l4.10
si:dkey-221l4.10
chr7_-_8635687 0.22 ENSDART00000081620
vax2
ventral anterior homeobox 2
chr11_-_36853345 0.21 ENSDART00000172074
NINJ1
ninjurin 1
chr19_-_19138287 0.18

chr9_-_42894582 0.17 ENSDART00000144744
col5a2a
collagen, type V, alpha 2a
chr8_+_39525254 0.17

chr12_+_30245620 0.17 ENSDART00000153116
ENSDART00000152900
ENSDARG00000020224
ENSDARG00000020224
chr1_+_13386937 0.17 ENSDART00000021693
ank2a
ankyrin 2a, neuronal
chr15_-_104637 0.15 ENSDART00000164323
ENSDART00000161218
cyp2y3
cytochrome P450, family 2, subfamily Y, polypeptide 3
chr2_-_42566339 0.15 ENSDART00000121452
slco5a1b
solute carrier organic anion transporter family member 5A1b
chr12_-_8920454 0.14 ENSDART00000041728
cyp26a1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr12_+_5673442 0.14 ENSDART00000017191
dlx3b
distal-less homeobox 3b
chr15_-_4154407 0.13 ENSDART00000090624
lpar6a
lysophosphatidic acid receptor 6a
chr22_+_470536 0.13 ENSDART00000135403
nuak2
NUAK family, SNF1-like kinase, 2
chr4_+_5826813 0.12 ENSDART00000055414
pex26
peroxisomal biogenesis factor 26
chr13_+_36459625 0.11 ENSDART00000030211
gmfb
glia maturation factor, beta
chr23_-_1008307 0.11 ENSDART00000110588
cdh26.1
cadherin 26, tandem duplicate 1
chr12_-_8920541 0.11 ENSDART00000041728
cyp26a1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr8_-_52728470 0.11

chr9_-_14916484 0.10

chr10_+_1812271 0.09

chr18_+_24932972 0.09 ENSDART00000008638
rgma
repulsive guidance molecule family member a
chr13_+_36459562 0.09 ENSDART00000030211
gmfb
glia maturation factor, beta
chr21_-_34891991 0.09 ENSDART00000065337
kif20a
kinesin family member 20A
chr7_-_20201693 0.09 ENSDART00000174001
ntn5
netrin 5
chr3_+_15122138 0.08 ENSDART00000141752
asphd1
aspartate beta-hydroxylase domain containing 1
chr7_+_5853590 0.07 ENSDART00000123660
HIST2H2AB (1 of many)
histone cluster 2 H2A family member b
chr2_-_30340646 0.07 ENSDART00000099078
jph1b
junctophilin 1b
chr9_-_15453448 0.07 ENSDART00000124346
ENSDART00000010521
ENSDART00000103753
fn1a
fibronectin 1a
chr8_+_29953399 0.07 ENSDART00000149372
ENSDART00000007640
ptch1
ptch1
patched 1
patched 1
chr21_+_28687401 0.06 ENSDART00000138017
puraa
purine-rich element binding protein Aa
chr17_+_52780715 0.05

chr14_+_10797695 0.05 ENSDART00000161311
NEXMIF (1 of many)
neurite extension and migration factor
chr10_+_5135537 0.04 ENSDART00000132627
ENSDART00000082295
zgc:113274
zgc:113274
chr12_+_35018663 0.04 ENSDART00000085774
si:ch73-127m5.1
si:ch73-127m5.1
chr14_+_49180737 0.04

chr7_-_38299544 0.04 ENSDART00000041055
celf1
cugbp, Elav-like family member 1
chr16_+_54350976 0.04 ENSDART00000172622
ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr7_+_1443102 0.04 ENSDART00000172830
supt16h
SPT16 homolog, facilitates chromatin remodeling subunit
chr16_-_2269074 0.03

chr5_+_33011105 0.03

chr10_+_6381994 0.03 ENSDART00000170548
ENSDARG00000100633
ENSDARG00000100633
chr23_+_39569262 0.02 ENSDART00000031616
mical1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr7_-_57680717 0.02

chr11_+_18817797 0.02

chr23_-_1008468 0.01 ENSDART00000110588
cdh26.1
cadherin 26, tandem duplicate 1
chr14_+_49180887 0.01

chr25_-_31952245 0.01 ENSDART00000153892
cep152
centrosomal protein 152
chr14_+_49180922 0.00

chr2_-_31817355 0.00 ENSDART00000112763
retreg1
reticulophagy regulator 1
chr2_-_44329092 0.00

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0003131 mesodermal-endodermal cell signaling(GO:0003131) response to vitamin A(GO:0033189) cellular response to vitamin A(GO:0071299) retinoic acid receptor signaling pathway involved in somitogenesis(GO:0090242)
0.0 0.1 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) actin filament debranching(GO:0071846)
0.0 0.9 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.1 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.2 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0090259 regulation of retinal ganglion cell axon guidance(GO:0090259) negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0 0.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0048635 negative regulation of muscle organ development(GO:0048635)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 0.2 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.1 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.9 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0051117 ATPase binding(GO:0051117)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type