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Results for tgif1_meis2a_meis1a
Z-value: 6.12
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Transcription factors associated with tgif1_meis2a_meis1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tgif1 | dr10_dc_chr24_-_9151146_9151153 | -0.92 | 4.1e-07 | Click! |
| meis2a | dr10_dc_chr17_+_52736844_52736926 | 0.16 | 5.4e-01 | Click! |
| meis1a | dr10_dc_chr1_+_50835265_50835384 | -0.05 | 8.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of tgif1_meis2a_meis1a
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_33449922 Show fit | 6.61 |
ENSDART00000115379
ENSDART00000163458 ENSDART00000078012 |
zgc:153345 |
|
| chr23_-_27579257 Show fit | 6.38 |
ENSDART00000137229
|
ankyrin repeat and SOCS box containing 8 |
|
| chr3_+_16572387 Show fit | 6.27 |
ENSDART00000008711
|
glycogen synthase 1 (muscle) |
|
| chr17_-_24569231 Show fit | 5.88 |
ENSDART00000105442
|
aftiphilin b |
|
| chr21_+_36938230 Show fit | 5.55 |
ENSDART00000027459
|
G protein-coupled receptor kinase 6 |
|
| chr8_-_32376710 Show fit | 5.13 |
ENSDART00000098850
|
lipase, endothelial |
|
| chr13_-_49749441 Show fit | 4.98 |
ENSDART00000136165
|
lysosomal trafficking regulator |
|
| chr2_+_28199458 Show fit | 4.75 |
ENSDART00000150330
|
bucky ball |
|
| chr25_+_17593164 Show fit | 4.39 |
ENSDART00000171965
|
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18a |
|
| chr21_+_37760978 Show fit | 4.38 |
ENSDART00000145828
|
phosphoglycerate kinase 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 15.2 | GO:0007040 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.2 | 10.6 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.2 | 9.4 | GO:0008643 | carbohydrate transport(GO:0008643) |
| 0.6 | 8.5 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
| 0.3 | 8.0 | GO:0006505 | GPI anchor metabolic process(GO:0006505) |
| 0.1 | 7.9 | GO:0006470 | protein dephosphorylation(GO:0006470) |
| 1.1 | 7.4 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.3 | 7.4 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.1 | 7.4 | GO:0007601 | visual perception(GO:0007601) |
| 0.5 | 7.1 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 55.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 33.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 15.6 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 14.3 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 13.5 | GO:0005829 | cytosol(GO:0005829) |
| 0.3 | 12.4 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 11.7 | GO:0005813 | centrosome(GO:0005813) |
| 0.3 | 11.5 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.2 | 10.3 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.2 | 8.6 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.0 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
| 0.1 | 19.8 | GO:0060589 | nucleoside-triphosphatase regulator activity(GO:0060589) |
| 0.1 | 19.0 | GO:0008234 | cysteine-type peptidase activity(GO:0008234) |
| 0.1 | 19.0 | GO:0019900 | kinase binding(GO:0019900) |
| 0.0 | 14.3 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.3 | 10.7 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.3 | 8.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 8.7 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.5 | 8.1 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 8.1 | GO:0030246 | carbohydrate binding(GO:0030246) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.4 | 8.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.8 | 7.5 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.2 | 6.8 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.4 | 6.7 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 6.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 5.5 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 4.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.3 | 3.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 3.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 11.6 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.4 | 11.1 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.2 | 8.5 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.1 | 8.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.4 | 7.4 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.2 | 7.3 | REACTOME PERK REGULATED GENE EXPRESSION | Genes involved in PERK regulated gene expression |
| 0.1 | 5.5 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.6 | 5.2 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.1 | 4.8 | REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | Genes involved in Recruitment of mitotic centrosome proteins and complexes |