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Results for tlx1

Z-value: 1.56

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Transcription factors associated with tlx1

Gene Symbol Gene ID Gene Info
tlx1
ENSDARG00000003965 T cell leukemia homeobox 1

Activity profile of tlx1 motif

Sorted Z-values of tlx1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of tlx1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_+_56970554 7.44 ENSDART00000162930
bahcc1a
BAH domain and coiled-coil containing 1a
chr5_+_12786897 5.91

chr19_-_30816780 4.74 ENSDART00000103475
agr2
anterior gradient 2
chr2_+_55859099 4.26 ENSDART00000097753
ENSDART00000141688
nmrk2
nicotinamide riboside kinase 2
chr16_+_23482744 4.06 ENSDART00000148961
s100a10b
S100 calcium binding protein A10b
chr2_-_8219329 3.96 ENSDART00000040209
ephb3a
eph receptor B3a
chr21_-_34623741 3.80 ENSDART00000023038
dacha
dachshund a
chr16_+_16941228 3.78 ENSDART00000142155
myh14
myosin, heavy chain 14, non-muscle
chr15_-_35034668 3.70 ENSDART00000153787
rnf183
ring finger protein 183
chr17_+_52736192 3.67 ENSDART00000158273
ENSDART00000161414
meis2a
Meis homeobox 2a
chr5_-_56984800 3.67 ENSDART00000074290
mia
melanoma inhibitory activity
chr7_-_24201833 3.44 ENSDART00000121684
nat8l
N-acetyltransferase 8-like
chr2_+_49358871 3.42 ENSDART00000179089
sema6ba
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba
chr19_+_9085377 3.22 ENSDART00000091443
ENSDARG00000062900
ENSDARG00000062900
chr18_-_39491932 3.05 ENSDART00000122930
scg3
secretogranin III
chr9_-_24431684 3.04 ENSDART00000039399
cavin2a
caveolae associated protein 2a
chr7_+_56807833 2.89 ENSDART00000055956
enosf1
enolase superfamily member 1
chr6_-_49674729 2.66 ENSDART00000112226
apcdd1l
adenomatosis polyposis coli down-regulated 1-like
chr20_+_34417665 2.64 ENSDART00000153207
ivns1abpa
influenza virus NS1A binding protein a
chr23_-_9556986 2.63 ENSDART00000139688
soga1
suppressor of glucose, autophagy associated 1
chr1_+_9612906 2.56 ENSDART00000152562
eif3f
eukaryotic translation initiation factor 3, subunit F
chr22_+_38276148 2.55 ENSDART00000104504
si:ch211-284e20.8
si:ch211-284e20.8
chr6_-_39311711 2.46

chr11_-_17620732 2.44 ENSDART00000154627
eogt
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr3_-_56969897 2.41

chr7_-_34854886 2.35 ENSDART00000141211
hsd11b2
hydroxysteroid (11-beta) dehydrogenase 2
chr17_+_38314814 2.31 ENSDART00000017493
nkx2.1
NK2 homeobox 1
chr23_+_7085389 2.24

chr22_-_28840467 2.14

chr6_+_53349584 2.09 ENSDART00000167079
si:ch211-161c3.5
si:ch211-161c3.5
chr4_-_16417703 2.06 ENSDART00000013085
dcn
decorin
chr6_+_2849460 2.05

chr8_-_31044627 2.04 ENSDART00000109885
snrnp200
small nuclear ribonucleoprotein 200 (U5)
chr10_-_17274395 2.02 ENSDART00000135679
rab36
RAB36, member RAS oncogene family
chr2_-_21960508 1.89 ENSDART00000027587
ralab
v-ral simian leukemia viral oncogene homolog Ab (ras related)
chr19_-_22182031 1.87 ENSDART00000104279
znf516
zinc finger protein 516
chr11_-_22200590 1.80 ENSDART00000006580
tfeb
transcription factor EB
chr10_+_36710393 1.75

chr19_+_43524904 1.75

chr12_+_3189489 1.74 ENSDART00000010569
g6pc3
glucose 6 phosphatase, catalytic, 3
chr22_-_11408859 1.71 ENSDART00000007649
mid1ip1b
MID1 interacting protein 1b
chr9_+_36051713 1.70 ENSDART00000134447
rcan1a
regulator of calcineurin 1a
chr17_-_42108276 1.58 ENSDART00000110871
ENSDART00000155484
nkx2.4a
NK2 homeobox 4a
chr20_-_15181042 1.57 ENSDART00000175585
prrc2c
proline-rich coiled-coil 2C
chr24_+_14093524 1.57

chr7_+_38008155 1.56 ENSDART00000169927
lrp3
low density lipoprotein receptor-related protein 3
chr5_-_45219030 1.53

chr17_+_52736535 1.48 ENSDART00000158273
ENSDART00000161414
meis2a
Meis homeobox 2a
chr7_+_37105966 1.48 ENSDART00000111842
sall1a
spalt-like transcription factor 1a
chr24_+_26922969 1.46

chr1_+_48923897 1.46 ENSDART00000101004
ENSDART00000164000
ENSDART00000142957
col17a1a
collagen, type XVII, alpha 1a
chr6_-_39311594 1.44

chr9_-_23547539 1.44 ENSDART00000046423
arl4cb
ADP-ribosylation factor-like 4Cb
chr2_-_23431625 1.43 ENSDART00000157318
BX548024.1
ENSDARG00000097593
chr8_-_34077387 1.40 ENSDART00000159208
ENSDART00000040126
ENSDART00000048994
ENSDART00000098822
pbx3b
pre-B-cell leukemia homeobox 3b
KN150670v1_-_61400 1.39

chr8_+_41639900 1.36 ENSDART00000136492
si:ch211-158d24.4
si:ch211-158d24.4
chr8_-_34077790 1.34

chr6_-_35417797 1.26 ENSDART00000016586
rgs5a
regulator of G protein signaling 5a
chr12_+_34615991 1.25

chr8_+_43334181 1.23 ENSDART00000038566
fam101a
family with sequence similarity 101, member A
chr5_-_56856570 1.21 ENSDART00000022866
pisd
phosphatidylserine decarboxylase
chr14_-_1081393 1.13

chr17_+_52736844 1.12 ENSDART00000160507
meis2a
Meis homeobox 2a
chr8_-_3974357 1.11 ENSDART00000163754
ENSDART00000169474
mtmr3
myotubularin related protein 3
chr10_+_7678087 1.10 ENSDART00000160673
hint1
histidine triad nucleotide binding protein 1
chr22_-_34619727 1.10

chr12_+_35911999 1.08 ENSDART00000167873
baiap2b
BAI1-associated protein 2b
chr9_+_3578084 1.03

chr12_+_27035744 1.03 ENSDART00000025966
hoxb6b
homeobox B6b
chr2_-_30005139 0.97 ENSDART00000146968
cnpy1
canopy1
chr25_-_35022528 0.95

chr22_-_22391686 0.92 ENSDART00000158555
camsap2a
calmodulin regulated spectrin-associated protein family, member 2a
chr4_-_72584439 0.92 ENSDART00000174112
si:cabz01071911.4
si:cabz01071911.4
chr25_+_4534280 0.91 ENSDART00000130299
deaf1
DEAF1 transcription factor
chr10_+_8132413 0.78 ENSDART00000143848
ENSDART00000075485
sub1a
SUB1 homolog, transcriptional regulator a
chr7_-_41188699 0.77 ENSDART00000150146
smarcd3b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b
chr2_+_45447068 0.76 ENSDART00000083957
ENSDART00000160867
camsap2b
calmodulin regulated spectrin-associated protein family, member 2b
chr10_-_42155708 0.73

chr3_+_24352261 0.73 ENSDART00000059179
nptxra
neuronal pentraxin receptor a
chr3_+_19186494 0.72 ENSDART00000111528
kri1
KRI1 homolog
chr14_-_32163041 0.72 ENSDART00000034883
mcf2a
MCF.2 cell line derived transforming sequence a
chr14_+_31525014 0.68 ENSDART00000039880
tm9sf5
transmembrane 9 superfamily protein member 5
chr1_-_22066408 0.68 ENSDART00000134719
ENSDART00000166891
prom1b
prominin 1 b
chr5_-_45219194 0.66

chr4_-_4241386 0.64 ENSDART00000103316
cd9b
CD9 molecule b
chr5_+_424486 0.62 ENSDART00000170350
thap1
THAP domain containing, apoptosis associated protein 1
chr14_-_28126346 0.62 ENSDART00000054062
nek12
NIMA-related kinase 12
chr18_-_16933517 0.59

chr1_+_34810895 0.58

chr1_-_27826175 0.58 ENSDART00000121758
ednrba
endothelin receptor Ba
chr25_-_31049247 0.57 ENSDART00000009126
kras
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
chr6_-_19812881 0.56 ENSDART00000151152
si:dkey-19e4.5
si:dkey-19e4.5
chr2_+_17116697 0.54

chr17_-_22047445 0.53 ENSDART00000156872
ttbk1b
tau tubulin kinase 1b
chr3_-_34470137 0.47 ENSDART00000055259
nmrk1
nicotinamide riboside kinase 1
chr23_-_38565866 0.46

chr17_-_15594907 0.44

chr8_+_21974863 0.43

chr19_+_43524684 0.39

chr6_+_23462412 0.39 ENSDART00000166192
pik3r5
phosphoinositide-3-kinase, regulatory subunit 5
chr5_-_56856527 0.36 ENSDART00000022866
pisd
phosphatidylserine decarboxylase
chr18_+_41570495 0.31 ENSDART00000169621
ENSDART00000162052
baz1b
bromodomain adjacent to zinc finger domain, 1B
chr25_-_34635697 0.31 ENSDART00000113870
ENSDARG00000075379
ENSDARG00000075379
chr23_-_18646217 0.31 ENSDART00000138599
ssr4
signal sequence receptor, delta
chr8_-_31044429 0.28 ENSDART00000109885
snrnp200
small nuclear ribonucleoprotein 200 (U5)
chr14_-_2342593 0.25

chr9_+_36051871 0.22 ENSDART00000144141
rcan1a
regulator of calcineurin 1a
chr5_+_30683387 0.21 ENSDART00000133743
camkk1a
calcium/calmodulin-dependent protein kinase kinase 1, alpha a
chr6_-_39201507 0.20 ENSDART00000131793
c1galt1b
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b
chr3_+_61158991 0.19 ENSDART00000126417
bri3
brain protein I3
chr7_-_73622585 0.15 ENSDART00000126541
zgc:173552
zgc:173552
chr3_-_41369324 0.13

chr8_+_9660683 0.08 ENSDART00000091848
gripap1
GRIP1 associated protein 1
chr6_+_54857805 0.07

chr18_+_7584079 0.07 ENSDART00000163709
zgc:77650
zgc:77650
chr10_+_572931 0.07 ENSDART00000129856
ENSDART00000110384
smad4a
SMAD family member 4a
chr6_+_33261144 0.04 ENSDART00000157428
pik3r3b
phosphoinositide-3-kinase, regulatory subunit 3b (gamma)

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.7 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.7 4.0 GO:0051963 regulation of synapse assembly(GO:0051963) positive regulation of synapse assembly(GO:0051965)
0.5 2.4 GO:0034650 cortisol metabolic process(GO:0034650)
0.4 1.1 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.3 1.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 1.7 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.2 1.9 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 1.1 GO:2000251 regulation of actin cytoskeleton reorganization(GO:2000249) positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.7 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.1 1.5 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 1.8 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 2.1 GO:0050654 chondroitin sulfate proteoglycan metabolic process(GO:0050654)
0.1 2.4 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 1.7 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.1 3.6 GO:0021854 hypothalamus development(GO:0021854)
0.1 6.3 GO:0009880 embryonic pattern specification(GO:0009880)
0.1 0.8 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 0.8 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 3.4 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.1 0.6 GO:0042310 vasoconstriction(GO:0042310)
0.1 1.1 GO:0009154 purine ribonucleotide catabolic process(GO:0009154)
0.0 2.5 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.7 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
0.0 2.7 GO:0021782 glial cell development(GO:0021782)
0.0 5.1 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 2.9 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.0 1.0 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.0 0.6 GO:0007338 single fertilization(GO:0007338)
0.0 0.7 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 3.8 GO:0048839 inner ear development(GO:0048839)
0.0 2.6 GO:0006413 translational initiation(GO:0006413)
0.0 1.9 GO:0017157 regulation of exocytosis(GO:0017157)
0.0 0.3 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 1.0 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.5 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.3 3.0 GO:0030667 secretory granule membrane(GO:0030667)
0.2 0.7 GO:0071914 prominosome(GO:0071914)
0.2 1.7 GO:0036449 microtubule minus-end(GO:0036449)
0.2 3.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 3.0 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 3.8 GO:0016459 myosin complex(GO:0016459)
0.1 0.4 GO:0097651 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.1 2.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.8 GO:0071564 npBAF complex(GO:0071564)
0.0 1.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 4.0 GO:0030425 dendrite(GO:0030425)
0.0 0.7 GO:0030686 90S preribosome(GO:0030686)
0.0 19.2 GO:0005576 extracellular region(GO:0005576)
0.0 4.2 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.4 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.6 2.4 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.4 1.7 GO:0030507 spectrin binding(GO:0030507)
0.4 1.9 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 4.0 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 4.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 3.0 GO:0005080 protein kinase C binding(GO:0005080)
0.1 2.6 GO:0070122 isopeptidase activity(GO:0070122)
0.1 2.1 GO:0005518 collagen binding(GO:0005518)
0.1 2.4 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.1 1.7 GO:0019203 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.1 2.5 GO:0019003 GDP binding(GO:0019003)
0.1 1.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 3.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 2.9 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 2.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 7.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 3.4 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 1.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.3 GO:0035173 histone kinase activity(GO:0035173)
0.0 4.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 3.8 GO:0003774 motor activity(GO:0003774)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0015485 cholesterol binding(GO:0015485)
0.0 7.1 GO:0003682 chromatin binding(GO:0003682)
0.0 1.1 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.6 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.4 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 3.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 3.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 0.6 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 2.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.1 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma