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Results for tp53

Z-value: 1.61

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Transcription factors associated with tp53

Gene Symbol Gene ID Gene Info
tp53
ENSDARG00000035559 tumor protein p53

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp53dr10_dc_chr5_+_23585492_235855550.766.5e-04Click!

Activity profile of tp53 motif

Sorted Z-values of tp53 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of tp53

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_35184996 4.98 ENSDART00000086954
ENSDART00000161594
sesn3
sestrin 3
chr3_+_22412059 4.90

chr23_+_23305483 4.29 ENSDART00000126479
plekhn1
pleckstrin homology domain containing, family N member 1
chr16_+_43468861 4.14

chr25_-_7346766 4.13 ENSDART00000170050
cdkn1cb
cyclin-dependent kinase inhibitor 1Cb
chr1_-_40536800 3.78 ENSDART00000134739
rgs12b
regulator of G protein signaling 12b
chr25_+_35438530 3.64 ENSDART00000171369
hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_+_23406078 3.49 ENSDART00000139543
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr21_+_25651712 3.44 ENSDART00000135123
si:dkey-17e16.17
si:dkey-17e16.17
chr6_+_49096966 2.89 ENSDART00000141042
ENSDART00000143369
slc25a22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr11_-_25962291 2.85

chr15_-_29454583 2.84 ENSDART00000145976
serpinh1b
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr22_+_37934447 2.71 ENSDART00000076082
fetub
fetuin B
chr10_+_8670564 2.52 ENSDART00000129643
aplnrb
apelin receptor b
chr15_+_4027133 2.42

chr19_-_27878747 2.35 ENSDART00000137638
si:ch73-25f10.6
si:ch73-25f10.6
chr15_-_23826312 2.17 ENSDART00000137918
bbc3
BCL2 binding component 3
chr24_-_3334678 2.15

chr23_+_22649686 2.05 ENSDART00000146709
CR388207.1
ENSDARG00000095377
KN150108v1_-_8893 2.05 ENSDART00000167033
ENSDARG00000100513
ENSDARG00000100513
chr5_+_23585492 2.02 ENSDART00000135083
tp53
tumor protein p53
chr10_-_4979688 1.81 ENSDART00000093228
mat2al
methionine adenosyltransferase II, alpha-like
chr23_-_5825177 1.81 ENSDART00000055087
phlda3
pleckstrin homology-like domain, family A, member 3
chr20_-_32429820 1.68 ENSDART00000062982
foxo3b
forkhead box O3b
chr18_+_45203251 1.67 ENSDART00000015786
gyltl1b
glycosyltransferase-like 1b
chr2_-_28244864 1.67 ENSDART00000137542
zgc:163121
zgc:163121
chr19_+_25569817 1.64 ENSDART00000163220
si:ch211-239d6.2
si:ch211-239d6.2
chr17_-_8111181 1.60 ENSDART00000149873
ENSDART00000148403
ahi1
Abelson helper integration site 1
chr8_-_45043860 1.57 ENSDART00000138269
BX005065.1
ENSDARG00000092243
chr16_-_25793780 1.57

chr7_+_34482282 1.57

chr16_+_21436660 1.54 ENSDART00000145886
osbpl3b
oxysterol binding protein-like 3b
chr10_+_38568464 1.49 ENSDART00000109752
serpinh1a
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a
chr15_+_666833 1.49 ENSDART00000157207
si:ch211-210b2.1
si:ch211-210b2.1
chr17_+_21433543 1.48 ENSDART00000079030
pla2g4f.1
phospholipase A2, group IVF, tandem duplicate 1
chr10_+_4987494 1.37 ENSDART00000121959
si:ch73-234b20.5
si:ch73-234b20.5
chr3_-_49242655 1.37 ENSDART00000142200
ENSDART00000139524
arl16
ADP-ribosylation factor-like 16
chr8_+_28584427 1.33 ENSDART00000097213
tcf15
transcription factor 15
chr7_+_48532749 1.30 ENSDART00000145375
cpt1aa
carnitine palmitoyltransferase 1Aa (liver)
chr13_+_24531753 1.27 ENSDART00000014176
msx3
muscle segment homeobox 3
chr14_+_35890811 1.26 ENSDART00000141766
elovl6
ELOVL fatty acid elongase 6
chr23_-_5825236 1.22 ENSDART00000055087
phlda3
pleckstrin homology-like domain, family A, member 3
chr19_-_27878556 1.20 ENSDART00000137638
si:ch73-25f10.6
si:ch73-25f10.6
chr23_+_22649652 1.19 ENSDART00000146709
CR388207.1
ENSDARG00000095377
chr25_-_35530474 1.18

chr21_+_15339960 1.18 ENSDART00000137491
si:dkey-11o15.10
si:dkey-11o15.10
chr11_+_6284324 1.16 ENSDART00000002459
ctns
cystinosin, lysosomal cystine transporter
chr7_+_25778546 1.14 ENSDART00000173611
si:dkey-6n21.12
si:dkey-6n21.12
chr5_-_34940744 1.14 ENSDART00000145779
si:dkey-204l11.1
si:dkey-204l11.1
chr22_-_11712371 1.12

chr17_-_10682357 1.10 ENSDART00000064597
lgals3b
lectin, galactoside binding soluble 3b
chr14_+_4489377 1.03 ENSDART00000041468
ap1ar
adaptor-related protein complex 1 associated regulatory protein
chr23_-_31502149 1.00 ENSDART00000053545
zgc:153284
zgc:153284
chr22_-_6772249 0.99 ENSDART00000108883
si:ch1073-188e1.1
si:ch1073-188e1.1
chr20_+_22813503 0.98

chr23_+_11412329 0.97 ENSDART00000135406
chl1a
cell adhesion molecule L1-like a
chr12_+_6065116 0.95 ENSDART00000139054
sgms1
sphingomyelin synthase 1
chr16_+_40610589 0.90 ENSDART00000038294
tp53inp1
tumor protein p53 inducible nuclear protein 1
chr12_+_29121368 0.89 ENSDART00000006505
mxtx2
mix-type homeobox gene 2
chr13_+_28574593 0.89 ENSDART00000126845
ldb1a
LIM domain binding 1a
chr18_-_40462054 0.89

chr5_+_27298136 0.89 ENSDART00000098604
adam28
ADAM metallopeptidase domain 28
chr5_-_57016269 0.79 ENSDART00000074264
crfb12
cytokine receptor family member B12
chr8_-_4638117 0.76 ENSDART00000019828
zgc:63587
zgc:63587
chr3_+_39821041 0.75

chr10_-_40905363 0.74 ENSDART00000076304
pcna
proliferating cell nuclear antigen
chr24_-_30924897 0.74 ENSDART00000168540
ptbp2a
polypyrimidine tract binding protein 2a
chr15_+_35185174 0.73 ENSDART00000086954
ENSDART00000161594
sesn3
sestrin 3
chr6_-_55332828 0.73

chr4_+_13932849 0.72 ENSDART00000141742
pphln1
periphilin 1
chr19_+_48166365 0.71

KN150663v1_+_55800 0.71

chr8_-_31044429 0.71 ENSDART00000109885
snrnp200
small nuclear ribonucleoprotein 200 (U5)
chr4_-_23405867 0.69

chr23_+_11350727 0.68

chr11_+_44809527 0.67 ENSDART00000037819
ENSDART00000159886
tmc6b
transmembrane channel-like 6b
chr5_-_62592627 0.66 ENSDART00000131274
tbcelb
tubulin folding cofactor E-like b
chr25_-_28932291 0.66 ENSDART00000073488
CU469568.1
ENSDARG00000051805
chr10_-_40904685 0.63

chr10_+_29964821 0.62 ENSDART00000117710
SNORD14
Small nucleolar RNA SNORD14
chr9_+_8951400 0.61 ENSDART00000102562
ankrd10b
ankyrin repeat domain 10b
chr8_+_15240122 0.60 ENSDART00000146965
dnttip2
deoxynucleotidyltransferase, terminal, interacting protein 2
chr3_+_23567458 0.60 ENSDART00000078466
hoxb3a
homeobox B3a
chr22_-_6772204 0.59 ENSDART00000108883
si:ch1073-188e1.1
si:ch1073-188e1.1
chr23_-_1008307 0.58 ENSDART00000110588
cdh26.1
cadherin 26, tandem duplicate 1
chr14_+_36529003 0.58 ENSDART00000111674
F2RL3
F2R like thrombin or trypsin receptor 3
chr6_+_30449742 0.58

chr19_+_9231110 0.56 ENSDART00000127803
clk2a
CDC-like kinase 2a
chr16_+_34157866 0.56 ENSDART00000140552
tcea3
transcription elongation factor A (SII), 3
chr22_-_13613870 0.55

chr7_+_34482202 0.55

chr10_+_29964521 0.54 ENSDART00000117710
SNORD14
Small nucleolar RNA SNORD14
chr8_+_23617861 0.53 ENSDART00000083108
nt5dc2
5'-nucleotidase domain containing 2
chr16_+_34157948 0.51 ENSDART00000140552
tcea3
transcription elongation factor A (SII), 3
chr19_-_12274044 0.51 ENSDART00000041960
ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr7_+_48532096 0.50

chr22_-_22234261 0.50 ENSDART00000113824
ENSDART00000169594
ENSDART00000158261
hdgfrp2
hepatoma-derived growth factor-related protein 2
chr7_+_48532543 0.50 ENSDART00000145375
cpt1aa
carnitine palmitoyltransferase 1Aa (liver)
chr25_+_35437993 0.49 ENSDART00000066985
hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr9_+_50413366 0.49 ENSDART00000162990
cobll1b
cordon-bleu WH2 repeat protein-like 1b
chr17_+_34854745 0.46

chr12_-_5470187 0.45 ENSDART00000159784
abi3b
ABI family, member 3b
chr5_-_56885580 0.44

chr13_-_25502297 0.44 ENSDART00000077627
ENSDART00000139237
ret
ret proto-oncogene receptor tyrosine kinase
chr13_-_8968218 0.44 ENSDART00000144142
ENSDART00000144714
HTRA2 (1 of many)
HtrA serine peptidase 2
chr16_-_48458505 0.44 ENSDART00000159372
eif3ha
eukaryotic translation initiation factor 3, subunit H, a
chr7_-_25777968 0.44 ENSDART00000101124
rnaseka
ribonuclease, RNase K a
chr10_+_29964412 0.41 ENSDART00000117710
SNORD14
Small nucleolar RNA SNORD14
chr3_-_45836485 0.40

chr5_-_54151518 0.39

chr11_+_16018035 0.38 ENSDART00000081054
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr16_-_31670211 0.38 ENSDART00000138216
CR855311.1
ENSDARG00000090352
chr17_+_40924000 0.37 ENSDART00000046003
slc4a1ap
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr13_-_8968136 0.36 ENSDART00000144714
HTRA2 (1 of many)
HtrA serine peptidase 2
chr11_+_42352106 0.35 ENSDART00000169938
il17rd
interleukin 17 receptor D
chr15_+_28370102 0.34 ENSDART00000175860
myo1cb
myosin Ic, paralog b
chr19_+_44185325 0.34 ENSDART00000063870
rpl11
ribosomal protein L11
chr3_+_25933164 0.33 ENSDART00000143697
si:dkeyp-69e1.8
si:dkeyp-69e1.8
chr19_-_11096542 0.33

chr5_-_69031855 0.31 ENSDART00000028954
rilpl2
Rab interacting lysosomal protein-like 2
chr5_-_28970034 0.29 ENSDART00000043259
entpd2a.2
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2
chr12_-_25931242 0.29 ENSDART00000166769
bmpr1ab
bone morphogenetic protein receptor, type IAb
chr25_+_34543860 0.28 ENSDART00000050237
hist1h2ba
histone cluster 1, H2ba
chr23_+_20936419 0.28 ENSDART00000129992
pax7b
paired box 7b
chr11_+_10991763 0.24 ENSDART00000160488
itgb6
integrin, beta 6
chr1_-_17898961 0.23 ENSDART00000082063
fam114a1
family with sequence similarity 114, member A1
chr9_-_7419306 0.22 ENSDART00000125054
slc23a3
solute carrier family 23, member 3
chr19_-_18671902 0.22

chr19_+_44413865 0.20 ENSDART00000136147
ENSDART00000151004
nkd3
naked cuticle homolog 3
chr15_+_17407258 0.20 ENSDART00000111753
vmp1
vacuole membrane protein 1
chr25_-_35539585 0.19 ENSDART00000073432
rbl2
retinoblastoma-like 2 (p130)
chr23_-_1008468 0.19 ENSDART00000110588
cdh26.1
cadherin 26, tandem duplicate 1
chr6_-_3354362 0.19 ENSDART00000082151
uqcrh
ubiquinol-cytochrome c reductase hinge protein
chr19_-_18672697 0.19

chr23_+_4544178 0.18 ENSDART00000092389
nup210
nucleoporin 210
chr25_+_34553195 0.18 ENSDART00000156838
zgc:112234
zgc:112234
chr13_+_4096622 0.18 ENSDART00000058242
ENSDART00000143456
mea1
male-enhanced antigen 1
chr23_+_23305376 0.18 ENSDART00000126479
plekhn1
pleckstrin homology domain containing, family N member 1
chr23_-_31585883 0.17 ENSDART00000157511
eya4
EYA transcriptional coactivator and phosphatase 4
chr24_-_16895179 0.16 ENSDART00000048823
c8g
complement component 8, gamma polypeptide
KN150583v1_-_1389 0.16

chr22_-_111624 0.16 ENSDART00000163198
capzb
capping protein (actin filament) muscle Z-line, beta
chr3_+_13040717 0.16

chr25_+_35540123 0.14 ENSDART00000126326
rpgrip1l
RPGRIP1-like
chr10_+_4987461 0.14 ENSDART00000121959
si:ch73-234b20.5
si:ch73-234b20.5
chr8_+_26336302 0.14

chr23_+_20936374 0.13 ENSDART00000129992
pax7b
paired box 7b
chr14_+_49921861 0.12 ENSDART00000173240
zgc:154054
zgc:154054
chr10_-_40905193 0.12 ENSDART00000172089
pcna
proliferating cell nuclear antigen
chr5_+_23585615 0.11 ENSDART00000135083
tp53
tumor protein p53
chr16_+_38251717 0.11 ENSDART00000044971
myo1eb
myosin IE, b
chr21_-_5692160 0.11 ENSDART00000075137
ENSDART00000151202
ccni
cyclin I
chr2_-_10571195 0.11

chr16_-_19154824 0.11 ENSDART00000088818
fhod3b
formin homology 2 domain containing 3b
chr23_+_20522512 0.10 ENSDART00000137294
slc35c2
solute carrier family 35 (GDP-fucose transporter), member C2
chr3_-_45669791 0.10 ENSDART00000169364
gcgra
glucagon receptor a
chr25_-_34642724 0.10 ENSDART00000121963
hist1h4l
histone 1, H4, like
chr8_-_47158799 0.10

chr20_-_23272102 0.08 ENSDART00000167197
spata18
spermatogenesis associated 18
chr10_+_4979788 0.08

chr16_+_11295005 0.07

chr16_-_19154920 0.06 ENSDART00000088818
fhod3b
formin homology 2 domain containing 3b
chr2_-_24806569 0.06 ENSDART00000033922
kcnn1a
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1a
chr4_-_885413 0.06 ENSDART00000022668
aim1b
crystallin beta-gamma domain containing 1b
chr2_+_37854726 0.04 ENSDART00000113337
parp2
poly (ADP-ribose) polymerase 2
chr19_+_7916050 0.04 ENSDART00000026276
cks1b
CDC28 protein kinase regulatory subunit 1B
chr3_-_49082769 0.04 ENSDART00000131913
hgs
hepatocyte growth factor-regulated tyrosine kinase substrate
chr6_-_42051775 0.04 ENSDART00000022949
parp3
poly (ADP-ribose) polymerase family, member 3
chr3_+_16080070 0.03 ENSDART00000137396
rpl19
ribosomal protein L19
chr21_-_13875945 0.03 ENSDART00000143874
akna
AT-hook transcription factor
chr20_+_52740555 0.03 ENSDART00000110777
eef1db
eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)
chr16_+_38251653 0.03 ENSDART00000044971
myo1eb
myosin IE, b
chr23_+_20936600 0.03 ENSDART00000129992
pax7b
paired box 7b
chr15_-_18130992 0.02 ENSDART00000113142
phldb1b
pleckstrin homology-like domain, family B, member 1b
chr20_-_25732204 0.01 ENSDART00000048164
paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:1904019 epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035)
1.1 4.5 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.7 5.7 GO:0071233 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.5 4.1 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.5 2.5 GO:0010524 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of calcium ion transport into cytosol(GO:0010524) positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) regulation of inhibitory G-protein coupled receptor phosphorylation(GO:1904323) positive regulation of inhibitory G-protein coupled receptor phosphorylation(GO:1904325)
0.5 1.5 GO:0070254 mucus secretion(GO:0070254)
0.4 2.2 GO:0090199 regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.4 1.7 GO:0050687 negative regulation of response to biotic stimulus(GO:0002832) negative regulation of defense response to virus(GO:0050687)
0.4 1.1 GO:0090280 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) positive regulation of calcium ion import(GO:0090280)
0.4 2.1 GO:0043525 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.3 3.0 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.3 1.8 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.3 1.0 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.2 0.7 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.2 0.7 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.2 1.5 GO:0044458 motile cilium assembly(GO:0044458)
0.2 4.3 GO:0030199 collagen fibril organization(GO:0030199)
0.2 1.2 GO:0072337 renal absorption(GO:0070293) modified amino acid transport(GO:0072337)
0.2 1.0 GO:1900024 regulation of substrate adhesion-dependent cell spreading(GO:1900024)
0.2 1.8 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 1.0 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 1.3 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 0.4 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.1 0.9 GO:0006272 leading strand elongation(GO:0006272)
0.1 0.3 GO:0060911 cardiac cell fate commitment(GO:0060911)
0.1 0.7 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 1.5 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 0.4 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.1 2.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.3 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.0 1.3 GO:0043049 otic placode formation(GO:0043049)
0.0 0.2 GO:2001239 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.5 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.3 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.8 GO:0007599 blood coagulation(GO:0007596) hemostasis(GO:0007599)
0.0 0.9 GO:0001706 endoderm formation(GO:0001706)
0.0 0.3 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.4 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 1.1 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.4 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 0.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.1 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.2 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.9 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.7 GO:0061700 GATOR2 complex(GO:0061700)
0.5 1.5 GO:0098594 mucin granule(GO:0098594)
0.2 1.1 GO:0001772 immunological synapse(GO:0001772)
0.1 1.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.8 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.8 GO:0016342 catenin complex(GO:0016342)
0.0 0.5 GO:0005902 microvillus(GO:0005902)
0.0 3.2 GO:0030425 dendrite(GO:0030425)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.9 GO:0005776 autophagosome(GO:0005776)
0.0 1.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 4.5 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 1.2 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 6.6 GO:0005615 extracellular space(GO:0005615)
0.0 0.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
1.0 3.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.7 4.5 GO:1901612 cardiolipin binding(GO:1901612)
0.7 5.7 GO:0070728 leucine binding(GO:0070728)
0.5 1.5 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.4 2.5 GO:0060182 apelin receptor activity(GO:0060182)
0.4 1.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.4 4.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.4 1.1 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.3 1.8 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.3 0.9 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.3 1.8 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.2 0.9 GO:0030274 LIM domain binding(GO:0030274)
0.2 4.3 GO:0005518 collagen binding(GO:0005518)
0.2 0.7 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 1.0 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 2.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 1.2 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.8 GO:0019894 kinesin binding(GO:0019894)
0.0 0.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.3 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.0 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 1.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 3.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.4 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.8 GO:0045296 cadherin binding(GO:0045296)
0.0 3.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0017046 peptide hormone binding(GO:0017046)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 2.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 2.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 0.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 1.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.9 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID FOXM1 PATHWAY FOXM1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 3.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 1.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 0.9 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 0.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade