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Results for tp53
Z-value: 1.61
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Transcription factors associated with tp53
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tp53 | dr10_dc_chr5_+_23585492_23585555 | 0.76 | 6.5e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of tp53
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_35184996 Show fit | 4.98 |
ENSDART00000086954
ENSDART00000161594 |
sestrin 3 |
|
| chr3_+_22412059 Show fit | 4.90 |
|
|
|
| chr23_+_23305483 Show fit | 4.29 |
ENSDART00000126479
|
pleckstrin homology domain containing, family N member 1 |
|
| chr16_+_43468861 Show fit | 4.14 |
|
|
|
| chr25_-_7346766 Show fit | 4.13 |
ENSDART00000170050
|
cyclin-dependent kinase inhibitor 1Cb |
|
| chr1_-_40536800 Show fit | 3.78 |
ENSDART00000134739
|
regulator of G protein signaling 12b |
|
| chr25_+_35438530 Show fit | 3.64 |
ENSDART00000171369
|
hydroxysteroid (17-beta) dehydrogenase 2 |
|
| chr4_+_23406078 Show fit | 3.49 |
ENSDART00000139543
|
MDM2 oncogene, E3 ubiquitin protein ligase |
|
| chr21_+_25651712 Show fit | 3.44 |
ENSDART00000135123
|
si:dkey-17e16.17 |
|
| chr6_+_49096966 Show fit | 2.89 |
ENSDART00000141042
ENSDART00000143369 |
solute carrier family 25 (mitochondrial carrier: glutamate), member 22 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.7 | GO:0071233 | response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031) |
| 1.1 | 4.5 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.2 | 4.3 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.5 | 4.1 | GO:1904030 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 1.2 | 3.5 | GO:1904019 | epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) |
| 0.3 | 3.0 | GO:0051898 | negative regulation of protein kinase B signaling(GO:0051898) |
| 0.1 | 2.7 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.5 | 2.5 | GO:0010524 | inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of calcium ion transport into cytosol(GO:0010524) positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) regulation of inhibitory G-protein coupled receptor phosphorylation(GO:1904323) positive regulation of inhibitory G-protein coupled receptor phosphorylation(GO:1904325) |
| 0.4 | 2.2 | GO:0090199 | regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.4 | 2.1 | GO:0043525 | regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.7 | 5.7 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 4.5 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.0 | 3.2 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 2.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 1.9 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.5 | 1.5 | GO:0098594 | mucin granule(GO:0098594) |
| 0.1 | 1.2 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 1.2 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.2 | 1.1 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.7 | GO:0070728 | leucine binding(GO:0070728) |
| 0.7 | 4.5 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.2 | 4.3 | GO:0005518 | collagen binding(GO:0005518) |
| 1.0 | 4.1 | GO:0047035 | testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.4 | 4.1 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 3.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 3.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.0 | 3.0 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 2.7 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.4 | 2.5 | GO:0060182 | apelin receptor activity(GO:0060182) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 2.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 1.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.0 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.9 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 0.6 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.4 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.3 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.3 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.3 | 3.5 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.2 | 1.3 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 0.9 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.7 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 0.5 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.2 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |