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Results for tp63

Z-value: 1.04

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Transcription factors associated with tp63

Gene Symbol Gene ID Gene Info
tp63
ENSDARG00000044356 tumor protein p63

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp63dr10_dc_chr6_+_28886741_288867830.932.7e-07Click!

Activity profile of tp63 motif

Sorted Z-values of tp63 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of tp63

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_25157675 5.05 ENSDART00000136984
fabp2
fatty acid binding protein 2, intestinal
chr24_+_35676505 3.21 ENSDART00000122734
cebpd
CCAAT/enhancer binding protein (C/EBP), delta
chr3_+_36146072 3.10 ENSDART00000148444
zgc:86896
zgc:86896
chr9_+_41720118 2.05

chr8_+_30491476 2.04 ENSDART00000062073
ENSDARG00000042329
ENSDARG00000042329
chr9_+_41301317 2.01 ENSDART00000000250
slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
chr23_+_14058972 1.90 ENSDART00000090864
lmod3
leiomodin 3 (fetal)
chr11_-_80746 1.88

chr17_-_14663139 1.80 ENSDART00000037371
ppp1r13ba
protein phosphatase 1, regulatory subunit 13Ba
chr19_+_22478256 1.80 ENSDART00000100181
sall3b
spalt-like transcription factor 3b
KN150108v1_-_8893 1.78 ENSDART00000167033
ENSDARG00000100513
ENSDARG00000100513
chr7_+_69418011 1.76 ENSDART00000166105
frem1a
Fras1 related extracellular matrix 1a
chr16_+_21098948 1.72 ENSDART00000006043
hoxa11b
homeobox A11b
chr10_-_5135388 1.68 ENSDART00000108587
sec31a
SEC31 homolog A, COPII coat complex component
chr1_+_46794847 1.59 ENSDART00000140846
lrrc58a
leucine rich repeat containing 58a
chr13_-_33137075 1.55 ENSDART00000138096
oip5-as1
oip5 antisense RNA 1
chr20_-_42821812 1.41 ENSDART00000138957
gpr31
G protein-coupled receptor 31
chr20_-_1293519 1.37 ENSDART00000152436
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr3_+_42380497 1.34 ENSDART00000163579
si:dkey-43p13.5
si:dkey-43p13.5
chr9_-_15453448 1.34 ENSDART00000124346
ENSDART00000010521
ENSDART00000103753
fn1a
fibronectin 1a
chr5_+_23585492 1.29 ENSDART00000135083
tp53
tumor protein p53
chr14_-_9216303 1.17 ENSDART00000054689
atoh8
atonal bHLH transcription factor 8
chr15_-_10532992 1.17 ENSDART00000175825
tenm4
teneurin transmembrane protein 4
chr8_-_4638117 1.10 ENSDART00000019828
zgc:63587
zgc:63587
chr17_-_43475725 1.09 ENSDART00000155313
hspa4l
heat shock protein 4 like
chr21_+_45693978 1.03 ENSDART00000160324
CABZ01102047.1
ENSDARG00000099648
chr23_+_25224499 0.96

chr22_+_16279764 0.96

chr11_-_11534819 0.90 ENSDART00000104254
krt15
keratin 15
chr16_+_21099550 0.85

chr19_-_31448000 0.84 ENSDART00000147504
bzw2
basic leucine zipper and W2 domains 2
chr18_+_17622557 0.77 ENSDART00000046891
cetp
cholesteryl ester transfer protein, plasma
chr4_+_23406078 0.77 ENSDART00000139543
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr8_-_12253026 0.76 ENSDART00000091612
dab2ipa
DAB2 interacting protein a
chr12_+_22455344 0.72 ENSDART00000172053
capgb
capping protein (actin filament), gelsolin-like b
chr20_-_25537241 0.68 ENSDART00000153266
itsn2a
intersectin 2a
chr10_+_5135537 0.67 ENSDART00000132627
ENSDART00000082295
zgc:113274
zgc:113274
chr3_+_21928819 0.65 ENSDART00000154622
kansl1b
KAT8 regulatory NSL complex subunit 1b
chr9_+_50609926 0.65 ENSDART00000098687
GRB14
growth factor receptor bound protein 14
chr16_+_41767229 0.58 ENSDART00000075937
mtdhb
metadherin b
chr10_-_40905193 0.58 ENSDART00000172089
pcna
proliferating cell nuclear antigen
chr24_+_41009372 0.42 ENSDART00000165952
CU633479.3
ENSDARG00000099523
chr16_+_21099213 0.41 ENSDART00000006043
hoxa11b
homeobox A11b
chr12_+_44829938 0.35 ENSDART00000098932
wbp2
WW domain binding protein 2
chr10_-_40904685 0.33

chr18_-_17410180 0.26 ENSDART00000060949
zfpm1
zinc finger protein, FOG family member 1
chr25_-_35530474 0.25

chr12_+_26579396 0.24 ENSDART00000144355
arhgap12b
Rho GTPase activating protein 12b
chr6_+_3120600 0.22 ENSDART00000151359
kdm4aa
lysine (K)-specific demethylase 4A, genome duplicate a
chr10_-_40905363 0.21 ENSDART00000076304
pcna
proliferating cell nuclear antigen
chr4_-_23405867 0.20

chr19_+_48166365 0.19

chr25_-_35742590 0.17 ENSDART00000073399
faap24
Fanconi anemia core complex associated protein 24
chr12_+_26579286 0.16 ENSDART00000144355
arhgap12b
Rho GTPase activating protein 12b
chr25_+_31501347 0.13 ENSDART00000153968
apba2a
amyloid beta (A4) precursor protein-binding, family A, member 2a
chr20_+_22813503 0.06

chr3_-_27989221 0.04 ENSDART00000151143
rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0045687 positive regulation of glial cell differentiation(GO:0045687) positive regulation of oligodendrocyte differentiation(GO:0048714)
0.3 1.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.3 1.2 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.3 2.0 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.3 0.8 GO:0055091 triglyceride-rich lipoprotein particle remodeling(GO:0034370) very-low-density lipoprotein particle remodeling(GO:0034372) reverse cholesterol transport(GO:0043691) phospholipid homeostasis(GO:0055091)
0.3 0.8 GO:1904019 epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035)
0.1 0.8 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1 0.8 GO:0006272 leading strand elongation(GO:0006272)
0.1 3.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 0.3 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.7 GO:0051014 actin filament severing(GO:0051014)
0.0 1.3 GO:0048484 enteric nervous system development(GO:0048484)
0.0 3.4 GO:0033993 response to lipid(GO:0033993)
0.0 1.8 GO:0033334 fin morphogenesis(GO:0033334)
0.0 0.1 GO:1901216 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.0 1.1 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 GO:0031430 M band(GO:0031430)
0.2 3.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.1 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.7 GO:0044545 NSL complex(GO:0044545)
0.0 2.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.7 GO:0001726 ruffle(GO:0001726)
0.0 0.9 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.5 5.1 GO:0005504 fatty acid binding(GO:0005504)
0.3 1.4 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.3 0.8 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.2 1.9 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.8 GO:0002039 p53 binding(GO:0002039)
0.1 0.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.8 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 3.1 GO:0051015 actin filament binding(GO:0051015)
0.0 1.8 GO:0060090 binding, bridging(GO:0060090)
0.0 1.2 GO:0042803 protein homodimerization activity(GO:0042803)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 0.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.7 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 0.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.8 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 0.8 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 3.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.1 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins