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Results for twist1a+twist1b+twist3

Z-value: 0.45

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Transcription factors associated with twist1a+twist1b+twist3

Gene Symbol Gene ID Gene Info
twist3
ENSDARG00000019646 twist3
twist1a
ENSDARG00000030402 twist family bHLH transcription factor 1a
twist1b
ENSDARG00000076010 twist family bHLH transcription factor 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
twist1adr10_dc_chr19_-_2399429_23994500.457.9e-02Click!
twist1bdr10_dc_chr16_+_19926776_199268080.185.1e-01Click!
twist3dr10_dc_chr23_+_2665_26710.077.8e-01Click!

Activity profile of twist1a+twist1b+twist3 motif

Sorted Z-values of twist1a+twist1b+twist3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of twist1a+twist1b+twist3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_17735989 1.06 ENSDART00000016658
chpt1
choline phosphotransferase 1
chr9_-_40212864 0.72 ENSDART00000166918
IKZF2
IKAROS family zinc finger 2
chr14_-_30747448 0.67 ENSDART00000002250
hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr14_-_30747259 0.60 ENSDART00000002250
hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr14_+_47229400 0.57 ENSDART00000136045
mgst2
microsomal glutathione S-transferase 2
chr17_-_25865861 0.55

chr20_-_22036656 0.46 ENSDART00000152290
daam1b
dishevelled associated activator of morphogenesis 1b
chr13_-_31165867 0.43 ENSDART00000030946
prdm8
PR domain containing 8
chr4_-_12792010 0.41 ENSDART00000067131
irak3
interleukin-1 receptor-associated kinase 3
chr1_-_5284684 0.41

chr4_-_17033790 0.39

chr9_-_40212643 0.34 ENSDART00000166918
IKZF2
IKAROS family zinc finger 2
chr20_+_36720896 0.33 ENSDART00000062895
srp9
signal recognition particle 9
chr16_-_31835463 0.31 ENSDART00000148389
chd4b
chromodomain helicase DNA binding protein 4b
chr13_-_47767713 0.29 ENSDART00000045475
itga9
integrin, alpha 9
chr15_-_16140187 0.28 ENSDART00000080413
srsf1a
serine/arginine-rich splicing factor 1a
chr6_+_30469823 0.23 ENSDART00000121492
FP236735.1
ENSDARG00000087805
chr18_-_40462054 0.22

chr14_-_30747372 0.22 ENSDART00000002250
hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr13_-_11667628 0.22 ENSDART00000079392
zmp:0000000662
zmp:0000000662
chr6_-_55411751 0.19 ENSDART00000159246
ENSDART00000158929
ctsa
cathepsin A
chr3_-_22082170 0.19 ENSDART00000155490
maptb
microtubule-associated protein tau b
chr20_-_22293402 0.17 ENSDART00000047624
tmem165
transmembrane protein 165
chr13_+_25356121 0.15 ENSDART00000057689
bag3
BCL2-associated athanogene 3
chr16_-_36061564 0.14 ENSDART00000175847
CABZ01065723.1
ENSDARG00000105999
chr9_-_40213104 0.14 ENSDART00000166918
IKZF2
IKAROS family zinc finger 2
chr13_+_25356184 0.12 ENSDART00000057689
bag3
BCL2-associated athanogene 3
chr6_-_10492439 0.12 ENSDART00000002247
sp3b
Sp3b transcription factor
chr3_+_24059652 0.10 ENSDART00000034762
prr15la
proline rich 15-like a
chr1_-_43323814 0.10 ENSDART00000148932
si:ch73-109d9.1
si:ch73-109d9.1
chr7_+_20829815 0.09 ENSDART00000173612
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr21_-_1412006 0.08

chr21_-_26678542 0.07 ENSDART00000053794
banf1
barrier to autointegration factor 1
chr4_+_1680973 0.05 ENSDART00000149826
ENSDART00000166437
ENSDART00000031135
ENSDART00000172300
ENSDART00000067446
slc38a4
solute carrier family 38, member 4
chr19_+_26838851 0.04 ENSDART00000136244
npr1a
natriuretic peptide receptor 1a
chr4_+_26507297 0.04 ENSDART00000160652
iqsec3a
IQ motif and Sec7 domain 3a
chr9_-_40213039 0.03 ENSDART00000166918
IKZF2
IKAROS family zinc finger 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.4 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.1 0.6 GO:0006691 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.1 0.3 GO:0010657 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.0 0.2 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.3 GO:0006448 regulation of translational elongation(GO:0006448)
0.0 0.4 GO:0014003 oligodendrocyte development(GO:0014003)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.3 1.5 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 0.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 0.3 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.0 GO:0004383 guanylate cyclase activity(GO:0004383)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.4 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.3 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.1 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus