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Results for vax2

Z-value: 0.55

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Transcription factors associated with vax2

Gene Symbol Gene ID Gene Info
vax2
ENSDARG00000058702 ventral anterior homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
vax2dr10_dc_chr7_-_8635989_8636026-0.911.4e-06Click!

Activity profile of vax2 motif

Sorted Z-values of vax2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of vax2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_34058331 2.77 ENSDART00000046599
zar1l
zygote arrest 1-like
chr5_+_37303599 2.57 ENSDART00000097754
ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr11_-_44539778 2.19 ENSDART00000161846
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr18_-_40718244 1.80 ENSDART00000077577
si:ch211-132b12.8
si:ch211-132b12.8
chr11_-_6442588 1.55 ENSDART00000137879
zgc:162969
zgc:162969
chr24_+_19270877 1.21

chr10_-_4641624 1.19 ENSDART00000163951
plppr1
phospholipid phosphatase related 1
chr2_+_6341404 1.17 ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr12_-_33256754 1.15 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr12_-_33256671 1.09 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr2_-_26941084 1.07 ENSDART00000134685
ENSDART00000056787
zgc:113691
zgc:113691
chr2_-_26941232 0.97 ENSDART00000134685
ENSDART00000056787
zgc:113691
zgc:113691
chr1_-_54570813 0.96 ENSDART00000098615
nanos3
nanos homolog 3
chr4_+_4825461 0.95 ENSDART00000150309
ptprz1b
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr25_-_28630138 0.95

chr11_-_18090243 0.93 ENSDART00000144659
zgc:173545
zgc:173545
chr12_-_33257026 0.93 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr12_+_33257120 0.89

chr2_-_601945 0.87

chr12_-_33256599 0.87 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr25_-_36678422 0.84 ENSDART00000087247
glg1a
golgi glycoprotein 1a
chr9_+_23813071 0.84

chr3_-_19890717 0.81 ENSDART00000104118
ENSDART00000170199
atxn7l3
ataxin 7-like 3
chr25_+_19302983 0.78

chr14_+_46362661 0.77 ENSDART00000025749
ttc9c
tetratricopeptide repeat domain 9C
chr12_-_33256934 0.74 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr21_-_13026036 0.74 ENSDART00000135623
fam219aa
family with sequence similarity 219, member Aa
chr15_+_21327206 0.71 ENSDART00000101000
gkup
glucuronokinase with putative uridyl pyrophosphorylase
chr4_-_62022037 0.70

chr2_-_26940965 0.70 ENSDART00000134685
ENSDART00000056787
zgc:113691
zgc:113691
chr20_+_29306863 0.70 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr21_+_31113731 0.69 ENSDART00000065366
st6gal1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr11_-_38856849 0.68 ENSDART00000113185
ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr13_-_36672424 0.64 ENSDART00000012357
sav1
salvador family WW domain containing protein 1
chr20_-_28898117 0.61 ENSDART00000049462
rab15
RAB15, member RAS oncogene family
chr8_+_24276275 0.61

chr25_-_13394261 0.61 ENSDART00000056721
ldhd
lactate dehydrogenase D
chr10_-_35377548 0.59 ENSDART00000131268
rhbdd2
rhomboid domain containing 2
chr16_-_31386496 0.59

chr5_+_37303707 0.58 ENSDART00000097754
ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr19_+_48731233 0.56

chr8_+_3364453 0.56 ENSDART00000164426
ctu1
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr20_+_29306677 0.52 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr13_-_8360779 0.51 ENSDART00000058107
mcfd2
multiple coagulation factor deficiency 2
chr11_-_44539726 0.49 ENSDART00000173360
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr21_-_2350090 0.47 ENSDART00000168946
si:ch211-241b2.4
si:ch211-241b2.4
chr20_+_35176069 0.47

chr20_-_37910887 0.46 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr19_+_48731140 0.45

chr19_+_5562075 0.45 ENSDART00000148794
jupb
junction plakoglobin b
chr16_+_23884575 0.44 ENSDART00000046922
rab13
RAB13, member RAS oncogene family
chr15_-_43402935 0.44 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr20_-_46079529 0.42 ENSDART00000153228
AL929237.3
ENSDARG00000096676
chr23_-_25853364 0.41 ENSDART00000110670
ENSDARG00000078574
ENSDARG00000078574
chr4_+_4825628 0.40 ENSDART00000150309
ptprz1b
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr14_+_29601073 0.39 ENSDART00000143763
fam149a
family with sequence similarity 149 member A
chr8_+_26040518 0.39 ENSDART00000009178
impdh2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr2_+_10209233 0.39 ENSDART00000160304
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr2_+_54267946 0.39 ENSDART00000015535
ctnnbl1
catenin, beta like 1
chr11_-_6442490 0.39 ENSDART00000137879
zgc:162969
zgc:162969
chr24_+_16402587 0.38 ENSDART00000164319
sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr20_-_38851375 0.37

chr21_-_13026077 0.35 ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr3_-_26657213 0.35

chr11_+_5522377 0.34 ENSDART00000013203
cse1l
CSE1 chromosome segregation 1-like (yeast)
chr23_-_33692244 0.32

chr17_+_1080921 0.31

chr12_-_49026424 0.31

chr10_-_2761480 0.30 ENSDART00000131749
ash2l
ash2 (absent, small, or homeotic)-like (Drosophila)
chr10_-_35377482 0.30 ENSDART00000131268
rhbdd2
rhomboid domain containing 2
chr12_+_19159391 0.28 ENSDART00000153428
tnrc6b
trinucleotide repeat containing 6b
chr17_+_28689850 0.27 ENSDART00000126967
strn3
striatin, calmodulin binding protein 3
chr12_+_19159234 0.27 ENSDART00000153428
tnrc6b
trinucleotide repeat containing 6b
chr2_+_54268010 0.26 ENSDART00000170799
ctnnbl1
catenin, beta like 1
chr25_-_12712431 0.25 ENSDART00000162750
ca5a
carbonic anhydrase Va
chr17_+_1799209 0.25 ENSDART00000112183
cep170b
centrosomal protein 170B
chr10_-_4641512 0.24 ENSDART00000163951
plppr1
phospholipid phosphatase related 1
chr16_-_42105733 0.24 ENSDART00000102798
zp3d.2
zona pellucida glycoprotein 3d tandem duplicate 2
chr20_+_29306945 0.24 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr17_+_8642373 0.23 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr21_+_10757086 0.23

chr16_-_42105636 0.23 ENSDART00000102798
zp3d.2
zona pellucida glycoprotein 3d tandem duplicate 2
chr14_+_29601252 0.23 ENSDART00000143763
fam149a
family with sequence similarity 149 member A
chr4_+_952596 0.23 ENSDART00000122535
rpap3
RNA polymerase II associated protein 3
chr9_-_11705194 0.21 ENSDART00000022358
zc3h15
zinc finger CCCH-type containing 15
chr21_+_17509116 0.20

chr3_-_19890791 0.20 ENSDART00000104118
ENSDART00000170199
atxn7l3
ataxin 7-like 3
chr1_-_5387933 0.20 ENSDART00000138891
ENSDART00000176913
pard3ba
par-3 family cell polarity regulator beta a
chr17_+_8642686 0.20 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr19_+_21783204 0.18 ENSDART00000024639
tshz1
teashirt zinc finger homeobox 1
chr9_+_26218474 0.17 ENSDART00000177394
CR391949.1
ENSDARG00000107108
chr13_-_36672285 0.17 ENSDART00000012357
sav1
salvador family WW domain containing protein 1
chr25_-_24440292 0.17 ENSDART00000156805
CR854832.1
ENSDARG00000096817
chr14_-_14353487 0.17 ENSDART00000172241
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr23_-_25853331 0.16 ENSDART00000110670
ENSDARG00000078574
ENSDARG00000078574
chr3_+_35277555 0.16

chr8_-_25015215 0.15 ENSDART00000170511
nfyal
nuclear transcription factor Y, alpha, like
chr23_+_28882409 0.15 ENSDART00000078171
pex14
peroxisomal biogenesis factor 14
chr6_+_3313515 0.14 ENSDART00000011785
rad54l
RAD54-like (S. cerevisiae)
chr4_-_1952230 0.14 ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr11_+_44414503 0.14

chr21_-_13875945 0.13 ENSDART00000143874
akna
AT-hook transcription factor
chr13_-_36672606 0.11 ENSDART00000179242
sav1
salvador family WW domain containing protein 1
chr16_-_15497269 0.11 ENSDART00000053754
has2
hyaluronan synthase 2
chr2_+_50873843 0.09

chr15_-_36490729 0.08

chr25_-_12712565 0.08 ENSDART00000162750
ca5a
carbonic anhydrase Va
chr23_-_2957203 0.07 ENSDART00000165955
zhx3
zinc fingers and homeoboxes 3
chr20_+_29307283 0.07 ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr15_-_11799447 0.03 ENSDART00000161445
fkrp
fukutin related protein
chr10_+_40362746 0.02 ENSDART00000062795
ENSDART00000113582
git2b
G protein-coupled receptor kinase interacting ArfGAP 2b
chr16_+_40396568 0.02 ENSDART00000139272
BX072576.2
ENSDARG00000090181
chr13_+_516546 0.01 ENSDART00000172469
ENSDART00000168523
ENSDART00000006892
tp53bp2a
tumor protein p53 binding protein, 2a
chr22_+_2074020 0.01 ENSDART00000106540
znf1161
zinc finger protein 1161
chr10_-_9294185 0.00

chr8_-_26210618 0.00 ENSDART00000133466
CR847503.1
ENSDARG00000092715

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.1 0.9 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 1.7 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 1.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.6 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.1 3.9 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 0.5 GO:1900151 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.1 1.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.3 GO:0007589 body fluid secretion(GO:0007589)
0.0 0.2 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.6 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 1.0 GO:0019827 stem cell population maintenance(GO:0019827)
0.0 0.4 GO:0046037 GMP biosynthetic process(GO:0006177) GTP biosynthetic process(GO:0006183) GMP metabolic process(GO:0046037)
0.0 0.1 GO:0046379 renal water homeostasis(GO:0003091) renal water transport(GO:0003097) extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.1 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.4 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.4 GO:0031297 replication fork processing(GO:0031297)
0.0 1.4 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.1 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.3 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.1 GO:1901910 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.6 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0002144 cytosolic tRNA wobble base thiouridylase complex(GO:0002144)
0.1 1.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.7 GO:0000421 autophagosome membrane(GO:0000421)
0.1 0.4 GO:0035101 FACT complex(GO:0035101)
0.0 0.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:1990429 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 1.0 GO:0043186 P granule(GO:0043186)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:1903231 mRNA binding involved in posttranscriptional gene silencing(GO:1903231)
0.7 4.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 0.9 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729) CCR5 chemokine receptor binding(GO:0031730)
0.2 0.6 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.1 1.2 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 0.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 3.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.5 GO:0032190 acrosin binding(GO:0032190)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.4 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 1.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 1.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.6 GO:0000049 tRNA binding(GO:0000049)
0.0 0.1 GO:0008486 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 1.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 ST GA13 PATHWAY G alpha 13 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 0.9 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.5 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.1 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import