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Results for xbp1
Z-value: 1.00
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Transcription factors associated with xbp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| xbp1 | dr10_dc_chr5_-_15448501_15448750 | 0.62 | 9.8e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of xbp1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_10609580 Show fit | 2.42 |
ENSDART00000102304
|
lectin, mannose-binding, 1 |
|
| chr13_+_13814142 Show fit | 2.09 |
ENSDART00000142997
|
eukaryotic translation initiation factor 2-alpha kinase 3 |
|
| chr11_+_30400284 Show fit | 2.09 |
ENSDART00000169833
|
expressed sequence EH507706 |
|
| chr10_-_34971985 Show fit | 1.86 |
ENSDART00000141201
|
cyclin A1 |
|
| chr1_-_8801877 Show fit | 1.71 |
ENSDART00000137821
|
mical-like 2b |
|
| chr8_-_32376710 Show fit | 1.70 |
ENSDART00000098850
|
lipase, endothelial |
|
| chr15_+_36075206 Show fit | 1.55 |
ENSDART00000019976
|
rhomboid domain containing 1 |
|
| chr21_+_10609341 Show fit | 1.50 |
ENSDART00000102304
|
lectin, mannose-binding, 1 |
|
| chr1_-_22617455 Show fit | 1.48 |
ENSDART00000137567
|
small integral membrane protein 14 |
|
| chr19_-_5186692 Show fit | 1.45 |
ENSDART00000037007
|
triosephosphate isomerase 1a |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | GO:1904029 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.1 | 3.2 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
| 0.1 | 2.3 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.3 | 2.1 | GO:2001106 | regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.2 | 2.1 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 2.1 | GO:0001666 | response to hypoxia(GO:0001666) |
| 0.1 | 1.8 | GO:0044818 | mitotic G2/M transition checkpoint(GO:0044818) |
| 0.0 | 1.8 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.3 | 1.7 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.0 | 1.7 | GO:0000045 | autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.6 | 1.9 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.3 | 1.8 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 1.8 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 1.5 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.2 | 1.4 | GO:0097134 | cyclin E1-CDK2 complex(GO:0097134) |
| 0.2 | 1.3 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.2 | 1.2 | GO:0005784 | Sec61 translocon complex(GO:0005784) |
| 0.1 | 1.2 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 1.1 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.9 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 3.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 2.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 2.2 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.4 | 2.1 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.1 | 2.1 | GO:0061608 | nuclear import signal receptor activity(GO:0061608) |
| 0.3 | 1.7 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.3 | 1.5 | GO:0016972 | flavin-linked sulfhydryl oxidase activity(GO:0016971) thiol oxidase activity(GO:0016972) |
| 0.5 | 1.4 | GO:0008929 | triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929) |
| 0.0 | 1.4 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 2.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.8 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 0.1 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 3.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 2.2 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 2.1 | REACTOME PERK REGULATED GENE EXPRESSION | Genes involved in PERK regulated gene expression |
| 0.0 | 2.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.3 | 1.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 1.1 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 0.8 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 0.8 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |