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Results for zbtb14
Z-value: 2.26
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Transcription factors associated with zbtb14
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zbtb14 | dr10_dc_chr24_-_42053682_42053815 | -0.32 | 2.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of zbtb14
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr24_+_32261533 Show fit | 7.60 |
ENSDART00000003745
|
vimentin |
|
| chr1_+_53286155 Show fit | 5.77 |
ENSDART00000139625
|
actin, alpha 1a, skeletal muscle |
|
| chr4_+_5733160 Show fit | 5.67 |
ENSDART00000110243
|
POU class 3 homeobox 2a |
|
| chr21_+_105327 Show fit | 5.14 |
ENSDART00000007672
|
dimethylglycine dehydrogenase |
|
| chr18_+_62936 Show fit | 4.90 |
ENSDART00000052638
|
solute carrier family 27 (fatty acid transporter), member 2a |
|
| chr23_-_20332076 Show fit | 4.73 |
ENSDART00000147326
|
laminin, beta 2 (laminin S) |
|
| chr4_-_73485204 Show fit | 4.52 |
ENSDART00000122898
|
PHD finger protein 21B |
|
| chr11_+_15796506 Show fit | 4.37 |
ENSDART00000081098
|
dorsal inhibitory axon guidance protein |
|
| chr7_+_67227810 Show fit | 4.22 |
ENSDART00000163840
|
glycine cleavage system protein H (aminomethyl carrier), b |
|
| chr2_-_58737903 Show fit | 4.05 |
|
|
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.7 | GO:0046653 | tetrahydrofolate metabolic process(GO:0046653) |
| 0.5 | 6.7 | GO:0046716 | muscle cell cellular homeostasis(GO:0046716) |
| 0.7 | 5.1 | GO:0072132 | mesenchyme morphogenesis(GO:0072132) |
| 0.1 | 5.0 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.5 | 4.9 | GO:0021754 | facial nucleus development(GO:0021754) |
| 0.7 | 4.7 | GO:0048680 | positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572) |
| 0.4 | 4.7 | GO:0016203 | muscle attachment(GO:0016203) |
| 0.1 | 4.6 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862) |
| 0.1 | 4.4 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.3 | 4.3 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.4 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.0 | 20.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 11.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 7.5 | GO:1990204 | oxidoreductase complex(GO:1990204) |
| 0.0 | 7.2 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.4 | 5.8 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.7 | 4.8 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.3 | 4.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 4.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 4.2 | GO:0030425 | dendrite(GO:0030425) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 31.8 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.2 | 8.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 6.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 5.8 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.1 | 5.5 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 5.5 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.7 | 5.1 | GO:0046997 | oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997) |
| 0.4 | 4.9 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) fatty acid transporter activity(GO:0015245) |
| 0.3 | 4.9 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 4.7 | GO:0005178 | integrin binding(GO:0005178) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 4.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 4.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 3.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 3.6 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.2 | 3.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 3.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 2.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 6.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 1.1 | 5.6 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.1 | 5.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 4.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 4.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.3 | 3.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 2.3 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.1 | 2.3 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 2.3 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 0.3 | 2.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |