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Results for zbtb3

Z-value: 0.74

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Transcription factors associated with zbtb3

Gene Symbol Gene ID Gene Info
zbtb3
ENSDARG00000036235 zinc finger and BTB domain containing 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zbtb3dr10_dc_chr14_+_35065189_35065257-0.552.6e-02Click!

Activity profile of zbtb3 motif

Sorted Z-values of zbtb3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of zbtb3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_3458086 2.16 ENSDART00000160977
ENSDART00000114168
CU469503.1
itga6a
ENSDARG00000099348
integrin, alpha 6a
chr16_-_42968807 1.79 ENSDART00000154757
txnipb
thioredoxin interacting protein b
chr3_-_60953138 1.49 ENSDART00000028219
pvalb4
parvalbumin 4
chr7_-_35161302 1.49 ENSDART00000026712
mmp2
matrix metallopeptidase 2
chr14_+_6239755 1.43 ENSDART00000097214
adam19b
ADAM metallopeptidase domain 19b
chr9_+_53788118 1.41 ENSDART00000125715
ENSDART00000166582
ENSDART00000162224
dct
dopachrome tautomerase
chr16_-_42968860 1.33 ENSDART00000102345
txnipb
thioredoxin interacting protein b
chr9_-_32942783 1.29 ENSDART00000060006
olig2
oligodendrocyte lineage transcription factor 2
chr7_-_25623974 1.29 ENSDART00000173602
cd99l2
CD99 molecule-like 2
chr9_-_34141609 1.22

chr12_+_24833569 1.12 ENSDART00000014868
calm3a
calmodulin 3a (phosphorylase kinase, delta)
chr20_-_42821812 1.11 ENSDART00000138957
gpr31
G protein-coupled receptor 31
chr7_-_25816549 1.09 ENSDART00000052989
ENSDART00000047951
ache
acetylcholinesterase
chr14_+_24637864 1.04 ENSDART00000170871
ppargc1b
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr7_-_25816655 0.98 ENSDART00000052989
ENSDART00000047951
ache
acetylcholinesterase
chr16_+_10531986 0.97 ENSDART00000161568
ino80e
INO80 complex subunit E
chr22_-_36552513 0.95 ENSDART00000129318
CABZ01045212.1
ENSDARG00000087525
chr17_+_34168095 0.93

chr23_+_6298911 0.92 ENSDART00000139795
syt2a
synaptotagmin IIa
chr22_+_528076 0.91

chr20_+_25441689 0.89 ENSDART00000063028
ctgfa
connective tissue growth factor a
chr22_-_29387056 0.84 ENSDART00000121599
pdgfba
platelet-derived growth factor beta polypeptide a
chr8_-_12171880 0.84 ENSDART00000132824
dab2ipa
DAB2 interacting protein a
chr1_+_50277442 0.82 ENSDART00000150420
otx1a
orthodenticle homeobox 1a
chr3_+_24327586 0.81 ENSDART00000153551
cbx6b
chromobox homolog 6b
chr11_-_23151247 0.81

chr17_-_45577704 0.78 ENSDART00000109831
BX088653.1
ENSDARG00000074434
chr16_+_10531926 0.75 ENSDART00000161568
ino80e
INO80 complex subunit E
chr16_-_32059848 0.73 ENSDART00000138701
gstk1
glutathione S-transferase kappa 1
chr1_-_53746151 0.72 ENSDART00000179565
CABZ01043826.1
ENSDARG00000108130
chr12_-_36191048 0.72 ENSDART00000177986
cep131
centrosomal protein 131
chr8_-_12171755 0.72 ENSDART00000132824
dab2ipa
DAB2 interacting protein a
chr5_+_19737802 0.70 ENSDART00000153643
ssh1a
slingshot protein phosphatase 1a
chr10_+_32007448 0.68 ENSDART00000019416
lhfp
lipoma HMGIC fusion partner
chr1_+_44113013 0.66 ENSDART00000059227
ndufs8a
NADH dehydrogenase (ubiquinone) Fe-S protein 8a
chr2_+_47885551 0.66

chr13_-_2083873 0.63 ENSDART00000129773
mlip
muscular LMNA-interacting protein
chr18_+_16948165 0.61

chr9_-_28464236 0.59 ENSDART00000146932
creb1b
cAMP responsive element binding protein 1b
chr13_+_23152038 0.58 ENSDART00000171676
khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr8_+_26103807 0.58

chr21_+_45325383 0.55 ENSDART00000029946
ube2b
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr7_-_25816498 0.53 ENSDART00000052989
ENSDART00000047951
ache
acetylcholinesterase
chr17_-_36894361 0.52 ENSDART00000176989
myo6b
myosin VIb
chr18_+_37034218 0.51

chr1_+_44141337 0.51

chr6_+_58704352 0.50 ENSDART00000172466
igsf8
immunoglobulin superfamily, member 8
chr20_+_38768950 0.48 ENSDART00000146544
mpv17
MpV17 mitochondrial inner membrane protein
chr18_+_48434068 0.48 ENSDART00000076861
fli1a
Fli-1 proto-oncogene, ETS transcription factor a
KN150171v1_+_3909 0.48 ENSDART00000171048
CABZ01071639.1
ENSDARG00000099435
chr1_-_44002772 0.48 ENSDART00000133210
si:dkey-28b4.8
si:dkey-28b4.8
chr25_+_13566205 0.47 ENSDART00000008989
ccdc113
coiled-coil domain containing 113
KN149781v1_+_4885 0.47 ENSDART00000165339
CDC37
cell division cycle 37
chr19_+_31944725 0.45 ENSDART00000136289
tmem64
transmembrane protein 64
chr21_-_45796826 0.44

chr19_-_2084281 0.43

chr16_-_24746483 0.43 ENSDART00000058959
pon3.2
paraoxonase 3, tandem duplicate 2
chr6_-_39009073 0.41 ENSDART00000150885
vdrb
vitamin D receptor b
chr25_-_35037680 0.38 ENSDART00000097651
si:ch211-87j1.4
si:ch211-87j1.4
chr16_-_24682800 0.37 ENSDART00000156407
ENSDART00000154072
si:dkey-56f14.4
si:dkey-56f14.4
chr14_-_1342450 0.34 ENSDART00000060417
cetn4
centrin 4
chr22_-_11106940 0.33 ENSDART00000016873
atp6ap2
ATPase, H+ transporting, lysosomal accessory protein 2
chr16_-_12095302 0.32 ENSDART00000148666
ENSDART00000029121
usp5
ubiquitin specific peptidase 5 (isopeptidase T)
chr14_-_33518100 0.32 ENSDART00000163877
ocrl
oculocerebrorenal syndrome of Lowe
chr24_+_6078848 0.31 ENSDART00000156419
si:ch211-37e10.2
si:ch211-37e10.2
chr14_-_23503974 0.30 ENSDART00000054264
nr3c1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr8_+_30912152 0.29 ENSDART00000171400
derl3
derlin 3
chr23_-_26961559 0.29 ENSDART00000038491
adcy6b
adenylate cyclase 6b
chr13_+_30968221 0.26 ENSDART00000014922
arhgap22
Rho GTPase activating protein 22
chr16_+_4865780 0.23 ENSDART00000039054
mecr
mitochondrial trans-2-enoyl-CoA reductase
chr8_-_8407754 0.21 ENSDART00000137382
cdk16
cyclin-dependent kinase 16
chr9_+_14052160 0.21 ENSDART00000124267
si:ch211-67e16.4
si:ch211-67e16.4
chr14_-_2873620 0.21

chr8_+_17493410 0.20 ENSDART00000147760
si:ch73-70k4.1
si:ch73-70k4.1
chr16_-_27289365 0.20 ENSDART00000126347
alg2
asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase)
chr13_+_23152160 0.20 ENSDART00000101134
khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr8_-_8408046 0.18 ENSDART00000132700
cdk16
cyclin-dependent kinase 16
chr24_+_6078791 0.18 ENSDART00000156419
si:ch211-37e10.2
si:ch211-37e10.2
chr3_+_52985863 0.17 ENSDART00000031234
stxbp2
syntaxin binding protein 2
chr17_+_52438099 0.17 ENSDART00000135246
dlst
dihydrolipoamide S-succinyltransferase
chr11_+_38858351 0.17 ENSDART00000155746
cdc42
cell division cycle 42
chr2_+_58658858 0.16

chr6_+_12805091 0.13 ENSDART00000091700
catip
ciliogenesis associated TTC17 interacting protein
chr14_+_1342695 0.11

chr7_-_25624212 0.11 ENSDART00000173505
cd99l2
CD99 molecule-like 2
chr16_-_24746425 0.09 ENSDART00000058959
pon3.2
paraoxonase 3, tandem duplicate 2
chr7_-_25624128 0.06 ENSDART00000173505
cd99l2
CD99 molecule-like 2
chr6_-_39008833 0.06 ENSDART00000150885
vdrb
vitamin D receptor b
chr14_-_33517822 0.05 ENSDART00000112268
ocrl
oculocerebrorenal syndrome of Lowe
chr5_+_61136262 0.05 ENSDART00000113508
hnrnpul1l
heterogeneous nuclear ribonucleoprotein U-like 1 like
chr8_-_52729505 0.04 ENSDART00000168241
tubb2b
tubulin, beta 2b
chr23_+_24711233 0.04

chr11_+_31362089 0.03 ENSDART00000158494
ENSDART00000173083
FO704610.1
ENSDARG00000100400
chr9_-_30692456 0.02

chr9_-_28464146 0.01 ENSDART00000137582
creb1b
cAMP responsive element binding protein 1b

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0006581 response to amphetamine(GO:0001975) acetylcholine catabolic process(GO:0006581) response to amine(GO:0014075)
0.4 1.8 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.4 1.3 GO:0021742 abducens nucleus development(GO:0021742)
0.3 1.6 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.2 0.5 GO:0046048 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.2 0.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 1.5 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.1 0.7 GO:0090317 negative regulation of intracellular protein transport(GO:0090317)
0.1 0.8 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 0.4 GO:0071869 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.1 1.4 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 0.2 GO:0051414 response to cortisol(GO:0051414) cellular response to cortisol stimulus(GO:0071387)
0.1 0.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.0 0.7 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.5 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 2.3 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.3 GO:0006171 cAMP biosynthetic process(GO:0006171)
0.0 1.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 1.0 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.3 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.5 GO:0060119 inner ear receptor cell development(GO:0060119)
0.0 1.7 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.5 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.7 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 0.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 0.8 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 1.2 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.7 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 0.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 2.2 GO:0008305 integrin complex(GO:0008305)
0.1 0.5 GO:0033503 HULC complex(GO:0033503)
0.1 0.6 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.3 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.0 1.5 GO:0030017 sarcomere(GO:0030017)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0004104 acetylcholinesterase activity(GO:0003990) cholinesterase activity(GO:0004104)
0.3 1.0 GO:0030331 estrogen receptor binding(GO:0030331)
0.2 0.6 GO:0005521 lamin binding(GO:0005521)
0.2 1.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 0.5 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.5 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.8 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.3 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.8 GO:0008143 poly(A) binding(GO:0008143)
0.0 3.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 2.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.0 0.6 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0034595 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.0 0.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.2 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.0 0.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0003707 steroid hormone receptor activity(GO:0003707)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression